Crystal structures of HbA2 and HbE and modeling of hemoglobin δ4: Interpretation of the thermal stability and the antisickling effect of HbA2 and identification of the ferrocyanide binding site in Hb

Biochemistry

Volumn 43, Issue 39, 2004, Pages 12477-12488

  Sen, Udayaditya ^a   Dasgupta, Jhimli ^a   Choudhury, Debi ^a   Datta, Poppy ^a   Chakrabarti, Abhijit ^a   Chakrabarty, Sudipa Basu ^b   Chakrabarty, Amit ^b   Dattagupta, Jiban K ^a  

^a SAHA INSTITUTE OF NUCLEAR PHYSICS   (India)

^b Thalassemia Hospital   (India)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; CRYSTAL STRUCTURE; DIAGNOSIS; DISEASES; MUTAGENESIS; POLYMERIZATION; THERMAL EFFECTS; THERMODYNAMIC STABILITY;

ANTISICKLING PROPERTY; CLINICAL DIAGNOSTICS; RED BLOOD CELLS; THERMAL DENATURATION;

HEMOGLOBIN;

BETA GLOBIN; FERROCYANIDE; HEMOGLOBIN; HEMOGLOBIN A2; HEMOGLOBIN BETA CHAIN; HEMOGLOBIN DELTA 4; HEMOGLOBIN DELTA CHAIN; HEMOGLOBIN E; HEMOGLOBIN GAMMA CHAIN; HEMOGLOBIN S; UNCLASSIFIED DRUG; ANTISICKLING AGENT; CYANOMETHEMOGLOBIN; DRUG DERIVATIVE; GLUTAMIC ACID; LYSINE; METHEMOGLOBIN; PROTEIN SUBUNIT;

ARTICLE; BETA CHAIN; BETA THALASSEMIA; BINDING SITE; CRYSTAL STRUCTURE; DENATURATION; ERYTHROCYTE; EXON; HIGH TEMPERATURE; OXYGEN AFFINITY; POLYMERIZATION; PRIORITY JOURNAL; SICKLE CELL TRAIT; THERMOSTABILITY; ALTERNATIVE RNA SPLICING; CHEMICAL STRUCTURE; CHEMISTRY; CRYSTALLIZATION; GENETICS; HUMAN; METABOLISM; MUTATION; PH; PROTEIN DENATURATION; PROTEIN PROCESSING; THERMODYNAMICS; X RAY CRYSTALLOGRAPHY;

ALTERNATIVE SPLICING; ANTISICKLING AGENTS; BINDING SITES; CRYSTALLIZATION; CRYSTALLOGRAPHY, X-RAY; FERROCYANIDES; GLUTAMIC ACID; HEMOGLOBIN A2; HEMOGLOBIN E; HEMOGLOBINS; HUMANS; HYDROGEN-ION CONCENTRATION; LYSINE; METHEMOGLOBIN; MODELS, MOLECULAR; MUTATION; PROTEIN DENATURATION; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEIN SUBUNITS; THERMODYNAMICS;

EID: 4744349087     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi048903i     Document Type: Article

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