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Volumn 4, Issue 3, 2011, Pages 353-366

Complications of thalassemia major and their treatment

Author keywords

cardiac failure; complications; hypogonadism; hypoparathyroidism; hypothyroidism; liver disease; osteoporosis; pseudoxanthoma elasticum; thalassemia; thrombosis

Indexed keywords

IRON CHELATING AGENT;

EID: 79959268119     PISSN: 17474086     EISSN: 17474094     Source Type: Journal    
DOI: 10.1586/ehm.11.29     Document Type: Review
Times cited : (121)

References (132)
  • 1
    • 77149153067 scopus 로고    scopus 로고
    • Galanello R. βthalassemia
    • Cao A, Galanello R. βthalassemia. Genet. Med. 12(2), 61-76 (2010)
    • (2010) Genet. Med. , vol.12 , Issue.2 , pp. 61-76
    • Cao, A.1
  • 2
    • 0002341637 scopus 로고
    • A series of cases of splenomegaly in children with anemia and peculiar bone changes
    • Cooley TB, Lee P. A series of cases of splenomegaly in children with anemia and peculiar bone changes. Trans. Am. Pediatr. Soc. 37, 29-34 (1925)
    • (1925) Trans. Am. Pediatr. Soc. , vol.37 , pp. 29-34
    • Cooley, T.B.1    Lee, P.2
  • 3
    • 79551583056 scopus 로고    scopus 로고
    • Hepcidin and disorders of iron metabolism
    • Ganz T, Nemeth E. Hepcidin and disorders of iron metabolism. Annu. Rev. Med. 62, 347-360 (2011)
    • (2011) Annu. Rev. Med. , vol.62 , pp. 347-360
    • Ganz, T.1    Nemeth, E.2
  • 5
    • 33646407268 scopus 로고    scopus 로고
    • Cardiac morbidity and mortality in deferoxamine- or deferiprone-treated patients with thalassemia major
    • Borgna-Pignatti C, Cappellini MD, De Stefano P et al. Cardiac morbidity and mortality in deferoxamine- or deferiprone-treated patients with thalassemia major. Blood 107(9), 3733-3737 (2006)
    • (2006) Blood , vol.107 , Issue.9 , pp. 3733-3737
    • Borgna-Pignatti, C.1    Cappellini, M.D.2    De Stefano, P.3
  • 6
  • 7
    • 33750001927 scopus 로고    scopus 로고
    • Action of chelators in iron-loaded cardiac cells: Accessibility to intracellular labile iron and functional consequences
    • Glickstein H, El RB, Link G et al. Action of chelators in iron-loaded cardiac cells: accessibility to intracellular labile iron and functional consequences. Blood 108(9), 3195-3203 (2006)
    • (2006) Blood , vol.108 , Issue.9 , pp. 3195-3203
    • Glickstein, H.1    El, R.B.2    Link, G.3
  • 8
    • 0020561803 scopus 로고
    • Rapid desensitisation for desferrioxamine anaphylactoid reaction
    • Bosquet J, Navarro M, Robert G, Aye P, Michel FB. Rapid desensitisation for desferrioxamine anaphylactoid reaction. Lancet 8, 2 (8354), 859-860 (1983)
    • (1983) Lancet , vol.8 , Issue.2-8354 , pp. 859-860
    • Bosquet, J.1    Navarro, M.2    Robert, G.3    Aye, P.4    Michel, F.B.5
  • 9
    • 0023812748 scopus 로고
    • Hearing loss and desferrioxamine in homozygous βthalassemia
    • Albera R, Pia F, Morra B et al. Hearing loss and desferrioxamine in homozygous βthalassemia. Audiology 27(4), 207-214 (1988)
    • (1988) Audiology , vol.27 , Issue.4 , pp. 207-214
    • Albera, R.1    Pia, F.2    Morra, B.3
  • 10
    • 0024310392 scopus 로고
    • Desferrioxamine ototoxicity: Evaluation of risk factors in thalassaemic patients and guidelines for safe dosage
    • Porter JB, Jaswon MS, Huehns ER, East CA, Hazell JW. Desferrioxamine ototoxicity: evaluation of risk factors in thalassaemic patients and guidelines for safe dosage. Br. J. Haematol. 73(3), 403-409 (1989)
    • (1989) Br. J. Haematol. , vol.73 , Issue.3 , pp. 403-409
    • Porter, J.B.1    Jaswon, M.S.2    Huehns, E.R.3    East, C.A.4    Hazell, J.W.5
  • 11
    • 0021707996 scopus 로고
    • Ocular changes in patients undergoing long-term desferrioxamine treatment
    • Arden GB, Wonke B, Kennedy C, Huehns ER. Ocular changes in patients undergoing long-term desferrioxamine treatment. Br. J. Ophthalmol. 68(12), 873-877 (1984)
    • (1984) Br. J. Ophthalmol. , vol.68 , Issue.12 , pp. 873-877
    • Arden, G.B.1    Wonke, B.2    Kennedy, C.3    Huehns, E.R.4
  • 12
    • 0021321289 scopus 로고
    • Visual loss in patient on high-dose subcutaneous desferrioxamine
    • Borgna-Pignatti C, De Stefano P, Broglia AM. Visual loss in patient on high-dose subcutaneous desferrioxamine. Lancet 1(8378), 681 (1984)
    • (1984) Lancet , vol.1 , Issue.8378 , pp. 681
    • Borgna-Pignatti, C.1    De Stefano, P.2    Broglia, A.M.3
  • 13
    • 0023708159 scopus 로고
    • Deferoxamine-induced growth retardation in patients with thalassemia major
    • De Virgiliis S, Congia M, Frau F et al. Deferoxamine-induced growth retardation in patients with thalassemia major. J. Pediatr. 113(4), 661-669 (1988)
    • (1988) J. Pediatr. , vol.113 , Issue.4 , pp. 661-669
    • De Virgiliis, S.1    Congia, M.2    Frau, F.3
  • 14
    • 0022637891 scopus 로고
    • Yersinia sepsis in patients with iron overload treated with deferoxamine
    • Gallant T, Freedman MH, Vellend H, Francombe WH. Yersinia sepsis in patients with iron overload treated with deferoxamine. N. Engl. J. Med. 314(25), 1643 (1986)
    • (1986) N. Engl. J. Med. , vol.314 , Issue.25 , pp. 1643
    • Gallant, T.1    Freedman, M.H.2    Vellend, H.3    Francombe, W.H.4
  • 16
    • 33646414765 scopus 로고    scopus 로고
    • A Phase 3 study of deferasirox ICL670 a once-daily oral iron chelator in patients with βthalassemia
    • Cappellini MD, Cohen A, Piga A et al. A Phase 3 study of deferasirox (ICL670), a once-daily oral iron chelator, in patients with βthalassemia. Blood 107(9), 55-3462 (2006)
    • (2006) Blood , vol.107 , Issue.9 , pp. 55-3462
    • Cappellini, M.D.1    Cohen, A.2    Piga, A.3
  • 17
    • 0030896601 scopus 로고    scopus 로고
    • Mortality and morbidity in thalassaemia with conventional treatment
    • Piga A, Longo F, Consolati A et al. Mortality and morbidity in thalassaemia with conventional treatment. Bone Marrow Transplant. 19, 1-13 (1997)
    • (1997) Bone Marrow Transplant. , vol.19 , pp. 1-13
    • Piga, A.1    Longo, F.2    Consolati, A.3
  • 18
    • 0033693160 scopus 로고    scopus 로고
    • Morbidity and mortality of iron intoxication in adult patients with thalassemia major and effectiveness of chelation
    • Ladis V, Berdousi H, Palamidou F et al. Morbidity and mortality of iron intoxication in adult patients with thalassemia major, and effectiveness of chelation. Transfus. Sci. 23(3), 255-256 (2000)
    • (2000) Transfus. Sci. , vol.23 , Issue.3 , pp. 255-256
