Multiple mechanisms induce ectopic expression of LYL1 in subsets of T-ALL cell lines

Leukemia Research

Volumn 34, Issue 4, 2010, Pages 521-528

  Nagel, Stefan ^a   Venturini, Letizia ^b   Meyer, Corinna ^a   Kaufmann, Maren ^a   Scherr, Michaela ^b   Drexler, Hans G ^a   MacLeod, Roderick A F ^a  

^a DSMZ German Collection of Microorganisms and Cell Cultures ^*  (Germany)

^b HANNOVER MEDICAL SCHOOL   (Germany)

Author keywords

Basic helix loop helix; Homeobox; LIM domain; Microdeletion

Indexed keywords

BASIC HELIX LOOP HELIX TRANSCRIPTION FACTOR; BASIC HELIX LOOP HELIX TRANSCRIPTION FACTOR B2; INHIBITOR OF DIFFERENTIATION 1; INHIBITOR OF DIFFERENTIATION 2; INHIBITOR OF DIFFERENTIATION 3; LIM DOMAIN ONLY 2 PROTEIN; NUCLEIC ACID BINDING PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR HES 4; TRANSCRIPTION FACTOR HOXA10; TRANSCRIPTION FACTOR LYL 1; TRANSCRIPTION FACTOR NKX2.5; TRANSCRIPTION FACTOR SIL; TRANSCRIPTION FACTOR STIL; TRANSCRIPTION FACTOR TAL1; TRANSCRIPTION FACTOR TRMT 1; UNCLASSIFIED DRUG;

ACUTE LYMPHOBLASTIC LEUKEMIA; ARTICLE; BINDING SITE; CONTROLLED STUDY; GENE AMPLIFICATION; GENE EXPRESSION PROFILING; GENE OVEREXPRESSION; GENE REARRANGEMENT; GENE STRUCTURE; IMMUNOPRECIPITATION; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; REPORTER GENE; SEQUENCE ANALYSIS; T CELL LEUKEMIA;

BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; CELL LINE, TUMOR; CLUSTER ANALYSIS; GENE AMPLIFICATION; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, LEUKEMIC; HELA CELLS; HUMANS; JURKAT CELLS; NEOPLASM PROTEINS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PRECURSOR T-CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; SEQUENCE DELETION; SIGNAL TRANSDUCTION; TRANSFECTION; UP-REGULATION;

EID: 77049121268     PISSN: 01452126     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.leukres.2009.06.020     Document Type: Article

References (44)

