Genomic analysis of individual differences in ethanol drinking: Evidence for non-genetic factors in C57Bl/6 mice

PLoS ONE

Volumn 6, Issue 6, 2011, Pages

  Wolstenholme, Jennifer T ^a   Warner, Jon A ^a   Capparuccini, Maria I ^a   Archer, Kellie J ^a   Shelton, Keith L ^a   Miles, Michael F ^a,b  

^a VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

^b VIRGINIA COMMONWEALTH UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOL; HISTONE DEACETYLASE INHIBITOR; TRICHOSTATIN A;

ALCOHOL CONSUMPTION; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN MAPPING; CONTROLLED STUDY; DNA MODIFICATION; DRINKING BEHAVIOR; EPIGENETICS; GENE REGULATORY NETWORK; GENETIC ANALYSIS; GENETIC TRANSCRIPTION; GENETIC VARIABILITY; GENOMICS; MALE; MESENCEPHALON; MICROARRAY ANALYSIS; MOLECULAR DYNAMICS; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; NUCLEUS ACCUMBENS; PREFRONTAL CORTEX; SYNAPSE VESICLE; ANIMAL; ANIMAL BEHAVIOR; C57BL MOUSE; GENE EXPRESSION; GENETICS; PRINCIPAL COMPONENT ANALYSIS; WESTERN BLOTTING;

ANIMALIA; MUS;

ALCOHOL DRINKING; ANIMALS; BEHAVIOR, ANIMAL; BLOTTING, WESTERN; GENE EXPRESSION; MALE; MICE; MICE, INBRED C57BL; PRINCIPAL COMPONENT ANALYSIS;

EID: 79959240698     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0021100     Document Type: Article

References (66)

