Mild subclinical hypothyroidism in thalassaemia major: Prevalence, multigated radionuclide test, clinical and laboratory long-term follow-up study

Pediatric Endocrinology Reviews

Volumn 6, Issue SUPPL. 1, 2008, Pages 174-180

  de Sanctis, Vincenzo ^a   de Sanctis, Elena ^a   Ricchieri, Paola ^a   Gubellini, Erika ^a   Gilli, Giuseppe ^a   Gamberini, Maria Rita ^a  

^a S ANNA HOSPITAL   (Italy)

Author keywords

Follow up; MUGA scan; Papillary carcinoma; Subclinical hypothyroidism; Thalassaemia major

Indexed keywords

DEFEROXAMINE MESYLATE; FERRITIN; IRON CHELATING AGENT; LEVOTHYROXINE; PROTIRELIN; TECHNETIUM 99M; THYROGLOBULIN; THYROTROPIN; THYROXINE;

ADOLESCENT; ADULT; ARTICLE; BLOOD TRANSFUSION; CHILD; CLINICAL EXAMINATION; CORRELATION ANALYSIS; DISEASE SEVERITY; EXERCISE; FEMALE; FERRITIN BLOOD LEVEL; FOLLOW UP; GATED IMAGING; GOITER; HEART ARRHYTHMIA; HEART LEFT VENTRICLE EJECTION FRACTION; HEART LEFT VENTRICLE FAILURE; HEART SCINTISCANNING; HUMAN; HYPOTHYROIDISM; IRON OVERLOAD; LABORATORY TEST; MAJOR CLINICAL STUDY; MALE; OUTCOME ASSESSMENT; PATIENT COMPLIANCE; PRACTICE GUIDELINE; PREVALENCE; REFERENCE VALUE; REST; THALASSEMIA MAJOR; THYROID FUNCTION TEST; THYROID PAPILLARY CARCINOMA; THYROTROPIN BLOOD LEVEL; THYROXINE BLOOD LEVEL; TREATMENT DURATION;

ADOLESCENT; ADULT; BETA-THALASSEMIA; CHILD; FEMALE; HUMANS; HYPOTHYROIDISM; IRON OVERLOAD; LONGITUDINAL STUDIES; MALE; THYROGLOBULIN; THYROTROPIN; THYROXINE; TRIIODOTHYRONINE; YOUNG ADULT;

EID: 58149507846     PISSN: 15654753     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (25)

