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Volumn 81, Issue 1, 2011, Pages 113-128

The two faces of ToxR: Activator of ompU, co-regulator of toxT in Vibrio cholerae

Author keywords

[No Author keywords available]

Indexed keywords

TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR TCPP; TRANSCRIPTION FACTOR TOXR; UNCLASSIFIED DRUG;

EID: 79959539601     PISSN: 0950382X     EISSN: 13652958     Source Type: Journal    
DOI: 10.1111/j.1365-2958.2011.07681.x     Document Type: Article
Times cited : (23)

References (45)
  • 1
    • 0036583638 scopus 로고    scopus 로고
    • Tandem DNA recognition by PhoB, a two-component signal transduction transcriptional activator
    • Blanco, A.G., Sola, M., Gomis-Ruth, F.X., and Coll, M. (2002) Tandem DNA recognition by PhoB, a two-component signal transduction transcriptional activator. Structure 10: 701-713.
    • (2002) Structure , vol.10 , pp. 701-713
    • Blanco, A.G.1    Sola, M.2    Gomis-Ruth, F.X.3    Coll, M.4
  • 2
    • 0030931193 scopus 로고    scopus 로고
    • Phase variation in tcpH modulates expression of the ToxR regulon in Vibrio cholerae
    • Carroll, P.A., Tashima, K.T., Rogers, M.B., DiRita, V.J., and Calderwood, S.B. (1997) Phase variation in tcpH modulates expression of the ToxR regulon in Vibrio cholerae. Mol Microbiol 25: 1099-1111.
    • (1997) Mol Microbiol , vol.25 , pp. 1099-1111
    • Carroll, P.A.1    Tashima, K.T.2    Rogers, M.B.3    DiRita, V.J.4    Calderwood, S.B.5
  • 3
    • 0031015444 scopus 로고    scopus 로고
    • A branch in the ToxR regulatory cascade of Vibrio cholerae revealed by characterization of toxT mutant strains
    • Champion, G.A., Neely, M.N., Brennan, M.A., and DiRita, V.J. (1997) A branch in the ToxR regulatory cascade of Vibrio cholerae revealed by characterization of toxT mutant strains. Mol Microbiol 23: 323-331.
    • (1997) Mol Microbiol , vol.23 , pp. 323-331
    • Champion, G.A.1    Neely, M.N.2    Brennan, M.A.3    DiRita, V.J.4
  • 4
    • 0031854047 scopus 로고    scopus 로고
    • Analysis of ToxR-dependent transcription activation of ompU, the gene encoding a major envelope protein in Vibrio cholerae
    • Crawford, J.A., Kaper, J.B., and DiRita, V.J. (1998) Analysis of ToxR-dependent transcription activation of ompU, the gene encoding a major envelope protein in Vibrio cholerae. Mol Microbiol 29: 235-246.
    • (1998) Mol Microbiol , vol.29 , pp. 235-246
    • Crawford, J.A.1    Kaper, J.B.2    DiRita, V.J.3
  • 5
    • 0037340113 scopus 로고    scopus 로고
    • Membrane localization of the ToxR winged-helix domain is required for TcpP-mediated virulence gene activation in Vibrio cholerae
    • Crawford, J.A., Krukonis, E.S., and DiRita, V.J. (2003) Membrane localization of the ToxR winged-helix domain is required for TcpP-mediated virulence gene activation in Vibrio cholerae. Mol Microbiol 47: 1459-1473.
    • (2003) Mol Microbiol , vol.47 , pp. 1459-1473
    • Crawford, J.A.1    Krukonis, E.S.2    DiRita, V.J.3
  • 6
    • 0026098804 scopus 로고
    • Periplasmic interaction between two membrane regulatory proteins, ToxR and ToxS, results in signal transduction and transcriptional activation
    • DiRita, V.J., and Mekalanos, J.J. (1991) Periplasmic interaction between two membrane regulatory proteins, ToxR and ToxS, results in signal transduction and transcriptional activation. Cell 64: 29-37.
