Predicting pituitary iron and endocrine dysfunction

Annals of the New York Academy of Sciences

Volumn 1202, Issue , 2010, Pages 123-128

  Wood, John C ^a   Noetzl, Leila ^a   Hyderi, Aleya ^a   Joukar, Mehrdad ^a   Coates, Thomas ^a   Mittelman, Steven ^a  

^a CHILDREN S HOSPITAL LOS ANGELES   (United States)

Author keywords

endocrine; iron; MRI; pituitary; thalassemia

Indexed keywords

DEFERASIROX; IRON;

ADULT; BRAIN; CHILD; CONFERENCE PAPER; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE SEVERITY; ENDOCRINE DISEASE; HEART; HUMAN; HYPOGONADOTROPIC HYPOGONADISM; HYPOPHYSIS; IRON OVERLOAD; LIVER; MAJOR CLINICAL STUDY; MONOTHERAPY; NOMOGRAM; NONLINEAR REGRESSION ANALYSIS; NUCLEAR MAGNETIC RESONANCE IMAGING; ONSET AGE; PANCREAS; PREDICTION; PRESCHOOL CHILD; PREVALENCE; SCHOOL CHILD; SEX DIFFERENCE; THALASSEMIA MAJOR;

EID: 77955909610     PISSN: 00778923     EISSN: 17496632     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.2010.05545.x     Document Type: Conference Paper

References (14)

1. McLaren, G.D., W.A. Muir & R.W. Kellermeyer. 1983. Iron overload disorders: natural history, pathogenesis, diagnosis, and therapy. Crit. Rev. Clin. Lab. Sci. 19: 205-266.
2. Vogiatzi, M.G., E.A. Macklin, F.L. Trachtenberg, et al. 2009. Differences in the prevalence of growth, endocrine and vitamin D abnormalities among the various thalassaemia syndromes in North America. Br. J. Haematol. 146: 546-556.
3. Borgna-Pignatti, C., S. Rugolotto, P. De Stefano, et al. 2004. Survival and complications in patients with thalassemiamajor treated with transfusion and deferoxamine. Haematologica 89: 1187-1193.
4. Noetzli, L.J., J. Papudesi, T.D. Coates & J.C. Wood. 2009. Pancreatic iron loading predicts cardiac iron loading in thalassemia major. Blood 144: 4021-4026.
5. Wood, J.C., J.M. Tyszka, N. Ghugre, et al. 2004. Myocardial iron loading in transfusion-dependent thalassemia and sickle-cell disease. Blood 103: 1934-1936.
6. Wood, J.C., R. Origa, A. Agus, et al. 2008. Onset of cardiac iron loading in pediatric patients with thalassemia major. Haematologica 93: 917-920.
7. Modell, B., M. Khan, M. Darlison, et al. 2008. Improved survival of thalassaemia major in the UK and relation to T2* cardiovascularmagnetic resonance. J. Cardiovasc.Magn. Reson. 10: 42.
8. Fujisawa, I., M. Morikawa, Y. Nakano & J. Konishi. 1988. Hemochromatosis of the pituitary gland: MR imaging. Radiology 168: 213-214.
9. Argyropoulou, M.I., Z.Metafratzi, D.N. Kiortsis, et al. 2000. T2 Relaxation rate as an index of pituitary iron overload in patientswith beta-thalassemiamajor. AJR Am. J. Roentgenol. 175: 1567-1569.
10. Sparacia, G, M. Midiri, P. D'Angelo & R. Lagalla. 1999. Magnetic resonance imaging of the pituitary gland in patients with secondary hypogonadism due to transfusional hemochromatosis. Magma 8: 87-90.
11. Sparacia, G., A. Iaia, A. Banco, et al. 2000. Transfusional hemochromatosis: quantitative relation of MR imaging pituitary signal intensity reduction to hypogonadotropic hypogonadism. Radiology 215: 818-823.
12. Lam, W.W., W.Y. Au, W.C. Chu, et al. 2008. One-stop measurement of iron deposition in the anterior pituitary, liver, and heart in thalassemia patients. J. Magn. Reson. Imaging 28: 29-33.
13. Christoforidis, A., A. Haritandi, V. Perifanis, et al. 2007. MRI for the determination of pituitary iron overload in children and young adults with beta-thalassaemia major. Eur. J. Radiol. 62: 138-142.
14. Argyropoulou, M.I., D.N. Kiortsis, Z.Metafratzi, et al. 2001. Pituitary gland height evaluated byMRin patientswith betathalassemia major: a marker of pituitary gland function. Neuroradiology 43: 1056-1058.