1. Administration SAaMHS (2005) Results from the 2004 National Survey on Drug Use and Health: National Findings Rockville, MD. Office of Applied Studies.
2. Chin JH, Goldstein DB, (1977) Drug tolerance in biomembranes: A spin label study of the effects of ethanol. Science 196: 684-685.
3. Mokdad AH, Marks JS, Stroup DF, Gerberding JL, (2004) Actual causes of death in the United States, 2000. Jama 291: 1238-1245.
4. Cloninger CR, (1987) Neurogenetic adaptive mechanisms in alcoholism. Science 236: 410-416.
5. Enoch MA, Goldman D, (2001) The genetics of alcoholism and alcohol abuse. Curr Psychiatry Rep 3: 144-151.
6. Gordis E, Tabakoff B, Goldman D, Berg K, (1990) Finding the gene(s) for alcoholism. Jama 263: 2094-2095.
7. Radel M, Goldman D, (2001) Pharmacogenetics of alcohol response and alcoholism: the interplay of genes and environmental factors in thresholds for alcoholism. Drug Metab Dispos 29: 489-494.
8. Crabbe JC, (2002) Genetic contributions to addiction. Annu Rev Psychol 53: 435-462.
9. Lovinger DM, Crabbe JC, (2005) Laboratory models of alcoholism: treatment target identification and insight into mechanisms. Nat Neurosci 8: 1471-1480.
10. Phillips TJ, Crabbe JC, Metten P, Belknap JK, (1994) Localization of genes affecting alcohol drinking in mice. Alcohol Clin Exp Res 18: 931-941.
11. Shirley RL, Walter NA, Reilly MT, Fehr C, Buck KJ, (2004) Mpdz is a quantitative trait gene for drug withdrawal seizures. Nat Neurosci 7: 699-700.
12. Fehr C, Shirley RL, Crabbe JC, Belknap JK, Buck KJ, et al. (2005) The syntaxin binding protein 1 gene (Stxbp1) is a candidate for an ethanol preference drinking locus on mouse chromosome 2. Alcohol Clin Exp Res 29: 708-720.
13. Bachmanov AA, Reed DR, Tordoff MG, Price RA, Beauchamp GK, (1996) Intake of ethanol, sodium chloride, sucrose, citric acid, and quinine hydrochloride solutions by mice: a genetic analysis. Behav Genet 26: 563-573.
14. Belknap JK, Crabbe JC, Young ER, (1993) Voluntary consumption of ethanol in 15 inbred mouse strains. Psychopharmacology (Berl) 112: 503-510.
15. McClearn GE, (1972) Genetics as a tool in alcohol research. Ann N Y Acad Sci 197: 26-31.
16. Dole VP, Ho A, Gentry RT, Chin A, (1988) Toward an analogue of alcoholism in mice: analysis of nongenetic variance in consumption of alcohol. Proc Natl Acad Sci U S A 85: 827-830.
17. Little HJ, O'Callaghan MJ, Butterworth AR, Wilson J, Cole J, et al. (1999) Low alcohol preference among the "high alcohol preference" C57 strain of mice; preference increased by saline injections. Psychopharmacology (Berl) 147: 182-189.
18. O'Callaghan MJ, Croft AP, Watson WP, Brooks SP, Little HJ, (2002) Low alcohol preference among the "high alcohol preference" C57/BL10 mice; factors affecting such preference. Pharmacol Biochem Behav 72: 475-481.
19. Khisti RT, Wolstenholme J, Shelton KL, Miles MF, (2006) Characterization of the ethanol-deprivation effect in substrains of C57BL/6 mice. Alcohol 40: 119-126.
20. Kerns RT, Ravindranathan A, Hassan S, Cage MP, York T, et al. (2005) Ethanol-responsive brain region expression networks: implications for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J mice. J Neurosci 25: 2255-2266.
21. Irizarry RA, Bolstad BM, Collin F, Cope LM, Hobbs B, et al. (2003) Summaries of Affymetrix GeneChip probe level data. Nucleic Acids Res 31: e15.
22. Pavlidis P, Noble WS, (2001) Analysis of strain and regional variation in gene expression in mouse brain. Genome Biol 2: RESEARCH0042.
23. Saeed AI SV, White J, Li J, Liang W, Bhagabati N, et al. (2003) TM4: a free, open-source system for microarray data management and analysis. J Biotechniques 34: 374-378.
24. Storey JD, Tibshirani R, (2003) Statistical significance for genomewide studies. Proc Natl Acad Sci U S A 100: 9440-9445.
25. Team RDC (2009) R: A Language and Environment for Statistical Computing.
26. Hosack DA, Dennis G Jr, Sherman BT, Lane HC, Lempicki RA, (2003) Identifying biological themes within lists of genes with EASE. Genome Biol 4: R70.
27. Mulligan MK, Ponomarev I, Hitzemann RJ, Belknap JK, Tabakoff B, et al. (2006) Toward understanding the genetics of alcohol drinking through transcriptome meta-analysis. Proc Natl Acad Sci U S A 103: 6368-6373.
28. Koob GF, (1992) Drugs of abuse: anatomy, pharmacology and function of reward pathways. Trends Pharmacol Sci 13: 177-184.
29. Zoltewicz JS, Stewart NJ, Leung R, Peterson AS, (2004) Atrophin 2 recruits histone deacetylase and is required for the function of multiple signaling centers during mouse embryogenesis. Development 131: 3-14.
30. Gregoretti IV, Lee YM, Goodson HV, (2004) Molecular evolution of the histone deacetylase family: functional implications of phylogenetic analysis. J Mol Biol 338: 17-31.
31. Smallwood A, Esteve PO, Pradhan S, Carey M, (2007) Functional cooperation between HP1 and DNMT1 mediates gene silencing. Genes Dev 21: 1169-1178.
32. Milne TA, Hughes CM, Lloyd R, Yang Z, Rozenblatt-Rosen O, et al. (2005) Menin and MLL cooperatively regulate expression of cyclin-dependent kinase inhibitors. Proc Natl Acad Sci U S A 102: 749-754.
33. Kitabayashi I, Aikawa Y, Nguyen LA, Yokoyama A, Ohki M, (2001) Activation of AML1-mediated transcription by MOZ and inhibition by the MOZ-CBP fusion protein. Embo J 20: 7184-7196.
34. Thomas MJ, Kalivas PW, Shaham Y, (2008) Neuroplasticity in the mesolimbic dopamine system and cocaine addiction. Br J Pharmacol 154: 327-342.
35. Russo SJ, Mazei-Robison MS, Ables JL, Nestler EJ, (2009) Neurotrophic factors and structural plasticity in addiction. Neuropharmacology 56 (Suppl 1): 73-82.
