TGF-β-mediated sustained ERK1/2 activity promotes the inhibition of intracellular growth of Mycobacterium avium in epithelioid cells surrogates

PLoS ONE

Volumn 6, Issue 6, 2011, Pages

  L'Abbate, Carolina ^a   Cipriano, Ivone ^a   Pérez Hurtado, Elizabeth Cristina ^a   Leão, Sylvia Cardoso ^a   CarneiroCé, Célia Regina Whitaker ^a   Machado Jr , Joel ^a  

^a FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 4 [4 (1,3 BENZODIOXOL 5 YL) 5 (2 PYRIDINYL) 1H IMIDAZOL 2 YL]BENZAMIDE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; TRANSFORMING GROWTH FACTOR BETA; INTERLEUKIN 13; INTERLEUKIN 4 RECEPTOR;

ANIMAL CELL; ARTICLE; AUTOCRINE EFFECT; BACTERIAL GROWTH; BACTERIAL LOAD; CELL DIFFERENTIATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME ACTIVATION; ENZYME ACTIVITY; EPITHELIOID CELL; GROWTH INHIBITION; GROWTH REGULATION; HOST PATHOGEN INTERACTION; MALE; MOUSE; MYCOBACTERIUM AVIUM; NONHUMAN; PERITONEUM MACROPHAGE; SIGNAL TRANSDUCTION; ANIMAL; BAGG ALBINO MOUSE; CELL SHAPE; CYTOLOGY; DRUG EFFECT; ENZYMOLOGY; GROWTH, DEVELOPMENT AND AGING; INTRACELLULAR SPACE; METABOLISM; MICROBIOLOGY; SECRETION;

BACTERIA (MICROORGANISMS); MURINAE; MYCOBACTERIUM AVIUM; MYCOBACTERIUM AVIUM COMPLEX;

ANIMALS; CELL DIFFERENTIATION; CELL SHAPE; ENZYME ACTIVATION; EPITHELIOID CELLS; INTERLEUKIN-13; INTRACELLULAR SPACE; MACROPHAGES, PERITONEAL; MALE; MICE; MICE, INBRED BALB C; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; MYCOBACTERIUM AVIUM; RECEPTORS, INTERLEUKIN-4; SIGNAL TRANSDUCTION; TRANSFORMING GROWTH FACTOR BETA;

EID: 79959443816     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0021465     Document Type: Article

References (60)

