Arterial and venous thrombosis in cancer patients

Cardiology Research and Practice

Volumn 1, Issue 1, 2011, Pages

  Blann, Andrew D ^a   Dunmore, Simon ^b  

^a UNIVERSITY DEPARTMENT OF MEDICINE   (United Kingdom)

^b UNIVERSITY OF WOLVERHAMPTON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIVITAMIN K; FONDAPARINUX; HEPARIN; LOW MOLECULAR WEIGHT HEPARIN; WARFARIN;

ARTERY THROMBOSIS; BLEEDING; CANCER PATIENT; CANCER STAGING; CARDIOVASCULAR DISEASE; CAUSE OF DEATH; DEEP VEIN THROMBOSIS; DRUG SAFETY; HEART ARREST; HEART MUSCLE CELL; HEART MUSCLE ISCHEMIA; HUMAN; LOW DRUG DOSE; LUNG EMBOLISM; MALIGNANT NEOPLASTIC DISEASE; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PULMONARY HYPERTENSION; REVIEW; RISK ASSESSMENT; RISK FACTOR; THROMBOSIS PREVENTION; VEIN THROMBOSIS; VENOUS THROMBOEMBOLISM;

EID: 79959450341     PISSN: None     EISSN: 20900597     Source Type: Journal    
DOI: 10.4061/2011/394740     Document Type: Review

References (175)

1. World Health Organization, Annex Table 2: deaths by cause, sex and mortality stratum in WHO regions, estimates for 2002. The world health report 2004changing history, 2004, http://www.who.int/entity/whr/2004/annex/topic/en/ annex2en.pdf
2. Blann A. D., How a damaged blood vessel wall contibutes to thrombosis and hypertension Pathophysiology of Haemostasis and Thrombosis 2003 33 5-6 445 448 (Pubitemid 40278722)
3. Kaplan M. J., Cardiovascular disease in rheumatoid arthritis Current Opinion in Rheumatology 2006 18 3 289 297 (Pubitemid 43740382)
4. Trousseau A., Phlegmasia alba dolens Clinique Medicale de lHotel Dieu de Paris 1865 3 654 712. translated by the New Sydenham Society, London as Lectures on Clinical Medicine delivered at the Hotel Dieu de Paris, pp. 28195, 1872
5. Sack G. H. Jr., Levin J., Bell W. R., Trousseau's syndrome and other manifestations of chronic disseminated coagulopathy in patients with neoplasms: clinical, pathophysiologic, and therapeutic features Medicine 1977 56 1 1 37 (Pubitemid 8029158)
6. Lip G. Y. H., Chin B. S. P., Blann A. D., Cancer and the prothrombotic state Lancet Oncology 2002 3 1 27 34 (Pubitemid 34121143)
7. Doni A., Lippi G., Leoncini G., Fedi S., Gabbrielli G., Piovanelli C., Hemostatic disorders in 25 patients with limited and uncomplicated thyroid and breast cancer: prophylactic and therapeutic considerations Chemioterapia 1984 3 2 90 96 (Pubitemid 14114114)
8. Rickles F. R., Levine M., Edwards R. L., Hemostatic alterations in cancer patients Cancer and Metastasis Reviews 1992 11 3-4 237 248
9. Prandoni P., Antithrombotic strategies in patients with cancer Thrombosis and Haemostasis 1997 78 1 141 144 (Pubitemid 27289232)
10. Saphner T., Tormey D. C., Gray R., Venous and arterial thrombosis in patients who received adjuvant therapy for breast cancer Journal of Clinical Oncology 1991 9 2 286 294
11. Yamamoto H., Noguchi S., Miyauchi K., Inaji H., Imaoka S., Koyama H., Iwanaga T., Changes in hematologic parameters during treatment with medroxyprogesterone acetate for breast cancer Japanese Journal of Cancer Research 1991 82 4 420 425
12. Khorana A. A., Francis C. W., Culakova E., Kuderer N. M., Lyman G. H., Thromboembolism is a leading cause of death in cancer patients receiving outpatient chemotherapy Journal of Thrombosis and Haemostasis 2007 5 3 632 634 (Pubitemid 46680709)
13. Virchow R., Gesammalte Abhandlungen zur Wissenschaftlichen Medtzin 1856 Frankfurt, Germany Medinger Sohn
14. Blann A. D., Lip G. Y. H., Virchow's triad revisited: the importance of soluble coagulation factors, the endothelium, and platelets Thrombosis Research 2001 101 4 321 327 (Pubitemid 32206588)
15. Dube B., Khanna M. N., Kulkarni B. J., Changes in platelets of cancer patients American Surgeon 1974 40 11 651 655
16. Abrahamsen A. F., Platelet turnover in metastatic cancer and the effect of platelet aggregation inhibitors Zeitschrift fur Krebsforschung und Klinische Onkologie 1976 86 1 109 111
17. Fritz E., Ludwig H., Scheithauer W., Sinzinger H., Shortened platelet half-life in multiple myeloma Blood 1986 68 2 514 520 (Pubitemid 16050677)
18. Scialla S. J., Speckart S. F., Haut M. J., Kimball D. B., Alterations in platelet surface sialyltransferase activity and platelet aggregation in a group of cancer patients with a high incidence of thrombosis Cancer Research 1979 39 6 I 2031 2035 (Pubitemid 9184995)
19. Blann A. D., Gurney D., Wadley M., Bareford D., Stonelake P., Lip G. Y. H., Increased soluble P-selectin in patients with haematological and breast cancer: a comparison with fibrinogen, plasminogen activator inhibitor and von Willebrand factor Blood Coagulation and Fibrinolysis 2001 12 1 43 50 (Pubitemid 32150251)