1. Rothenberg E.V., Moore J.E., and Yui M.A. Launching the T-cell-lineage developmental programme. Nat Rev Immunol 8 1 (2008) 9-21
2. Aifantis I., Raetz E., and Buonamici S. Molecular pathogenesis of T-cell leukaemia and lymphoma. Nat Rev Immunol 8 5 (2008) 380-390
3. Ferrando A.A., Neuberg D.S., Staunton J., Loh M.L., Huard C., Raimondi S.C., et al. Gene expression signatures define novel oncogenic pathways in T cell acute lymphoblastic leukemia. Cancer Cell 1 1 (2002) 75-87
4. Graux C., Cools J., Michaux L., Vandenberghe P., and Hagemeijer A. Cytogenetics and molecular genetics of T-cell acute lymphoblastic leukemia: from thymocyte to lymphoblast. Leukemia 20 9 (2006) 1496-1510
5. Massari M.E., and Murre C. Helix-loop-helix proteins: regulators of transcription in eucaryotic organisms. Mol Cell Biol 20 2 (2000) 429-440
6. O'Neil J., Shank J., Cusson N., Murre C., and Kelliher M. TAL1/SCL induces leukemia by inhibiting the transcriptional activity of E47/HEB. Cancer Cell 5 6 (2004) 587-596
7. Zhong Y., Jiang L., Hiai H., Toyokuni S., and Yamada Y. Overexpression of a transcription factor LYL1 induces T- and B-cell lymphoma in mice. Oncogene 26 48 (2007) 6937-6947
8. Herblot S., Steff A.M., Hugo P., Aplan P.D., and Hoang T. SCL and LMO1 alter thymocyte differentiation: inhibition of E2A-HEB function and pre-T alpha chain expression. Nat Immunol 1 2 (2000) 138-144
9. Bain G., Engel I., Robanus Maandag E.C., te Riele H.P., Voland J.R., Sharp L.L., et al. E2A deficiency leads to abnormalities in alphabeta T-cell development and to rapid development of T-cell lymphomas. Mol Cell Biol 17 8 (1997) 4782-4791
10. Ferrando A.A., Herblot S., Palomero T., Hansen M., Hoang T., Fox E.A., et al. Biallelic transcriptional activation of oncogenic transcription factors in T-cell acute lymphoblastic leukemia. Blood 103 5 (2004) 1909-1911
11. Giroux S., Kaushik A.L., Capron C., Jalil A., Kelaidi C., Sablitzky F., et al. Lyl-1 and tal-1/scl, two genes encoding closely related bHLH transcription factors, display highly overlapping expression patterns during cardiovascular and hematopoietic ontogeny. Gene Expr Patterns 7 3 (2007) 215-226
12. Begley C.G., Aplan P.D., Davey M.P., Nakahara K., Tchorz K., Kurtzberg J., et al. Chromosomal translocation in a human leukemic stem-cell line disrupts the T-cell antigen receptor delta-chain diversity region and results in a previously unreported fusion transcript. Proc Natl Acad Sci USA 86 6 (1989) 2031-2035
13. Mellentin J.D., Smith S.D., and Cleary M.L. Lyl-1, a novel gene altered by chromosomal translocation in T cell leukemia, codes for a protein with a helix-loop-helix DNA binding motif. Cell 58 1 (1989) 77-83
14. Aplan P.D., Lombardi D.P., Ginsberg A.M., Cossman J., Bertness V.L., and Kirsch I.R. Disruption of the human SCL locus by "illegitimate" V-(D)-J recombinase activity. Science 250 4986 (1990) 1426-1429
15. Brown L., Cheng J.T., Chen Q., Siciliano M.J., Crist W., Buchanan G., et al. Site-specific recombination of the tal-1 gene is a common occurrence in human T cell leukemia. EMBO J 9 10 (1990) 3343-3351
16. Drexler H.G. Guide to Leukemia-Lymphoma Cell Lines (2005) Braunschweig (compact disc)
17. Nagel S., Burek C., Venturini L., Scherr M., Quentmeier H., Meyer C., et al. Comprehensive analysis of homeobox genes in Hodgkin lymphoma cell lines identifies dysregulated expression of HOXB9 mediated via ERK5 signaling and BMI1. Blood 109 7 (2007) 3015-3023
18. van Dongen J.J.M., Macintyre E.A., Gabert J.A., Delabesse E., Rossi V., Saglio G., et al. Standardized RT-PCR analysis of fusion gene transcripts from chromosome aberrations in acute leukemia for detection of minimal residual disease. Report of the BIOMED-1 Concerted Action: investigation of minimal residual disease in acute leukaemia. Leukemia 13 12 (1999) 1901-1928
19. Bernard O., Lecointe N., Jonveaux P., Souyri M., Mauchauffé M., Berger R., et al. Two site-specific deletions and t(1;14) translocation restricted to human T-cell acute leukemias disrupt the 5′ part of the tal-1 gene. Oncogene 6 8 (1991) 1477-1488
20. MacLeod R.A., Kaufmann M., and Drexler H.G. Cytogenetic harvesting of commonly used tumor cell lines. Nat Protoc 2 2 (2007) 372-382
21. Nagel S., Venturini L., Przybylski G.K., Grabarczyk P., Schmidt C.A., Meyer C., et al. Activation of miR-17-92 by NK-like homeodomain proteins suppresses apoptosis via reduction of E2F1 in T-cell acute lymphoblastic leukemia. Leuk Lymphoma 50 1 (2009) 101-108
22. Scherr M., Battmer K., Ganser A., and Eder M. Modulation of gene expression by lentiviral-mediated delivery of small interfering RNA. Cell Cycle 2 3 (2003) 251-257