    • Ladis, V.1    Berdousi, H.2    Palamidou, F.3
  • 19
    • 0028912833 scopus 로고
    • Thalassemia major 1995: Older patients new therapies
    • Rund D, Rachmilewitz E. Thalassemia major 1995: older patients, new therapies. Blood Rev. 9(1), 25-32 (1995)
    • (1995) Blood Rev. , vol.9 , Issue.1 , pp. 25-32
    • Rund, D.1    Rachmilewitz, E.2
  • 20
    • 20844460608 scopus 로고    scopus 로고
    • Survival and complications in patients with thalassemia major treated with transfusion and deferoxamine
    • Borgna-Pignatti C, Rugolotto S, De Stefano P et al. Survival and complications in patients with thalassemia major treated with transfusion and deferoxamine. Haematologica 89(10), 1187-1193 (2004)
    • (2004) Haematologica , vol.89 , Issue.10 , pp. 1187-1193
    • Borgna-Pignatti, C.1    Rugolotto, S.2    De Stefano, P.3
  • 21
    • 79953860139 scopus 로고    scopus 로고
    • Cardiac iron and cardiac disease in males and females with transfusion-dependent thalassemia major: A T2. * MRI study
    • Marsella M, Borgna-Pignatti C, Meloni A et al. Cardiac iron and cardiac disease in males and females with transfusion-dependent thalassemia major: a T2. * MRI study. Haematologica 96(4), 15-20 (2011)
    • (2011) Haematologica , vol.96 , Issue.4 , pp. 15-20
    • Marsella, M.1    Borgna-Pignatti, C.2    Meloni, A.3
  • 22
    • 0036401485 scopus 로고    scopus 로고
    • The heart in thalassaemia
    • Walker JM, The heart in thalassaemia. Eur. Heart J. 23(2), 102-105 (2002)
    • (2002) Eur. Heart J. , vol.23 , Issue.2 , pp. 102-105
    • Walker, J.M.1
  • 23
    • 18044399191 scopus 로고    scopus 로고
    • Cardiovascular T2-star T2. * magnetic resonance for the early diagnosis of myocardial iron overload
    • Anderson LJ, Holden S, Davis B et al. Cardiovascular T2-star (T2. *) magnetic resonance for the early diagnosis of myocardial iron overload. Eur. Heart J. 22(23), 2171-2179 (2001)
    • (2001) Eur. Heart J. , vol.22 , Issue.23 , pp. 2171-2179
    • Anderson, L.J.1    Holden, S.2    Davis, B.3
  • 24
    • 72449177984 scopus 로고    scopus 로고
    • Cardiac T2. * magnetic resonance for prediction of cardiac complications in thalassemia major
    • Kirk P, Roughton M, Porter JB et al. Cardiac T2. * magnetic resonance for prediction of cardiac complications in thalassemia major. Circulation 120(20), 1961-1968 (2009)
    • (2009) Circulation , vol.120 , Issue.20 , pp. 1961-1968
    • Kirk, P.1    Roughton, M.2    Porter, J.B.3
  • 25
    • 70349628638 scopus 로고    scopus 로고
    • Myocardial scarring by delayed enhancement cardiovascular magnetic resonance in thalassaemia major
    • Pepe A, Positano V, Capra M et al. Myocardial scarring by delayed enhancement cardiovascular magnetic resonance in thalassaemia major. Heart 95(20), 1688-1693 (2009).
    • (2009) Heart , vol.95 , Issue.20 , pp. 1688-1693
    • Pepe, A.1    Positano, V.2    Capra, M.3
  • 26
    • 79953304982 scopus 로고    scopus 로고
    • Low prevalence of fibrosis in thalassemia major assessed by late gadolinium enhancement cardiovascular magnetic resonance
    • Kirk P, Carpenter JP, Tanner MA, Pennell DJ. Low prevalence of fibrosis in thalassemia major assessed by late gadolinium enhancement cardiovascular magnetic resonance. J. Cardiovasc. Magn. Reson. 13, 8 (2011)
    • (2011) J. Cardiovasc. Magn. Reson. , vol.13 , pp. 8
    • Kirk, P.1    Carpenter, J.P.2    Tanner, M.A.3    Pennell, D.J.4
  • 28
    • 78650996705 scopus 로고    scopus 로고
    • Continued improvement in myocardial T2. * over two years of deferasirox therapy in βthalassemia major patients with cardiac iron overload
    • Pennell DJ, Porter JB, Cappellini MD et al. Continued improvement in myocardial T2. Over two years of deferasirox therapy in βthalassemia major patients with cardiac iron overload. Haematologica 96(1), 48-54 (2011)
    • (2011) Haematologica , vol.96 , Issue.1 , pp. 48-54
    • Pennell, D.J.1    Porter, J.B.2    Cappellini, M.D.3
  • 29
    • 77953779950 scopus 로고    scopus 로고
    • The effect of deferasirox on cardiac iron in thalassemia major: Impact of total body iron stores
    • Wood JC, Kang BP, Thompson A et al. The effect of deferasirox on cardiac iron in thalassemia major: impact of total body iron stores. Blood 116(4), 537-543 (2010)
    • (2010) Blood , vol.116 , Issue.4 , pp. 537-543
    • Wood, J.C.1    Kang, B.P.2    Thompson, A.3
  • 30
    • 44049102508 scopus 로고    scopus 로고
    • Combined chelation therapy in thalassemia major for the treatment of severe myocardial siderosis with left ventricular dysfunction
    • Tanner MA, Galanello R, Dessi C et al. Combined chelation therapy in thalassemia major for the treatment of severe myocardial siderosis with left ventricular dysfunction. J. Cardiovasc. Magn. Reson. 10, 12 (2008)
    • (2008) J. Cardiovasc. Magn. Reson. , vol.10 , pp. 12
    • Tanner, M.A.1    Galanello, R.2    Dessi, C.3
  • 31
    • 77955274109 scopus 로고    scopus 로고
    • Increased survival and reversion of iron-induced cardiac disease in patients with thalassemia major receiving intensive combined chelation therapy as compared to desferoxamine alone
    • Lai ME, Grady RW, Vacquer S et al. Increased survival and reversion of iron-induced cardiac disease in patients with thalassemia major receiving intensive combined chelation therapy as compared to desferoxamine alone. Blood Cells Mol. Dis. 45(2), 136-139 (2010)
    • (2010) Blood Cells Mol. Dis. , vol.45 , Issue.2 , pp. 136-139
    • Lai, M.E.1    Grady, R.W.2    Vacquer, S.3
  • 32
    • 73149099158 scopus 로고    scopus 로고
    • Improved survival in thalassemia major patients on switching from desferrioxamine to combined chelation therapy with desferrioxamine and deferiprone
    • Telfer PT, Warburton F, Christou S et al. Improved survival in thalassemia major patients on switching from desferrioxamine to combined chelation therapy with desferrioxamine and deferiprone. Haematologica 94(12), 1777-1778 (2009)
    • (2009) Haematologica , vol.94 , Issue.12 , pp. 1777-1778
    • Telfer, P.T.1    Warburton, F.2    Christou, S.3
  • 33
    • 77956957627 scopus 로고    scopus 로고
    • Relation of chelation regimes to cardiac mortality and morbidity in patients with thalassaemia major: An observational study from a large Greek unit
