메뉴 건너뛰기




Volumn 9, Issue 6, 2011, Pages 746-756

Pharmacologic inhibition of ALK5 causes selective induction of terminal differentiation in mouse keratinocytes expressing oncogenic HRAS

Author keywords

[No Author keywords available]

Indexed keywords

4 [4 (1,3 BENZODIOXOL 5 YL) 5 (2 PYRIDINYL) 1H IMIDAZOL 2 YL]BENZAMIDE; CORNIFIED ENVELOPE LIKE PROLINE RICH PROTEIN; CORNIFIED ENVELOPE LIKE PROLINE RICH PROTEIN 1A; CORNIFIED ENVELOPE LIKE PROLINE RICH PROTEIN 2H; CYCLIN DEPENDENT KINASE INHIBITOR 2A; DOXYCYCLINE; PROTEIN GLUTAMINE GAMMA GLUTAMYLTRANSFERASE; PROTEIN GLUTAMINE GAMMA GLUTAMYLTRANSFERASE 1; PROTEIN GLUTAMINE GAMMA GLUTAMYLTRANSFERASE 3; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 1; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG;

EID: 79959230184     PISSN: 15417786     EISSN: 15573125     Source Type: Journal    
DOI: 10.1158/1541-7786.MCR-11-0112     Document Type: Article
Times cited : (6)

References (41)
  • 2
    • 0028990043 scopus 로고    scopus 로고
    • Chemical skin carcinogenesis is prevented in mice by the induced expression of a TGF-beta related transgene
    • Blessing M, Nanney LB, King LE, Hogan BL. Chemical skin carcinogenesis is prevented in mice by the induced expression of a TGF-β related transgene. Teratog Carcinog Mutagen 1995;15:11-21. (Pubitemid 126684648)
    • (1996) Teratogenesis Carcinogenesis and Mutagenesis , vol.15 , Issue.1 , pp. 11-21
    • Blessing, M.1    Nanney, L.B.2    King, L.E.3    Hogan, B.L.M.4
  • 4
    • 67650999753 scopus 로고    scopus 로고
    • Progressive tumor formation in mice with conditional deletion of TGF-beta signaling in head and neck epithelia is associated with activation of the PI3K/Akt pathway
    • Bian Y, Terse A, Du J, Hall B, Molinolo A, Zhang P, et al. Progressive tumor formation in mice with conditional deletion of TGF-beta signaling in head and neck epithelia is associated with activation of the PI3K/Akt pathway. Cancer Res 2009;69:5918-26.
    • (2009) Cancer Res , vol.69 , pp. 5918-5926
    • Bian, Y.1    Terse, A.2    Du, J.3    Hall, B.4    Molinolo, A.5    Zhang, P.6
  • 5
    • 0032500010 scopus 로고    scopus 로고
    • Expression of a dominant negative type II TGF-beta receptor in mouse skin results in an increase in carcinoma incidence and an acceleration of carcinoma development
    • Amendt C, Schirmacher P, Weber H, Blessing M. Expression of a dominant negative type II TGF-β receptor in mouse skin results in an increase in carcinoma incidence and an acceleration of carcinoma development. Oncogene 1998;17:25-34. (Pubitemid 28360526)
    • (1998) Oncogene , vol.17 , Issue.1 , pp. 25-34
    • Amendt, C.1    Schirmacher, P.2    Weber, H.3    Blessing, M.4
  • 6
    • 79953180846 scopus 로고    scopus 로고
    • Multiple self-healing squamous epithelioma is caused by a disease-specific spectrum of mutations in TGFBR1
    • Goudie DR, D'Alessandro M, Merriman B, Lee H, Szeverenyi I, Avery S, et al. Multiple self-healing squamous epithelioma is caused by a disease-specific spectrum of mutations in TGFBR1. Nat Genet 2011;43:365-9.
