Evaluation of NTF1836 as an inhibitor of the mycothiol biosynthetic enzyme MshC in growing and non-replicating Mycobacterium tuberculosis

Bioorganic and Medicinal Chemistry

Volumn 19, Issue 13, 2011, Pages 3956-3964

  Newton, Gerald L ^a   Buchmeier, Nancy ^a   La Clair, James J ^a   Fahey, Robert C ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Antibiotic discovery; Biosynthesis; Mycothiol; Redox thiols; Tuberculosis

Indexed keywords

ANTIINFECTIVE AGENT; BACTERIAL ENZYME; CDC 1551; ENZYME INHIBITOR; MYCOTHIOL; NTF 1836; PROTEIN MSHC; RIFAMPICIN; THIOL; UCSD 14768; UNCLASSIFIED DRUG; VA 1215; VA 1345;

ANIMAL CELL; ARTICLE; BACTERIAL GROWTH; BACTERIAL STRAIN; BACTERICIDAL ACTIVITY; BACTERIUM CULTURE; CONTROLLED STUDY; DRUG STRUCTURE; DRUG SYNTHESIS; IC 50; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; STRUCTURE ACTIVITY RELATION; VERO CELL;

ANIMALS; BACTERIAL PROTEINS; CERCOPITHECUS AETHIOPS; CYSTEINE; DIBENZOTHIAZEPINES; DRUG EVALUATION, PRECLINICAL; ENZYME INHIBITORS; GLYCOPEPTIDES; INOSITOL; MYCOBACTERIUM TUBERCULOSIS; STRUCTURE-ACTIVITY RELATIONSHIP; VERO CELLS;

MYCOBACTERIUM TUBERCULOSIS;

EID: 79959502290     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2011.05.028     Document Type: Article

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