20. Lane D. A., Ireland H., Wolff S., Ranasinghe E., Dawes J., Detection of enhanced in vivo platelet -granule release in different patient groupscomparison of -thromboglobulin, platelet factor 4 and thrombospondin assays Thrombosis and Haemostasis 1984 52 2 183 187 (Pubitemid 14024008)
21. Landolfi R., Storti S., Sacco F., Scribano D., Cudillo L., Leone G., Platelet activation in patients with benign and malignant ovarian diseases Tumori 1984 70 5 459 462 (Pubitemid 15212594)
22. Panici P. B., Scambia G., Massidda B., Chessa P., Tarquini A., Mancuso S., Elevated plasma levels of beta-thromboglobulin in breast cancer Oncology 1986 43 4 208 211 (Pubitemid 16013587)
23. Jain R., Tabor D. C., Engle J. C., Plasma -thromboglobulin levels in lung cancer Southern Medical Journal 1983 76 11 1380 1382 (Pubitemid 14203647)
24. Schernthaner G., Ludwig H., Silberbauer K., Elevated plasma -thromboglobulin levels in multiple myeloma and in polycythaemia vera Acta Haematologica 1979 62 4 219 222 (Pubitemid 10195272)
25. Farrell R. J., Duffy M. J., Moriarty M. J., Duffy G. J., Plasma concentrations of the platelet-specific -thromboglobulin in malignant disease British Journal of Cancer 1980 41 6 989 991 (Pubitemid 10039360)
26. Al-Mondhiry H., Manni A., Owen J., Gordon R., Hemostatic effects of hormonal stimulation in patients with metastatic prostate cancer American Journal of Hematology 1988 28 3 141 145
27. Mehta P., Potential role of platelets in the pathogenesis of tumor metastasis Blood 1984 63 1 55 63 (Pubitemid 14224521)
28. Gasic G. J., Role of plasma, platelets, and endothelial cells in tumor metastasis Cancer and Metastasis Reviews 1984 3 2 99 114
29. Bastida E., Ordinas A., Platelet contribution to the formation of metastatic foci: the role of cancer cell-induced platelet activation Haemostasis 1988 18 1 29 36
30. Walz D. A., Thrombospondin as a mediator of cancer cell adhesion in metastasis Cancer and Metastasis Reviews 1992 11 3-4 313 324
31. Honn K. V., Tang D. G., Crissman J. D., Platelets and cancer metastasis: a causal relationship? Cancer and Metastasis Reviews 1992 11 3-4 325 351
32. Grignani G., Jamieson G. A., Tissue factor-dependent activation of platelets by cells and microvesicles of SK-OS-10 human osteogenic sarcoma cell line Invasion and Metastasis 1987 7 3 172 182 (Pubitemid 17128762)
33. Scarlett J. D., Thurlow P. J., Connellan J. M., Louis C. J., Plasma-dependent and -independent mechanisms of platelet aggregation induced by human tumour cell lines Thrombosis Research 1987 46 5 715 726 (Pubitemid 17085259)
34. Pulcinelli F. M., Manzari G., Faggioni A., La Mancusa R., Martinico E., Torrisi M. R., Zompetta C., Gazzaniga P. P., Differential platelet proaggregating activity of three Burkitt's lymphoma-derived human cell lines Thrombosis Research 1991 62 1-2 9 22
35. Lampugnani M. G., Crawford N., Tumour-cell-induced platelet aggregation: studies with cloned metastatic and non-metastatic variants Invasion and Metastasis 1987 7 5 311 324
36. Grignani G., Jamieson G. A., Platelets in tumor metastasis: generation of adenosine diphosphate by tumor cells is specific but unrelated to metastatic potential Blood 1988 71 4 844 849
37. Canobbio L., Fassio T., Ardizzoni A., Hypercoagulable state induced by cytostatic drugs in Stage II breast cancer patients Cancer 1986 58 5 1032 1036 (Pubitemid 16046932)
38. Sierko E., Wojtukiewicz M. Z., Inhibition of platelet function: does it offer a chance of better cancer progression control? Seminars in Thrombosis and Hemostasis 2007 33 7 712 721 (Pubitemid 350157017)
39. Borsig L., The role of platelet activation in tumor metastasis Expert Review of Anticancer Therapy 2008 8 8 1247 1255
40. Ho-Tin-Noé B., Goerge T., Wagner D. D., Platelets: guardians of tumor vasculature Cancer Research 2009 69 14 5623 5626
41. Serebruany V. L., Aggressive chronic platelet inhibition with prasugrel and increased cancer risks: revising oral antiplatelet regimens? Fundamental and Clinical Pharmacology 2009 23 4 411 417
42. Blann A., Shantsila E., Shantsila A., Microparticles and arterial disease Seminars in Thrombosis and Hemostasis 2009 35 5 488 496
43. Amin C., MacKman N., Key N. S., Microparticles and cancer Pathophysiology of Haemostasis and Thrombosis 2008 36 3-4 177 183
44. Toth B., Liebhardt S., Steinig K., Ditsch N., Rank A., Bauerfeind I., Spannagl M., Friese K., Reininger A. J., Platelet-derived microparticles and coagulation activation in breast cancer patients Thrombosis and Haemostasis 2008 100 4 663 669
45. Hron G., Kollars M., Weber H., Sagaster V., Quehenberger P., Eichinger S., Kyrle P. A., Weltermann A., Tissue factor-positive microparticles: cellular origin and association with coagulation activation in patients with colorectal cancer Thrombosis and Haemostasis 2007 97 1 119 123 (Pubitemid 46242392)