    • (2011) Nat Genet , vol.43 , pp. 365-369
    • Goudie, D.R.1    D'Alessandro, M.2    Merriman, B.3    Lee, H.4    Szeverenyi, I.5    Avery, S.6
  • 7
    • 0030598681 scopus 로고    scopus 로고
    • TGFbeta1 inhibits the formation of benign skin tumors, but enhances progression to invasive spindle carcinomas in transgenic mice
    • DOI 10.1016/S0092-8674(00)80127-0
    • Cui W, Fowlis DJ, Bryson S, Duffie E, Ireland H, Balmain A, et al. TGFβ1 inhibits the formation of benign skin tumors, but enhances progression to invasive spindle carcinomas in transgenic mice. Cell 1996;86:531-42. (Pubitemid 26299485)
    • (1996) Cell , vol.86 , Issue.4 , pp. 531-542
    • Cui, W.1    Fowlis, D.J.2    Bryson, S.3    Duffie, E.4    Ireland, H.5    Balmain, A.6    Akhurst, R.J.7
  • 8
    • 0035887461 scopus 로고    scopus 로고
    • Inducible expression of transforming growth factor beta1 in papillomas causes rapid metastasis
    • Weeks BH, He W, Olson KL, Wang XJ. Inducible expression of transforming growth factor beta1 in papillomas causes rapid metastasis. Cancer Res 2001;61:7435-43. (Pubitemid 32995031)
    • (2001) Cancer Research , vol.61 , Issue.20 , pp. 7435-7443
    • Weeks, B.H.1    He, W.2    Olson, K.L.3    Wang, X.-J.4
  • 9
    • 78649796293 scopus 로고    scopus 로고
    • Use of a TGFbeta type I receptor inhibitor in mouse skin carcinogenesis reveals a dual role for TGFbeta signaling in tumor promotion and progression
    • Mordasky Markell L, Perez-Lorenzo R , Masiuk KE , Kennett MJ , Glick AB. Use of a TGFbeta type I receptor inhibitor in mouse skin carcinogenesis reveals a dual role for TGFbeta signaling in tumor promotion and progression. Carcinogenesis 2010;31:2127-35.
    • (2010) Carcinogenesis , vol.31 , pp. 2127-2135
    • Mordasky Markell, L.1    Perez-Lorenzo, R.2    Masiuk, K.E.3    Kennett, M.J.4    Glick, A.B.5
  • 10
    • 15244340251 scopus 로고    scopus 로고
    • TGFbeta1, back to the future: Revisiting its role as a transforming growth factor
    • Glick AB. TGFbeta1, back to the future: revisiting its role as a transforming growth factor. Cancer Biol Ther 2004;3:276-83. (Pubitemid 41350879)
    • (2004) Cancer Biology and Therapy , vol.3 , Issue.3 , pp. 276-283
    • Glick, A.B.1
  • 11
    • 0028351556 scopus 로고
    • The pathogenesis of squamous cell cancer: Lessons learned from studies of skin carcinogenesis - Thirty-third G. H. A. Clowes Memorial Award Lecture
    • Yuspa SH. The pathogenesis of squamous cell cancer: lessons learned from studies of skin carcinogenesis-Thirty-third G.H.A. Clowes Memorial Award Lecture. Cancer Res 1994;54:1178-89. (Pubitemid 24108054)
    • (1994) Cancer Research , vol.54 , Issue.5 , pp. 1178-1189
    • Yuspa, S.H.1
  • 12
    • 0034704916 scopus 로고    scopus 로고
    • Defects in TGFbeta signaling overcome senescence of mouse keratinocytes expressing v-ras(Ha)
    • Tremain R, Marko M, Kinnimulki V, Ueno H, Bottinger E, Glick A. Defects in TGFbsignaling overcome senescence of mouse keratinocytes expressing v-ras. Oncogene 2000;19:1698-709. (Pubitemid 30200972)
    • (2000) Oncogene , vol.19 , Issue.13 , pp. 1698-1709
    • Tremain, R.1    Marko, M.2    Kinnimulki, V.3    Ueno, H.4    Bottinger, E.5    Glick, A.6
  • 13
    • 0028609621 scopus 로고
    • Alterations in murine keratinocyte differentiation induced by activated rasHa genes are mediated by protein kinase C-alpha
    • Dlugosz AA, Cheng C, Williams EK, Dharia AG, Denning MF, Yuspa SH. Alterations in murine keratinocyte differentiation induced by activated rasHa genes are mediated by protein kinase C-alpha. Cancer Res 1994;54:6413-20.