    • Ladis V, Chouliaras G, Berdoukas V et al. Relation of chelation regimes to cardiac mortality and morbidity in patients with thalassaemia major: an observational study from a large Greek unit. Eur. J. Haematol. 85(4), 335-344 (2010)
    • (2010) Eur. J. Haematol. , vol.85 , Issue.4 , pp. 335-344
    • Ladis, V.1    Chouliaras, G.2    Berdoukas, V.3
  • 34
    • 42049114471 scopus 로고    scopus 로고
    • Society for the Study of Thalassemia and Hemoglobinopathies SoSTEGuideline recommendations for heart complications in thalassemia major
    • Cogliandro T, Derchi G, Mancuso L et al. Society for the Study of Thalassemia and Hemoglobinopathies (SoSTE)Guideline recommendations for heart complications in thalassemia major. J. Cardiovasc. Med. 9(5), 515-525 (2008)
    • (2008) J. Cardiovasc. Med. , vol.9 , Issue.5 , pp. 515-525
    • Cogliandro, T.1    Derchi, G.2    Mancuso, L.3
  • 35
    • 33751321207 scopus 로고    scopus 로고
    • Epidemiology of hepatitis B hepatitis C and human immunodeficiency virus infections in patients with βthalassemia in Iran: A multicenter study
    • Mirmomen S, Alavian SM, Hajarizadeh B et al. Epidemiology of hepatitis B, hepatitis C, and human immunodeficiency virus infections in patients with βthalassemia in Iran: a multicenter study. Arch. Iran Med. 9(4), 319-323 (2006)
    • (2006) Arch. Iran Med. , vol.9 , Issue.4 , pp. 319-323
    • Mirmomen, S.1    Alavian, S.M.2    Hajarizadeh, B.3
  • 36
    • 0037528891 scopus 로고    scopus 로고
    • High frequency of hepatitis B virus infection in patients with βthalassemia receiving multiple transfusions
    • Singh H, Pradhan M, Singh RL et al. High frequency of hepatitis B virus infection in patients with βthalassemia receiving multiple transfusions. Vox Sang. 84(4), 292-299 (2003)
    • (2003) Vox Sang. , vol.84 , Issue.4 , pp. 292-299
    • Singh, H.1    Pradhan, M.2    Singh, R.L.3
  • 37
    • 0036222153 scopus 로고    scopus 로고
    • Hepatitis- C-virus genotypes and hepatitis-G-virus infection in Lebanese thalassaemics
    • Ramia S, Koussa S, Taher A et al. Hepatitis- C-virus genotypes and hepatitis-G-virus infection in Lebanese thalassaemics. Ann. Trop. Med. Parasitol. 96(2), 197-202 (2002)
    • (2002) Ann. Trop. Med. Parasitol. , vol.96 , Issue.2 , pp. 197-202
    • Ramia, S.1    Koussa, S.2    Taher, A.3
  • 38
    • 0033106284 scopus 로고    scopus 로고
    • A prospective study on TT virus infection in transfusion-dependent patients with βthalassemia
    • Prati D, Lin YH, De Mattei C et al. A prospective study on TT virus infection in transfusion-dependent patients with βthalassemia. Blood 93(5), 1502-1505 (1999)
    • (1999) Blood , vol.93 , Issue.5 , pp. 1502-1505
    • Prati, D.1    Lin, Y.H.2    De Mattei, C.3
  • 39
    • 34848872294 scopus 로고    scopus 로고
    • Current risk for transfusion transmitted infections
    • Dodd RY. Current risk for transfusion transmitted infections. Curr. Opin. Hematol. 14(6), 671-676 (2007)
    • (2007) Curr. Opin. Hematol. , vol.14 , Issue.6 , pp. 671-676
    • Dodd, R.Y.1
  • 40
    • 77955485983 scopus 로고    scopus 로고
    • Transient elastography in the assessment of liver fibrosis in adult thalassemia patients
    • Fraquelli M, Cassinerio E, Roghi A et al. Transient elastography in the assessment of liver fibrosis in adult thalassemia patients. Am. J. Hematol. 85(8), 564-568 (2010)
    • (2010) Am. J. Hematol. , vol.85 , Issue.8 , pp. 564-568
    • Fraquelli, M.1    Cassinerio, E.2    Roghi, A.3
  • 41
    • 74049109710 scopus 로고    scopus 로고
    • Noninvasive assessment of liver fibrosis in thalassaemia major patients by transient elastography TE: Lack of interference by iron deposition
    • Di Marco V, Bronte F, Cabibi D et al. Noninvasive assessment of liver fibrosis in thalassaemia major patients by transient elastography (TE): lack of interference by iron deposition. Br. J. Haematol. 148(3), 476-479 (2009)
    • (2009) Br. J. Haematol. , vol.148 , Issue.3 , pp. 476-479
    • Di Marco, V.1    Bronte, F.2    Cabibi, D.3
  • 42
    • 0036660189 scopus 로고    scopus 로고
    • Effects of iron overload and hepatitis C virus positivity in determining progression of liver fibrosis in thalassemia following bone marrow transplantation
    • Angelucci E, Muretto P, Nicolucci A et al. Effects of iron overload and hepatitis C virus positivity in determining progression of liver fibrosis in thalassemia following bone marrow transplantation. Blood 100(1), 17-21 (2002)
    • (2002) Blood , vol.100 , Issue.1 , pp. 17-21
    • Angelucci, E.1    Muretto, P.2    Nicolucci, A.3
  • 43
    • 11244355277 scopus 로고    scopus 로고
    • Noninvasive measurement and imaging of liver iron concentrations using proton magnetic resonance
    • St Pierre TG, Clark PC, Chua-Anusorn W et al. Noninvasive measurement and imaging of liver iron concentrations using proton magnetic resonance. Blood 105(2), 855-861 (2005)
    • (2005) Blood , vol.105 , Issue.2 , pp. 855-861
    • St Pierre, T.G.1    Clark, P.C.2    Chua-Anusorn, W.3
  • 44
    • 23744459788 scopus 로고    scopus 로고
    • MRI R2 and R2. * mapping accurately estimates hepatic iron concentration in transfusion-dependent thalassemia and sickle cell disease patients
    • Wood JC, Enriquez C, Ghugre N et al. MRI R2 and R2. * mapping accurately estimates hepatic iron concentration in transfusion-dependent thalassemia and sickle cell disease patients. Blood 106(4), 1460-1465 (2005)
    • (2005) Blood , vol.106 , Issue.4 , pp. 1460-1465
    • Wood, J.C.1    Enriquez, C.2    Ghugre, N.3
  • 45
    • 34247159083 scopus 로고    scopus 로고
    • Magnetic resonance imaging measurement of iron overload
    • Wood JC. Magnetic resonance imaging measurement of iron overload. Curr. Opin. Hematol. 14(3), 183-190 (2007)
    • (2007) Curr. Opin. Hematol. , vol.14 , Issue.3 , pp. 183-190
    • Wood, J.C.1
  • 46
    • 34247216563 scopus 로고    scopus 로고
    • Asian Pacific Association for the Study of the Liver consensus statements on the diagnosis management and treatment of hepatitis C virus infection
    • McCaughan GW, Omata M, Amarapurkar D et al. Asian Pacific Association for the Study of the Liver consensus statements on the diagnosis, management and treatment of hepatitis C virus infection. J. Gastroenterol. Hepatol. 22(5), 615-633 (2007)
    • (2007) J. Gastroenterol. Hepatol. , vol.22 , Issue.5 , pp. 615-633
    • McCaughan, G.W.1    Omata, M.2    Amarapurkar, D.3
  • 47
    • 0029039362 scopus 로고
    • Histological grading and staging of chronic hepatitis