    • (1991) Cell , vol.64 , pp. 29-37
    • DiRita, V.J.1    Mekalanos, J.J.2
  • 8
    • 0034708205 scopus 로고    scopus 로고
    • Structure of the winged-helix protein hRFX1 reveals a new mode of DNA binding
    • Gajiwala, K.S., Chen, H., Cornille, F., Roques, B.P., Reith, W., Mach, B., and Burley, S.K. (2000) Structure of the winged-helix protein hRFX1 reveals a new mode of DNA binding. Nature 403: 916-921.
    • (2000) Nature , vol.403 , pp. 916-921
    • Gajiwala, K.S.1    Chen, H.2    Cornille, F.3    Roques, B.P.4    Reith, W.5    Mach, B.6    Burley, S.K.7
  • 9
    • 77957727984 scopus 로고    scopus 로고
    • Identification of the TcpP-binding site in the toxT promoter of Vibrio cholerae and the role of ToxR in TcpP-mediated activation
    • Goss, T.J., Seaborn, C.P., Gray, M.D., and Krukonis, E.S. (2010) Identification of the TcpP-binding site in the toxT promoter of Vibrio cholerae and the role of ToxR in TcpP-mediated activation. Infect Immun 78: 4122-4133.
    • (2010) Infect Immun , vol.78 , pp. 4122-4133
    • Goss, T.J.1    Seaborn, C.P.2    Gray, M.D.3    Krukonis, E.S.4
  • 10
    • 0031930690 scopus 로고    scopus 로고
    • TcpP protein is a positive regulator of virulence gene expression in Vibrio cholerae
    • Häse, C.C., and Mekalanos, J.J. (1998) TcpP protein is a positive regulator of virulence gene expression in Vibrio cholerae. Proc Natl Acad Sci USA 95: 730-734.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 730-734
    • Häse, C.C.1    Mekalanos, J.J.2
  • 11
    • 0028027746 scopus 로고
    • Transcriptional control of toxT, a regulatory gene in the ToxR regulon of Vibrio cholerae
    • Higgins, D.E., and DiRita, V.J. (1994) Transcriptional control of toxT, a regulatory gene in the ToxR regulon of Vibrio cholerae. Mol Microbiol 14: 17-29.
    • (1994) Mol Microbiol , vol.14 , pp. 17-29
    • Higgins, D.E.1    DiRita, V.J.2
  • 12
    • 0032524908 scopus 로고    scopus 로고
    • RICK, a novel protein kinase containing a caspase recruitment domain, interacts with CLARP and regulates CD95-mediated apoptosis
    • Inohara, N., Peso, L., Koseki, T., Chen, S., and Nunez, G. (1998) RICK, a novel protein kinase containing a caspase recruitment domain, interacts with CLARP and regulates CD95-mediated apoptosis. J Biol Chem 273: 12296-12300.
    • (1998) J Biol Chem , vol.273 , pp. 12296-12300
    • Inohara, N.1    Peso, L.2    Koseki, T.3    Chen, S.4    Nunez, G.5
  • 13
    • 0032510783 scopus 로고    scopus 로고
    • A bacterial two-hybrid system based on a reconstituted signal transduction pathway
    • Karimova, G., Pidoux, J., Ullmann, A., and Ladant, D. (1998) A bacterial two-hybrid system based on a reconstituted signal transduction pathway. Proc Natl Acad Sci USA 95: 5752-5756.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 5752-5756
    • Karimova, G.1    Pidoux, J.2    Ullmann, A.3    Ladant, D.4
  • 14
    • 0035151432 scopus 로고    scopus 로고
    • Protein-protein interaction between Bacillus stearothermophilus tyrosyl-tRNA synthetase subdomains revealed by a bacterial two-hybrid system
    • Karimova, G., Ullmann, A., and Ladant, D. (2001) Protein-protein interaction between Bacillus stearothermophilus tyrosyl-tRNA synthetase subdomains revealed by a bacterial two-hybrid system. J Mol Microbiol Biotechnol 3: 73-82.