    • (1994) Cancer Res , vol.54 , pp. 6413-6420
    • Dlugosz, A.A.1    Cheng, C.2    Williams, E.K.3    Dharia, A.G.4    Denning, M.F.5    Yuspa, S.H.6
  • 14
    • 0029162341 scopus 로고
    • Isolation and utilization of epidermal keratinocytes for oncogene research
    • Vogt PK, Verma IM, editors. New York: Academic Press
    • Dlugosz AA, Glick AB, Tennenbaum T, Weinberg WC, Yuspa SH. Isolation and utilization of epidermal keratinocytes for oncogene research. In: Vogt PK, Verma IM, editors. Methods in enzymology. New York: Academic Press; 1995. p. 3-20.
    • (1995) Methods in Enzymology , pp. 3-20
    • Dlugosz, A.A.1    Glick, A.B.2    Tennenbaum, T.3    Weinberg, W.C.4    Yuspa, S.H.5
  • 16
    • 0033731551 scopus 로고    scopus 로고
    • Conditional gene expression in the epidermis of transgenic mice using the tetracycline regulated transactivators tTA and rTA linked to the keratin 5 promoter
    • Diamond I, Owolabi T, Marco M, Lam C, Glick A. Conditional gene expression in the epidermis of transgenic mice using the tetracycline regulated transactivators tTA and rTA linked to the keratin 5 promoter. J Invest Dermatol 2000;115:788-94.
    • (2000) J Invest Dermatol , vol.115 , pp. 788-794
    • Diamond, I.1    Owolabi, T.2    Marco, M.3    Lam, C.4    Glick, A.5
  • 17
    • 0025995656 scopus 로고
    • Quantitation of cross-linked protein: An alternative to counting cornified envelopes as an index of keratinocyte differentiation
    • Hough-Monroe L, Milstone LM. Quantitation of cross-linked protein: an alternative to counting cornified envelopes as an index of keratinocyte differentiation. Anal Biochem 1991;199:25-8.
    • (1991) Anal Biochem , vol.199 , pp. 25-28
    • Hough-Monroe, L.1    Milstone, L.M.2
  • 18
    • 0023223930 scopus 로고
    • Effect of retinoic acid on cornified envelope formation: Difference between spontaneous envelope formation in vivo or in vitro and expression of envelope competence
    • Nagae S, Lichti U, De Luca LM, Yuspa SH. Effect of retinoic acid on cornified envelope formation: difference between spontaneous envelope formation in vivo or in vitro and expression of envelope competence. J Invest Dermatol 1987;89:51-8. (Pubitemid 17084184)
    • (1987) Journal of Investigative Dermatology , vol.89 , Issue.1 , pp. 51-58
    • Nagae, S.1    Lichti, U.2    De Luca, L.M.3    Yuspa, S.H.4
  • 19
    • 0033990048 scopus 로고    scopus 로고
    • Primer3 on the WWW for general users and for biologist programmers
    • Rozen S, Skaletsky H. Primer3 on the WWW for general users and for biologist programmers. Methods Mol Biol 2000;132:365-86.
