Analysis of streptomyces coelicolor phosphopantetheinyl transferase, AcpS, reveals the basis for relaxed substrate specificity

Biochemistry

Volumn 50, Issue 25, 2011, Pages 5704-5717

  Dall Aglio, Patrick ^a   Arthur, Christopher J ^a   Williams, Christopher ^a   Vasilakis, Konstantinos ^a   Maple, Hannah J ^a   Crosby, John ^a   Crump, Matthew P ^a   Hadfield, Andrea T ^a  

^a UNIVERSITY OF BRISTOL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYL-COA; ACTIVE SITE; ACYL CARRIER PROTEINS; COENZYME A; LIGAND-FREE; MUTATIONAL ANALYSIS; POLYKETIDE SYNTHESIS; STREPTOMYCES COELICOLOR; SUBSTRATE SPECIFICITY; SYNTHASES;

BACTERIA; BIOSYNTHESIS; CATALYSIS; CRYSTAL STRUCTURE; KETONES; MAGNESIUM; SUBSTRATES;

FATTY ACIDS;

ACYL CARRIER PROTEIN; ACYL CARRIER PROTEIN SYNTHETASE; ACYL COENZYME A; COENZYME A; MAGNESIUM; PANTETHEINE PHOSPHATE; PHOSPHOPANTETHEINYLTRANSFERASE; TRANSFERASE; UNCLASSIFIED DRUG;

ACYLATION; ARTICLE; BINDING AFFINITY; BINDING SITE; BIOSYNTHESIS; CATALYSIS; CRYSTAL STRUCTURE; CRYSTALLIZATION; CRYSTALLOGRAPHY; ENZYME BINDING; ENZYME SPECIFICITY; NONHUMAN; OLIGOMERIZATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FOLDING; PROTEIN INTERACTION; STREPTOMYCES COELICOLOR; STRUCTURE ANALYSIS;

AMINO ACID SEQUENCE; BACTERIAL PROTEINS; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; ESCHERICHIA COLI PROTEINS; LIGANDS; MAGNESIUM; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PROTEIN BINDING; PROTEIN FOLDING; STREPTOMYCES COELICOLOR; SUBSTRATE SPECIFICITY; TRANSFERASES; TRANSFERASES (OTHER SUBSTITUTED PHOSPHATE GROUPS);

STREPTOMYCES COELICOLOR;

EID: 79959401975     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi2003668     Document Type: Article

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