Identification of the function of gene lndM2 encoding a bifunctional oxygenase-reductase involved in the biosynthesis of the antitumor antibiotic landomycin E by Streptomyces globisporus 1912 supports the originally assigned structure for landomycinone

Journal of Organic Chemistry

Volumn 70, Issue 2, 2005, Pages 631-638

  Zhu, Lili ^a   Ostash, Bohdan ^b   Rix, Uwe ^a   Nur E Alam, Mohammad ^a   Mayers, Almuth ^c   Luzhetskyy, Andriy ^c   Mendez, Carmen ^d   Salas, Jose A ^d   Bechthold, Andreas ^d   Fedorenko, Victor ^b   Rohr, Jürgen ^a  

^a University of Kentucky   (United States)

^b IVAN FRANKO NATIONAL UNIVERSITY OF LVIV   (Ukraine)

^c UNIVERSITY OF FREIBURG   (Germany)

^d DEPARTAMENTO DE BIOQUÍMICA Y BIOLOGÍA MOLECULAR   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTICS; BIOSYNTHESIS; ENZYMES; HYDROXYLATION; REDUCTION; TUMORS;

GENE ENCODING; MUTANTS; POST POLYKETIDE SYNTHASE (PKS); STREPTOMYCES GLOBISPORUS 1912;

GENES;

11 HYDROXYTETRANGOMYCIN; 4 HYDROXYTETRANGOMYCIN; ANGUCYCLINE DERIVATIVE; LANDOMYCIN E; LANDOMYCINONE; OLEANDOMYCIN DERIVATIVE; OXIDOREDUCTASE; POLYKETIDE SYNTHASE; TETRANGOMYCIN; TETRANGULOL; UNCLASSIFIED DRUG;

ANTIMICROBIAL ACTIVITY; ANTINEOPLASTIC ACTIVITY; ARTICLE; BACTERIAL GENE; BIOSYNTHESIS; COMPARATIVE STUDY; DRUG DESIGN; DRUG HYDROXYLATION; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVITY; GENE FUNCTION; GENE MUTATION; GENE SEQUENCE; GENETIC CODE; GLYCOSYLATION; LNDM2 GENE; NONHUMAN; PROTEIN FUNCTION; SEQUENCE ANALYSIS; STREPTOMYCES;

AMINOGLYCOSIDES; ANTIBIOTICS, ANTINEOPLASTIC; DNA, BACTERIAL; GENE EXPRESSION REGULATION, BACTERIAL; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENES, BACTERIAL; MOLECULAR STRUCTURE; MULTIGENE FAMILY; MUTATION; NAPHTHOQUINONES; OLIGOSACCHARIDES; OXIDOREDUCTASES; STREPTOMYCES;

EID: 19944430903     PISSN: 00223263     EISSN: None     Source Type: Journal    
DOI: 10.1021/jo0483623     Document Type: Article

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