Transforming growth factor-β1 as a common target molecule for development of cardiovascular diseases, renal insufficiency and metabolic syndrome

Cardiology Research and Practice

Volumn 1, Issue 1, 2011, Pages

  Aihara, Ken Ichi ^a   Ikeda, Yasumasa ^a   Yagi, Shusuke ^a   Akaike, Masashi ^a   Matsumoto, Toshio ^a  

^a UNIVERSITY OF TOKUSHIMA   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; ANGIOTENSIN II; BEZAFIBRATE; CONNECTIVE TISSUE GROWTH FACTOR; ENDOTHELIAL NITRIC OXIDE SYNTHASE; FENOFIBRATE; GEMFIBROZIL; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; PIOGLITAZONE; PRAVASTATIN; SMAD PROTEIN; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 1; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 2; TRANSFORMING GROWTH FACTOR BETA1;

ATHEROSCLEROTIC PLAQUE; CARDIOVASCULAR DISEASE; CHRONIC KIDNEY DISEASE; CORONARY ARTERY ATHEROSCLEROSIS; CORONARY ARTERY DISEASE; DISEASE ASSOCIATION; DYSLIPIDEMIA; EXTRACELLULAR MATRIX; GLOMERULONEPHRITIS; GLOMERULOSCLEROSIS; HEART FAILURE; HEART MUSCLE FIBROSIS; HEART VENTRICLE HYPERTROPHY; HUMAN; HYPERTENSION; INSULIN RESISTANCE; KIDNEY FAILURE; KIDNEY POLYCYSTIC DISEASE; METABOLIC SYNDROME X; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OBESITY; PRIORITY JOURNAL; RESTENOSIS; REVIEW; TRANSLUMINAL CORONARY ANGIOPLASTY;

EID: 79959385890     PISSN: None     EISSN: 20900597     Source Type: Journal    
DOI: 10.4061/2011/175381     Document Type: Review

References (76)

1. Massagué J., Seoane J., Wotton D., Smad transcription factors Genes and Development 2005 19 23 2783 2810 (Pubitemid 41739965)
2. Javelaud D., Mauviel A., Mammalian transforming growth factor-β s: smad signaling and physio-pathological roles International Journal of Biochemistry and Cell Biology 2004 36 7 1161 1165 (Pubitemid 38515657)
3. Heldin C. H., Landstrm M., Moustakas A., Mechanism of TGF-β signaling to growth arrest, apoptosis, and epithelial-mesenchymal transition Current Opinion in Cell Biology 2009 21 2 166 176
4. Ruiz-Ortega M., Rodrguez-Vita J., Sanchez-Lopez E., Carvajal G., Egido J., TGF-β signaling in vascular fibrosis Cardiovascular Research 2007 74 2 196 206
5. Annes J. P., Munger J. S., Rifkin D. B., Making sense of latent TGF activation Journal of Cell Science 2003 116 2 217 224 (Pubitemid 36163863)
6. Leask A., Abraham D. J., TGF-β signaling and the fibrotic response FASEB Journal 2004 18 7 816 827
7. Gibbons G. H., Pratt R. E., Dzau V. J., Vascular smooth muscle cell hypertrophy vs. hyperplasia. Autocrine transforming growth factor- expression determines growth response to angiotensin II Journal of Clinical Investigation 1992 90 2 456 461
8. Weigert C., Brodbeck K., Klopfer K., Hring H. U., Schleicher E. D., Angiotensin II induces human TGF-beta 1 promoter activation: similarity to hyperglycaemia Diabetologia 2002 45 6 890 898
9. Cambien F., Ricard S., Troesch A., Mallet C., Généré naz L., Evans A., Arveiler D., Luc G., Ruidavets J. B., Poirier O., Polymorphisms of the transforming growth factor- 1 gene in relation to myocardial infarction and blood pressure: the etude cas-temoin de l'infarctus du myocarde (ECTIM) study Hypertension 1996 28 5 881 887 (Pubitemid 26365534)
10. Schultz J. E. J., Witt S. A., Glascock B. J., Nieman M. L., Reiser P. J., Nix S. L., Kimballand T. R., Doetschman T., TGF-β 1 mediates the hypertrophic cardiomyocyte growth induced by angiotensin II Journal of Clinical Investigation 2002 109 6 787 796 (Pubitemid 34263155)
