The characterization of Lucilia cuprina acetylcholinesterase as a drug target, and the identification of novel inhibitors by high throughput screening

Insect Biochemistry and Molecular Biology

Volumn 41, Issue 7, 2011, Pages 470-483

  Ilg, Thomas ^a   Cramer, Jörg ^a,b   Lutz, Jürgen ^a   Noack, Sandra ^a   Schmitt, Harald ^a   Williams, Heike ^a   Newton, Trevor ^a,c  

^a Intervet Innovation GmbH   (Germany)

^b BAYER AG   (Germany)

^c BASF SE   (Germany)

Author keywords

Acetylcholinesterase; Blowfly; Cholinergic system; High throughput screening; Pesticidal target

Indexed keywords

ACETYLCHOLINESTERASE; CARBAMIC ACID DERIVATIVE; CHOLINESTERASE INHIBITOR; DRUG DERIVATIVE; GLYCOSYLPHOSPHATIDYLINOSITOL; INSECTICIDE; ORGANOPHOSPHATE; RECOMBINANT PROTEIN; THIOCHOLINE;

AMINO ACID SEQUENCE; ANIMAL; ARTICLE; CELL STRAIN HEK293; DRUG DELIVERY SYSTEM; DRUG EFFECT; ENZYME SPECIFICITY; FLY; GENETIC TRANSFECTION; GENETICS; HIGH THROUGHPUT SCREENING; HUMAN; IC 50; INSECT CONTROL; KINETICS; METABOLISM; METHODOLOGY; MOLECULAR CLONING; MOLECULAR GENETICS; PHYLOGENY; PHYSIOLOGY; SYNTHESIS;

ACETYLCHOLINESTERASE; AMINO ACID SEQUENCE; ANIMALS; CARBAMATES; CHOLINESTERASE INHIBITORS; CLONING, MOLECULAR; DIPTERA; DRUG DELIVERY SYSTEMS; GLYCOSYLPHOSPHATIDYLINOSITOLS; HEK293 CELLS; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; INHIBITORY CONCENTRATION 50; INSECT CONTROL; INSECTICIDES; KINETICS; MOLECULAR SEQUENCE DATA; PHOSPHORIC ACID ESTERS; PHYLOGENY; RECOMBINANT PROTEINS; SUBSTRATE SPECIFICITY; THIOCHOLINE; TRANSFECTION;

ARTHROPODA; CALLIPHORIDAE; HEXAPODA; LUCILIA CUPRINA; LUCILIA SERICATA; OVIS ARIES;

EID: 79959254989     PISSN: 09651748     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ibmb.2011.04.003     Document Type: Article

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