46. Kim H. K., Song K. S., Park Y. S., Kang Y. H., Lee Y. J., Lee K. R., Kim H. K., Ryu K. W., Bae J. M., Kim S., Elevated levels of circulating platelet microparticles, VEGF, IL-6 and RANTES in patients with gastric cancer: possible role of a metastasis predictor European Journal of Cancer 2003 39 2 184 191 (Pubitemid 36057068)
47. Varon D., Shai E., Role of platelet-derived microparticles in angiogenesis and tumor progression Discovery Medicine 2009 8 43 237 241
48. Kim H. K., Song K. S., Chung J. H., Lee K. R., Lee SE. N., Platelet microparticles induce angiogenesis in vitro British Journal of Haematology 2004 124 3 376 384 (Pubitemid 38167990)
49. Langer F., Spath B., Haubold K., Holstein K., Marx G., Wierecky J., Brmmendorf T. H., Dierlamm J., Bokemeyer C., Eifrig B., Tissue factor procoagulant activity of plasma microparticles in patients with cancer-associated disseminated intravascular coagulation Annals of Hematology 2008 87 6 451 457
50. Tesselaar M. E. T., Romijn F. P. H. T. M., Van Der Linden I. K., Bertina R. M., Osanto S., Microparticle-associated tissue factor activity in cancer patients with and without thrombosis Journal of Thrombosis and Haemostasis 2009 7 8 1421 1423
51. Dashevsky O., Varon D., Brill A., Platelet-derived microparticles promote invasiveness of prostate cancer cells via upregulation of MMP-2 production International Journal of Cancer 2009 124 8 1773 1777
52. Thomas G. M., Panicot-Dubois L., Lacroix R., Dignat-George F., Lombardo D., Dubois C., Cancer cell-derived microparticles bearing P-selectin glycoprotein ligand 1 accelerate thrombus formation in vivo Journal of Experimental Medicine 2009 206 9 1913 1927
53. Zwicker J. I., Liebman H. A., Neuberg D., Lacroix R., Bauer K. A., Furie B. C., Furie B., Tumor-derived tissue factor-bearing microparticles are associated with venous thromboembolic events in malignancy Clinical Cancer Research 2009 15 22 6830 6840
54. Baran J., Baj-Krzyworzeka M., Weglarczyk K., Szatanek R., Zembela M., Barbasz J., Czupryna A., Szczepanik A., Zembala M., Circulating tumour-derived microvesicles in plasma of gastric cancer patients Cancer Immunology, Immunotherapy 2010 59 6 841 850
55. Chomet B., LaPorte J., McGrew E. A., Atypical monocytes in patients with malignant tumors Acta Cytologica 1966 10 3 197 199
56. Samak R., Edelstein R., Bogucki D., Samak M., Isral L., Testing the monocyte-macrophage system in human cancer Biomedicine 1980 32 4 165 169 (Pubitemid 11161225)
57. Bartholeyns J., Monocytes and macrophages in cancer immunotherapy Research in Immunology 1993 144 4 288 291 (Pubitemid 23227808)
58. Morgan D., Edwards R. L., Rickles F. R., Monocyte procoagulant activity as a peripheral marker of clotting activation in cancer patients Haemostasis 1988 18 1 55 65
59. sterud B., Tissue factor expression by monocytes: regulation and pathophysiological roles Blood Coagulation and Fibrinolysis 1998 9 1 S9 S14
60. Lwaleed B. A., Bass P. S., Cooper A. J., The biology and tumour-related properties of monocyte tissue factor Journal of Pathology 2001 193 1 3 12 (Pubitemid 32051106)
61. Mackman N., Role of tissue factor in hemostasis and thrombosis Blood Cells, Molecules, and Diseases 2006 36 2 104 107
62. Grignani G., Maiolo A., Cytokines and hemostasis Haematologica 2000 85 9 967 972
63. Lewis C. E., De Palma M., Naldini L., Tie2-expressing monocytes and tumor angiogenesis: regulation by hypoxia and angiopoietin-2 Cancer Research 2007 67 18 8429 8432 (Pubitemid 47437413)
64. Kanazawa S., Nomura S., Kuwana M., Muramatsu M., Yamaguchi K., Fukuhara S., Monocyte-derived microparticles may be a sign of vascular complication in patients with lung cancer Lung Cancer 2003 39 2 145 149 (Pubitemid 36173614)
65. Amirkhosravi A., Alexander M., May K., Francis D. A., Warnes G., Biggerstaff J., Francis J. L., The importance of platelets in the expression of monocyte tissue factor antigen measured by a new whole blood flow cytometric assay Thrombosis and Haemostasis 1996 75 1 87 95 (Pubitemid 26051200)
66. Rickles F. R., Mechanisms of cancer-induced thrombosis Pathophysiology of Haemostasis and Thrombosis 2006 35 1-2 P103 P110
67. Nachman R. L., Silverstein R., Hypercoagulable states Annals of Internal Medicine 1993 119 8 819 827 (Pubitemid 24012648)
68. Zacharski L. R., Memoli V. A., Ornstein D. L., Rousseau S. M., Kisiel W., Kudryk B. J., Tumor cell procoagulant and urokinase expression in carcinoma of the ovary Journal of the National Cancer Institute 1993 85 15 1225 1230 (Pubitemid 23223528)
69. Van Wersch J. W. J., Tjwa M. K. T., Coagulation/fibrinolysis balance and lung cancer Haemostasis 1991 21 2 117 123
70. Milsom C., Rak J., Tissue factor and cancer Pathophysiology of Haemostasis and Thrombosis 2008 36 3-4 160 176
