Expression of membrane-bound mucins in human nasal mucosa: Different patterns for MUC4 and MUC16

Archives of Otolaryngology - Head and Neck Surgery

Volumn 136, Issue 6, 2010, Pages 603-609

  Woo, Hyun Jae ^a,b   Bae, Chang Hoon ^b   Song, Si Youn ^b   Lee, Heung Man ^c   Kim, Yong Dae ^b  

^a CHA University   (South Korea)

^b Yeungnam University College of Medicine   (South Korea)

^c Korea University College of Medicine   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

DEXAMETHASONE; GLYCOPROTEIN; INTERLEUKIN 1BETA; MUCIN; MUCIN 16; MUCIN 4; PHORBOL 13 ACETATE 12 MYRISTATE; RETINOIC ACID; UNCLASSIFIED DRUG;

ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; FEMALE; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOASSAY; MALE; NOSE MUCOSA; NOSE POLYP; PROTEIN EXPRESSION; PROTEIN FUNCTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; UPREGULATION;

ADULT; CA-125 ANTIGEN; CELLS, CULTURED; DEXAMETHASONE; FEMALE; GENE EXPRESSION; HUMANS; IMMUNOASSAY; INTERLEUKIN-1BETA; MALE; MEMBRANE PROTEINS; MUCIN-4; NASAL MUCOSA; NASAL POLYPS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TETRADECANOYLPHORBOL ACETATE; TRETINOIN;

EID: 77953876894     PISSN: 08864470     EISSN: 1538361X     Source Type: Journal    
DOI: 10.1001/archoto.2010.71     Document Type: Article

References (19)

1. Desseyn JL, Tetaert D, Gouyer V. Architecture of the large membrane-bound mucins. Gene. 2008;410(2):215-222.
2. Rose MC, Voynow JA. Respiratory tract mucin genes and mucin glycoproteins in health and disease. Physiol Rev. 2006;86(1):245-278.
3. Ali MS, Pearson JP. Upper airway mucin gene expression: a review. Laryngoscope. 2007;117(5):932-938. (Pubitemid 46699374)
4. Nustad K, Lebedin Y, Lloyd KO, et al; ISOBM TD-1 Workshop. Epitopes on CA 125 from cervical mucus and ascites fluid and characterization of six new antibodies: third report from the ISOBM TD-1 Workshop. Tumour Biol. 2002;23(5):303-314. (Pubitemid 36302488)
5. Argüeso P, Spurr-Michaud S, Russo CL, Tisdale A, Gipson IK. MUC16 mucin is expressed by the human ocular surface epithelia and carries the H185 carbohydrate epitope. Invest Ophthalmol Vis Sci. 2003;44(6):2487-2495. (Pubitemid 36618405)
6. Davies JR, Kirkham S, Svitacheva N, Thornton DJ, Carlstedt I. MUC16 is produced in tracheal surface epithelium and submucosal glands and is present in secretions from normal human airway and cultured bronchial epithelial cells. Int J Biochem Cell Biol. 2007;39(10):1943-1954.
7. Jetten AM. Growth and differentiation factors in tracheobronchial epithelium. Am J Physiol. 1991;260(6, pt 1):L361-L373.
8. Park JA, Crews AL, Lampe WR, Fang S, Park J, Adler KB. Protein kinase Cδ regulates airway mucin secretion via phosphorylation of MARCKS protein. Am J Pathol. 2007;171(6):1822-1830.
9. Hewson CA, Edbrooke MR, Johnston SL. PMA induces the MUC5AC respiratory mucin in human bronchial epithelial cells, via PKC, EGF/TGF-α, Ras/Raf, MEK, ERK and Sp1-dependent mechanisms. J Mol Biol. 2004;344(3):683-695.
10. Okazaki K, Chiba T, Hajiro K. Downregulation of gastric mucin gene expression and its biosynthesis by dexamethasone in the human. J Clin Gastroenterol. 1998; 27(suppl 1):S91-S96.
11. Bai CH, Song SY, Kim YD. Effect of glucocorticoid on the MUC4 gene in nasal polyps. Laryngoscope. 2007;117(12):2169-2173.
12. Pawankar R. Nasal polyposis: an update: editorial review. Curr Opin Allergy Clin Immunol. 2003;3(1):1-6.
13. Bernacki SH, Nelson AL, Abdullah L, et al. Mucin gene expression during differentiation of human airway epithelia in vitro: MUC4 and MUC5B are strongly induced. Am J Respir Cell Mol Biol. 1999;20(4):595-604.
14. Kim YD, Kwon EJ, Park DW, Song SY, Yoon SK, Baek SH. Interleukin-1β induces MUC2 and MUC5AC synthesis through cyclooxygenase-2 in NCI-H292 cells. Mol Pharmacol. 2002;62(5):1112-1118.
15. Kim YD, Kwon EJ, Kwon TK, Baek SH, Song SY, Suh JS. Regulation of IL-1β-mediated MUC2 gene in NCI-H292 human airway epithelial cells. Biochem Biophys Res Commun. 2000;274(1):112-116.
16. Yuan-Chen Wu D, Wu R, Reddy SP, Lee YC, Chang MM. Distinctive epidermal growth factor receptor/extracellular regulated kinase-independent and -dependent signaling pathways in the induction of airway mucin 5B and mucin 5AC expression by phorbol 12-myristate 13-acetate. Am J Pathol. 2007;170(1):20-32.
17. Gipson IK, Spurr-Michaud S, Argueso P, Tisdale A, Ng TF, Russo CL. Mucin gene expression in immortalized human corneal-limbal and conjunctival epithelial cell lines. Invest Ophthalmol Vis Sci. 2003;44(6):2496-2506.
18. Seo KY, Chung SH, Lee JH, Park MY, Kim EK. Regulation of membrane-associated mucins in the human corneal epithelial cells by dexamethasone. Cornea. 2007; 26(6):709-714.
19. Beato M, Herrlich P, Schutz G. Steroid hormone receptors: many actors in search of a plot. Cell. 1995;83(6):851-857. (Pubitemid 26006527)