    • (2000) Methods Mol Biol , vol.132 , pp. 365-386
    • Rozen, S.1    Skaletsky, H.2
  • 20
    • 3242671305 scopus 로고    scopus 로고
    • Tetracycline-regulated transactivators driven by the involucrin promoter to achieve epidermal conditional gene expression
    • DOI 10.1111/j.0022-202X.2004.23203.x
    • Jaubert J, Patel S, Cheng J, Segre JA. Tetracycline-regulated transactivators driven by the involucrin promoter to achieve epidermal conditional gene expression. J Invest Dermatol 2004;123:313-8. (Pubitemid 38951826)
    • (2004) Journal of Investigative Dermatology , vol.123 , Issue.2 , pp. 313-318
    • Jaubert, J.1    Patel, S.2    Cheng, J.3    Segre, J.A.4
  • 22
    • 0030935565 scopus 로고    scopus 로고
    • The epidermal keratinocyte as a model for the study of gene regulation and cell differentiation
    • Eckert RL, Crish JF, Robinson NA. The epidermal keratinocyte as a model for the study of gene regulation and cell differentiation. Physiol Rev 1997;77:397-424. (Pubitemid 27184344)
    • (1997) Physiological Reviews , vol.77 , Issue.2 , pp. 397-424
    • Eckert, R.L.1    Crish, J.F.2    Robinson, N.A.3
  • 23
    • 4544286927 scopus 로고    scopus 로고
    • Strain-dependent differences in malignant conversion of mouse skin tumors is an inherent property of the epidermal keratinocyte
    • DOI 10.1093/carcin/bgh170
    • Woodworth CD, Michael E, Smith L, Vijayachandra K, Glick A, Hennings H, et al. Strain-dependent differences in malignant conversion of mouse skin tumors is an inherent property of the epidermal keratinocyte. Carcinogenesis 2004;25:1771-8. (Pubitemid 39214320)
    • (2004) Carcinogenesis , vol.25 , Issue.9 , pp. 1771-1778
    • Woodworth, C.D.1    Michael, E.2    Smith, L.3    Vijayachandra, K.4    Glick, A.5    Hennings, H.6    Yuspa, S.H.7
  • 24
    • 0025260543 scopus 로고
    • Transforming growth factor-beta modulates plasminogen activator activity and plasminogen activator inhibitor type-1 expression in human keratinocytes in vitro
    • Wikner NE, Elder JT, Persichitte KA, Mink P, Clark RA. Transforming growth factor-beta modulates plasminogen activator activity and plasminogen activator inhibitor type-1 expression in human keratinocytes in vitro. J Invest Dermatol 1990;95:607-13.
    • (1990) J Invest Dermatol , vol.95 , pp. 607-613
    • Wikner, N.E.1    Elder, J.T.2    Persichitte, K.A.3    Mink, P.4    Clark, R.A.5
  • 25
    • 0019158157 scopus 로고
    • A survey of transformation markers in differentiating epidermal cell lines in culture
    • Yuspa SH, Hawley-Nelson P, Koehler B, Stanley JR. A survey of transformation markers in differentiating epidermal cell lines in culture. Cancer Res 1980;40:4694-703. (Pubitemid 11199740)
    • (1980) Cancer Research , vol.40 , Issue.12 , pp. 4694-4703
    • Yuspa, S.H.1    Hawley-Nelson, P.2    Koehler, B.3    Stanley, J.R.4
  • 26
    • 0021027781 scopus 로고
    • Properties of carcinogen altered mouse epidermal cells resistant to calcium-induced terminal differentiation
    • Kulesz-Martin M, Kilkenny AE, Holbrook KA, Digernes V, Yuspa SH. Properties of carcinogen altered mouse epidermal cells resistant to calcium-induced terminal differentiation. Carcinogenesis 1983;4:1367-77. (Pubitemid 14249312)
    • (1983) Carcinogenesis , vol.4 , Issue.11 , pp. 1367-1377
    • Kulesz, M.M.1    Kilkenny, A.E.2    Holbrook, K.A.3
  • 27
    • 0021928956 scopus 로고
    • Keratinocytes blocked in phorbol ester-responsive early stage of terminal differentiation by sarcoma viruses
    • DOI 10.1038/314459a0
    • Yuspa SH, Kilkenny AE, Stanley J, Lichti U. Keratinocytes blocked in phorbol ester-responsive early stage of terminal differentiation by sarcoma viruses. Nature 1985;314:459-62. (Pubitemid 15145589)
    • (1985) Nature , vol.314 , Issue.6010 , pp. 459-462
    • Yuspa, S.H.1    Kilkenny, A.E.2    Stanley, J.3    Lichti, U.4
  • 28
    • 0021042222 scopus 로고
    • Altered growth and differentiation of cultured mouse epidermal cells infected with oncogenic retrovirus: Contrasting effects of viruses and chemicals
    • Yuspa SH, Vass W, Scolnick E. Altered growth and differentiation of cultured mouse epidermal cells infected with oncogenic retrovirus: contrasting effects of viruses and chemicals. Cancer Res 1983;43:6021-30. (Pubitemid 14212675)
    • (1983) Cancer Research , vol.43 , Issue.12 I , pp. 6021-6030
    • Yuspa, S.H.1    Vass, W.2    Scolnick, E.3
  • 29
    • 0025293021 scopus 로고
    • Regulation of transglutaminase type II by transforming growth factor-β 1 in normal and transformed human epidermal keratinocytes
    • George MD, Vollberg TM, Floyd EE, Stein JP, Jetten AM. Regulation of transglutaminase type II by transforming growth factor-β 1 in normal and transformed human epidermal keratinocytes. J Biol Chem 1990;265:11098-104.
