Cardiac iron and cardiac disease in males and females with transfusion-dependent thalassemia major: A T2* magnetic resonance imaging study

Haematologica

Volumn 96, Issue 4, 2011, Pages 515-520

  Marsella, Maria ^a   Borgna Pignatti, Caterina ^a   Meloni, Antonella ^b   Caldarelli, Valeria ^a   Dell'Amico, Maria Chiara ^b   Spasiano, Anna ^c   Pitrolo, Lorella ^d   Cracolici, Eliana ^e   Valeri, Gianluca ^f   Positano, Vincenzo ^b   Lombardi, Massimo ^b   Pepe, Alessia ^b  

^a Department of Clinical and Experimental Medicine ^*  (Italy)

^b FONDAZIONE TOSCANA GABRIELE MONASTERIO   (Italy)

^c CARDARELLI HOSPITAL   (Italy)

^d Villa Sofia CTO Hospital   (Italy)

^e UNIVERSITY OF PALERMO   (Italy)

^f UNIVERSITÀ POLITECNICA DELLE MARCHE   (Italy)

Author keywords

Cardiac iron; MRI; Sex; T2*; Thalassemia

Indexed keywords

DEFERASIROX; DEFERIPRONE; DEFEROXAMINE; FERRITIN; IRON;

ADULT; ARTICLE; BLOOD TRANSFUSION; CARDIOVASCULAR RISK; CONTROLLED STUDY; FEMALE; FERRITIN BLOOD LEVEL; HEART ARRHYTHMIA; HEART DISEASE; HEART LEFT VENTRICLE EJECTION FRACTION; HUMAN; IMAGE ANALYSIS; IRON OVERLOAD; IRON STORAGE; ITALY; MAJOR CLINICAL STUDY; MALE; NORMAL VALUE; NUCLEAR MAGNETIC RESONANCE IMAGING; OXIDATIVE STRESS; PREVALENCE; RETROSPECTIVE STUDY; SEX DIFFERENCE; THALASSEMIA MAJOR; TISSUE LEVEL;

ADOLESCENT; ADULT; AGE FACTORS; BETA-THALASSEMIA; BLOOD TRANSFUSION; CHILD; FEMALE; HEART DISEASES; HUMANS; IRON OVERLOAD; MAGNETIC RESONANCE IMAGING; MALE; RETROSPECTIVE STUDIES; SEX FACTORS; YOUNG ADULT;

EID: 79953860139     PISSN: 03906078     EISSN: 15928721     Source Type: Journal    
DOI: 10.3324/haematol.2010.025510     Document Type: Article

References (22)

