Diabetes mellitus and impaired glucose tolerance in thalassaemia major: Incidence, prevalence, risk factors and survival in patients followed in the Ferrara Center

Pediatric Endocrinology Reviews

Volumn 2, Issue SUPPL. 2, 2004, Pages 285-291

  Gamberini, Maria Rita ^a   Fortini, Monica ^a   De Sanctis, Vincenzo ^a   Gilli, Giuseppe ^a   Testa, Maria Rosaria ^a  

^a S ANNA HOSPITAL   (Italy)

Author keywords

Diabetes mellitus; Impaired glucose tolerance; Iron overload; Liver cirrhosis; Thalassaemia major

Indexed keywords

ASCORBIC ACID; DEFERIPRONE; DEFEROXAMINE; HAEMOPHILUS INFLUENZAE TYPE B VACCINE; PENICILLIN DERIVATIVE; PNEUMOCOCCUS VACCINE;

ADULT; CAUSE OF DEATH; CONFERENCE PAPER; CONTROLLED STUDY; DIABETES MELLITUS; FAMILY HISTORY; FEMALE; FOLLOW UP; GLUCOSE METABOLISM; HEART DISEASE; HUMAN; HYPOGONADISM; HYPOPARATHYROIDISM; HYPOTHYROIDISM; IMPAIRED GLUCOSE TOLERANCE; INSULIN DEPENDENT DIABETES MELLITUS; IRON OVERLOAD; ITALY; LIVER CIRRHOSIS; LIVER FIBROSIS; LONGITUDINAL STUDY; MAJOR CLINICAL STUDY; MALE; PATIENT COMPLIANCE; PREVALENCE; RISK FACTOR; SURVIVAL; THALASSEMIA MAJOR;

ADULT; BETA-THALASSEMIA; CHELATION THERAPY; DIABETES MELLITUS, TYPE 1; FEMALE; FERRITINS; GLUCOSE INTOLERANCE; GLUCOSE TOLERANCE TEST; HUMANS; INCIDENCE; IRON OVERLOAD; ITALY; LIVER; LONGITUDINAL STUDIES; MALE; PATIENT COMPLIANCE; PREVALENCE; SURVIVAL ANALYSIS;

EID: 12544259078     PISSN: 15654753     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (17)

1. Flynn DM, Fairney A, Jackson D, Clayton BE. Hormonal changes in thalassaemia major. Arch Dis Child 1976;51:828-836
2. Zuppinger K, Molinari B, Hirt A, Imbach P, Gugler E, Tonz O, Zurbrugg RP. Increased risk of diabetes mellitus in beta-thalassemia major due to iron overload. Helv Paediat Acta 1978;34:197-207
3. Capra L, Atti G, De Sanctis V, Candini C. Glucose tolerance and chelation therapy in patients with thalassaemia major. Haematologica 1983;68:63-68
4. De Sanctis V, Zurlo MG, Senesi E, Boffa C, Cavallo L, Di Gregorio F. Insulin dependent diabetes in thalassaemia. Arch Dis Child 1988;63:58-62
5. el-Hazami MA, al-Swailem A, al-Fawaz I, Warsey SA, al-Swailem A. Diabetes mellitus in children suffering from beta-thalassaemia. J Trop Pediatr 1994;40:261-266
6. Italian Working Group on Endocrine Complications in Non-Endocrine Diseases. Multicentre study on prevalence of endocrine complications in thalassaemia major. Clin Endocrinol 1995;42:581-586
7. Cao A, Galanello R, Rosatelli MC, Argioulu F, De Virgiliis S. Clinical experience of management of thalassemia: the Sardinian experience. Sem Hematol 1996;33:66-75
8. Jensen CE, Tuck SM, Old J, Morris RW, Yardumian A, De Sanctis V, Hoffbrand AV, Wonke B. Incidence of endocrine complications and clinical disease severity related to genotype analysis and iron overload in patients with beta thalassaemia. Eur J Haematol 1997;59:76-81
9. Chern JP, Lin KH, Lu MY, Lin KS, Chen JD, Fu CC. Abnormal glucose tolerance in transfusion-dependent beta-thalassemic patients. Diabetes Care 2001;24:850-854
10. Gabutti V, Piga A. Result of long-term iron-chelation therapy. Acta Haematol 1996;95:26-36
11. Borgna-Pignatti C, Rugolotto S, De Stefano P, Pisa A, Di Gregorio F, Gamberini MR, Sabato V, Melevendi C, Cappellini MD, Verlato G. Survival and disease complications in thalassemia major. Ann NY Acad Sci 1998;850:227-231
12. De Sanctis V, D'Ascola G, Wonke B. The development of diabetes mellitus and chronic liver disease in long term chelated beta-thalassaemic patients. Postgrad Med J 1986;62:831-836
13. Brittenam GM, Griffith PM, Nienhuis AW, McLarenm CE, Young NS, Tucker EE, Allen CJ, Farrell DE, Harris JW. Efficacy of deferioxamine in preventing complications of iron overload in patients with thalassemia major. N Engl J Med 1994;331:567-573
14. Zurlo MG, De Stefano P, Borgna-Pignatti C, Di Palma A, Piga A, Melevendi C, Di Gregorio F, Burattini MG, Terzoli S. Survival and cause of death in thalassemia major. Lancet 1989;2:27-30
15. Desmet VJ, Gerber M, Hoofnagle JH, Manns M, Scheuer PJ. Classification of chronic hepatitis: diagnosis, grading and staging. Hepatology 1994;19:1513-1520
16. Nielsen P, Fischer R, Engelhardt R, Tondury P, Gabbe EE, Janka GE. Liver iron stores in patients with secondary haemosiderosis under iron chelation therapy with deferioxamine or deferiprone. Br J Haematol 1995;91:827-833
17. World Health Organization. WHO Expert Committee on Diabetes Mellitus, 2nd Report. Geneva: WHO Technical Report Series 646, 1980, 1-80