11. Leask A., Potential therapeutic targets for cardiac fibrosis: TGF, angiotensin, endothelin, CCN2, and PDGF, partners in fibroblast activation Circulation Research 2010 106 11 1675 1680
12. Nikol S., Isner J. M., Pickering J. G., Kearney M., Leclerc G., Weir L., Expression of transforming growth factor- 1 is increased in human vascular restenosis lesions Journal of Clinical Investigation 1992 90 4 1582 1592
13. Harradine K. A., Akhurst R. J., Mutations of TGF signaling molecules in human disease Annals of Medicine 2006 38 6 403 414 (Pubitemid 44484878)
14. Bobik A., Agrotis A., Kanellakis P., Dilley R., Krushinsky A., Smirnov V., Tararak E., Condron M., Kostolias G., Distinct patterns of transforming growth factor- isoform and receptor expression in human atherosclerotic lesions: colocalization implicates TGF-β in fibrofatty lesion development Circulation 1999 99 22 2883 2891 (Pubitemid 29258976)
15. Suthanthiran M., Gerber L. M., Schwartz J. E., Sharma V. K., Medeiros M., Marion R., Pickering T. G., August P., Circulating transforming growth factor- 1 levels and the risk for kidney disease in African Americans Kidney International 2009 76 1 72 80
16. Sciarretta S., Ferrucci A., Ciavarella G. M., De Paolis P., Venturelli V., Tocci G., De Biase L., Rubattu S., Volpe M., Markers of inflammation and fibrosis are related to cardiovascular damage in hypertensive patients with metabolic syndrome American Journal of Hypertension 2007 20 7 784 791 (Pubitemid 46951019)
17. ten Dijke P., Arthur H. M., Extracellular control of TGF signalling in vascular development and disease Nature Reviews Molecular Cell Biology 2007 8 11 857 869 (Pubitemid 47622560)
18. Gordon K. J., Blobe G. C., Role of transforming growth factor- superfamily signaling pathways in human disease Biochimica et Biophysica Acta 2008 1782 4 197 228
19. Holderfield M. T., Hughes C. C. W., Crosstalk between vascular endothelial growth factor, notch, and transforming growth factor- in vascular morphogenesis Circulation Research 2008 102 6 637 652 (Pubitemid 351457853)
20. Redondo S., Santos-Gallego C. G., Tejerina T., TGF-β 1: a novel target for cardiovascular pharmacology Cytokine and Growth Factor Reviews 2007 18 3-4 279 286 (Pubitemid 46891292)
21. Heldin C. H., Miyazono K., ten Dijke P., TGF-β signalling from cell membrane to nucleus through SMAD proteins Nature 1997 390 6659 465 471 (Pubitemid 28013118)
22. Shi Y., Massagué J., Mechanisms of TGF-β signaling from cell membrane to the nucleus Cell 2003 113 6 685 700 (Pubitemid 36724933)
23. Schmierer B., Hill C. S., TGF -SMAD signal transduction: molecular specificity and functional flexibility Nature Reviews Molecular Cell Biology 2007 8 12 970 982 (Pubitemid 350174642)
24. Grainger D. J., Transforming growth factor and atherosclerosis: so far, so good for the protective cytokine hypothesis Arteriosclerosis, Thrombosis, and Vascular Biology 2004 24 3 399 404 (Pubitemid 38326130)
25. Derynck R., Zhang Y., Feng X. H., Smads: transcriptional activators of TGF-β responses Cell 1998 95 6 737 740 (Pubitemid 29014453)
26. Majesky M. W., Lindner V., Twardzik D. R., Schwartz S. M., Reidy M. A., Production of transforming growth factor during repair of arterial injury Journal of Clinical Investigation 1991 88 3 904 910
