Elucidation of oxygenation steps during oviedomycin biosynthesis and generation of derivatives with increased antitumor activity

ChemBioChem

Volumn 10, Issue 2, 2009, Pages 296-303

  Lombó, Felipe ^a   Abdelfattah, Mohamed S ^b,c   Braña, Alfredo F ^a   Salas, José A ^a   Rohr, Jürgen ^b   Méndez, Carmen ^a  

^a DEPARTAMENTO DE BIOQUÍMICA Y BIOLOGÍA MOLECULAR   (Spain)

^b University of Kentucky   (United States)

^c Helwan University   (Egypt)

Author keywords

Angucycline; Antitumor agents; Combinatorial biosynthesis; Polyketides; Streptomyces

Indexed keywords

5 HYDROXYDEHYDRORABELOMYCIN; 9 HYDROXYRABELOMYCIN; ANGUCYCLINONE DERIVATIVE; ANTINEOPLASTIC AGENT; OVIEDOMYCIN; OXYGENASE; POLYKETIDE SYNTHASE; PREJADOMYCIN; PREJADOMYCIN 2 CARBOXYLATE; RABELOMYCIN; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CATALYSIS; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG STRUCTURE; DRUG SYNTHESIS; GENE CLUSTER; GENE FUNCTION; GENE SEQUENCE; HUMAN; HUMAN CELL; NONHUMAN; NUCLEOTIDE SEQUENCE; OXYGENATION; PRIORITY JOURNAL; STREPTOMYCES ALBUS;

AMINOGLYCOSIDES; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL PROLIFERATION; ETHERS, CYCLIC; FLAVIN-ADENINE DINUCLEOTIDE; GENE EXPRESSION REGULATION, BACTERIAL; HUMANS; OXYGEN; OXYGENASES; PLASMIDS; STREPTOMYCES;

STREPTOMYCES; STREPTOMYCES ALBUS; STREPTOMYCES ANTIBIOTICUS;

EID: 60349090133     PISSN: 14394227     EISSN: 14397633     Source Type: Journal    
DOI: 10.1002/cbic.200800425     Document Type: Article

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