Murine macrophages cultured with IL-4 acquire a phenotype similar to that of epithelioid cells from granulomatous inflammation

Inflammation

Volumn 27, Issue 4, 2003, Pages 201-211

  Cipriano, Ivone Martins ^a   Mariano, Mario ^a   Freymüller, Edna ^a   Whitaker Carneiro, Celia Regina ^a  

^a FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Epithelioid cells; GM CSF; Granuloma; IL 4; Macrophages

Indexed keywords

CELL PROTEIN; FC RECEPTOR; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 4; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; MANNOSE RECEPTOR; MIGRATION INHIBITION FACTOR RELATED PROTEIN 14; RECOMBINANT INTERLEUKIN 4; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIGEN EXPRESSION; ARTICLE; CELL CULTURE; CELL DIFFERENTIATION; CELL ISOLATION; CELL MEMBRANE; CELL SHAPE; CELL ULTRASTRUCTURE; CELL VACUOLE; CONTROLLED STUDY; EPITHELIOID CELL; GOLGI COMPLEX; GRANULOMATOUS INFLAMMATION; IN VITRO STUDY; MACROPHAGE; MONONUCLEAR PHAGOCYTE; MOUSE; NONHUMAN; PERITONEUM MACROPHAGE; PHAGOCYTOSIS; PHENOTYPE; PROTEIN FUNCTION; ROUGH ENDOPLASMIC RETICULUM;

ANIMALS; CELLS, CULTURED; EPITHELIOID CELLS; GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR; GRANULOMA, FOREIGN-BODY; IMMUNOPHENOTYPING; INTERLEUKIN-4; MACROPHAGES; MALE; MICE; MICE, INBRED BALB C; PHAGOCYTOSIS; RECOMBINANT PROTEINS;

ANIMALIA; MURINAE;

EID: 0041382811     PISSN: 03603997     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1025084413767     Document Type: Article

References (39)