    • (2001) J Mol Microbiol Biotechnol , vol.3 , pp. 73-82
    • Karimova, G.1    Ullmann, A.2    Ladant, D.3
  • 15
    • 15244361175 scopus 로고    scopus 로고
    • Interaction network among Escherichia coli membrane proteins involved in cell division as revealed by bacterial two-hybrid analysis
    • Karimova, G., Dautin, N., and Ladant, D. (2005) Interaction network among Escherichia coli membrane proteins involved in cell division as revealed by bacterial two-hybrid analysis. J Bacteriol 187: 2233-2243.
    • (2005) J Bacteriol , vol.187 , pp. 2233-2243
    • Karimova, G.1    Dautin, N.2    Ladant, D.3
  • 16
    • 0029160348 scopus 로고
    • Gene activation by the Escherichia coli positive regulator OmpR: a mutational study of the DNA-binding domain of OmpR
    • Kato, N., Tsuzuki, M., Aiba, H., and Mizuno, T. (1995) Gene activation by the Escherichia coli positive regulator OmpR: a mutational study of the DNA-binding domain of OmpR. Mol Gen Genet 248: 399-406.
    • (1995) Mol Gen Genet , vol.248 , pp. 399-406
    • Kato, N.1    Tsuzuki, M.2    Aiba, H.3    Mizuno, T.4
  • 17
    • 0029938842 scopus 로고    scopus 로고
    • Suppressor mutations in alpha-subunit of RNA polymerase for a mutant of the positive regulator, OmpR, in Escherichia coli
    • Kato, N., Aiba, H., and Mizuno, T. (1996) Suppressor mutations in alpha-subunit of RNA polymerase for a mutant of the positive regulator, OmpR, in Escherichia coli. FEMS Microbiol Lett 139: 175-180.
    • (1996) FEMS Microbiol Lett , vol.139 , pp. 175-180
    • Kato, N.1    Aiba, H.2    Mizuno, T.3
  • 18
    • 0042671266 scopus 로고    scopus 로고
    • DNA binding and ToxR responsiveness by the wing domain of TcpP, an activator of virulence gene expression in Vibrio cholerae
    • Krukonis, E.S., and DiRita, V.J. (2003) DNA binding and ToxR responsiveness by the wing domain of TcpP, an activator of virulence gene expression in Vibrio cholerae. Mol Cell 12: 157-165.
    • (2003) Mol Cell , vol.12 , pp. 157-165
    • Krukonis, E.S.1    DiRita, V.J.2
  • 19
    • 0033815224 scopus 로고    scopus 로고
    • The Vibrio cholerae ToxR/TcpP/ToxT virulence cascade: distinct roles for two membrane-localized transcriptional activators on a single promoter
    • Krukonis, E.S., Yu, R.R., and Dirita, V.J. (2000) The Vibrio cholerae ToxR/TcpP/ToxT virulence cascade: distinct roles for two membrane-localized transcriptional activators on a single promoter. Mol Microbiol 38: 67-84.
    • (2000) Mol Microbiol , vol.38 , pp. 67-84
    • Krukonis, E.S.1    Yu, R.R.2    Dirita, V.J.3
  • 20
    • 0023949676 scopus 로고
    • Volunteer studies of deletion mutants of Vibrio cholerae O1 prepared by recombinant techniques
    • Levine, M.M., Kaper, J.B., Herringtion, D., Losonsky, G., Morris, J.G., Clements, M.L., etal. (1988) Volunteer studies of deletion mutants of Vibrio cholerae O1 prepared by recombinant techniques. Infect Immun 56: 161-167.
    • (1988) Infect Immun , vol.56 , pp. 161-167
    • Levine, M.M.1    Kaper, J.B.2    Herringtion, D.3    Losonsky, G.4    Morris, J.G.5    Clements, M.L.6
  • 21
    • 0033982811 scopus 로고    scopus 로고
    • Molecular cloning and transcriptional regulation of ompT, a ToxR-repressed gene in Vibrio cholerae
    • Li, C.C., Crawford, J.A., DiRita, V.J., and Kaper, J.B. (2000) Molecular cloning and transcriptional regulation of ompT, a ToxR-repressed gene in Vibrio cholerae. Mol Microbiol 35: 189-203.