1. Reilly AF, McGowan KL, (2004) Atypical mycobacterial infections in children with cancer. Pediatr Blood Cancer 43: 698-702.
2. Horsburgh CR Jr, Metchock BG, McGowan JE Jr, Thompson SE, (1992) Clinical implications of recovery of Mycobacterium avium complex from the stool or respiratory tract of HIV-infected individuals. AIDS 6: 512-514.
3. Hanak V, Kalra S, Aksamit TR, Hartman TE, Tazelaar HD, et al. (2006) Hot tub lung: presenting features and clinical course of 21 patients. Respir Med 100: 610-615.
4. Yajko DM, Chin DP, Gonzalez PC, Nassos PS, Hopewell PC, et al. (1995) Mycobacterium avium complex in water, food, and soil samples collected from the environment of HIV-infected individuals. J Acquir Immune Defic Syndr Hum Retrovirol 9: 176-182.
5. Secott TE, Lin TL, Wu CC, (2002) Fibronectin attachment protein is necessary for efficient attachment and invasion of epithelial cells by Mycobacterium avium subsp. paratuberculosis. Infect Immun 70: 2670-2675.
6. Sangari FJ, Goodman J, Petrofsky M, Kolonoski P, Bermudez LE, (2001) Mycobacterium avium invades the intestinal mucosa primarily by interacting with enterocytes. Infect Immun 69: 1515-1520.
7. Adams DO, Hamilton TA, (1984) The cell biology of macrophage activation. Annu Rev Immunol 2: 283-318.
8. Davis JM, Clay H, Lewis JL, Ghori N, Herbomel P, et al. (2002) Real-time visualization of mycobacterium-macrophage interactions leading to initiation of granuloma formation in zebrafish embryos. Immunity 17: 693-702.
9. Dannenberg AM Jr, (1993) Immunopathogenesis of pulmonary tuberculosis. Hosp Pract (Off Ed) 28: 51-58.
10. Bouley DM, Ghori N, Mercer KL, Falkow S, Ramakrishnan L, (2001) Dynamic nature of host-pathogen interactions in Mycobacterium marinum granulomas. Infect Immun 69: 7820-7831.
11. Grosset J, (2003) Mycobacterium tuberculosis in the extracellular compartment: an underestimated adversary. Antimicrob Agents Chemother 47: 833-836.
12. Ding A, Nathan CF, Graycar J, Derynck R, Stuehr DJ, et al. (1990) Macrophage deactivating factor and transforming growth factors-beta 1-beta 2 and-beta 3 inhibit induction of macrophage nitrogen oxide synthesis by IFN-gamma. J Immunol 145: 940-944.
13. Khanolkar-Young S, Snowdon D, Lockwood DN, (1998) Immunocytochemical localization of inducible nitric oxide synthase and transforming growth factor-beta (TGF-β) in leprosy lesions. Clin Exp Immunol 113: 438-442.
14. Letterio JJ, Roberts AB, (1998) Regulation of immune responses by TGF-β. Annu Rev Immunol 16: 137-161.
15. Rich J, Borton A, Wang X, (2001) Transforming growth factor-β signaling in cancer. Microsc Res Tech 52: 363-373.
16. Xu Z, Shen MX, Ma DZ, Wang LY, Zha XL, (2003) TGF-β1-promoted epithelial-to-mesenchymal transformation and cell adhesion contribute to TGF-β1 enhanced cell migration in SMMC-7721 cells. Cell Res 13: 343-350.
17. Li MO, Wan YY, Sanjabi S, Robertson AK, Flavell RA, (2006) Transforming growth factor-β regulation of immune responses. Annu Rev Immunol 24: 99-146.
18. Mulder KM, Morris SL, (1992) Activation of p21ras by transforming growth factor β in epithelial cells. J Biol Chem 267: 5029-5031.
19. Wang W, Zhou G, Hu MC, Yao Z, Tan TH, (1997) Activation of the hematopoietic progenitor kinase-1 (HPK1)-dependent, stress-activated c-Jun N-terminal kinase (JNK) pathway by transforming growth factor beta (TGF-β)-activated kinase (TAK1), a kinase mediator of TGF β signal transduction. J Biol Chem 272: 22771-22775.
20. Hanafusa H, Torii S, Yasunaga T, Nishida E, (2002) Sprouty1 and Sprouty2 provide a control mechanism for the Ras/MAPK signalling pathway. Nat Cell Biol 4: 850-858.
21. Blumenthal A, Ehlers S, Ernst M, Flad HD, Reiling N, (2002) Control of mycobacterial replication in human macrophages: roles of extracellular signal-regulated kinases 1 and 2 and p38 mitogen-activated protein kinase pathways. Infect Immun 70: 4961-4967.
22. Roach SK, Schorey JS, (2002) Differential regulation of the mitogen-activated protein kinases by pathogenic and nonpathogenic mycobacteria. Infect Immun 70: 3040-3052.