27. Kanzaki T., Tamura K., Takahashi K., Saito Y., Akikusa B., Oohashi H., Kasayuki N., Ueda M., Morisaki N., In vivo effect of TGF-β 1: enhanced intimal thickening by administration of TGF-β 1 in rabbit arteries injured with a balloon catheter Arteriosclerosis, Thrombosis, and Vascular Biology 1995 15 11 1951 1957
28. Chen Y. L., Wu H. W., Jiang M. J., Transforming growth factor- 1 gene and protein expression associated with atherogenesis of cholesterol-fed rabbits Histology and Histopathology 2000 15 2 421 428 (Pubitemid 30218835)
29. Gourdy P., Schambourg A., Filipe C., Douin-Echinard V., Garmy-Susini B., Calippe B., Tercé F., Bayard F., Arnal J. F., Transforming growth factor activity is a key determinant for the effect of estradiol on fatty streak deposit in hypercholesterolemic mice Arteriosclerosis, Thrombosis, and Vascular Biology 2007 27 10 2214 2221 (Pubitemid 350287252)
30. Verrecchia F., Mauviel A., Transforming growth factor- signaling through the Smad pathway: role in extracellular matrix gene expression and regulation Journal of Investigative Dermatology 2002 118 2 211 215 (Pubitemid 34158472)
31. Cipollone F., Fazia M., Mincione G., Iezzi A., Pini B., Cuccurullo C., Ucchino S., Spigonardo F., Di Nisio M., Cuccurullo F., Mezzetti A., Porreca E., Increased expression of transforming growth factor- 1 as a stabilizing factor in human atherosclerotic plaques Stroke 2004 35 10 2253 2257 (Pubitemid 39311245)
32. Draude G., Lorenz R. L., TGF-β 1 downregulates CD36 and scavenger receptor A but upregulates LOX-1 in human macrophages American Journal of Physiology 2000 278 4 H1042 H1048
33. Mallat Z., Gojova A., Marchiol-Fournigault C., Esposito B., Kamaté C., Merval R., Fradelizi D., Tedgui A., Inhibition of transforming growth factor- signaling accelerates atherosclerosis and induces an unstable plaque phenotype in mice Circulation Research 2001 89 10 930 934 (Pubitemid 34627899)
34. Ruiz-Ortega M., Ruperez M., Esteban V., Egido J., Molecular mechanisms of angiotensin II-induced vascular injury Current Hypertension Reports 2003 5 1 73 79 (Pubitemid 38898935)
35. Li J. H., Huang X. R., Zhu H. J., Johnson R., Lan H. Y., Role of TGF-β signaling in extracellular matrix production under high glucose conditions Kidney International 2003 63 6 2010 2019 (Pubitemid 36605812)
36. Li J. H., Huang X. R., Zhu H. J., Oldfield M., Cooper M., Truong L. D., Johnson R. J., Lan H. Y., Advanced glycation end products activate Smad signaling via TGF-beta-dependent and independent mechanisms: implications for diabetic renal and vascular disease The FASEB Journal 2004 18 1 176 178
37. Yagi S., Aihara K., Ikeda Y., Sumitomo Y., Yoshida S., Ise T., Iwase T., Ishikawa K., Azuma H., Akaike M., Matsumoto T., Pitavastatin, an HMG-CoA reductase inhibitor, exerts eNOS-independent protective actions against angiotensin II-induced cardiovascular remodeling and renal insufficiency Circulation Research 2008 102 1 68 76
38. Ikeda Y., Aihara K., Sato T., Akaike M., Yoshizumi M., Suzaki Y., Izawa Y., Fujimura M., Hashizume S., Kato M., Yagi S., Tamaki T., Kawano H., Matsumoto T., Azuma H., Kato S., Matsumoto T., Androgen receptor gene knockout male mice exhibit impaired cardiac growth and exacerbation of angiotensin II-induced cardiac fibrosis Journal of Biological Chemistry 2005 280 33 29661 29666 (Pubitemid 41177042)
