Role of phosphopantetheinyl transferase genes in antibiotic production by Streptomyces coelicolor

Journal of Bacteriology

Volumn 190, Issue 20, 2008, Pages 6903-6908

  Lu, Ya Wen ^a   San Roman, Adrianna K ^a   Gehring, Amy M ^a  

^a WILLIAMS COLLEGE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTINORHODINE; ANTIBIOTIC AGENT; PHOSPHOPANTETHEINYL TRANSFERASE; TRANSFERASE; UNCLASSIFIED DRUG;

ARTICLE; BACTERIAL GENE; DRUG MANUFACTURE; MICROMORPHOLOGY; MUTANT; MUTATION; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; SCO5883 GENE; SCO6673; STREPTOMYCES COELICOLOR;

ANTHRAQUINONES; ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; GENE DELETION; MUTAGENESIS, INSERTIONAL; PEPTIDES; PRODIGIOSIN; STREPTOMYCES COELICOLOR; TRANSFERASES (OTHER SUBSTITUTED PHOSPHATE GROUPS);

STREPTOMYCES COELICOLOR;

EID: 53849110598     PISSN: 00219193     EISSN: None     Source Type: Journal    
DOI: 10.1128/JB.00865-08     Document Type: Article

References (34)

1. Bentley, S. D., K. F. Chater, A.-M. Cerdeño-Tárraga, G. L. Challis, N. R. Thomson, K. D. James, D. E. Harris, M. A. Quail, H. Keiser, D. Harper, A. Bateman, S. Brown, G. Chandra, C. W. Chen, M. Collins, A. Cronin, A. Fraser, A. Goble, J. Hidalgo, T. Hornsby, S. Howarth, C.-H. Huang, T. Keiser, L. Larke, L. Murphy, K. Oliver, S. O'Neil, E. Rabbinowitsch, M.-A. Rajandream, K. Rutherford, S. Rutter, K. Seeger, D. Saunders, S. Sharp, R. Squares, S. Squares, K. Taylor, T. Warren, A. Wietzorrek, J. Woodward, B. G. Barrell, J. Parkhill, and D. A. Hopwood. 2002. Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2). Nature 417:141-147.
2. Bibb, M. J. 2005. Regulation of secondary metabolism in streptomycetes. Curr. Opin. Microbiol. 8:208-215.
3. Bystrykh, L. V., M. A. Fernández-Moreno, J. K. Herrema, F. Malpartida, D. A. Hopwood, and L. Dijkhuizen. 1996. Production of actinorhodin "blue pigments" by Streptomyces coelicolor A3(2). J. Bacteriol. 178:2238-2244.
4. Cerdeno, A. M., M. J. Bibb, and G. L. Challis. 2001. Analysis of the prodiginine biosynthesis gene cluster of Streptomyces coelicolor A3(2): new mechanisms for chain initiation and termination in modular multienzymes. Chem. Biol. 8:817-829.
5. Champness, W. 2000. Actinomycete development, antibiotic production, and phylogeny: questions and challenges, p. 11-31. In Y. V. Brun and L. J. Shimkets (ed.), Prokaryotic development. ASM Press, Washington, DC.
6. Cox, R. J., J. Crosby, O. Daltrop, F. Glod, M. E. Jarzabek, T. P. Nicholson, M. Reed, T. J. Simpson, L. H. Smith, F. Soulas, A. E. Szafranska, and J. Westcott. 2002. Streptomyces coelicolor phosphopantetheinyl transferase: a promiscuous activator of polyketide and fatty acid synthase acyl carrier proteins. J. Chem. Soc. Perkin Trans. 1 2002:1644-1649.
7. Flett, F., V. Mersinias, and C. P. Smith. 1997. High efficiency intergenic conjugal transfer of plasmid DNA from Escherichia coli to methyl DNA-restricting streptomycetes. FEMS Microbiol. Lett. 155:223-229.
8. Galm, U., J. Schimana, H. Fiedler, J. Schmidt, S. Li, and L. Heide. 2002. Cloning and analysis of the simocyclinone biosynthetic gene cluster of Streptomyces antibioticus Tü 6040. Arch. Microbiol. 178:102-114.