23. Yadav M, Roach SK, Schorey JS, (2004) Increased mitogen-activated protein kinase activity and TNF-alpha production associated with Mycobacterium smegmatis- but not Mycobacterium avium-infected macrophages requires prolonged stimulation of the calmodulin/calmodulin kinase and cyclic AMP/protein kinase A pathways. J Immunol 172: 5588-5597.
24. Cipriano IM, Mariano M, Freymuller E, Carneiro CR, (2003) Murine macrophages cultured with IL-4 acquire a phenotype similar to that of epithelioid cells from granulomatous inflammation. Inflammation 27: 201-211.
25. Chinen LT, Cipriano IM, de Oliveira RS, Leao SC, Mariano M, et al. (2006) Recombinant interleukin-4-treated macrophages, epithelioid cell surrogates, harbor and arrest Mycobacterium avium multiplication in vitro. Microbes Infect 8: 965-973.
26. Chomarat P, Banchereau J, (1998) Interleukin-4 and interleukin-13: their similarities and discrepancies. Int Rev Immunol 17: 1-52.
27. Kelly-Welch AE, Hanson EM, Boothby MR, Keegan AD, (2003) Interleukin-4 and interleukin-13 signaling connections maps. Science 300: 1527-1528.
28. Inman GJ, Nicolas FJ, Callahan JF, Harling JD, Gaster LM, et al. (2002) SB-431542 is a potent and specific inhibitor of transforming growth factor-beta superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7. Mol Pharmacol 62: 65-74.
29. Barral-Netto M, de Freitas LA, Andrade ZA, (1987) Histopathologic changes induced by vaccination in experimental cutaneous leishmaniasis of BALB/c mice. Am J Pathol 127: 271-278.
30. Wilson ME, Weinstock JV, (1996) Hepatic Granulomas in Murine Visceral Leishmaniasis Caused by Leishmania chagasi. Methods 9: 248-254.
31. Borges-Walmsley MI, Chen D, Shu X, Walmsley AR, (2002) The pathobiology of Paracoccidioides brasiliensis. Trends Microbiol 10: 80-87.
32. Shimizu T, Tomioka H, Matsuoka M, Sano C, (2002) Profiles of the mRNA expression by macrophages infected with Mycobacterium leprae and Mycobacterium avium complex. Int J Lepr Other Mycobact Dis 70: 250-259.
33. Bermudez LE, Covaro G, Remington J, (1993) Infection of murine macrophages with Toxoplasma gondii is associated with release of transforming growth factor β and downregulation of expression of tumor necrosis factor receptors. Infect Immun 61: 4126-4130.
34. Seyler I, Appel M, Devissaguet JP, Legrand P, Barratt G, (1997) Modulation of nitric oxide production in RAW 264.7 cells by transforming growth factor-β and interleukin-10: differential effects on free and encapsulated immunomodulator. J Leukoc Biol 62: 374-380.
35. Tomioka H, Sato K, Shimizu T, Sano C, Akaki T, et al. (1997) Effects of benzoxazinorifamycin KRM-1648 on cytokine production at sites of Mycobacterium avium complex infection induced in mice. Antimicrob Agents Chemother 41: 357-362.
36. Wills-Karp M, Finkelman FD, (2008) Untangling the complex web of IL-4- and IL 13-mediated signaling pathways. Sci Signal 1: 55.
37. Yamaguchi K, Shirakabe K, Shibuya H, Irie K, Oishi I, et al. (1995) Identification of a member of the MAPKKK family as a potential mediator of TGF-β signal transduction. Science 270: 2008-2011.
38. Hartsough MT, Frey RS, Zipfel PA, Buard A, Cook SJ, et al. (1996) Altered transforming growth factor signaling in epithelial cells when ras activation is blocked. J Biol Chem 271: 22368-22375.
39. Atfi A, Djelloul S, Chastre E, Davis R, Gespach C, (1997) Evidence for a role of Rho-like GTPases and stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK) in transforming growth factor β-mediated signaling. J Biol Chem 272: 1429-1432.
40. Klug K, Ehlers S, Uhlig S, Reiling N, (2010) Mitogen-activated protein kinases p38 and ERK1/2 regulated control of Mycobacterium avium replication in primary murine macrophages is independent of tumor necrosis factor-α and interleukin-10. Innate Immun August 3 doi:10.1177/1753425910377799.
41. Dewas C, Fay M, Gougerot-Pocidalo MA, El-Benna J, (2000) The mitogen-activated protein kinase extracellular signal-regulated kinase 1/2 pathway is involved in formyl methionyl-leucyl-phenylalanine-induced p47phox phosphorylation in human neutrophils. J Immunol 165: 5238-5244.