39. Parker T. G., Packer S. E., Schneider M. D., Peptide growth factors can provoke 'fetal' contractile protein gene expression in rat cardiac myocytes Journal of Clinical Investigation 1990 85 2 507 514 (Pubitemid 20070059)
40. Rosenkranz S., Flesch M., Amann K., Haeuseler C., Kilter H., Seeland U., Schlter K. D., Bhm M., Alterations of -adrenergic signaling and cardiac hypertrophy in transgenic mice overexpressing TGF-β American Journal of Physiology 2002 283 3 H1253 H1262
41. Yagi S., Akaike M., Aihara K., Ishikawa K., Iwase T., Ikeda Y., Soeki T., Yoshida S., Sumitomo-Ueda Y., Matsumoto T., Sata M., Endothelial nitric oxide synthase-independent protective action of statin against angiotensin ii-induced atrial remodeling via reduced oxidant injury Hypertension 2010 55 4 918 923
42. Sumitomo-Ueda Y., Aihara K., Ise T., Yoshida S., Ikeda Y., Uemoto R., Yagi S., Iwase T., Ishikawa K., Hirata Y., Akaike M., Sata M., Kato S., Matsumoto T., Heparin cofactor II protects against angiotensin II-induced cardiac remodeling via attenuation of oxidative stress in mice Hypertension 2010 56 3 430 436
43. Zacchigna L., Vecchione C., Notte A., Cordenonsi M., Dupont S., Maretto S., Cifelli G., Ferrari A., Maffei A., Fabbro C., Braghetta P., Marino G., Selvetella G., Aretini A., Colonnese C., Bettarini U., Russo G., Soligo S., Adorno M., Bonaldo P., Volpin D., Piccolo S., Lembo G., Bressan G. M., Emilin1 links TGF-β maturation to blood pressure homeostasis Cell 2006 124 5 929 942 (Pubitemid 43344234)
44. August P., Suthanthiran M., Transforming growth factor signaling, vascular remodeling, and hypertension The New England Journal of Medicine 2006 354 25 2721 2644
45. Tashiro H., Shimokawa H., Sadamatu K., Yamamoto K., Sobel B. E., Maseri A., Yacoub M., Prognostic significance of plasma concentrations of transforming growth factor- in patients with coronary artery disease Coronary Artery Disease 2002 13 3 139 143 (Pubitemid 34747960)
46. Wildgruber M., Weiss W., Berger H., Wolf O., Eckstein H. H., Heider P., Association of circulating transforming growth factor beta, tumor necrosis factor alpha and basic fibroblast growth factor with restenosis after transluminal angioplasty European Journal of Vascular and Endovascular Surgery 2007 34 1 35 43 (Pubitemid 46852386)
47. Fukuda N., Tahira Y., Matsuda H., Matsumoto K., Transforming growth factor- as a treatment target in renal diseases Journal of Nephrology 2009 22 6 708 715
48. Ito Y., Goldschmeding R., Kasuga H., Claessen N., Nakayama M., Yuzawa Y., Sawai A., Matsuo S., Weening J. J., Aten J., Expression patterns of connective tissue growth factor and of TGF-β isoforms during glomerular injury recapitulate glomerulogenesis American Journal of Physiology 2010 299 3 F545 F558
49. Garca-Snchez O., Lpez-Hernndez F. J., Lpez-Novoa J. M., An integrative view on the role of TGF-β in the progressive tubular deletion associated with chronic kidney disease Kidney International 2010 77 950 955
50. Lee H. S., Song C. Y., Effects of TGF-β on podocyte growth and disease progression in proliferative podocytopathies Kidney and Blood Pressure Research 2010 33 1 24 29
51. Hassane S., Leonhard W. N., van der Wal A., Hawinkels L. J. A. C., Lantinga-van Leeuwen I. S., Ten Dijke P., Breuning M. H., De Heer E., Peters D. J.M., Elevated TGF -Smad signalling in experimental Pkd1 models and human patients with polycystic kidney disease Journal of Pathology 2010 222 1 21 31