9. Gehring, A. M., N. J. Yoo, and R. Losick. 2001. RNA polymerase sigma factor that blocks morphological differentiation by Streptomyces coelicolor. J. Bacteriol. 183:5991-5996.
10. Gruenwald, S., H. D. Mootz, P. Stehmeier, and T. Stachelhaus. 2004. In vivo production of artificial nonribosomal peptide products in the heterologous host Escherichia coli. Appl. Environ. Microbiol. 70:3282-3291.
11. Ho, T. F., C. J. Ma, C. H. Lu, Y. T. Tsai, Y. H. Wei, J. S. Chang, J. K. Lai, P. J. Cheuh, C. T. Yeh, P. C. Tang, J. T. Chang, J. L. Ko, F. S. Liu, H. E. Yen, and C. C. Chang. 2007. Undecylprodigiosin selectively induces apoptosis in human breast carcinoma cells independent of p53. Toxicol. Appl. Pharmacol. 225:318-328.
12. Hu, H., Q. Zhang, and K. Ochi. 2002. Activation of antibiotic biosynthesis by specified mutations in the rpoB gene (encoding the RNA polymerase β subunit) of Streptomyces lividans. J. Bacteriol. 184:3984-3991.
13. Huang, J., C. Lih, K. Pan, and S. N. Cohen. 2001. Global analysis of growth phase responsive gene expression and regulation of antibiotic biosynthetic pathways in Streptomyces coelicolor using DNA microarrays. Genes Dev. 15:3183-3192.
14. Huang, J., J. Shi, V. Molle, B. Sohlberg, D. Weaver, M. J. Bibb, N. Karoonuthaisiri, C. Lih, C. M. Kao, M. J. Buttner, and S. N. Cohen. 2005. Cross-regulation among disparate antibiotic biosynthetic pathways of Streptomyces coelicolor. Mol. Microbiol. 58:1276-1287.
15. Ikeda, H., J. Ishikawa, A. Hanamoto, M. Shinose, H. Kikuchi, T. Shiba, Y. Sakaki, M. Hattori, and S. Omura. 2003. Complete genome sequence and comparative analysis of the industrial microorganism Streptomyces avermitilis. Nat. Biotechnol. 21:526-531.
16. Kealey, J. T., L. Liu, D. V. Santi, M. C. Betlach, and P. J. Barr. 1998. Production of a polyketide natural product in nonpolyketide-producing prokaryotic and eukaryotic hosts. Proc. Natl. Acad. Sci. USA 95:505-509.
17. Kieser, T., M. J. Bibb, M. J. Buttner, K. F. Chater, and D. A. Hopwood. 2000. Practical Streptomyces genetics. The John Innes Foundation, Norwich, England.
18. Lambalot, R. H., A. M. Gehring, R. S. Flugel, P. Zuber, M. LaCelle, M. A. Marahiel, R. Reid, C. Khosla, and C. T. Walsh. 1996. A new enzyme superfamily - the phosphopantetheinyl transferases. Chem. Biol. 3:923-936.
19. Lautru, S., R. J. Deeth, L. M. Bailey, and G. L. Challis. 2005. Discovery of a new peptide natural product by Streptomyces coelicolor genome mining. Nat. Chem. Biol. 1:265-269.
20. Márquez-Fernández, O., A. Trigos, J. L. Ramos-Balderas, G. Viniegra-González, H. B. Deising, and J. Aguirre. 2007. Phosphopantetheinyl transferase CfwA/NpgA is required for Aspergillus nidulans secondary metabolism and asexual development. Eukaryot. Cell 6:710-720.
21. Oh, S. H., and K. F. Chater. 1997. Denaturation of circular or linear DNA facilitates targeted integrative transformation of Streptomyces coelicolor A3(2): possible relevance to other organisms. J. Bacteriol. 179:122-127.