    • (2000) Mol Microbiol , vol.35 , pp. 189-203
    • Li, C.C.1    Crawford, J.A.2    DiRita, V.J.3    Kaper, J.B.4
  • 22
    • 0032936785 scopus 로고    scopus 로고
    • A new use for the 'wing' of the 'winged' helix-turn-helix motif in the HSF-DNA cocrystal
    • Littlefield, O., and Nelson, H.C.M. (1999) A new use for the 'wing' of the 'winged' helix-turn-helix motif in the HSF-DNA cocrystal. Nat Struct Biol 6: 464-470.
    • (1999) Nat Struct Biol , vol.6 , pp. 464-470
    • Littlefield, O.1    Nelson, H.C.M.2
  • 23
    • 0031566431 scopus 로고    scopus 로고
    • Structural relationships in the OmpR family of winged-helix transcription factors
    • Martinez-Hackert, E., and Stock, A.M. (1997) Structural relationships in the OmpR family of winged-helix transcription factors. J Mol Biol 269: 301-312.
    • (1997) J Mol Biol , vol.269 , pp. 301-312
    • Martinez-Hackert, E.1    Stock, A.M.2
  • 24
    • 0031568318 scopus 로고    scopus 로고
    • The DNA-binding domain of OmpR: crystal structures of a winged helix transcription factor
    • Martínez-Hackert, E., and Stock, A.M. (1997) The DNA-binding domain of OmpR: crystal structures of a winged helix transcription factor. Structure 5: 109-124.
    • (1997) Structure , vol.5 , pp. 109-124
    • Martínez-Hackert, E.1    Stock, A.M.2
  • 25
    • 28044455049 scopus 로고    scopus 로고
    • Degradation of the membrane-localized virulence activator TcpP by the YaeL protease in Vibrio cholerae
    • Matson, J.S., and DiRita, V.J. (2005) Degradation of the membrane-localized virulence activator TcpP by the YaeL protease in Vibrio cholerae. Proc Natl Acad Sci USA 102: 16403-16408.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 16403-16408
    • Matson, J.S.1    DiRita, V.J.2
  • 26
    • 0021021637 scopus 로고
    • Cholera toxin genes: nucleotide sequence, deletion analysis and vaccine development
    • Mekalanos, J.J., Swartz, D.J., Pearson, G.D.N., Harford, N., Groyne, F., and de Wilde, M. (1983) Cholera toxin genes: nucleotide sequence, deletion analysis and vaccine development. Nature 306: 551-557.
    • (1983) Nature , vol.306 , pp. 551-557
    • Mekalanos, J.J.1    Swartz, D.J.2    Pearson, G.D.N.3    Harford, N.4    Groyne, F.5    de Wilde, M.6
  • 27
    • 0003785155 scopus 로고
    • Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press.
    • Miller, J.H. (1972) Experiments in Molecular Genetics. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press.
    • (1972) Experiments in Molecular Genetics
    • Miller, J.H.1
  • 28
    • 0542390231 scopus 로고
    • Synthesis of cholera toxin is positively regulated at the transcriptional level by ToxR
    • Miller, V.L., and Mekalanos, J.J. (1984) Synthesis of cholera toxin is positively regulated at the transcriptional level by ToxR. Proc Natl Acad Sci USA 81: 3471-3475.
    • (1984) Proc Natl Acad Sci USA , vol.81 , pp. 3471-3475
    • Miller, V.L.1    Mekalanos, J.J.2
  • 29
    • 0023667819 scopus 로고
    • Cholera toxin transcriptional activator ToxR is a transmembrane DNA binding protein
    • Miller, V.L., Taylor, R.K., and Mekalanos, J.J. (1987) Cholera toxin transcriptional activator ToxR is a transmembrane DNA binding protein. Cell 48: 271-279.