36. Samad TA, Krezel W, Chambon P, Borrelli E, (1997) Regulation of dopaminergic pathways by retinoids: activation of the D2 receptor promoter by members of the retinoic acid receptor-retinoid X receptor family. Proc Natl Acad Sci U S A 94: 14349-14354.
37. Brami-Cherrier K, Valjent E, Herve D, Darragh J, Corvol JC, et al. (2005) Parsing molecular and behavioral effects of cocaine in mitogen- and stress-activated protein kinase-1-deficient mice. J Neurosci 25: 11444-11454.
38. Li J, Guo Y, Schroeder FA, Youngs RM, Schmidt TW, et al. (2004) Dopamine D2-like antagonists induce chromatin remodeling in striatal neurons through cyclic AMP-protein kinase A and NMDA receptor signaling. J Neurochem 90: 1117-1131.
39. Dokmanovic M, Marks PA, (2005) Prospects: histone deacetylase inhibitors. J Cell Biochem 96: 293-304.
40. Villar-Garea A, Esteller M, (2004) Histone deacetylase inhibitors: understanding a new wave of anticancer agents. Int J Cancer 112: 171-178.
41. Korzus E, Rosenfeld MG, Mayford M, (2004) CBP histone acetyltransferase activity is a critical component of memory consolidation. Neuron 42: 961-972.
42. Sng JC, Taniura H, Yoneda Y, (2005) Inhibition of histone deacetylation by trichostatin A intensifies the transcriptions of neuronal c-fos and c-jun genes after kainate stimulation. Neurosci Lett 386: 150-155.
43. Brake WG, Zhang TY, Diorio J, Meaney MJ, Gratton A, (2004) Influence of early postnatal rearing conditions on mesocorticolimbic dopamine and behavioural responses to psychostimulants and stressors in adult rats. Eur J Neurosci 19: 1863-1874.
44. Meaney MJ, Brake W, Gratton A, (2002) Environmental regulation of the development of mesolimbic dopamine systems: a neurobiological mechanism for vulnerability to drug abuse? Psychoneuroendocrinology 27: 127-138.
45. Holmes A, le Guisquet AM, Vogel E, Millstein RA, Leman S, et al. (2005) Early life genetic, epigenetic and environmental factors shaping emotionality in rodents. Neurosci Biobehav Rev 29: 1335-1346.
46. Lathe R, (2004) The individuality of mice. Genes Brain Behav 3: 317-327.
47. Rhodes JS, Best K, Belknap JK, Finn DA, Crabbe JC, (2005) Evaluation of a simple model of ethanol drinking to intoxication in C57BL/6J mice. Physiol Behav 84: 53-63.
48. Krishnan V, Han MH, Graham DL, Berton O, Renthal W, et al. (2007) Molecular adaptations underlying susceptibility and resistance to social defeat in brain reward regions. Cell 131: 391-404.
49. Rockman GE, Glavin GB, (1984) Ethanol-stress interaction: differences among ethanol-preferring rats' responses to restraint. Alcohol 1: 293-295.
50. Rockman GE, Hall A, Hong J, Glavin GB, (1987) Unpredictable cold-immobilization stress effects on voluntary ethanol consumption in rats. Life Sci 40: 1245-1251.
51. Volpicelli JR, Ulm RR, Hopson N, (1990) The Bidirectional Effects of Shock on Alcohol Preference in Rats. Alcoholism: Clinical and Experimental Research 14: 913-916.
52. Mulligan MK, Ponomarev I, Boehm SL 2nd, Owen JA, Levin PS, et al. (2008) Alcohol trait and transcriptional genomic analysis of C57BL/6 substrains. Genes Brain Behav 7: 677-689.
53. Ramachandra V, Phuc S, Franco AC, Gonzales RA, (2007) Ethanol preference is inversely correlated with ethanol-induced dopamine release in 2 substrains of C57BL/6 mice. Alcohol Clin Exp Res 31: 1669-1676.
54. Shukla SD, Velazquez J, French SW, Lu SC, Ticku MK, et al. (2008) Emerging Role of Epigenetics in the Actions of Alcohol. Alcohol Clin Exp Res.
55. Rulten SL, Ripley TL, Manerakis E, Stephens DN, Mayne LV, (2006) Ethanol modifies the effect of handling stress on gene expression: problems in the analysis of two-way gene expression studies in mouse brain. Brain Res 1102: 39-43.
56. Marutha Ravindran CR, Ticku MK, (2004) Changes in methylation pattern of NMDA receptor NR2B gene in cortical neurons after chronic ethanol treatment in mice. Brain Res Mol Brain Res 121: 19-27.
57. Pandey SC, Ugale R, Zhang H, Tang L, Prakash A, (2008) Brain chromatin remodeling: a novel mechanism of alcoholism. J Neurosci 28: 3729-3737.
58. Tsankova NM, Kumar A, Nestler EJ, (2004) Histone modifications at gene promoter regions in rat hippocampus after acute and chronic electroconvulsive seizures. J Neurosci 24: 5603-5610.
59. Geppert M, Bolshakov VY, Siegelbaum SA, Takei K, De Camilli P, et al. (1994) The role of Rab3A in neurotransmitter release. Nature 369: 493-497.
60. Kapfhamer D, Bettinger JC, Davies AG, Eastman CL, Smail EA, et al. (2008) Loss of RAB-3/A in Caenorhabditis elegans and the mouse affects behavioral response to ethanol. Genes Brain Behav 7: 669-676.
61. Yamada MK, Nakanishi K, Ohba S, Nakamura T, Ikegaya Y, et al. (2002) Brain-derived neurotrophic factor promotes the maturation of GABAergic mechanisms in cultured hippocampal neurons. J Neurosci 22: 7580-7585.
62. Beattie EC, Howe CL, Wilde A, Brodsky FM, Mobley WC, (2000) NGF signals through TrkA to increase clathrin at the plasma membrane and enhance clathrin-mediated membrane trafficking. J Neurosci 20: 7325-7333.
63. Thakker-Varia S, Alder J, Crozier RA, Plummer MR, Black IB, (2001) Rab3A is required for brain-derived neurotrophic factor-induced synaptic plasticity: transcriptional analysis at the population and single-cell levels. J Neurosci 21: 6782-6790.
64. Joe KH, Kim YK, Kim TS, Roh SW, Choi SW, et al. (2007) Decreased plasma brain-derived neurotrophic factor levels in patients with alcohol dependence. Alcohol Clin Exp Res 31: 1833-1838.
65. McGough NN, He DY, Logrip ML, Jeanblanc J, Phamluong K, et al. (2004) RACK1 and brain-derived neurotrophic factor: a homeostatic pathway that regulates alcohol addiction. J Neurosci 24: 10542-10552.
66. Koob GF, Volkow ND, (2010) Neurocircuitry of addiction. Neuropsychopharmacology 35: 217-238.