1. Chouliaras G, Yiannoutsos CT, Berdoukas V, Ladis V. Cardiac related death in thalas-saemia major: time trend and risk factors in a large Greek Unit. Eur J Haematol. 2009; 82(5):381-387.
2. Borgna-Pignatti C, Rugolotto S, De Stefano P, Zhao H, Cappellini MD, Del Vecchio GC, et al. Survival and complications in patients with thalassemia major treated with transfusion and deferoxamine. Haematologica. 2004(10);89:1187-1193.
3. Telfer PT, Warburton F, Christou S, Hadjigavriel M, Sitarou M, Kolnagou A, et al. Improved survival in thalassemia major patients on switching from desferrioxamine to combined chelation therapy with desfer-rioxamine and deferiprone. Haematologica. 2009;94(12):1777-1778.
4. Telfer P, Coen PG, Christou S, Hadjigavriel M, Kolnakou A, Pangalou E, et al. Survival of medically treated thalassemia patients in Cyprus. Trends and risk factors over the period 1980-2004. Haematologica. 2006;91 (9):1187-1192.
5. Ramazzotti A, Pepe A, Positano V, Rossi G, De Marchi D, Brizi MG, et al. Multicenter validation of the magnetic resonance T2* technique for segmental and global quantification of myocardial iron. J Magn Reson Imaging. 2009;30(30):62-68.
6. Meloni A, Ramazzotti A, Positano V, Salvatori C, Mangione M, Marcheschi P, et al. Evaluation of a web-based network for reproducible T2* MRI assessment of iron overload in thalassemia. Int J Med Inform. 2009;78(8):503-512.
7. Pepe A, Positano V, Santarelli MF, Sorrentino F, Cracolici E, De Marchi D, et al. Multislice multiecho T2* cardiovascular magnetic resonance for detection of the heterogeneous distribution of myocardial iron overload. J Magn Reson Imaging. 2006;23 (5):662-668.
8. Positano V, Pepe A, Santarelli MF, Ramazzotti A, Meloni A, De Marchi D, et al. Multislice multiecho T2* cardiac magnetic resonance for the detection of heterogeneous myocardial iron distribution in tha-lassaemia patients. NMR Biomed. 2009; 22(7):707-715
9. Positano V, Salani B, Pepe A, Santarelli MF, De Marchi D, Ramazzotti A, et al. Improved T2* assessment in liver iron overload by magnetic resonance imaging. Magn Reson Imaging. 2009;27(2):188-197.
10. Cerqueira MD, Weissman NJ, Dilsizian V, Jacobs AK, Kaul S, Laskey WK, et al. Standardized myocardial segmentation and nomenclature for tomographic imaging of the heart: a statement for healthcare professionals from the Cardiac Imaging Committee of the Council on Clinical Cardiology of the American Heart Association. Circulation. 2002;18(1):539-542.
11. Anderson LJ, Holden S, Davis B, Prescott E, Charrier CC, Bunce NH, et al. Cardiovascular T2-star (T2*) magnetic resonance for the early diagnosis of myocardial iron overload. Eur Heart J. 2001;22 (23):2171-2179.
12. Positano V, Pepe A, Santarelli M F, Scattini B, De Marchi D, Ramazzotti A, et al. Standardized T2* map of normal human heart in vivo to correct T2* segmental artefacts. NMR Biomed. 2007;20(6):578-590.
13. Maceira AM, Prasad SK, Khan M, Pennell DJ. Normalized left ventricular systolic and diastolic function by steady state free precession cardiovascular magnetic resonance. J Cardiovasc Magn Reson. 2006;8(3):417-426.
14. Pepe A, Positano V, Capra M, Maggio A, Lo Pinto C, Spasiano A., et al. Prevalence and clinical-Instrumental correlates of myocar-dial scarring by delayed enhancement cardiovascular magnetic resonance in tha-lassemia major. Heart. 2009;95:1688-1693.
15. Westwood MA, Anderson LJ, Maceira AM, Shah FT, Prescott E, Porter JB, et al. Normalized left ventricular volumes and function in thalassemia major patients with normal myocardial iron. J Magn Reson Imaging. 2007;25(6):1147-1151.
16. Kirk P, Roughton M, Porter JB, Walker JM, Tanner MA, Patel J, et al. Cardiac T2* magnetic resonance for prediction of cardiac complications in thalassemia major. Circulation. 2009;120(20):1961-1968.
17. Pepe A, Lombardi M, Positano V, Cracolici E, Capra M, Malizia R, et al. Evaluation of the efficacy of oral deferiprone in beta-tha-lassemia major by multislice multiecho T2*. Eur J Haematol. 2006;76(3):183-192.
18. Kremastinos DT, Flevari P, Spyropoulou M, Vrettou H, Tsiapras D, Stavropoulos-Giokas CG. Association of heart failure in homozy-gous beta-thalassemia with the major histo-compatibility complex. Circulation 1999;16(100):2074-2078.
19. Bonneux LG, Huisman CC, de Beer JA. Mortality in 272 European regions, 2002-2004. An update. Eur J Epidemiol. 2010;25 (2):77-85.
20. Shalev H, Kapelushnik J, Moser A, Knobler H, Tamary H. Hypocholesterolemia in chronic anemias with increased erythropoi-etic activity. Am J Hematol. 2007;82(3):199-202.
21. Austad SN. Why women live longer than men: sex differences in longevity. Gend Med. 2006;3(2):79-92.
22. Proteggente AR, England TG, Rehman A, Rice-Evans CA, Halliwell B. Gender differences in steady-state levels of oxidative damage to DNA in healthy individuals. Free Radic Res. 2002;36(2):157-162.