71. Kakkar A. K., DeRuvo N., Chinswangwatanakul V., Tebbutt S., Williamson R. C. N., Extrinsic-pathway activation in cancer with high factor VIIa and tissue factor Lancet 1995 346 8981 1004 1005
72. Lwaleed B. A., Chisholm M., Francis J. L., The significance of measuring monocyte tissue factor activity in patients with breast and colorectal cancer British Journal of Cancer 1999 80 1-2 279 285 (Pubitemid 29210119)
73. Shigemori C., Wada H., Matsumoto K., Shiku H., Nakamura S., Suzuki H., Tissue factor expression and metastatic potential of colorectal cancer Thrombosis and Haemostasis 1998 80 6 894 898 (Pubitemid 28556688)
74. Rickles F. R., Hair G. A., Zeff R. A., Lee E., Bona R. D., Tissue factor expression in human leukocytes and tumor cells Thrombosis and Haemostasis 1995 74 1 391 395
75. Kakkar A. K., Lemoine N. R., Scully M. F., Tebbutt S., Williamson R. C. N., Tissue factor expression correlates with histological grade in human pancreatic cancer British Journal of Surgery 1995 82 8 1101 1104
76. Mielicki W. P., Biochemistry of cancer procoagulant Haemostasis 2001 31 supplement 1 8 10
77. Gordon S. G., Mielicki W. P., Cancer procoagulant: a factor X activator, tumor marker and growth factor from malignant tissue Blood Coagulation and Fibrinolysis 1997 8 2 73 86 (Pubitemid 27211720)
78. Raasi S., Mielicki W. P., Gordon S. G., Korte W., Properties of proteins in cancer procoagulant preparations that are detected by anti-tissue factor antibodies Archives of Biochemistry and Biophysics 2004 428 2 131 135 (Pubitemid 38891555)
79. Tallman M. S., Kwaan H. C., Reassessing the hemostatic disorder associated with acute promyelocytic leukemia Blood 1992 79 3 543 553
80. Kamocka M., Rzalski M., Krajewska U., Wierzbicki R., Mielicki W. P., Effect of cancer procoagulant (CP) on the growth and adhesion of MCF-7 cells to vitronectin in vitro Cancer Letters 2005 222 1 89 94 (Pubitemid 40544851)
81. Jozwik M., Szajda S. D., Skrzydlewski Z., Jozwik M., Sulkowski S., The activity of cancer procoagulant in cases of uterine leiomyomas European Journal of Gynaecological Oncology 2005 26 4 407 410 (Pubitemid 41139469)
82. Kamierczak M., Lewandowski K., Wojtukiewicz M. Z., Turowiecka Z., Koacz E., ojko A., Skrzydlewska E., Zawilska K., Komarnicki M., Cancer procoagulant in patients with adenocarcinomas Blood Coagulation and Fibrinolysis 2005 16 8 543 547 (Pubitemid 41658972)
83. De Lucia D., De Vita F., Orditura M., Renis V., Belli A., Conte M., Di Grazia M., Lacoviello L., Donati M. B., Catalano G., Hypercoagulable state in patients with advanced gastrointestinal cancer: evidence for an acquired resistance to activated protein C Tumori 1997 83 6 948 952 (Pubitemid 28090598)
84. Nand S., Fisher S. G., Salgia R., Fisher R. I., Hemostatic abnormalities in untreated cancer: incidence and correlation with thrombotic and hemorrhagic complications Journal of Clinical Oncology 1987 5 12 1998 2003 (Pubitemid 18010161)
85. Green D., Maliekel K., Sushko E., Akhtar R., Soff G. A., Activated-protein-C resistance in cancer patients Haemostasis 1997 27 3 112 118 (Pubitemid 27368568)
86. Falanga A., Ofosu F. A., Delaini F., Oldani E., Dewar L., Lui L., Barbui T., The hypercoagulable state in cancer patients: evidence for impaired thrombin inhibitions Blood Coagulation and Fibrinolysis 1994 5 supplement 1 S19 S23
87. Adamson A. S., Francis J. L., Witherow R. O., Snell M. E., Coagulopathy in the prostate cancer patient: prevalence and clinical relevance Annals of the Royal College of Surgeons of England 1993 75 2 100 104 (Pubitemid 23089475)
88. Mitter C. G., Zielinski C. C., Plasma levels of D-dimer: a crosslinked fibrin-degradation product in female breast cancer Journal of Cancer Research and Clinical Oncology 1991 117 3 259 262
89. Taguchi O., Gabazza E. C., Yasui H., Kobayashi T., Yoshida M., Kobayashi H., Prognostic significance of plasma D-dimer levels in patients with lung cancer Thorax 1997 52 6 563 565 (Pubitemid 27298511)
90. Kelly J., Rudd A., Lewis R. R., Hunt B. J., Plasma D-dimers in the diagnosis of venous thromboembolism Archives of Internal Medicine 2002 162 7 747 756 (Pubitemid 34273296)
91. Knowlson L., Bacchu S., Paneesha S., McManus A., Randall K., Rose P., Elevated D-dimers are also a marker of underlying malignancy and increased mortality in the absence of venous thromboembolism Journal of Clinical Pathology 2010 63 9 818 822
92. Blann A. D., Taberner D. A., A reliable marker of endothelial cell dysfunction: does it exist? British Journal of Haematology 1995 90 2 244 248
93. Blombck M., Hedlund P. O., Swe U., Changes in blood coagulation and fibrinolyis in patients on different treatment regimens for prostatic cancer. Predictors for cardiovascular complications? Thrombosis Research 1988 49 1 111 121 (Pubitemid 18037063)