    • (1987) Cell , vol.48 , pp. 271-279
    • Miller, V.L.1    Taylor, R.K.2    Mekalanos, J.J.3
  • 30
    • 0032856768 scopus 로고    scopus 로고
    • Differential transcription of the tcpPH operon confers biotype-specific control of the Vibrio cholerae ToxR virulence regulon
    • Murley, Y.M., Carroll, P.A., Skorupski, K., Taylor, R.K., and Calderwood, S.B. (1999) Differential transcription of the tcpPH operon confers biotype-specific control of the Vibrio cholerae ToxR virulence regulon. Infect Immun 67: 5117-5123.
    • (1999) Infect Immun , vol.67 , pp. 5117-5123
    • Murley, Y.M.1    Carroll, P.A.2    Skorupski, K.3    Taylor, R.K.4    Calderwood, S.B.5
  • 31
    • 0033941006 scopus 로고    scopus 로고
    • Vibrio cholerae H-NS silences virulence gene expression at multiple steps in the ToxR regulatory cascade
    • Nye, M.B., Pfau, J.D., Skorupski, K., and Taylor, R.K. (2000) Vibrio cholerae H-NS silences virulence gene expression at multiple steps in the ToxR regulatory cascade. J Bacteriol 182: 4295-4303.
    • (2000) J Bacteriol , vol.182 , pp. 4295-4303
    • Nye, M.B.1    Pfau, J.D.2    Skorupski, K.3    Taylor, R.K.4
  • 32
    • 0034602919 scopus 로고    scopus 로고
    • Structural comparison of the PhoB and OmpR DNA-binding/transactivation domains and the arrangement of PhoB molecules on the phosphate box
    • Okamura, H., Hanaoka, S., Nagadoi, A., Makino, K., and Nishimura, Y. (2000) Structural comparison of the PhoB and OmpR DNA-binding/transactivation domains and the arrangement of PhoB molecules on the phosphate box. J Mol Biol 295: 1225-1236.
    • (2000) J Mol Biol , vol.295 , pp. 1225-1236
    • Okamura, H.1    Hanaoka, S.2    Nagadoi, A.3    Makino, K.4    Nishimura, Y.5
  • 33
    • 0026715095 scopus 로고
    • ToxR proteins with substitutions in residues conserved with OmpR fail to activate transcription from the cholera toxin promoter
    • Ottemann, K.M., DiRita, V.J., and Mekalanos, J.J. (1992) ToxR proteins with substitutions in residues conserved with OmpR fail to activate transcription from the cholera toxin promoter. J Bacteriol 174: 6807-6814.
    • (1992) J Bacteriol , vol.174 , pp. 6807-6814
    • Ottemann, K.M.1    DiRita, V.J.2    Mekalanos, J.J.3
  • 34
    • 0023700080 scopus 로고
    • Characterization of the Vibrio cholerae ToxR regulon: identification of novel genes involved in intestinal colonization
    • Peterson, K.M., and Mekalanos, J.J. (1988) Characterization of the Vibrio cholerae ToxR regulon: identification of novel genes involved in intestinal colonization. Infect Immun 56: 2822-2829.
    • (1988) Infect Immun , vol.56 , pp. 2822-2829
    • Peterson, K.M.1    Mekalanos, J.J.2
  • 36
    • 0028131766 scopus 로고
    • OmpR Mutants Specifically Defective for Transcriptional Activation
    • Pratt, L.A., and Silhavy, T.J. (1994) OmpR Mutants Specifically Defective for Transcriptional Activation. J Mol Biol 243: 579-594.
    • (1994) J Mol Biol , vol.243 , pp. 579-594
    • Pratt, L.A.1    Silhavy, T.J.2
  • 37
    • 0034730163 scopus 로고    scopus 로고
    • Altered expression of the ToxR-regulated porins OmpU and OmpT dimishes Vibrio cholerae bile resistance, virulence factor expression, and intestinal colonization
    • Provenzano, D., and Klose, K.E. (2000) Altered expression of the ToxR-regulated porins OmpU and OmpT dimishes Vibrio cholerae bile resistance, virulence factor expression, and intestinal colonization. Proc Natl Acad Sci USA 97: 10220-10224.