    • Ishak K, Baptista A, Bianchi L et al. Histological grading and staging of chronic hepatitis. J. Hepatol. 22(6), 696-699 (1995)
    • (1995) J. Hepatol. , vol.22 , Issue.6 , pp. 696-699
    • Ishak, K.1    Baptista, A.2    Bianchi, L.3
  • 48
    • 0029778988 scopus 로고    scopus 로고
    • An algorithm for the grading of activity in chronic hepatitis C
    • The metavir Cooperative Study Group
    • Bedossa P, Poynard T. An algorithm for the grading of activity in chronic hepatitis C: the METAVIR Cooperative Study Group. Hepatology 24(2), 289-293 (1996)
    • (1996) Hepatology , vol.24 , Issue.2 , pp. 289-293
    • Bedossa, P.1    Poynard, T.2
  • 49
    • 24944522397 scopus 로고    scopus 로고
    • Prevalence and severity of liver disease in patients with βthalassemia major: A single institution fifteen-year experience
    • Perifanis V, Tziomalos K, Tsatra I et al. Prevalence and severity of liver disease in patients with βthalassemia major: a single institution fifteen-year experience. Haematologica 90(8), 1136-1138 (2005)
    • (2005) Haematologica , vol.90 , Issue.8 , pp. 1136-1138
    • Perifanis, V.1    Tziomalos, K.2    Tsatra, I.3
  • 50
    • 9144224804 scopus 로고    scopus 로고
    • Hepatocellular carcinoma in the thalassaemia syndromes
    • Borgna-Pignatti C, Vergine G, Lombardo T et al. Hepatocellular carcinoma in the thalassaemia syndromes. Br. J. Haematol. 124 (1), 114-117 (2004)
    • (2004) Br. J. Haematol. , vol.124 , Issue.1 , pp. 114-117
    • Borgna-Pignatti, C.1    Vergine, G.2    Lombardo, T.3
  • 51
    • 58149296156 scopus 로고    scopus 로고
    • EASL Clinical Practice Guidelines: Management of chronic hepatitis B
    • European Association for the Study of the Liver
    • European Association for the Study of the Liver. EASL Clinical Practice Guidelines: management of chronic hepatitis B. J. Hepatol. 50(2), 227-242 (2009)
    • (2009) J. Hepatol. , vol.50 , Issue.2 , pp. 227-242
  • 52
    • 77958177906 scopus 로고    scopus 로고
    • Management of chronic viral hepatitis in patients with thalassemia: Recommendations from an international panel
    • Italian Society for the Study of Thalassemia and Haemoglobinopathies; Italian Association for the Study of the Liver
    • Di Marco V, Capra M, Angelucci E et al. Italian Society for the Study of Thalassemia and Haemoglobinopathies; Italian Association for the Study of the Liver. Management of chronic viral hepatitis in patients with thalassemia: recommendations from an international panel. Blood 116(16), 2875-2883 (2010)
    • (2010) Blood , vol.116 , Issue.16 , pp. 2875-2883
    • Di Marco, V.1    Capra, M.2    Angelucci, E.3
  • 53
    • 48749083577 scopus 로고    scopus 로고
    • Safety and efficacy of pegylated interferon a-2a and ribavirin for the treatment of hepatitis C in patients with thalassemia
    • Harmatz P, Jonas MM, Kwiatkowski JL et al. Safety and efficacy of pegylated interferon a-2a and ribavirin for the treatment of hepatitis C in patients with thalassemia. Haematologica 93(8), 1247-1251 (2008)
    • (2008) Haematologica , vol.93 , Issue.8 , pp. 1247-1251
    • Harmatz, P.1    Jonas, M.M.2    Kwiatkowski, J.L.3
  • 56
    • 58149522761 scopus 로고    scopus 로고
    • Hypogonadism diabetes mellitus hypothyroidism hypoparathyroidism: Incidence and prevalence related to iron overload and chelation therapy in patients with thalassaemia major followed from 1980 to 2007 in the Ferrara Centre
    • Gamberini MR, De Sanctis V, Gilli G. Hypogonadism, diabetes mellitus, hypothyroidism, hypoparathyroidism: incidence and prevalence related to iron overload and chelation therapy in patients with thalassaemia major followed from 1980 to 2007 in the Ferrara Centre. Ped. Endocrinol. Rev. 6(Suppl. 1), 158-169 (2008)
    • (2008) Ped. Endocrinol. Rev. , vol.6 , Issue.1 , pp. 158-169
    • Gamberini, M.R.1    De Sanctis, V.2    Gilli, G.3
  • 57
    • 0029063078 scopus 로고
    • Multicentre study on prevalence of endocrine complications in thalassemia major
    • Italian Working Group on Endocrine Complications in Non-Endocrine Disease
    • Italian Working Group on Endocrine Complications in Non-Endocrine Disease. Multicentre study on prevalence of endocrine complications in thalassemia major. Clin. Endocrinol. 42(6), 581-586 (1995).
    • (1995) Clin. Endocrinol. , vol.42 , Issue.6 , pp. 581-586
  • 58
    • 12944260630 scopus 로고    scopus 로고
    • Serum ferritin level as a predictor of impaired growth and puberty in thalassemia major patients
    • Shalitin S, Carmi D, Weintrob N et al. Serum ferritin level as a predictor of impaired growth and puberty in thalassemia major patients. Eur. J. Haematol. 74(2), 93-100 (2005)
    • (2005) Eur. J. Haematol. , vol.74 , Issue.2 , pp. 93-100
    • Shalitin, S.1    Carmi, D.2    Weintrob, N.3
  • 59
    • 33646823167 scopus 로고    scopus 로고
    • Impact of long-term iron chelation therapy on growth and endocrine function in thalassaemia
    • De Sanctis V, Roos M, Gasser T et al. Impact of long-term iron chelation therapy on growth and endocrine function in thalassaemia. J. Pediatr. Endocrinol. Metab. 19(4), 417-480 (2006)
    • (2006) J. Pediatr. Endocrinol. Metab. , vol.19 , Issue.4 , pp. 417-480
    • De Sanctis, V.1    Roos, M.2    Gasser, T.3
  • 60
    • 12544251076 scopus 로고    scopus 로고
    • Prevalence of diabetes mellitus and impaired glucose tolerance in βthalassemia patients with and without hepatitis C virus infection
    • Mowla A, Karimi M, Afrasiabi A, De Sanctis V. Prevalence of diabetes mellitus and impaired glucose tolerance in βthalassemia patients with and without hepatitis C virus infection. Pediatr. Endocrinol. Rev. 2(Suppl. 2), 282-284 (2004)
    • (2004) Pediatr. Endocrinol. Rev. , vol.2 , Issue.2 , pp. 282-284
    • Mowla, A.1    Karimi, M.2    Afrasiabi, A.3    De Sanctis, V.4
  • 61
    • 3042758517 scopus 로고    scopus 로고
    • Complications of βthalassemia major in North America
    • Cunningham MJ, Macklin EA, Neufeld EJ, Cohen AR. Complications of βthalassemia major in North America. Blood 104(1), 34-39 (2004)
    • (2004) Blood , vol.104 , Issue.1 , pp. 34-39
    • Cunningham, M.J.1    Macklin, E.A.2    Neufeld, E.J.3    Cohen, A.R.4
  • 62
    • 0030848911 scopus 로고    scopus 로고
    • Incidence of endocrine complications and clinical disease severity related to genotype analysis in patients with βthalassemia