94. Van Wersch J. W. J., Tjwa M. K. T., Coagulation/fibrinolysis balance and lung cancer Haemostasis 1991 21 2 117 123
95. Lindahl A. K., Boffa M. C., Abildgaard U., Increased plasma thrombomodulin in cancer patients Thrombosis and Haemostasis 1993 69 2 112 114 (Pubitemid 23041178)
96. Liu P.-L., Tsai J.-R., Chiu C.-C., Hwang J.-J., Chou S.-H., Wang C.-K., Wu S.-J., Chen Y.-L., Chen W.-C., Chen Y.-H., Chong I.-W., Decreased expression of thrombomodulin is correlated with tumor cell invasiveness and poor prognosis in nonsmall cell lung cancer Molecular Carcinogenesis 2010 49 10 874 881
97. Banks R. E., Gearing A. J. H., Hemingway I. K., Norfolk D. R., Perren T. J., Selby P. J., Circulating intercellular adhesion molecule-1 (ICAM-1), E-selectin and vascular cell adhesion molecule-1 (VCAM-1) in human malignancies British Journal of Cancer 1993 68 1 122 124 (Pubitemid 23178563)
98. Pober J. S., Cytokine-mediated activation of vascular endothelium American Journal of Pathology 1988 133 3 426 433
99. Kemik O., Sumer A., Kemik A. S., Hasirci I., Purisa S., Dulger A. C., Demiriz B., Tuzun S., The relationship among acute-phase response proteins, cytokines and hormones in cachectic patients with colon cancer World Journal of Surgical Oncology 2010 8, article 85
100. Dvorak H. F., Thrombosis and cancer Human Pathology 1987 18 3 275 284 (Pubitemid 17051260)
101. Ross R., Vogel A., The platelet-derived growth factor Cell 1978 14 2 203 210
102. Ohi M., Miki C., Tissue concentration of platelet-derived endothelial cell growth factor in colorectal cancer Scandinavian Journal of Gastroenterology 2000 35 4 413 418 (Pubitemid 30304426)
103. Contrino J., Hair G., Kreutzer D. L., Rickles F. R., In situ detection of tissue factor in vascular endothelial cells: correlation with the malignant phenotype of human breast disease Nature Medicine 1996 2 2 209 215 (Pubitemid 26054985)
104. Koomgi R., Volm M., Tissue-factor expression in human non-small-cell lung carcinoma measured by immunohistochemistry: correlation between tissue factor and angiogenesis International Journal of Cancer 1998 79 1 19 22 (Pubitemid 28157720)
105. Abdulkadir S. A., Carvalhal G. F., Kaleem Z., Kisiel W., Humphrey P. A., Catalona W. J., Milbrandt J., Tissue factor expression and angiogenesis in human prostate carcinoma Human Pathology 2000 31 4 443 447 (Pubitemid 30262866)
106. Hippenstiel S., Krll M., Ikemann A., Risau W., Clauss M., Suttorp N., VEGF induces hyperpermeability by a direct action on endothelial cells American Journal of Physiology 1998 274 5 L678 L684
107. Verheul H. M. W., Jorna A. S., Hoekman K., Broxterman H. J., Gebbink M. F. B. G., Pinedo H. M., Vascular endothelial growth factor-stimulated endothelial cells promote adhesion and activation of platelets Blood 2000 96 13 4216 4221
108. Peterson J. E., Zurakowski D., Italiano J. E. Jr., Michel L. V., Fox L., Klement G. L., Folkman J., Normal ranges of angiogenesis regulatory proteins in human platelets American Journal of Hematology 2010 85 7 487 493
109. Caine G. J., Lip G. Y. H., Blann A. D., Platelet-derived VEGF, Flt-1, angiopoietin-1 and P-selectin in breast and prostate cancer: further evidence for a role of platelets in tumour angiogenesis Annals of Medicine 2004 36 4 273 277 (Pubitemid 38789281)
110. Wiesner T., Bugl S., Mayer F., Hartmann J. T., Kopp H. G., Differential changes in platelet VEGF, Tsp, CXCL12, and CXCL4 in patients with metastatic cancer Clinical and Experimental Metastasis 2010 27 3 141 149
111. Pallwein L., Mitterberger M., Gradl J., Aigner F., Horninger W., Strasser H., Bartsch G., Zur Nedden D., Frauscher F., Value of contrast-enhanced ultrasound and elastography in imaging of prostate cancer Current Opinion in Urology 2007 17 1 39 47 (Pubitemid 44901089)
112. Davies P. F., Civelek M., Fang Y., Guerraty M. A., Passerini A. G., Endothelial heterogeneity associated with regional athero-susceptibility and adaptation to disturbed blood flow in vivo Seminars in Thrombosis and Hemostasis 2010 36 3 265 275
113. Jadhav S., Konstantopoulos K., Fluid shear- and time-dependent modulation of molecular interactions between PMNs and colon carcinomas American Journal of Physiology 2002 283 4 C1133 C1143
114. Von Tempelhoff G. F., Heilmann L., Hommel G., Pollow K., Impact of rheological variables in cancer Seminars in Thrombosis and Hemostasis 2003 29 5 499 513 (Pubitemid 37352650)
115. Humphreys W. V., Walker A., Charlesworth D., Altered viscosity and yield stress in patients with abdominal malignancy: relationship to deep vein thrombosis British Journal of Surgery 1976 63 7 559 561
