Targeting norovirus infection - Multivalent entry inhibitor design based on NMR experiments

Chemistry - A European Journal

Volumn 17, Issue 27, 2011, Pages 7442-7453

  Rademacher, Christoph ^a,b   Guiard, Julie ^c   Kitov, Pavel I ^c   Fiege, Brigitte ^a   Dalton, Kevin P ^d   Parra, Francisco ^d   Bundle, David R ^c   Peters, Thomas ^a  

^a UNIVERSITY OF LÜBECK   (Germany)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

^c UNIVERSITY OF ALBERTA   (Canada)

^d DEPARTAMENTO DE BIOQUÍMICA Y BIOLOGÍA MOLECULAR   (Spain)

Author keywords

carbohydrates; entry inhibitor; NMR spectroscopy; norovirus; polymers; virology

Indexed keywords

BINDING STUDIES; BLOOD GROUP ANTIGEN; ENTRY INHIBITOR; HOST CELLS; INHIBITION ASSAYS; INHIBITOR DESIGN; LARGE COMPOUND LIBRARIES; NOROVIRUS; NOROVIRUSES; RATIONAL DESIGN; SATURATION-TRANSFER DIFFERENCES; SPINLOCK; VIROLOGY; VIRUS-LIKE PARTICLES;

CARBOHYDRATES; DESIGN; EXPERIMENTS; LIGANDS; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; SURFACE PLASMON RESONANCE; VIRUSES;

ENVIRONMENTAL REGULATIONS;

ANTIVIRUS AGENT; LIGAND;

ARTICLE; CHEMICAL STRUCTURE; CHEMISTRY; DRUG DESIGN; DRUG EFFECT; GENETICS; MICROBIOLOGICAL EXAMINATION; MOLECULAR LIBRARY; NOROVIRUS; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; STEREOISOMERISM; STRUCTURE ACTIVITY RELATION; SURFACE PLASMON RESONANCE; SYNTHESIS;

ANTIVIRAL AGENTS; DRUG DESIGN; LIGANDS; MAGNETIC RESONANCE SPECTROSCOPY; MICROBIAL SENSITIVITY TESTS; MOLECULAR STRUCTURE; NOROVIRUS; SMALL MOLECULE LIBRARIES; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; SURFACE PLASMON RESONANCE;

EID: 79959461095     PISSN: 09476539     EISSN: 15213765     Source Type: Journal    
DOI: 10.1002/chem.201003432     Document Type: Article

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