1. Sabato AR, De Sanctis V, Atti G, Capra L, Bagni B, Vullo C. Primary hypothyroidism and low T3 syndrome in thalassaemia major. Arch Dis Child 1983;58:120-127
2. Agarwal MB, Shah S, Vishwanathan C, Rajadhyaksha G, Bhave AA, Dube SR, Billa V, Malkon G, Bajan K. Thyroid dysfunction in multitransfused iron loaded thalassemia patients. Indian Pediatr 1992;29:997-1102
3. Pantelakis S. Thyroid disorders and diabetes mellitus as complications of thalassaemia major. Acta Paediatr 1994;(Suppl 406):111-113
4. De Sanctis V, Wonke B. Growth and endocrine complications in thalassaemia. Rome, Italy: Mediprint Ed, 1999
5. De Sanctis V, Pintor C, Gamberini MR. Multicentre study on prevalence of endocrine complications in thalassaemia major. Clin Endocrinol 1995;42:581-586
6. Zervas A, Katopodi A, Protonotariou A, Livadas S, Karagiorga M, Politis C, Tolis G. Assessment of thyroid function in two hundred patients with beta-thalassemia major. Thyroid 2002;12:151-154
7. Filosa A, Di Maio S, Aloj G, Acampora C. Longitudinal study on thyroid function in patients with thalassaemia major. J Pediatr Endocrinol Metab 2006;19:1397-1404
8. Jensen CE, Tuck SM, Old J, Morris RW, Yardumian A, De Sanctis V, Hoffbrand AV, Wonke B. Incidence of endocrine complications and clinical disease severity related to genotype analysis and iron overload in patients with beta-thalassaemia. Eur J Haematol 1997;59:76-81
9. McDermott MT, Ridgway EC. Subclinical hypothyrodism is mild thyroid failure and should be treated. J Clin Endocrinol Metab 2001;86:4585-4590
10. Evered DC, Ormston BJ, Smith PA, Hall R, Bird T. Grades of hypothyroidism. BMJ 1973;17:657-662
11. Aldouri MA, Wonke B, Hoffbrand AV, Flynn DM, Ward SE, Agnew JE, Hilson AJ. High incidence of cardiomyopathy in beta-thalassaemia patients receiving regular transfusion and iron chelation: reversal by intensified chelation. Acta Haematol 1990;84:113-117
12. Hecht HS, Josephson MA, Hopkins JM, Singh BM. Reproducibility of equilibrium radionuclide ventriculography in patients with coronary artery disease: response of left ventricular ejection fraction and regional wall motion to supine bicycle exercise. Am Heart J 1982;104:567-574
13. Helfand M, Redfern EC. Screening for thyroid disease. Ann Int Med 1998;129:144-158
14. O'Kone MJ, Neely RDG, Trimble ER, Nicholls DP. The incidence of asymptomatic hypothyroidism in new referrals to hospital lipid clinic. Ann Clin Biochem 1991;28:509-511
15. Tunbridge WMG, Evered DC, Hall R, Apopleton D, Brewsi M, Clark F, Evans JC, Young E, Bird T. The spectrum of thyroid disease in a community: the Whickham survey. Clin Endocrinol 1977;7:481-493
16. Zappulla F, Cassio A, Mazzanti L, Colaiuda B, Frejaville E, Bergamaschi R, Martelli E, Giorgi A. Studio della funzione tiroidea in bambini con talassemia. Min Ped 1982;34:801-804
17. Antonelli A, Ferri C, Fallahi P. Thyroid cancer in patients with hepatitis C infection (letter). JAMA 1999;281:1588
18. Antonelli A, Ferri C, Fallahi P, Giuggioli D, Nesti C, Longobardo G, Fadda P, Pampana A, Maccheroni M, Ferrarini E. Thyroid involvement in patients with overt HCV-related mixed cryoglobutinaemia. Q J Med 2004;97:499-506
19. Benetatos L, Alymara U, Vassou A, Bourantas KL. Malignancies in beta-thalassemia patients: a single-center experience and a concise review of the literature. Int J Lab Haematol 2008;30:167-172
20. Valko M, Izakovic M, Mazur M, Rhodes CJ, Telser J. Role of oxygen radicals in DNA damage and cancer incidence. Mol Cell Biochem 2004;266:37-56
21. Kahaly GJ, Dillmann WH. Thyroid hormone action in the heart. Endocrine Rev 2005;26:704-728
22. Monzani F, Di Bello V, Caraccio N, Bertini A, Giorgi D, Giusti C, Ferrarini E. Effect of levothyroxine on cardiac function and structure in subclinical hypothyroidism: a double blind, piacebo-controlled study. J Clin Endocrinol Metab 2001;86:1110-1115
23. Aghini-Lombardi F, Di Bello V, Talini E, Di Cori A, Monzani F, Antonangeli L, Palagi C, Caraccio N, Delle Donne MG, Nardi C, Dardano A, Balbarini A, Mariani M, Pinchera A. Early testural and functional alterations of left ventricular myocardium in mild hypothyroidism. Eur J Endocrinol 2006;155:3-9
24. Iervasi G, Molinaro S, Landi P, Taddei MC, Galli E, Marani F, L'Abbate A, Pingitore A. Association between increased mortility and mild thyroid dysfunction in cardiac patients. Arch Inter Med 2007;167:1526-1532
25. De Sanctis V, Tanas R, Gamberini MR, Sprocati M, Govoni MR, Marsella M. Exaggerated TSH response to TRH ("sub-biochemical" hypothyroidism) in prepubertal and adolescent thalassaemic patients with iron overload: prevalence and 20-year natural history. Ped Endocrinol Rev 2008;6(Supp 1):170-173