116. Levine M. N., Gent M., Hirsh J., The thrombogenic effect of anticancer drug therapy in women with stage II breast cancer The New England Journal of Medicine 1988 318 404 407 (Pubitemid 18044179)
117. Goodnough L. T., Saito H., Manni A., Jones P. K., Pearson O. H., Increased incidence of thromboembolism in stage IV breast cancer patients treated with a five-drug chemotherapy regimen. A study of 159 patients Cancer 1984 54 7 1264 1268 (Pubitemid 14003521)
118. Rickles F. R., Levine M. N., Venous thromboembolism in malignancy and malignancy in venous thromboembolism Haemostasis 1998 28 supplement 3 43 49 (Pubitemid 29049320)
119. Di Nisio M., Ferrante N., De Tursi M., Iacobelli S., Cuccurullo F., Bller H. R., Feragalli B., Porreca E., Incidental venous thromboembolism in ambulatory cancer patients receiving chemotherapy Thrombosis and Haemostasis 2010 104 5 1049 1054
120. Starling N., Rao S., Cunningham D., Iveson T., Nicolson M., Coxon F., Middleton G., Daniel F., Oates J., Norman A. R., Thromboembolism in patients with advanced gastroesophageal cancer treated with anthracycline, platinum, and fluoropyrimidine combination chemotherapy: a report from the UK National Cancer Research Institute Upper Gastrointestinal Clinical Studies Group Journal of Clinical Oncology 2009 27 23 3786 3793
121. Uaprasert N., Voorhees P. M., Mackman N., Key N. S., Venous thromboembolism in multiple myeloma: current perspectives in pathogenesis European Journal of Cancer 2010 46 10 1790 1799
122. Zhou X., Teegala S., Huen A., Ji Y., Fayad L., Hagemeister F. B., Gladish G., Vadhan-Raj S., Incidence and risk factors of venous thromboembolic events in lymphoma American Journal of Medicine 2010 123 10 935 941
123. Kanz R., Vukovich T., Vormittag R., Thrombosis risk and survival in cancer patients with elevated C-reactive protein Journal of Thrombosis and Haemostasis 2011 9 1 57 63
124. Bertsias G. K., Salmon J. E., Boumpas D. T., Therapeutic opportunities in systemic lupus erythematosus: state of the art and prospects for the new decade Annals of the Rheumatic Diseases 2010 69 9 1603 1611
125. Dubois C. L., Pappas C., Belmans A., Erven K., Adriaenssens T., Sinnaeve P., Coosemans M., Kayaert P., Weltens C., Desmet W., Clinical outcome of coronary stenting after thoracic radiotherapy: a case-control study Heart 2010 96 9 678 682
126. Byrne M., Reynolds J. V., O'Donnell J. S., Keogan M., White B., Byrne M., Murphy S., Maher S. G., Pidgeon G. P., Long-term activation of the pro-coagulant response after neoadjuvant chemoradiation and major cancer surgery British Journal of Cancer 2010 102 1 73 79
127. Hiller E., Cancer and thrombosis: managing the risks and approaches to thromboprophylaxis Onkologie 2006 29 10 474 478 (Pubitemid 44495515)
128. Gadducci A., Baicchi U., Marrai R., Facchini V., Del Bravo B., Fosella P. V., Fioretti P., Pretreatment plasma levels of fibrinopeptide-A (FPA), D-dimer (DD), and von Willebrand Factor (vWF) in patients with operable cervical cancer: influence of surgical-pathological stage, tumor size, histologic type, and lymph node status Gynecologic Oncology 1993 49 3 354 358 (Pubitemid 23191210)
129. Seitz R., Rappe N., Kraus M., Immel A., Wolf M., Maasberg M., Egbring R., Pfab R., Havemann K., Activation of coagulation and fibrinolysis in patients with lung cancer: relation to tumour stage and prognosis Blood Coagulation and Fibrinolysis 1993 4 2 249 254 (Pubitemid 23103801)
130. Mirshahi S. S., Pujade-Lauraine E., Soria C., Mirshahi M., Fretault J., Bernadou A., Soria J., D-dimer and CA 125 levels in patients with ovarian cancer during antineoplastic therapy: prognostic significance for the success of anti- cancer treatment Cancer 1992 69 9 2289 2292
131. Nakanishi M., Yagawa K., Hayashi S., Ogino H., Ogata K., Yatsunami J., Miyagawa Y., Hirano H., Miyazaki M., Yoshida M., Ichinose Y., Hara N., Ohta M., Plasma thrombosis-inducing activity in 120 patients with primary lung cancer Oncology 1991 48 4 297 300
132. McCulloch P., Lowe G. D. O., Douglas J. T., Murray G. D., George W. D., Haemostatic abnormalities and outcome in patients with operable breast cancer European Journal of Cancer 1990 26 9 950 953
133. Sack G. H. Jr., Levin J., Bell W. R., Trousseau's syndrome and other manifestations of chronic disseminated coagulopathy in patients with neoplasms: clinical, pathophysiologic, and therapeutic features Medicine 1977 56 1 1 37 (Pubitemid 8029158)
134. Naschitz J. E., Yeshurun D., Abrahamson J., Arterial occlusive disease in occult cancer American Heart Journal 1992 124 3 738 745
135. Uchiyama T., Matsumoto M., Kobayashi N., Studies on the pathogenesis of coagulopathy in patients with arterial thromboembolism and malignancy Thrombosis Research 1990 59 6 955 965 (Pubitemid 20383667)