    • Jensen CE, Tuck CM, Morris RW et al. Incidence of endocrine complications and clinical disease severity related to genotype analysis in patients with βthalassemia. Eur. J. Haematol. 59(2), 76-81 (1997)
    • (1997) Eur. J. Haematol. , vol.59 , Issue.2 , pp. 76-81
    • Jensen, C.E.1    Tuck, C.M.2    Morris, R.W.3
  • 63
    • 0034884847 scopus 로고    scopus 로고
    • Management of puberty for optimal auxological result in βthalassaemia major
    • Caruso-Nicoletti M, De Sanctis V, Cavallo L et al. Management of puberty for optimal auxological result in βthalassaemia major. J. Pediatr. Endocrinol. Metab. 14(Suppl. 2), 939-944 (2001)
    • (2001) J. Pediatr. Endocrinol. Metab. , vol.14 , Issue.2 , pp. 939-944
    • Caruso-Nicoletti, M.1    De Sanctis, V.2    Cavallo, L.3
  • 66
    • 77949716941 scopus 로고    scopus 로고
    • Pregnancy and βthalassemia: An Italian multicenter experience
    • Origa R, Piga A, Quarta G et al. Pregnancy and βthalassemia: an Italian multicenter experience. Haematologica 95(3), 376-381 (2010)
    • (2010) Haematologica , vol.95 , Issue.3 , pp. 376-381
    • Origa, R.1    Piga, A.2    Quarta, G.3
  • 67
    • 0036193617 scopus 로고    scopus 로고
    • Assessment of thyroid function in two hundred patients with βthalassemia major
    • Zervas A, Katopodi A, Protonotariou A et al. Assessment of thyroid function in two hundred patients with βthalassemia major. Thyroid 12(2), 151-154 (2002)
    • (2002) Thyroid , vol.12 , Issue.2 , pp. 151-154
    • Zervas, A.1    Katopodi, A.2    Protonotariou, A.3
  • 68
    • 33846002778 scopus 로고    scopus 로고
    • Longitudinal study on thyroid function in patients with thalassaemia major
    • Filosa A, Di Maio S, Aloj G, Acampora C. Longitudinal study on thyroid function in patients with thalassaemia major. J. Pediatr. Endocrinol. Metab. 19(12), 1397-1404 (2006)
    • (2006) J. Pediatr. Endocrinol. Metab. , vol.19 , Issue.12 , pp. 1397-1404
    • Filosa, A.1    Di Maio, S.2    Aloj, G.3    Acampora, C.4
  • 69
    • 58149512142 scopus 로고    scopus 로고
    • Exaggerated TSH response to TRH suβbiochemical hypothyroidism in prepubertal and adolescent thalassaemic patients with iron overload: Prevalence and 20-year natural history
    • De Sanctis V, Tanas R, Gamberini MR, Sprocati M, Govoni MR, Marsella M. Exaggerated TSH response to TRH ( suβbiochemical hypothyroidism) in prepubertal and adolescent thalassaemic patients with iron overload: prevalence and 20-year natural history. Ped. Endocrinol. Rev. 6(Suppl. 1), 170-173 (2008)
    • (2008) Ped. Endocrinol. Rev. , vol.6 , Issue.1 , pp. 170-173
    • De Sanctis, V.1    Tanas, R.2    Gamberini, M.R.3    Sprocati, M.4    Govoni, M.R.5    Marsella, M.6
  • 71
    • 74049116227 scopus 로고    scopus 로고
    • Normalisation of total body iron load with very intensive combined chelation reverses cardiac and endocrine complications of thalassaemia major
    • Farmaki K, Tzoumari I, Pappa C, Chouliaras G, Berdoukas V. Normalisation of total body iron load with very intensive combined chelation reverses cardiac and endocrine complications of thalassaemia major. Br. J. Haematol. 148(3), 466-475 (2010)
    • (2010) Br. J. Haematol. , vol.148 , Issue.3 , pp. 466-475
    • Farmaki, K.1    Tzoumari, I.2    Pappa, C.3    Chouliaras, G.4    Berdoukas, V.5
  • 72
    • 58149507846 scopus 로고    scopus 로고
    • Mild subclinical hypothyroidism in thalassaemia major: Prevalence multigated radionuclide test clinical and laboratory long-term follow-up study
    • De Sanctis V, De Sanctis E, Ricchieri P, Gubellini E, Gilli G, Gamberini MR. Mild subclinical hypothyroidism in thalassaemia major: prevalence, multigated radionuclide test, clinical and laboratory long-term follow-up study. Pediatr. Endocrinol. Rev. 6(Suppl. 1), 174-180 (2008)
    • (2008) Pediatr. Endocrinol. Rev. , vol.6 , Issue.1 , pp. 174-180
    • De Sanctis, V.1    De Sanctis, E.2    Ricchieri, P.3    Gubellini, E.4    Gilli, G.5    Gamberini, M.R.6
  • 73
    • 0032969047 scopus 로고    scopus 로고
    • High prevalence of thyroid dysfunction in adult patients with βthalassemia major submitted to amiodarone treatment
    • Mariotti S, Loviselli A, Murenu S et al. High prevalence of thyroid dysfunction in adult patients with βthalassemia major submitted to amiodarone treatment. J. Endocrinol. Invest. 22(1), 55-63 (1999)
    • (1999) J. Endocrinol. Invest. , vol.22 , Issue.1 , pp. 55-63
    • Mariotti, S.1    Loviselli, A.2    Murenu, S.3
  • 74
    • 0027056483 scopus 로고
    • Hypoparathyroidism in βthalassemia major clinical and laboratory observations in 24 patients
    • De Sanctis V, Vullo C, Bagni B, Chiccoli L. Hypoparathyroidism in βthalassemia major. Clinical and laboratory observations in 24 patients. Acta Haematol. 88(2-3), 105-108 (1992)
    • (1992) Acta Haematol. , vol.88 , Issue.2-3 , pp. 105-108
    • De Sanctis, V.1    Vullo, C.2    Bagni, B.3    Chiccoli, L.4
  • 75
    • 33646478331 scopus 로고    scopus 로고
    • Hypoparathyroidism in transfusion-dependent patients with βthalassemia
    • Angelopoulos NG, Goula A, Rombopoulos G et al. Hypoparathyroidism in transfusion-dependent patients with βthalassemia. J. Bone Miner. Metab. 24(2), 138-145 (2006)
    • (2006) J. Bone Miner. Metab. , vol.24 , Issue.2 , pp. 138-145
    • Angelopoulos, N.G.1    Goula, A.2    Rombopoulos, G.3
  • 77
    • 12544259078 scopus 로고    scopus 로고
    • Diabetes mellitus and impaired glucose tolerance in thalassaemia major: Incidence prevalence risk factors and survival in patients followed in the Ferrara Center
    • Gamberini MR, Fortini M, De Sanctis V, Gilli G, Tetsa R. Diabetes mellitus and impaired glucose tolerance in thalassaemia major: incidence, prevalence, risk factors and survival in patients followed in the Ferrara Center. Ped. Endocrinol. Rev. 2(Suppl. 2), 285-291 (2004)
    • (2004) Ped. Endocrinol. Rev. , vol.2 , Issue.2 , pp. 285-291
    • Gamberini, M.R.1    Fortini, M.2    De Sanctis, V.3    Gilli, G.4    Tetsa, R.5
  • 79
    • 0023841064 scopus 로고
    • Insulin resistance and hyperinsulinemia in patients with thalassemia major treated by hypertransfusion
    • Merkel PA, Simonson DC, Amiel SA et al. Insulin resistance and hyperinsulinemia in patients with thalassemia major treated by hypertransfusion. N. Engl. J. Med. 318(13), 809-814 (1988)
    • (1988) N. Engl. J. Med. , vol.318 , Issue.13 , pp. 809-814
    • Merkel, P.A.1    Simonson, D.C.2    Amiel, S.A.3