23. Wang J., Jani-Sait S.N., Escalon E.A., Carroll A.J., de Jong P.J., Kirsch I.R., et al. The t(14;21)(q11; 2;q22) chromosomal translocation associated with T-cell acute lymphoblastic leukemia activates the BHLHB1 gene. Proc Natl Acad Sci USA 97 7 (2000) 3497-3502
24. Kawamata S., Du C., Li K., and Lavau C. Overexpression of the Notch target genes Hes in vivo induces lymphoid and myeloid alterations. Oncogene 21 24 (2002) 3855-3863
25. Sun X.H., Copeland N.G., Jenkins N.A., and Baltimore D. Id proteins Id1 and Id2 selectively inhibit DNA binding by one class of helix-loop-helix proteins. Mol Cell Biol 11 11 (1991) 5603-5611
26. Aggarwal B.B. Signalling pathways of the TNF superfamily: a double-edged sword. Nat Rev Immunol 3 9 (2003) 745-756
27. Screaton R.A., Conkright M.D., Katoh Y., Best J.L., Canettieri G., Jeffries S., et al. The CREB coactivator TORC2 functions as a calcium- and cAMP-sensitive coincidence detector. Cell 119 1 (2004) 61-74
28. Bedford F.K., Ashworth A., Enver T., and Wiedemann L.M. HEX: a novel homeobox gene expressed during haematopoiesis and conserved between mouse and human. Nucleic Acids Res 21 5 (1993) 1245-1249
29. Landry J.R., Kinston S., Knezevic K., de Bruijn M.F., Wilson N., Nottingham W.T., et al. Runx genes are direct targets of Scl/Tal1 in the yolk sac and fetal liver. Blood 111 6 (2008) 3005-3014
30. Soulier J., Clappier E., Cayuela J.M., Regnault A., García-Peydró M., Dombret H., et al. HOXA genes are included in genetic and biologic networks defining human acute T-cell leukemia (T-ALL). Blood 106 1 (2005) 274-286
31. Janssen J.W., Ludwig W.D., Sterry W., and Bartram C.R. SIL-TAL1 deletion in T-cell acute lymphoblastic leukemia. Leukemia 7 8 (1993) 1204-1210
32. Redon R., Ishikawa S., Fitch K.R., Feuk L., Perry G.H., Andrews T.D., et al. Global variation in copy number in the human genome. Nature 444 (2006) 444-454
33. Van Vlierberghe P., van Grotel M., Tchinda J., Lee C., Beverloo H.B., van der Spek P.J., et al. The recurrent SET-NUP214 fusion as a new HOXA activation mechanism in pediatric T-cell acute lymphoblastic leukemia. Blood 111 9 (2008) 4668-4680
34. Graux C., Cools J., Melotte C., Quentmeier H., Ferrando A., Levine R., et al. Fusion of NUP214 to ABL1 on amplified episomes in T-cell acute lymphoblastic leukemia. Nat Genet 36 10 (2004) 1084-1089
35. De Keersmaecker K., Graux C., Odero M.D., Mentens N., Somers R., Maertens J., et al. Fusion of EML1 to ABL1 in T-cell acute lymphoblastic leukemia with cryptic t(9;14)(q34;q32). Blood 105 12 (2005) 4849-4852
36. Van Vlierberghe P., van Grotel M., Beverloo H.B., Lee C., Helgason T., Buijs-Gladdines J., et al. The cryptic chromosomal deletion del(11)(p12p13) as a new activation mechanism of LMO2 in pediatric T-cell acute lymphoblastic leukemia. Blood 108 10 (2006) 3520-3529
37. Nagel S., Meyer C., Quentmeier H., Kaufmann M., Drexler H.G., and MacLeod R.A. MEF2C is activated by multiple mechanisms in a subset of T-acute lymphoblastic leukemia cell lines. Leukemia 22 3 (2008) 600-607
38. Barton K., Muthusamy N., Chanyangam M., Fischer C., Clendenin C., and Leiden J.M. Defective thymocyte proliferation and IL-2 production in transgenic mice expressing a dominant-negative form of CREB. Nature 379 6560 (1996) 81-85
39. Terme J.M., Wencker M., Favre-Bonvin A., Bex F., Gazzolo L., Duc Dodan M., et al. Cross talk between expression of the human T-cell leukemia virus type 1 Tax transactivator and the oncogenic bHLH transcription factor TAL1. J Virol 82 16 (2008) 7913-7922
40. Dik W.A., Pike-Overzet K., Weerkamp F., de Ridder D., de Haas E.F., Baert M.R., et al. New insights on human T cell development by quantitative T cell receptor gene rearrangement studies and gene expression profiling. J Exp Med 201 11 (2005) 1715-1723
41. Nagel S., Kaufmann M., Drexler H.G., and MacLeod R.A. The cardiac homeobox gene NKX2-5 is deregulated by juxtaposition with BCL11B in pediatric T-ALL cell lines via a novel t(5;14)(q35; 1;q32. 2). Cancer Res 63 17 (2003) 5329-5334
42. San-Marina S., Han Y., Suarez Saiz F., Trus M.R., and Minden M.D. Lyl1 interacts with CREB1 and alters expression of CREB1 target genes. Biochim Biophys Acta 1783 3 (2008) 503-517
43. Porcher C., Swat W., Rockwell K., Fujiwara Y., Alt F.W., and Orkin S.H. The T cell leukemia oncoprotein SCL/tal-1 is essential for development of all hematopoietic lineages. Cell 86 1 (1996) 47-57
44. Souroullas G.P., Salmon J.M., Sablitzky F., Curtis D.J., and Goodell M.A. Adult hematopoietic stem and progenitor cells require either Lyl1 or Scl for survival. Cell Stem Cell 4 2 (2009) 180-186