136. Grage T. B., Vassilopoulos P. P., Shingleton W. W., Results of a prospective randomized study of hepatic artery infusion with 5-fluorouracil versus intravenous 5-fluorouracil in patients with hepatic metastases from colorectal cancer: a central oncology group study Surgery 1979 86 4 550 555 (Pubitemid 10211221)
137. Barnett K. T., Malafa M. P., Complications of hepatic artery infusion: a review of 4580 reported cases International Journal of Gastrointestinal Cancer 2001 30 3 147 160 (Pubitemid 36306730)
138. Tolcher A. W., Giusti R. M., O'Shaughnessy J. A., Cowan K. H., Arterial thrombosis associated with granulocyte-macrophage colony-stimulating factor (GM-CSF) administration in breast cancer patients treated with dose-intensive chemotherapy: a report of two cases Cancer Investigation 1995 13 2 188 192
139. Scholz K. H., Herrmann C., Tebbe U., Chemnitius J. M., Helmchen U., Kreuzer H., Myocardial infarction in young patients with Hodgkin's diseasepotential pathogenic role of radiotherapy, chemotherapy, and splenectomy Clinical Investigator 1993 71 1 57 64 (Pubitemid 23041978)
140. Minjarez D. A., Delorit M. A., Davidson S. A., Spontaneous arterial thrombosis with an advanced ovarian malignancy Gynecologic Oncology 1997 64 1 176 179 (Pubitemid 27026979)
141. Bertomeu M. C., Gallo S., Lauri D., Levine M. N., Orr F. W., Buchanan M. R., Chemotherapy enhances endothelial cell reactivity to platelets Clinical and Experimental Metastasis 1990 8 6 511 518 (Pubitemid 20355466)
142. Ross J. S., Stagliano N. E., Donovan M. J., Breitbart R. E., Ginsburg G. S., Atherosclerosis: a cancer of the blood vessels? American Journal of Clinical Pathology 2001 116 supplement S97 S107
143. Lowe G. D. O., Common risk factors for both arterial and venous thrombosis British Journal of Haematology 2008 140 5 488 495 (Pubitemid 351230085)
144. Clagett G. P., Anderson F. A., Geerts W., Heit J. A., Knudson M., Lieberman J. R., Merli G. J., Wheeler H. B., Prevention of venous thromboembolism Chest 1998 114 5, supplement 531S 560S (Pubitemid 28535780)
145. Levine M., Hirsh J., Gent M., Arnold A., Warr D., Falanga A., Samosh M., Bramwell V., Pritchard K. I., Stewart D., Goodwin P., Double-blind randomised trial of very-low-dose warfarin for prevention of thromboembolism in stage IV breast cancer Lancet 1994 343 8902 886 889 (Pubitemid 24113632)
146. Palareti G., Legnani C., Lee A., Manotti C., Hirsh J., D'Angelo A., Pengo V., Moia M., Coccheri S., A comparison of the safety and efficacy of oral antiocoagulation for the treatment of venous thromboembolic disease in patients with or without malignancy Thrombosis and Haemostasis 2000 84 5 805 810
147. Smorenburg S. M., Vink R., Otten H. M., Swaneveld F., Bller H. R., The effects of vitamin K-antagonists on survival of patients with malignancy: a systematic analysis Thrombosis and Haemostasis 2001 86 6 1586 1587 (Pubitemid 34007540)
148. Lyman G. H., Khorana A. A., Falanga A., Clarke-Pearson D., Flowers C., Jahanzeb M., Kakkar A., Kuderer N. M., Levine M. N., Liebman H., Mendelson D., Raskob G., Somerfield M. R., Thodiyil P., Trent D., American Society of Clinical Oncology Guideline: recommendations for venous thromboembolism prophylaxis and treatment in patients with cancer Journal of Clinical Oncology 2007 25 34 5490 5505 (Pubitemid 350232226)
149. Khorana A. A., The NCCN clinical practice guidelines on venous thromboembolic disease: strategies for improving VTE prophylaxis in hospitalized cancer patients Oncologist 2007 12 11 1361 1370 (Pubitemid 350232610)
150. National Institute for Health and Clinical Excellence (NICE), Venous thromboembolism: reducing the risk. Guideline 92; 17-18, http://www.nice.org.uk/ guidance/CG92
151. Iodice S., Gandini S., Lhr M., Lowenfels A. B., Maisonneuve P., Venous thromboembolic events and organ-specific occult cancers: a review and meta-analysis Journal of Thrombosis and Haemostasis 2008 6 5 781 788 (Pubitemid 351524538)
152. Paneesha S., McManus A., Arya R., Scriven N., Farren T., Nokes T., Bacon S., Nieland A., Cooper D., Smith H., O'Shaughnessy D., Rose P., Frequency, demographics and risk (according to tumour type or site) of cancer-associated thrombosis among patients seen at outpatient DVT clinics Thrombosis and Haemostasis 2010 103 2 338 343
153. Sallah S., Wan J. Y., Nguyen N. P., Venous thrombosis in patients with solid tumors: determination of frequency and characteristics Thrombosis and Haemostasis 2002 87 4 575 579 (Pubitemid 34302943)
154. Blom J. W., Vanderschoot J. P. M., Oostindir M. J., Osanto S., Van Der Meer F. J. M., Rosendaal F. R., Incidence of venous thrombosis in a large cohort of 66 329 cancer patients: results of a record linkage study Journal of Thrombosis and Haemostasis 2006 4 3 529 535