  • 80
    • 34248654567 scopus 로고    scopus 로고
    • The pancreas in βthalassemia major: MR imaging features and correlation with iron stores and glucose disturbances
    • Papakonstantinou O, Ladis V, Kostaridou S et al. The pancreas in βthalassemia major: MR imaging features and correlation with iron stores and glucose disturbances. Eur. Radiol. 17(6), 1535-1543 (2007)
    • (2007) Eur. Radiol. , vol.17 , Issue.6 , pp. 1535-1543
    • Papakonstantinou, O.1    Ladis, V.2    Kostaridou, S.3
  • 82
    • 0019977931 scopus 로고
    • HLA-A B C and DR antigen frequencies in relation to development of diabetes and variations in white cell antibody formation in highly transfused thalassemia patients
    • Pollack MS, Levine LS, Oberfield SE, Markenson AL. HLA-A, B, C, and DR antigen frequencies in relation to development of diabetes and variations in white cell antibody formation in highly transfused thalassemia patients. Transfusion 22(4), 279-282 (1982)
    • (1982) Transfusion , vol.22 , Issue.4 , pp. 279-282
    • Pollack, M.S.1    Levine, L.S.2    Oberfield, S.E.3    Markenson, A.L.4
  • 83
    • 12544253095 scopus 로고    scopus 로고
    • Effects of acarbose in patients with βthalassaemia major and abnormal glucose homeostasis
    • Mangiagli A, Campisi S, De Sanctis V et al. Effects of acarbose in patients with βthalassaemia major and abnormal glucose homeostasis. Pediatr. Endocrinol. Rev. 2(Suppl. 2), 276-278 (2004)
    • (2004) Pediatr. Endocrinol. Rev. , vol.2 , Issue.2 , pp. 276-278
    • Mangiagli, A.1    Campisi, S.2    De Sanctis, V.3
  • 84
  • 85
    • 0014834406 scopus 로고
    • Growth of children with thalassaemia: Effect of different transfusion regimens
    • Kattamis C, Touliatos N, Haidas S, Matsaniotis N. Growth of children with thalassaemia: effect of different transfusion regimens. Arch. Dis. Child. 45(242), 502-509 (1970)
    • (1970) Arch. Dis. Child. , vol.45 , Issue.242 , pp. 502-509
    • Kattamis, C.1    Touliatos, N.2    Haidas, S.3    Matsaniotis, N.4
  • 86
    • 0028308279 scopus 로고
    • Effect of different treatment regimes on linear growth and final height in βthalassaemia major
    • De Sanctis V, Katz M, Vullo C, Bagni B, Ughi M, Wonke B. Effect of different treatment regimes on linear growth and final height in βthalassaemia major. Clin. Endocrinol. (Oxf)40(6), 791-798 (1994)
    • (1994) Clin. Endocrinol. Oxf , vol.40 , Issue.6 , pp. 791-798
    • De Sanctis, V.1    Katz, M.2    Vullo, C.3    Bagni, B.4    Ughi, M.5    Wonke, B.6
  • 87
    • 0029963993 scopus 로고    scopus 로고
    • Growth and development in thalassaemia major patients with severe bone lesions due to desferrioxamine
    • De Sanctis V, Pinamonti A, Di Palma A et al. Growth and development in thalassaemia major patients with severe bone lesions due to desferrioxamine. Eur. J. Pediatr. 155(5), 368-372 (1996)
    • (1996) Eur. J. Pediatr. , vol.155 , Issue.5 , pp. 368-372
    • De Sanctis, V.1    Pinamonti, A.2    Di Palma, A.3
  • 88
    • 0018900942 scopus 로고
    • Depressed serum somatomedin activity in βthalassemia
    • Saenger P, Schwartz E, Markenson AL et al. Depressed serum somatomedin activity in βthalassemia. J. Pediatr. 96(2), 214-218 (1980)
    • (1980) J. Pediatr. , vol.96 , Issue.2 , pp. 214-218
    • Saenger, P.1    Schwartz, E.2    Markenson, A.L.3
  • 89
    • 0030788711 scopus 로고    scopus 로고
    • Growth deficiency in polytransfused β-thalassaemia patients is not growth hormone dependent
    • Cavallo L, Gurrado R, Gallo F, Zacchino C, De Mattia D, Tatò L. Growth deficiency in polytransfused βthalassaemia patients is not growth hormone dependent. Clin. Endocrinol. 46(6), 701-706 (1997)
    • (1997) Clin. Endocrinol. , vol.46 , Issue.6 , pp. 701-706
    • Cavallo, L.1    Gurrado, R.2    Gallo, F.3    Zacchino, C.4    De Mattia, D.5    Tatò, L.6
  • 90
    • 0242439285 scopus 로고    scopus 로고
    • Growth hormone GH deficiency in patients with βthalassemia major and the efficacy of recombinant GH treatment
    • Wu KH, Tsai FJ, Peng CT. Growth hormone (GH) deficiency in patients with βthalassemia major and the efficacy of recombinant GH treatment. Ann. Hematol. 82(10), 637-640 (2003).
    • (2003) Ann. Hematol. , vol.82 , Issue.10 , pp. 637-640
    • Wu, K.H.1    Tsai, F.J.2    Peng, C.T.3
  • 91
    • 73949087911 scopus 로고    scopus 로고
    • Growth and factors affecting it in thalassemia major
    • Soliman AT, Khalafallah H, Ashour R. Growth and factors affecting it in thalassemia major. Hemoglobin 33(Suppl. 1), S116-S126 (2009)
    • (2009) Hemoglobin , vol.33 , Issue.1
    • Soliman, A.T.1    Khalafallah, H.2    Ashour, R.3
  • 92
    • 0032424337 scopus 로고    scopus 로고
    • Short-term therapy with recombinant growth hormone in polytransfused thalassaemia major patients with growth deficiency
    • Cavallo L, Gurrado R, Zecchino C et al. Short-term therapy with recombinant growth hormone in polytransfused thalassaemia major patients with growth deficiency. J. Pediatr. Endocrinol. Metab. 11(Suppl. 3), 845-849 (1998)
    • (1998) J. Pediatr. Endocrinol. Metab. , vol.11 , Issue.3 , pp. 845-849
    • Cavallo, L.1    Gurrado, R.2    Zecchino, C.3
  • 93
    • 20444482450 scopus 로고    scopus 로고
    • Growth hormone secretion in adult patients with thalassaemia
    • La Rosa C, De Sanctis V, Mangiagli A et al. Growth hormone secretion in adult patients with thalassaemia. Clin. Endocrinol. 62(6), 667-671 (2005)
    • (2005) Clin. Endocrinol. , vol.62 , Issue.6 , pp. 667-671
    • La Rosa, C.1    De Sanctis, V.2    Mangiagli, A.3
  • 95
    • 78049382528 scopus 로고    scopus 로고
    • Prevalence of growth hormone deficiency in adult polytransfused βthalassemia patients and correlation with transfusional and chelation parameters
    • Poggi M, Pascucci C, Monti S et al. Prevalence of growth hormone deficiency in adult polytransfused βthalassemia patients and correlation with transfusional and chelation parameters. J. Endocrinol. Invest. 33(8), 534-538 (2010)
    • (2010) J. Endocrinol. Invest. , vol.33 , Issue.8 , pp. 534-538
    • Poggi, M.1    Pascucci, C.2    Monti, S.3
  • 96
    • 0023127646 scopus 로고
    • Adrenal function in thalassemia major following long-term treatment with multiple transfusions and chelation therapy. Evidence for dissociation of cortisol and adrenal androgen secretion
