Structural and functional studies indicating altered redox properties of hemoglobin E: Implications for production of bioactive nitric oxide

Journal of Biological Chemistry

Volumn 286, Issue 26, 2011, Pages 23452-23466

  Roche, Camille J ^a   Malashkevich, Vladimir ^a   Balazs, Tatiana C ^a   Dantsker, David ^a   Chen, Qiuying ^a   Moreira, Juan ^a   Almo, Steven C ^a   Friedman, Joel M ^a   Hirsch, Rhoda Elison ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALLOSTERIC TRANSITION; BINDING PROPERTIES; CLINICAL MANIFESTATION; L-CYSTEINE; MICROENVIRONMENTS; NITRITE REDUCTASE; NITRITE REDUCTION; OVERALL RATE; PATHOPHYSIOLOGICAL; PATHOPHYSIOLOGY; PHYSIOLOGICAL PH; RATE OF REDUCTION; RED BLOOD CELL; REDOX POTENTIALS; REDOX PROPERTY; SOL-GEL ENCAPSULATION;

AMINO ACIDS; BINDING ENERGY; BLOOD; CARBON MONOXIDE; ENZYME ACTIVITY; HEMOGLOBIN; HYDROGEN BONDS; PH; REDOX REACTIONS;

NITRIC OXIDE;

CARBON MONOXIDE; CYSTEINE; DEOXYHEMOGLOBIN; HEMOGLOBIN A; HEMOGLOBIN E; METHEMOGLOBIN; METHEMOGLOBIN E; NITRIC OXIDE; NITRITE; NITRITE REDUCTASE; OXYGEN; UNCLASSIFIED DRUG;

ALLOSTERISM; ARTICLE; BETA THALASSEMIA; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENCAPSULATION; ENZYME ACTIVITY; GENE MUTATION; HYDROGEN BOND; MOUSE; NONHUMAN; OXIDATION REDUCTION POTENTIAL; OXIDATION REDUCTION REACTION; PATHOPHYSIOLOGY; PH; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN FUNCTION; PROTEIN STRUCTURE; PROTEIN TERTIARY STRUCTURE;

ALLOSTERIC REGULATION; CATALYSIS; CRYSTALLOGRAPHY, X-RAY; HEMOGLOBIN E; HUMANS; MODELS, MOLECULAR; MUTATION; NITRIC OXIDE; OXIDATION-REDUCTION; OXYGEN; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 79959535344     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.183186     Document Type: Article

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