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 10220-10224
    • Provenzano, D.1    Klose, K.E.2
  • 38
    • 77954065271 scopus 로고    scopus 로고
    • I-TASSER: a unified platform for automated protein structure and function prediction
    • Roy, A., Kucukural, A., and Zhang, Y. (2010) I-TASSER: a unified platform for automated protein structure and function prediction. Nat Protoc 5: 725-738.
    • (2010) Nat Protoc , vol.5 , pp. 725-738
    • Roy, A.1    Kucukural, A.2    Zhang, Y.3
  • 39
    • 0039391898 scopus 로고
    • Use of phoA gene fusions to identify a pilus colonization factor coordinately regulated with cholera toxin
    • Taylor, R.K., Miller, V.L., Furlong, D.B., and Mekalanos, J.J. (1987) Use of phoA gene fusions to identify a pilus colonization factor coordinately regulated with cholera toxin. Proc Natl Acad Sci USA 84: 2833-2837.
    • (1987) Proc Natl Acad Sci USA , vol.84 , pp. 2833-2837
    • Taylor, R.K.1    Miller, V.L.2    Furlong, D.B.3    Mekalanos, J.J.4
  • 40
    • 34447557139 scopus 로고    scopus 로고
    • Cholera unveiled
    • WHO In World Health Organization
    • WHO (2003) Cholera unveiled. In Global Task Force on Cholera Control. World Health Organization, pp. 1-12.
    • (2003) Global Task Force on Cholera Control , pp. 1-12
  • 41
    • 33645471024 scopus 로고    scopus 로고
    • The toxbox: specific DNA sequence requirements for activation of Vibrio cholerae virulence genes by ToxT
    • Withey, J.H., and DiRita, V.J. (2006) The toxbox: specific DNA sequence requirements for activation of Vibrio cholerae virulence genes by ToxT. Mol Microbiol 59: 1779-1789.
    • (2006) Mol Microbiol , vol.59 , pp. 1779-1789
    • Withey, J.H.1    DiRita, V.J.2
  • 42
    • 44349089769 scopus 로고    scopus 로고
    • Water-mediated interactions between DNA and PhoB DNA-binding/transactivation domain: NMR-restrained molecular dynamics in explicit water environment
    • Yamane, T., Okamura, H., Ikeguchi, M., Nishimura, Y., and Kidera, A. (2008) Water-mediated interactions between DNA and PhoB DNA-binding/transactivation domain: NMR-restrained molecular dynamics in explicit water environment. Proteins 71: 1970-1983.
    • (2008) Proteins , vol.71 , pp. 1970-1983
    • Yamane, T.1    Okamura, H.2    Ikeguchi, M.3    Nishimura, Y.4    Kidera, A.5
  • 43
    • 0036195527 scopus 로고    scopus 로고
    • Regulation of gene expression in Vibrio cholerae by ToxT involves both antirepression and RNA polymerase stimulation
    • Yu, R.R., and DiRita, V.J. (2002) Regulation of gene expression in Vibrio cholerae by ToxT involves both antirepression and RNA polymerase stimulation. Mol Microbiol 43: 119-134.
    • (2002) Mol Microbiol , vol.43 , pp. 119-134
    • Yu, R.R.1    DiRita, V.J.2
  • 44
    • 39449115394 scopus 로고    scopus 로고
    • I-TASSER server for protein 3D structure prediction
    • 1-8.
    • Zhang, Y. (2008) I-TASSER server for protein 3D structure prediction. BMC Bioinformatics 9: #40, 1-8.
    • (2008) BMC Bioinformatics , vol.9
    • Zhang, Y.1
  • 45
    • 74249106219 scopus 로고    scopus 로고
    • I-TASSER: fully automated protein structure prediction in CASP8
    • Zhang, Y. (2009) I-TASSER: fully automated protein structure prediction in CASP8. Proteins 77 (Suppl. 9): 100-113.
    • (2009) Proteins , vol.77 , Issue.9 SUPPL. , pp. 100-113
    • Zhang, Y.1


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