    • Sklar CA, Lew LQ, Yoon DJ, David R. Adrenal function in thalassemia major following long-term treatment with multiple transfusions and chelation therapy. Evidence for dissociation of cortisol and adrenal androgen secretion. Am. J. Dis. Child. 141(3), 327-330 (1987)
    • (1987) Am. J. Dis. Child. , vol.141 , Issue.3 , pp. 327-330
    • Sklar, C.A.1    Lew, L.Q.2    Yoon, D.J.3    David, R.4
  • 97
    • 12744273682 scopus 로고    scopus 로고
    • Assessment of adrenal endocrine function in Asian thalassemics
    • Srivatsa A, Marwaha RK, Muraldharan R, Trehan A. Assessment of adrenal endocrine function in Asian thalassemics. Indian Pediatr. 42(1), 31-35 (2005)
    • (2005) Indian Pediatr. , vol.42 , Issue.1 , pp. 31-35
    • Srivatsa, A.1    Marwaha, R.K.2    Muraldharan, R.3    Trehan, A.4
  • 98
    • 73949128588 scopus 로고    scopus 로고
    • The pituitary-adrenal axis in adult thalassaemic patients
    • Scacchi M, Danesi L, Cattaneo A et al. The pituitary-adrenal axis in adult thalassaemic patients. Eur. J. Endocrinol. 162(1), 43-48 (2010)
    • (2010) Eur. J. Endocrinol. , vol.162 , Issue.1 , pp. 43-48
    • Scacchi, M.1    Danesi, L.2    Cattaneo, A.3
  • 99
    • 66249120658 scopus 로고    scopus 로고
    • Predisposing factors for adrenal insufficiency
    • Bornstein SR. Predisposing factors for adrenal insufficiency. N. Engl. J. Med. 360(22), 2328-2339 (2009)
    • (2009) N. Engl. J. Med. , vol.360 , Issue.22 , pp. 2328-2339
    • Bornstein, S.R.1
  • 100
    • 68949208818 scopus 로고    scopus 로고
    • Differences in the prevalence of growth endocrine and vitamin D abnormalitues among the various thalassaemia syndromes in North America
    • Vogiatzi MG, Macklin EA, Trachtenberg FL et al. Differences in the prevalence of growth, endocrine and vitamin D abnormalitues among the various thalassaemia syndromes in North America. Br. J. Haematol. 146(5), 546-556 (2009)
    • (2009) Br. J. Haematol. , vol.146 , Issue.5 , pp. 546-556
    • Vogiatzi, M.G.1    Macklin, E.A.2    Trachtenberg, F.L.3
  • 101
    • 29744462903 scopus 로고    scopus 로고
    • Osteoporosis in βthalassemia: Clinical and genetic aspects
    • Origa R, Fiumana E, Gamberini MR et al. Osteoporosis in βthalassemia: clinical and genetic aspects. Ann. NY Acad. Sci. 1054, 451-456 (2005)
    • (2005) Ann. NY Acad. Sci. , vol.1054 , pp. 451-456
    • Origa, R.1    Fiumana, E.2    Gamberini, M.R.3
  • 102
    • 0032411128 scopus 로고    scopus 로고
    • High prevalence of low bone mass in thalassaemia major
    • Jensen CE, Tuck SM, Agnew JE et al. High prevalence of low bone mass in thalassaemia major. Br. J. Haematol. 103(4), 911-915 (1998)
    • (1998) Br. J. Haematol. , vol.103 , Issue.4 , pp. 911-915
    • Jensen, C.E.1    Tuck, S.M.2    Agnew, J.E.3
  • 103
    • 3242795997 scopus 로고    scopus 로고
    • Osteoprotegerin and RANKL in the pathogenesis of thalassemia-induced osteoporosis: New pieces of the puzzle
    • Morabito N, Gaudio A, Lasco A et al. Osteoprotegerin and RANKL in the pathogenesis of thalassemia-induced osteoporosis: new pieces of the puzzle. J. Bone Miner Res. 19(5), 722-727 (2004)
    • (2004) J. Bone Miner Res. , vol.19 , Issue.5 , pp. 722-727
    • Morabito, N.1    Gaudio, A.2    Lasco, A.3
  • 104
    • 40549136796 scopus 로고    scopus 로고
    • Continuous increase in erythropoietic activity despite the improvement in bone mineral density by zoledronic acid in patients with thalassemia intermedia-induced osteoporosis
    • Voskaridou E, Christoulas D, Antoniadou L, Terpos E. Continuous increase in erythropoietic activity despite the improvement in bone mineral density by zoledronic acid in patients with thalassemia intermedia-induced osteoporosis. Acta Haematol. 119(1), 40-44 (2008)
    • (2008) Acta Haematol. , vol.119 , Issue.1 , pp. 40-44
    • Voskaridou, E.1    Christoulas, D.2    Antoniadou, L.3    Terpos, E.4
  • 105
    • 34447514029 scopus 로고    scopus 로고
    • Vitamin D deficiency
    • Holick MF. Vitamin D deficiency. N. Engl. J. Med. 357(3), 266-281 (2007)
    • (2007) N. Engl. J. Med. , vol.357 , Issue.3 , pp. 266-281
    • Holick, M.F.1
  • 106
    • 32644467389 scopus 로고    scopus 로고
    • Calcium plus vitamin D supplementation and the risk of fractures
    • Jackson RD, LaCroix AZ, Gass M et al. Calcium plus vitamin D supplementation and the risk of fractures. N. Engl. J. Med. 354 (7), 669-683 (2006)
    • (2006) N. Engl. J. Med. , vol.354 , Issue.7 , pp. 669-683
    • Jackson, R.D.1    LaCroix, A.Z.2    Gass, M.3
  • 107
    • 2642570130 scopus 로고    scopus 로고
    • The effects of potassium and magnesium supplementations on urinary risk factors of renal stone patients
    • Jaipakdee S, Prasongwatana V, Premgamone A et al. The effects of potassium and magnesium supplementations on urinary risk factors of renal stone patients. J. Med. Assoc. Thai. 87(3), 255-263 (2004)
    • (2004) J. Med. Assoc. Thai. , vol.87 , Issue.3 , pp. 255-263
    • Jaipakdee, S.1    Prasongwatana, V.2    Premgamone, A.3
  • 108
    • 23444450423 scopus 로고    scopus 로고
    • Teriparatide osteoporosis calcium and vitamin D
    • Vieth R, Cole DE. Teriparatide, osteoporosis, calcium, and vitamin D. N. Engl. J. Med. 353(6), 634-635 (2005)
    • (2005) N. Engl. J. Med. , vol.353 , Issue.6 , pp. 634-635
    • Vieth, R.1    Cole, D.E.2
  • 109
    • 73349090939 scopus 로고    scopus 로고
    • Strontium ranelate: The first agent of a new therapeutic class in osteoporosis
    • Neuprez A, Hiligsmann M, Scholtissen S, Bruyere O, Reginster JY. Strontium ranelate: the first agent of a new therapeutic class in osteoporosis. Adv. Ther. 25(12), 1235-1256 (2008)
    • (2008) Adv. Ther. , vol.25 , Issue.12 , pp. 1235-1256
    • Neuprez, A.1    Hiligsmann, M.2    Scholtissen, S.3    Bruyere, O.4    Reginster, J.Y.5
  • 110
    • 0023930820 scopus 로고
    • Electroretinographic and visual-evoked potential abnormalities in patients with βthalassemia major
    • Gelmi C, Borgna-Pignatti C, Franchin S, Tacchini M, Trimarchi F. Electroretinographic and visual-evoked potential abnormalities in patients with βthalassemia major. Ophthalmologica 196(1), 29-34 (1988)
    • (1988) Ophthalmologica , vol.196 , Issue.1 , pp. 29-34
    • Gelmi, C.1    Borgna-Pignatti, C.2    Franchin, S.3    Tacchini, M.4    Trimarchi, F.5
  • 115
    • 4444226202 scopus 로고    scopus 로고
    • Aneurysmatic dilatation of ascending aorta in a patient with βthalassemia and a pseudoxanthoma elasticum-like syndrome