52. Rosmond R., Chagnon M., Bouchard C., Bjrntorp P., Increased abdominal obesity, insulin and glucose levels in nondiabetic subjects with a T29C polymorphism of the transforming growth factor- gene Hormone Research 2003 59 4 191 194 (Pubitemid 36356913)
53. Xu H., Barnes G. T., Yang Q., Tan G., Yang D., Chou C. J., Sole J., Nichols A., Ross J. S., Tartaglia L. A., Chen H., Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance Journal of Clinical Investigation 2003 112 12 1821 1830 (Pubitemid 38063705)
54. Weisberg S. P., McCann D., Desai M., Rosenbaum M., Leibel R. L., Ferrante A. W., Obesity is associated with macrophage accumulation in adipose tissue Journal of Clinical Investigation 2003 112 12 1796 1808 (Pubitemid 38063703)
55. Spencer M., Yao-Borengasser A., Unal R., Adipose tissue macrophages in insulin-resistant subjects are associated with collagen VI and fibrosis and demonstrate alternative activation American Journal of Physiology 2010 299 6 E1016 E1027
56. Samad F., Yamamoto K., Pandey M., Loskutoff D. J., Elevated expression of transforming growth factor- in adipose tissue from obese mice Molecular Medicine 1997 3 1 37 48 (Pubitemid 27142523)
57. Raju J., Bajaj G., Chrusch J., Bird R. P., Obese state leads to elevated levels of TGF-β and COX isoforms in platelets of Zucker rats Molecular and Cellular Biochemistry 2006 284 1-2 19 24 (Pubitemid 44404406)
58. Herder C., Zierer A., Koenig W., Roden M., Meisinger C., Thorand B., Transforming growth factor- 1 and incident type 2 diabetes: results from the MONICA/KORA case-cohort study, 19842002 Diabetes Care 2009 32 10 1921 1923
59. Nakano S., Nagasawa T., Ijiro T., Inada Y., Tamura T., Maruyama K., Kuroda J., Yamazaki Y., Kusama H., Shibata N., Bezafibrate prevents hepatic stellate cell activation and fibrogenesis in a murine steatohepatitis model, and suppresses fibrogenic response induced by transforming growth factor- 1 in a cultured stellate cell line Hepatology Research 2008 38 10 1026 1039
60. Keech A., Simes R J., Barter P., Effects of long-term fenofibrate therapy on cardiovascular events in 9795 people with type 2 diabetes mellitus (the FIELD study): randomised controlled trial The Lancet 2005 366 1849 1861
61. Tenenbaum A., Motro M., Fisman E. Z., Tanne D., Boyko V., Behar S., Bezafibrate for the secondary prevention of myocardial infarction in patients with metabolic syndrome Archives of Internal Medicine 2005 165 10 1154 1160 (Pubitemid 40720740)
62. Tenkanen L., Mnttri M., Kovanen P. T., Virkkunen H., Manninen V., Gemfibrozil in the treatment of dyslipidemia: an 18-year mortality follow-up of the Helsinki Heart Study Archives of Internal Medicine 2006 166 7 743 748
63. Davidson M. H., Armani A., McKenney J. M., Jacobson T. A., Safety considerations with fibrate therapy American Journal of Cardiology 2007 99 6 S3 S18
64. Shi Y., O'Brien J. E. Jr., Fard A., Zalewski A., Transforming growth factor- 1 expression and myofibroblast formation during arterial repair Arteriosclerosis, Thrombosis, and Vascular Biology 1996 16 10 1298 1305 (Pubitemid 26339719)
65. Smith J. D., Bryant S. R., Couper L. L., Vary C. P. H., Gotwals P. J., Koteliansky V. E., Lindner V., Soluble transforming growth factor- type II receptor inhibits negative remodeling, fibroblast transdifferentiation, and intimal lesion formation but not endothelial growth Circulation Research 1999 84 10 1212 1222 (Pubitemid 29244783)
