Structure of bacterial 3β/17β-hydroxysteroid dehydrogenase at 1.2 Å resolution: A model for multiple steroid recognition

Biochemistry

Volumn 41, Issue 50, 2002, Pages 14659-14668

  Benach, Jordi ^a,d   Filling, Charlotta ^a   Oppermann, Udo C T ^a   Roversi, Pietro ^b   Bricogne, Gérard ^b   Berndt, Kurt D ^a,c   Jörnvall, Hans ^a   Ladenstein, Rudolf ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b GLOBAL PHASING LTD   (United Kingdom)

^c SÖDERTÖRN UNIVERSITY   (Sweden)

^d Och Spine at New York Presbyterian Hospitals   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIA; CATALYSIS; CONFORMATIONS; CRYSTALLOGRAPHY; DEHYDROGENATION; ENZYMES; HORMONES; OLIGOMERS;

BINDING LOOPS;

BIOCHEMISTRY;

3(OR 17)BETA HYDROXYSTEROID DEHYDROGENASE; BACTERIAL ENZYME; STEROID; 3 (OR 17) BETA HYDROXYSTEROID DEHYDROGENASE; 3 (OR 17)-BETA-HYDROXYSTEROID DEHYDROGENASE; ANDROGEN; APOENZYME; BACTERIAL PROTEIN; BILE ACID; ESTROGEN; HYDROXYSTEROID DEHYDROGENASE;

ALPHA HELIX; ARTICLE; BETA SHEET; CATALYSIS; COMAMONAS TESTOSTERONI; CRYSTALLOGRAPHY; ENZYME ACTIVE SITE; ENZYME STRUCTURE; GRAM NEGATIVE BACTERIUM; MOLECULAR RECOGNITION; NONHUMAN; PRIORITY JOURNAL; REDUCTION; STRUCTURE ACTIVITY RELATION; SURFACE PROPERTY; BINDING SITE; CHEMICAL STRUCTURE; CHEMISTRY; ENZYME SPECIFICITY; ENZYMOLOGY; GENETICS; POINT MUTATION; PROTEIN FOLDING; PROTEIN TERTIARY STRUCTURE; STEREOISOMERISM; X RAY CRYSTALLOGRAPHY;

BACTERIA (MICROORGANISMS); COMAMONAS TESTOSTERONI; NEGIBACTERIA;

17-HYDROXYSTEROID DEHYDROGENASES; ANDROGENS; APOENZYMES; BACTERIAL PROTEINS; BILE ACIDS AND SALTS; BINDING SITES; COMAMONAS TESTOSTERONI; CRYSTALLOGRAPHY, X-RAY; ESTROGENS; MODELS, MOLECULAR; POINT MUTATION; PROTEIN FOLDING; PROTEIN STRUCTURE, TERTIARY; STEREOISOMERISM; SUBSTRATE SPECIFICITY;

EID: 0037126640     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi0203684     Document Type: Article

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