    • Farmakis D, Vesleme V, Papadogianni A, Tsaftaridis P, Kapralos P, Aessopos A. Aneurysmatic dilatation of ascending aorta in a patient with βthalassemia and a pseudoxanthoma elasticum-like syndrome. Ann. Hematol. 83(9), 596-599 (2004)
    • (2004) Ann. Hematol. , vol.83 , Issue.9 , pp. 596-599
    • Farmakis, D.1    Vesleme, V.2    Papadogianni, A.3    Tsaftaridis, P.4    Kapralos, P.5    Aessopos, A.6
  • 116
    • 0037000806 scopus 로고    scopus 로고
    • Cardiovascular involvement in thalassaemic patients with pseudoxanthoma elasticum-like skin lesions: A long-term follow-up study
    • Cianciulli P, Sorrentino F, Maffei L et al. Cardiovascular involvement in thalassaemic patients with pseudoxanthoma elasticum-like skin lesions: a long-term follow-up study. Eur. J. Clin. Invest. 32(9), 700-706 (2002)
    • (2002) Eur. J. Clin. Invest. , vol.32 , Issue.9 , pp. 700-706
    • Cianciulli, P.1    Sorrentino, F.2    Maffei, L.3
  • 117
    • 77953454937 scopus 로고    scopus 로고
    • Magnesium carbonate-containing phosphate binder prevents connective tissue mineralization in Abcc6-/- mice-potential for treatment of pseudoxanthoma elasticum
    • Li Q, Larusso J, Grand-Pierre AE, Uitto J. Magnesium carbonate-containing phosphate binder prevents connective tissue mineralization in Abcc6-/- mice-potential for treatment of pseudoxanthoma elasticum. Clin. Transl. Sci. 2(6), 398-404 (2009)
    • (2009) Clin. Transl. Sci. , vol.2 , Issue.6 , pp. 398-404
    • Li, Q.1    Larusso, J.2    Grand-Pierre, A.E.3    Uitto, J.4
  • 118
    • 0031930888 scopus 로고    scopus 로고
    • Thromboembolic events in b thalassemia major: an Italian multicenter study
    • Borgna Pignatti C, Carnelli V, Caruso V et al. Thromboembolic events in b thalassemia major: an Italian multicenter study. Acta Haematol. 99(2), 76-79 (1998)
    • (1998) Acta Haematol. , vol.99 , Issue.2 , pp. 76-79
    • Borgna Pignatti, C.1    Carnelli, V.2    Caruso, V.3
  • 119
    • 33749872392 scopus 로고    scopus 로고
    • Prevalence of thromboembolic events among 8860 patients with thalassaemia major and intermedia in the Mediterranean area and Iran
    • Taher A, Isma eel H, Mehio G et al. Prevalence of thromboembolic events among 8,860 patients with thalassaemia major and intermedia in the Mediterranean area and Iran. Thromb. Haemost. 96(4), 488-491 (2006)
    • (2006) Thromb. Haemost. , vol.96 , Issue.4 , pp. 488-491
    • Taher, A.1    Ismaeel, H.2    Mehio, G.3
  • 120
    • 0036092892 scopus 로고    scopus 로고
    • The hypercoagulable state in thalassemia
    • Eldor A, Rachmilewitz EA. The hypercoagulable state in thalassemia. Blood 99(1), 36-43 (2002)
    • (2002) Blood , vol.99 , Issue.1 , pp. 36-43
    • Eldor, A.1    Rachmilewitz, E.A.2
  • 123
    • 70350701847 scopus 로고    scopus 로고
    • Effects of chelators deferoxamine deferiprone and deferasirox on the growth of Klebsiella pneumoniae and Aeromonas hydrophila isolated from transfusion-dependent thalassemia patients
    • Chan GC, Chan S, Ho PL, Ha SY. Effects of chelators (deferoxamine, deferiprone and deferasirox) on the growth of Klebsiella pneumoniae and Aeromonas hydrophila isolated from transfusion-dependent thalassemia patients. Hemoglobin 33(5), 352-360 (2009)
    • (2009) Hemoglobin , vol.33 , Issue.5 , pp. 352-360
    • Chan, G.C.1    Chan, S.2    Ho, P.L.3    Ha, S.Y.4
  • 124
    • 0035122579 scopus 로고    scopus 로고
    • Asplenic- hyposplenic overwhelming sepsis: Postsplenectomy sepsis revisited
    • Hansen K, Singer DB. Asplenic- hyposplenic overwhelming sepsis: postsplenectomy sepsis revisited. Pediatr. Dev. Pathol. 4(2), 105-121 (2001)
    • (2001) Pediatr. Dev. Pathol. , vol.4 , Issue.2 , pp. 105-121
    • Hansen, K.1    Singer, D.B.2
  • 125
    • 0036760048 scopus 로고    scopus 로고
    • Update of guidelines for the prevention and treatment of infection in patients with an absent or dysfunctional spleen
    • Davies JM, Barnes R, Milligan D. Update of guidelines for the prevention and treatment of infection in patients with an absent or dysfunctional spleen. Clin. Med. 2(5), 440-443 (2002).
    • (2002) Clin. Med. , vol.2 , Issue.5 , pp. 440-443
    • Davies, J.M.1    Barnes, R.2    Milligan, D.3
  • 126
    • 57649194798 scopus 로고    scopus 로고
    • Cholelithiasis in thalassemia major
    • Origa R, Galanello R, Perseu L et al. Cholelithiasis in thalassemia major. Eur. J. Haematol. 82(1), 22-25 (2009)
    • (2009) Eur. J. Haematol. , vol.82 , Issue.1 , pp. 22-25
    • Origa, R.1    Galanello, R.2    Perseu, L.3
  • 127
    • 0019481026 scopus 로고
    • Spinal cord compression in thalassemia. Report of 12 cases and recommendations for treatment
    • Issaragrisil S, Piankigagum A, Wasi P. Spinal cord compression in thalassemia. Report of 12 cases and recommendations for treatment. Arch. Intern. Med. 141(8), 1033-1036 (1981)
    • (1981) Arch. Intern. Med. , vol.141 , Issue.8 , pp. 1033-1036
    • Issaragrisil, S.1    Piankigagum, A.2    Wasi, P.3
  • 128
    • 77956928344 scopus 로고    scopus 로고
    • Transfusion independence and HMGA2 activation after gene therapy of human βthalassaemia
    • Cavazzana-Calvo M, Payen E, Negre O et al. Transfusion independence and HMGA2 activation after gene therapy of human βthalassaemia. Nature 467(7313), 318-322 (2010)
    • (2010) Nature , vol.467 , Issue.7313 , pp. 318-322
    • Cavazzana-Calvo, M.1    Payen, E.2    Negre, O.3
  • 131
    • 29744432093 scopus 로고    scopus 로고
    • Unrelated bone marrow transplantation for βthalassemia patients: The experience of the Italian bone marrow transplant group
    • La Nasa G, Argiolu F, Giardini C et al. Unrelated bone marrow transplantation for βthalassemia patients: the experience of the Italian Bone Marrow Transplant Group. Ann. NY Acad. Sci. 1054, 186-189 (2005)
    • (2005) Ann. NY Acad. Sci. , vol.1054 , pp. 186-189
    • La Nasa, G.1    Argiolu, F.2    Giardini, C.3
  • 132
    • 0029679804 scopus 로고    scopus 로고
    • Control of βthalassaemia by carrier screening, genetic counselling and prenatal diagnosis: The Sardinian experience
    • Cao A, Rosatelli MC, Galanello R. Control of βthalassaemia by carrier screening, genetic counselling and prenatal diagnosis: the Sardinian experience. Ciba Found Symp. 197, 137-151 (1996).
    • (1996) Ciba Found Symp. , vol.197 , pp. 137-151
    • Cao, A.1    Rosatelli, M.C.2    Galanello, R.3


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