Hydroxylation and ring-opening mechanism of an unusual flavoprotein monooxygenase, 2-Methyl-3-hydroxypyridine-5-carboxylic Acid oxygenase: A theoretical study

Chemistry - A European Journal

Volumn 16, Issue 8, 2010, Pages 2557-2566

  Tian, Boxue ^a,b   Tu, Yaoquan ^a   Strid, Åke ^a   Eriksson, Leif A ^a,b  

^a ÖREBRO UNIVERSITY   (Sweden)

^b NATIONAL UNIVERSITY OF IRELAND   (Ireland)

Author keywords

Flavoprotein monooxygenase; Hydroxylation; Molecular modeling; Ring opening reactions; Vitamins

Indexed keywords

ACTIVE SITE; AQUEOUS SOLUTIONS; AROMATIC RINGS; BACTERIAL DEGRADATION; BARRIER HEIGHTS; ENZYME CATALYSIS; FLAVOPROTEIN MONOOXYGENASE; HYDROXYLASES; HYDROXYPYRIDINE; MONOOXYGENASES; OXYGENASES; RING OPENING; RING OPENING REACTION; RING-OPENING REACTIONS; SUCCINIC ACIDS; THEORETICAL STUDY; VITAMIN B-6;

AROMATIC HYDROCARBONS; CARBOXYLIC ACIDS; DENSITY FUNCTIONAL THEORY; ENZYMES; MOLECULAR MODELING; NUTRITION; ORGANIC ACIDS; VITAMINS;

HYDROXYLATION;

2 METHYL 3 HYDROXYPYRIDINE 5 CARBOXYLIC ACID; 2-METHYL-3-HYDROXYPYRIDINE-5-CARBOXYLIC ACID; FLAVOPROTEIN; NICOTINIC ACID DERIVATIVE; OXYGENASE; VITAMIN;

ARTICLE; BINDING SITE; CATALYSIS; CHEMICAL STRUCTURE; CHEMISTRY; HYDROXYLATION; THEORETICAL MODEL;

BINDING SITES; CATALYSIS; FLAVOPROTEINS; HYDROXYLATION; MODELS, MOLECULAR; MODELS, THEORETICAL; NICOTINIC ACIDS; OXYGENASES; VITAMINS;

EID: 77149131524     PISSN: 09476539     EISSN: 15213765     Source Type: Journal    
DOI: 10.1002/chem.200902253     Document Type: Article

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