42. Ebisuya M, Kondoh K, Nishida E, (2005) The duration, magnitude and compartmentalization of ERK MAP kinase activity: mechanisms for providing signaling specificity. J Cell Sci 118: 2997-3002.
43. Martiny A, Meyer-Fernandes JR, de Souza W, Vannier-Santos MA, (1999) Altered tyrosine phosphorylation of ERK1 MAP kinase and other macrophage molecules caused by Leishmania amastigotes. Mol Biochem Parasitol 102: 1-12.
44. Nandan D, Yi T, Lopez M, Lai C, Reiner NE, (2002) Leishmania EF-1α activates the Src homology 2 domain containing tyrosine phosphatase SHP-1 leading to macrophage deactivation. J Biol Chem 277: 50190-50197.
45. Cameron P, McGachy A, Anderson M, Paul A, Coombs GH, et al. (2004) Inhibition of lipopolysaccharide-induced macrophage IL-12 production by Leishmania mexicana amastigotes: the role of cysteine peptidases and the NF-kappaB signaling pathway. J Immunol 173: 3297-3304.
46. Toossi Z, Gogate P, Shiratsuchi H, Young T, Ellner JJ, (1995) Enhanced production of TGF-β by blood monocytes from patients with active tuberculosis and presence of TGF-β in tuberculous granulomatous lung lesions. J Immunol 154: 465-473.
47. Dahl KE, Shiratsuchi H, Hamilton BD, Ellner JJ, Toossi Z, (1996) Selective induction of transforming growth factor beta in human monocytes by lipoarabinomannan of Mycobacterium tuberculosis. Infect Immun 64: 399-405.
48. Reed SG, (1999) TGF-β in infections and infectious diseases. Microbes Infect 1: 1313-1325.
49. Bermudez LE, (1993) Production of transforming growth factor-beta by Mycobacterium avium-infected human macrophages is associated with unresponsiveness to IFN- gamma. J Immunol 155: 1838-1845.
50. Tomioka H, Shimizu T, Maw WW, Ogasawara K, (2000) Roles of tumor necrosis factor-alpha (TNF-α), transforming growth factor-beta (TGF-β), and IL-10 in the modulation of intercellular adhesion molecule-1 (ICAM-1) expression by macrophages during mycobacterial infection. Clin Exp Immunol 122: 335-342.
51. Shiratsuchi H, Hamilton B, Toossi Z, Ellner J J, (1996) Evidence against a role for interleukin-10 in the regulation of growth of Mycobacterium avium in human monocytes. J Infect Dis 173: 410-417.
52. Warwick-Davies J, Lowrie DB, Cole PJ, (1995) Selective deactivation of human monocyte functions by TGF-β. J Immunol 155: 3186-3193.
53. Sano C, Sato K, Shimizu T, Kajitani H, Kawauchi H, et al. (1999) The modulating effects of proinflammatory cytokines interferon-gamma (IFN-γ) and tumour necrosis factor-alpha (TNF-α), and immunoregulating cytokines IL-10 and transforming growth factor-beta (TGF-β), on anti-microbial activity of murine peritoneal macrophages against Mycobacterium avium-intracellulare complex. Clin Exp Immunol 115: 435-442.
54. Ulrichs T, Kaufmann SH, (2006) New insights into the function of granulomas inhuman tuberculosis. J Pathol 208: 261-269.
55. Flynn JL, Chan J, (2001) Immunology of tuberculosis. Annu Rev Immunol 19: 93-129.
56. Fujita J, Ohtsuki Y, Suemitsu I, Yamadori I, Shigeto E, et al. (2002) Immunohistochemical distribution of epithelioid cell, myofibroblast, and transforming growth factor-β1 in the granuloma caused by Mycobacterium avium intracellulare complex pulmonary infection. Microbiol Immunol 46: 67-74.
57. Oliveira RS, Sircili MP, Ueki SY, Telles MA, Schnabel B, et al. (2000) PCR restriction enzyme analysis of a bone marrow isolate from a human immunodeficiency virus-positive patient discloses polyclonal infection with two Mycobacterium avium strains. J Clin Microbiol 38: 4643-4645.
58. Doi T, Ando M, Akaike T, Suga M, Sato K, et al. (1993) Resistance to nitric oxide in Mycobacterium avium complex and its implication in pathogenesis. Infect Immun 61: 1980-1989.
59. Xander P, Vigna AF, Feitosa Ldos S, Pugliese L, Bailao AM, et al. (2007) A surface 75-kDa protein with acid phosphatase activity recognized by monoclonal antibodies that inhibit Paracoccidioides brasiliensis growth. Microbes Infect 9: 1484-1492.
60. Alvarez-Rueda N, Biron M, Le Pape P, (2009) Infectivity of Leishmania mexicana is associated with differential expression of protein kinase C-like triggered during a cell cell contact. PLoS One 4: e7581.