66. Kingston P. A., Sinha S., David A., Castro M. G., Lowenstein P. R., Heagerty A. M., Adenovirus-mediated gene transfer of a secreted transforming growth factor- type II receptor inhibits luminal loss and constrictive remodeling after coronary angioplasty and enhances adventitial collagen deposition Circulation 2001 104 21 2595 2601 (Pubitemid 33104799)
67. Grygielko E. T., Martin W. M., Tweed C., Thornton P., Harling J., Brooks D. P., Laping N. J., Inhibition of gene markers of fibrosis with a novel inhibitor of transforming growth factor- type I receptor kinase in puromycin-induced nephritis Journal of Pharmacology and Experimental Therapeutics 2005 313 3 943 951 (Pubitemid 40726998)
68. de Gouville A. C., Boullay V., Krysa G., Pilot J., Brusq J. M., Loriolle F., Gauthier J. M., Papworth S. A., Laroze A., Gellibert F., Huet S., Inhibition of TGF-β signaling by an ALK5 inhibitor protects rats from dimethylnitrosamine-induced liver fibrosis British Journal of Pharmacology 2005 145 2 166 177 (Pubitemid 40756521)
69. Bonniaud P., Margetts P. J., Kolb M., Schroeder J. A., Kapoun A. M., Damm D., Murphy A., Chakravarty S., Dugar S., Higgins L., Protter A. A., Gauldie J., Progressive transforming growth factor 1-induced lung fibrosis is blocked by an orally active ALK5 kinase inhibitor American Journal of Respiratory and Critical Care Medicine 2005 171 8 889 898 (Pubitemid 40562720)
70. Redondo S., Santos-Gallego C. G., Ganado P., Garca M., Rico L., Del Rio M., Tejerina T., Acetylsalicylic acid inhibits cell proliferation by involving transforming growth factor- Circulation 2003 107 4 626 629 (Pubitemid 36176815)
71. Redondo S., Ruiz E., Santos-Gallego C. G., Padilla E., Tejerina T., Pioglitazone induces vascular smooth muscle cell apoptosis through a peroxisome proliferator-activated receptor-, transforming growth factor- 1, and a Smad2-dependent mechanism Diabetes 2005 54 3 811 817 (Pubitemid 40322086)
72. Porreca E., Di Febbo C., Baccante G., Di Nisio M., Cuccurullo F., Increased transforming growth factor-beta circulating levels and production in human monocytes after 3-hydroxy-3-methyl-glutaryl-coenzyme a reductase inhibition with pravastatin Journal of the American College of Cardiology 2002 39 11 1752 1757 (Pubitemid 34595284)
73. Mizuguchi Y., Miyajima A., Kosaka T., Asano T., Asano T., Hayakawa M., Atorvastatin ameliorates renal tissue damage in unilateral ureteral obstruction Journal of Urology 2004 172 6 I 2456 2459 (Pubitemid 39507552)
74. Rumble J. R., Gilbert R. E., Cox A., Wu L., Cooper M. E., Angiotensin converting enzyme inhibition reduces the expression of transforming growth factor- and type IV collagen in diabetic vasculopathy Journal of Hypertension 1998 16 11 1603 1609 (Pubitemid 28515486)
75. Matsumoto Y., Uwatoku T., Oi K., Abe K., Hattori T., Morishige K., Eto Y., Fukumoto Y., Nakamura K. I., Shibata Y., Matsuda T., Takeshita A., Shimokawa H., Long-term inhibition of Rho-kinase suppresses neointimal formation after stent implantation in porcine coronary arteries: involvement of multiple mechanisms Arteriosclerosis, Thrombosis, and Vascular Biology 2004 24 1 181 186 (Pubitemid 38082431)
76. Peng H., Carretero O. A., Vuljaj N., Liao T. D., Motivala A., Peterson E. L., Rhaleb N. E., Angiotensin-converting enzyme inhibitors: a new mechanism of action Circulation 2005 112 16 2436 2445 (Pubitemid 41504493)