1. Adams, D. O. 1976. The granulomatous inflammatory response - A review. Am. J. Pathol. 84:164-191.
2. Williams, G. T. and W. J. Williams. 1983. Granulomatous inflammation - A review. J. Clin. Pathol. 36:723-733.
3. Sutton, J. S. and L. Weiss. 1966. Transformation of monocytes in tissue culture into macrophages, epithelioid cells, and multinucleated giant cells. An electron microscopy study. J. Cell Biol. 28:303-332.
4. Bainton, D. F. and D. W. Golde. 1978. Differentiation of macrophages from normal human bone marrow in liquid culture. J. Clin. Invest. 61:1555-1569.
5. Kaplan, G. and G. Gaudernack. 1982. In vitro differentiation of human monocytes. J. Exp. Med. 156:1101-1114.
6. Sallusto, F. and A. Lanzavecchia. 1994. Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulation factor plus interleukin 4 and downregulated by tumor necrosis factor α. J. Exp. Med. 179:1109-1118.
7. McNally, A. K and J. M. Anderson. 1995. Interleukin-4 induces foreign body giant cells from human monocytes/macrophages. Am. J. Patrol. 147:1487-1499.
8. Dugast, C., A. Gaudin, and L. Toujas. 1997. Generation of multinucleated giant cells by culture of monocyte-derived macrophages with IL-4. J. Leukoc. Biol. 61:517-521.
9. Akagawa, K. S., N. Takasuka, I. Komuro, M. Azuma, M. Ueda, M Naito, and K. Takahashi. 1996. Generation of CD1+RelB+ dendritic cells and tartrate-resistant acid phosphatase-positive osteoclast-like multinucleated giant cells from human monocytes. Blood 88:4029-4039.
10. Möst, J., L. Spötl, G. Mayr, A. Gasser, A. Sarti, and M. P. Dierich. 1997. Formation of multinucleated giant cells in vitro is dependent on the stage of monocyte to macrophage maturation. Blood 89:662-671.
11. Wynn, A. A., K. Miyakawa, E. Miyata, G. Dranoff, M. Takeya, and K. Takahashi. 2001. Role of granulocyte/macrophage colony-stimulating factor in zymocel-induced hepatic granuloma formation. Am. J. Patrol. 158:131-145.
12. Wynn, T. A. and A. W. Cheever. 1995. Cytokine regulation of granuloma formation in schistosomiasis. Curr. Opin. Immunol. 7:505-511.
13. Jankovic, D., M. C. Kullberg, N. Noben-Trauth, P. Caspar, J. M. Ward, A. W. Cheerer, W. E. Paul, and A. Sher. 1999. Schistosome-infected IL-4 receptor knockout (KO) mice, in contrast to IL-4 KO mice, fail to develop granulomatous pathology while maintaining the same lymphokine expression profile. J. Immunol. 163:337-342.
14. Chensue, S. W., P. D. Terebuh, K. S. Warmington, S. D. Hershey, H. L. Evanoff, S. L. Kunkel, and G. I. Higashi. 1992. Role of IL-4 and IFN-γ in Schistosoma mansoni egg-induced hypersensitivity granuloma formation. Orchestration, relative contribution, and relationship to macrophage function. J. Immunol. 148:900-906.
15. Kao, W. J., A. K. McNally, A. Hiltner, and J. M. Anderson. 1995. Role for interleukin-4 in foreign-body giant cell formation on a poly (etherurethane urea) in vivo. J. Biomed. Mater. Res. 9:1267-1275.
16. Mariano, M., T. Nikitin, and B. E. Malucelli. 1976. Immunological and non-immunological phagocytosis by inflammatory macrophages, epithelioid cells and macrophage polykarions from foreign body granulomata. J. Pathol. 20:151-159.
17. Nemoto, Y., T. Otsuka, H. Niiro, K. Izuhara, K. Yamaoka, H. Nakashima, and Y. Niho. 1999. Differential effects of interleukin-4 and interleukin-10 on nitric oxide production by murine macrophages. Inflamm. Res. 48:643-650.
18. Giorgi, R., R. L. Pagano, M. A. A. Dias, T. Aguiar-Passeti, C. Sorg, and M. Mariano. 1998. Antinociceptive effect of the calcium-binding protein MRP-14 and the role played by neutrophils on the control of inflammatory pain. J. Leukoc. Biol. 64:214-220.
19. Ridley, M. J., D. S. Ridley, and J. L. Turk. 1978. Surface markers on lymphocytes and cells of the mononuclear phagocyte series in skin sections in leprosy. J. Pathol. 125:91-98.
20. Kreuger, M. R., D. R. Tames, and M. Mariano. 1998. Expression of NO-synthase in cells of foreign-body and BCG-induced granulomata in mice: Influence of L-NAME on the evolution of the lesion. Immunology 95:278-282.
21. Aguiar-Passeti, T., E. Postol, C. Sorg, and M. Mariano. 1997. Epithelioid cells from foreign-body granuloma selectively express the calcium-binding protein MRP-14, a novel down-regulatory molecule of macrophage activation. J. Leukoc. Biol. 62:852-858.
22. Delabie, J., C. De Wolf-Peeters, J. J. Van Der Oord, and V. J. Desmet. 1990. Differential expression of the calcium-binding proteins MRP8 and MRP14 in granulomatous conditions: An immunohistochemical study. Clin. Exp. Immunol. 81:123-126.
23. Von Maarsseveen, T., R. Mullink, R. Rensen,s and J. Stam. 1985. HLA-DR antigens in epithelioid cell granulomas of sarcoidosis, using semithin frozen sections. A concept about granuloma formation. Sarcoidosis 2:148-153.
24. Izaki, S., O. Tanji, M. Okuma, H. Shimoda, N. P. Hsu-Oyama, T. Hibino, and K. Kitamura. 1991. IA antigen-positive epithelioid cells in experimentally induced granulomatous inflammation. J. Dermatol. Sci. 2:24-32.
25. Cain H. and B. Kraus. 1982. Cellular aspects of granulomas. Pathol. Res. Pract. 175:13-37.
26. van der Rhee, H., C. P. M. van der Burgh-de Winter, and Wth. Daems. 1979. The differentiation of monocytes into macrophages, epithelioid cells, and multinucleated giant cells in subcutaneous granulomas. I: Fine Structure. Cell Tissue Res. 197:355-378.
27. Papadimitriou, J. M. and W. G. Spector. 1971. The origin, properties and fate of epithelioid cells. J. Pathol. 105:187-203.
28. Sievers, H. and D. von Domarus. 1984. Foreign-body reaction against intraocular lenses. Ams. J. Ophthalmol. 97:743-751.
29. Lee, T. T., F. C. Martin, and J. E. Merril. 1993. Lymphokine induction of rat microglia multinucleated giant cell formation. Glia 8:51-61.
30. Rezzani, R., L. Rodella, G. Zauli, L. Caimi, and M. Vitale. 1999. Mouse peritoneal cells as reservoir of late dendritic cell progenitors. Br. J. Haematol. 104:111-118.
31. Makala, L. H. C., Y. Nishikawa, M. Mishima, N. Inoue, X. Xuan, H. Suzuki, K. Fujisaki, T. Mikami, and H. Nagasawa. 2002. Phenotype and functional of murine peritoneal cavity macrophage derived-dendritic cells. J. Vet. Med. Sci. 64:813-820.
32. Te Velde A. A., R. J. F. Huijbens, J. E. De Vries, and C. G. Figdor. 1990. IL-4 decreases FcγR membrane expression and FcγR-mediated cytotoxic activity of human monocytes. J. Immunol. 144:3046-3051.
33. Becker, S. and E. G. Daniel. 1990. Antagonistic and additive effects of IL-4 and interferon-γ on human monocytes and macrophages: Effects on Fc receptors, HLA-D antigens, and superoxide production. Cell Immunol. 129:351-362.
34. Erbe, D. V., J. E. Collins, L. Shen, R. F. Graziano, and M. W. Fanger. 1990. The effect of cytokines on the expression and function of Fc receptors for IgG on myeloid cells. Mol. Immunol. 27:57-67.
35. Rossman, M. D., P. Ruiz, P. Comber, F. Gomez, M. Rottem, and A. D. Schreiber. 1993. Modulation of macrophage Fcγ receptors by rGM-CSF. Exp. Hematol. 21:177-183.
36. Kedzierska, K., N. V. Vardaxix, A. Jaworowski and S. M. Crowe. 2001. FcγR-mediated phagocytosis by human macrophages involves Hck, Syk, and Pyk2 and is augmented by GM-CSF. J. Leukoc. Biol. 70:322-328.
37. Goldman, D. L., S. C. Lee, A. J. Mednick, L. Montella and A. Casadevall. 2000. Persistent Cryptococcus neoformans pulmonary infection in the rat is associated with intracellular parasitism, decreased inducible nitric synthase expression, and altered antibody responsiveness to cryptococcal polysaccharide. Infect. Immun. 68:832-838.
38. Hirata, M., K. Hirata, M. Kage, M. Zhang, T. Hara, and T. Fukuma. 2001. Effect of nitric oxide synthase inhibition on Schistosoma japonicum egg-induced granuloma formation in the mouse liver. Parasite Immunol. 23:281-289.
39. Facchetti F., W. Vermi, S. Fiorentini, M. Chilosi, A. Caruso, M. Duse, L. D. Notarangelo, and R. Badolato. 1999. Expression of inducible nitric oxide synthase in human granulomas and histiocytic reactions. Am. J. Pathol. 154:145-152.