22. Oliynyk, M., M. Samborskyy, J. B. Lester, T. Mironenko, N. Scott, S. Dickens, S. F. Haydock, and P. F. Leadlay. 2007. Complete genome sequence of the erythromycin-producing bacterium Saccharopolyspora erythraea NRRL23338. Nat. Biotechnol. 25:447-453.
23. Omura, S., H. Ikeda, J. Ishikawa, A. Hanamoto, C. Takahashi, M. Shinose, Y. Takahashi, H. Horikawa, H. Nakazawa, T. Osonoe, H. Kikuchi, T. Shiba, Y. Sakaki, and M. Hattori. 2001. Genome sequence of an industrial microorganism Streptomyces avermitilis: deducing the ability of producing secondary metabolites. Proc. Natl. Acad. Sci. USA 98:12215-12220.
24. Prentki, P., and H. M. Krisch. 1984. In vitro insertional mutagenesis with a selectable DNA fragment. Gene 29:303-313.
25. Reuter, K., M. R. Mofid, M. A. Marahiel, and R. Ficner. 1999. Crystal structure of the surfactin synthetase-activating enzyme Sfp: a prototype of the 4′-phosphopantetheinyl transferase superfamily. EMBO J. 18:6823-6831.
26. Sánchez, C., L. Du, D. J. Edwards, M. D. Toney, and B. Shen. 2001. Cloning and characterization of a phosphopantetheinyl transferase from Streptomyces verticillus ATCC15003, the producer of the hybrid peptide-polyketide antitumor drug bleomycin. Chem. Biol. 8:725-738.
27. Sevcikova, B., and J. Kormanec. 2004. Differential production of two antibiotics of Streptomyces coelicolor A3(2), actinorhodin and undecylprodigiosin, upon salt stress conditions. Arch. Microbiol. 181:384-389.
28. Stanley, A. E., L. J. Walton, M. K. Zerikly, C. Corre, and G. L. Challis. 2006. Elucidation of the Streptomyces coelicolor pathway to 4-methoxy-2,2′-bipyrrole-5-carboxaldehyde, an intermediate in prodiginine biosynthesis. Chem. Commun. 2006:3981-3983.
29. Thompson, C. J., D. Fink, and L. D. Nguyen. 2002. Principles of microbial alchemy: insights from the Streptomyces coelicolor genome sequence. Genome Biol. 3:reviews1020.1-1020.4.
30. Volokhan, O., H. Sletta, O. N. Sekurova, T. E. Ellingsen, and S. B. Zotchev. 2005. An unexpected role for the putative 4′- phosphopantetheinyl transferase-encoding gene nysF in the regulation of nystatin biosynthesis in Streptomyces noursei ATCC 11455. FEMS Microbiol. Lett. 249:57-64.
31. Walsh, C. T., A. M. Gehring, P. H. Weinreb, L. E. N. Quadri, and R. S. Flugel. 1997. Post-translational modification of polyketide and nonribosomal peptide synthases. Curr. Opin. Chem. Biol. 1:309-315.
32. Weissman, K. J., H. Hong, M. Oliynyk, A. P. Siskos, and P. F. Leadlay. 2004. Identification of a phosphopantetheinyl transferase for erythromycin biosynthesis in Saccharopolyspora erythraea. ChemBioChem 5:116-125.
33. Williamson, N. R., H. T. Simonsen, R. A. A. Ahmed, G. Goldet, H. Slater, L. Woodley, F. J. Leeper, and G. P. C. Salmond. 2005. Biosynthesis of the red antibiotic, prodigiosin, in Serratia: identification of a novel 2-methyl-3-n-amyl-pyrrole (MAP) assembly pathway, definition of the terminal condensing enzyme, and implications for undecylprodigiosin biosynthesis in Streptomyces. Mol. Microbiol. 56:971-989.
34. Yanisch-Perron, C., J. Vieira, and J. Messing. 1985. Improved M13 phage cloning vectors and host strains: nucleotide sequences of the M13mp18 and pUC19 vectors. Gene 33:103-119.