155. Lee A. Y. Y., The role of low-molecular-weight heparins in the prevention and treatment of venous thromboembolism in cancer patients Current Opinion in Pulmonary Medicine 2003 9 5 351 355 (Pubitemid 36994060)
156. Lazo-Langer A., Goss G. D., Spaans J. N., Rodger M. A., The effect of low molecular weight heparin on cancer survival. A systematic review and
157. Lee A. Y. Y., Levine M. N., Baker R. I., Bowden C., Kakkar A. K., Prins M., Rickles F. R., Julian J. A., Math M., Haley S., Kovacs M. J., Gent M., Low-molecular-weight heparin versus a coumarin for the prevention of recurrent venous thromboembolism in patients with cancer New England Journal of Medicine 2003 349 2 146 153 (Pubitemid 36818784)
158. Lee A. Y.Y., Rickles F. R., Julian J. A., Gent M., Baker R. I., Bowden C., Kakkar A. K., Prins M., Levine M. N., Randomized comparison of low molecular weight heparin and coumarin derivatives on the survival of patients with cancer and venous thromboembolism Journal of Clinical Oncology 2005 23 10 2123 2129 (Pubitemid 46218703)
159. Kakkar A. K., Antithrombotic therapy and survival in cancer patients Best Practice and Research: Clinical Haematology 2009 22 1 147 151
160. Levine M. N., Lee A. Y., Kakkar A. K., From Trousseau to targeted therapy: new insights and innovations in thrombosis and cancer Journal of Thrombosis and Haemostasis 2003 1 7 1456 1463
161. Sproul E. E., Carcinoma and venous thrombosis: the frequency of association of carcinoma in the body of tail of the pancreas with multiple venous thrombosis American Journal of Cancer 1938 566 585
162. Lee A. Y. Y., Management of thrombosis in cancer: primary prevention and secondary prophylaxis British Journal of Haematology 2004 128 3 291 302
163. Agnelli G., Venous thromboembolism and cancer: a two-way clinical association Thrombosis and Haemostasis 1997 78 1 117 120 (Pubitemid 27289227)
164. Srensen H. T., Mellemkjr L., Olsen J. H., Baron J. A., Prognosis of cancers associated with venous thromboembolism New England Journal of Medicine 2000 343 25 1846 1850 (Pubitemid 32104130)
165. Srensen H. T., Pedersen L., Mellemkjr L., Johnsen S. P., Skriver M. V., Olsen J. H., Baron J. A., The risk of a second cancer after hospitalisation for venous thromboembolism British Journal of Cancer 2005 93 7 838 841 (Pubitemid 41486447)
166. Becattini C., Vedovati M. C., Ageno W., Dentali F., Agnelli G., Incidence of arterial cardiovascular events after venous thromboembolism: a systemic review and a meta-analysis Journal of Thrombosis and Haemostasis 2010 8 891 897
167. Ay C., Simanek R., Vormittag R., Dunkler D., Alguel G., Koder S., Kornek G., Marosi C., Wagner O., Zielinski C., Pabinger I., High plasma levels of soluble P-selectin are predictive of venous thromboembolism in cancer patients: results from the Vienna Cancer and Thrombosis Study (CATS) Blood 2008 112 7 2703 2708
168. Hara Y., Steiner M., Baldini M. G., Platelets as a source of growth-promoting factor(s) for tumor cells Cancer Research 1980 40 4 1212 1216 (Pubitemid 10135833)
169. Khorana A. A., Francis C. W., Culakova E., Lyman G. H., Risk factors for chemotherapy-associated venous thromboembolism in a prospective observational study Cancer 2005 104 12 2822 2829 (Pubitemid 41798294)
170. Di Nisio M., Ferrante N., De Tursi M., Iacobelli S., Cuccurullo F., Bller H. R., Feragalli B., Porreca E., Incidental venous thromboembolism in ambulatory cancer patients receiving chemotherapy Thrombosis and Haemostasis 2010 104 5 1049 1054
171. Khorana A. A., Streiff M. B., Farge D., Mandala M., Debourdeau P., Cajfinger F., Marty M., Falanga A., Lyman G. H., Venous thromboembolism prophylaxis and treatment in cancer: a consensus statement of major guidelines panels and call to action Journal of Clinical Oncology 2009 27 29 4919 4926
172. Connolly G. C., Khorana A. A., Emerging risk stratification approaches to cancer-associated thrombosis: risk factors, biomarkers and a risk score Thrombosis Research 2010 125 supplement 2 S1 S7
173. Simanek R., Vormittag R., Ay C., Alguel G., Dunkler D., Schwarzinger I., Steger G., Jaeger U., Zielinski C., Pabinger I., High platelet count associated with venous thromboembolism in cancer patients: results from the Vienna Cancer and Thrombosis Study (CATS) Journal of Thrombosis and Haemostasis 2010 8 1 114 120
174. Connolly G. C., Khorana A. A., Kuderer N. M., Culakova E., Francis C. W., Lyman G. H., Leukocytosis, thrombosis and early mortality in cancer patients initiating chemotherapy Thrombosis Research 2010 126 113 118
175. Ay C., Dunkler D., Marosi C., Chiriac A.-L., Vormittag R., Simanek R., Quehenberger P., Zielinski C., Pabinger I., Prediction of venous thromboembolism in cancer patients Blood 2010 116 24 5377 5382