A new β-chain haemoglobin variant with increased oxygen affinity: Hb Roma [β115(g17)Ala → Val]

Biochimica et Biophysica Acta - General Subjects

Volumn 1800, Issue 3, 2010, Pages 327-335

  Manconi, Barbara ^a   De Rosa, Maria Cristina ^b   Cappabianca, Maria Pia ^c   Olianas, Alessandra ^a   Alinovi, Cristiana Carelli ^b   Mastropietro, Fabrizio ^c   Ponzini, Donatella ^c   Amato, Antonio ^c   Pellegrini, Mariagiuseppina ^a  

^a UNIVERSITY OF CAGLIARI   (Italy)

^b CATHOLIC UNIVERSITY   (Italy)

^c ANMI Onlus Centro Studi Microcitemie of Rome (CSMR)   (Italy)

Author keywords

1 1 interface; Codon 115 globin gene; Haemoglobin variant; Homology modeling; Oxygen affinity

Indexed keywords

ALANINE; BETA GLOBIN; GENOMIC DNA; HEMOGLOBIN A; HEMOGLOBIN BETA CHAIN; VALINE; 2,3 DIPHOSPHOGLYCERIC ACID; HEMOGLOBIN ROMA; HEMOGLOBIN VARIANT; UNCLASSIFIED DRUG;

ADULT; AMINO ACID SUBSTITUTION; ARTICLE; BETA THALASSEMIA; CASE REPORT; CODON; CONTROLLED STUDY; DNA SEQUENCE; FEMALE; GENE MUTATION; HUMAN; HUMAN CELL; IRON DEFICIENCY ANEMIA; MATHEMATICAL MODEL; OXYGEN AFFINITY; PRIORITY JOURNAL; AMINO ACID SEQUENCE; CONFERENCE PAPER; PROTEIN BINDING; PROTEIN STABILITY;

ADULT; ALANINE; AMINO ACID SUBSTITUTION; BETA-GLOBINS; BETA-THALASSEMIA; CARRIER STATE; FEMALE; GENETIC VARIATION; HEMOGLOBINS, ABNORMAL; HUMANS; MODELS, MOLECULAR; OXYHEMOGLOBINS; POLYMORPHISM, SINGLE NUCLEOTIDE; PROTEIN CONFORMATION; PROTEIN SUBUNITS; VALINE;

EID: 76849086554     PISSN: 03044165     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbagen.2009.10.010     Document Type: Article

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