    • (1990) J Biol Chem , vol.265 , pp. 11098-11104
    • George, M.D.1    Vollberg, T.M.2    Floyd, E.E.3    Stein, J.P.4    Jetten, A.M.5
  • 30
    • 0023584578 scopus 로고
    • Regulation of growth and differentiation of human keratinocytes by type beta transforming growth factor and epidermal growth factor
    • Reiss M, Sartorelli AC. Regulation of growth and differentiation of human keratinocytes by Type β transforming growth factor and epidermal growth factor. Cancer Res 1987;47:6705-9. (Pubitemid 18019674)
    • (1987) Cancer Research , vol.47 , Issue.24 I , pp. 6705-6709
    • Reiss, M.1    Sartorelli, A.C.2
  • 31
    • 0028031981 scopus 로고
    • Control of growth regulatory and differentiation-specific genes in human epidermal keratinocytes by interferon γ: Antagonism by retinoic acid and transforming growth factor beta1
    • Saunders NA, Jetten AM. Control of growth regulatory and differentiation- specific genes in human epidermal keratinocytes by interferon gamma. Antagonism by retinoic acid and transforming growth factor beta 1. J Biol Chem 1994;269:2016-22. (Pubitemid 24035408)
    • (1994) Journal of Biological Chemistry , vol.269 , Issue.3 , pp. 2016-2022
    • Saunders, N.A.1    Jetten, A.M.2
  • 32
    • 0035112809 scopus 로고    scopus 로고
    • Suppression of keratinocyte growth and differentiation by transforming growth factor beta1 involves multiple signaling pathways
    • DOI 10.1046/j.1523-1747.2001.01243.x
    • Dahler AL, Cavanagh LL, Saunders NA. Suppression of keratinocyte growth and differentiation by transforming growth factor beta1 involves multiple signaling pathways. J Invest Dermatol 2001;116: 266-74. (Pubitemid 32173731)
    • (2001) Journal of Investigative Dermatology , vol.116 , Issue.2 , pp. 266-274
    • Dahler, A.L.1    Cavanagh, L.L.2    Saunders, N.A.3
  • 33
    • 0024344464 scopus 로고
    • Uncoupling of the calcium-induced terminal differentiation and the activation of membrane-associated transglutaminase in murine keratinocytes by type-beta transforming growth factor
    • DOI 10.1016/0014-4827(89)90421-7
    • Reiss M, Zhou ZL. Uncoupling of the calcium-induced terminal differentiation and the activation of membrane-associated transglutaminase in murine keratinocytes by type-beta transforming growth factor. Exp Cell Res 1989;183:101-11. (Pubitemid 19166513)
    • (1989) Experimental Cell Research , vol.183 , Issue.1 , pp. 101-111
    • Reiss, M.1    Zhou, Z.-L.2
  • 34
    • 0037742433 scopus 로고    scopus 로고
    • Smad3 regulates senescence and malignant conversion in a mouse multistage skin carcinogenesis model
    • Vijayachandra K, Lee J, Glick AB. Smad3 regulates senescence and malignant conversion in a mouse multistage skin carcinogenesis model. Cancer Res 2003;63:3447-52. (Pubitemid 36793018)
    • (2003) Cancer Research , vol.63 , Issue.13 , pp. 3447-3452
    • Vijayachandra, K.1    Lee, J.2    Glick, A.B.3
  • 35
    • 62349129614 scopus 로고    scopus 로고
    • Induction of p16(ink4a) and p19(ARF) by TGFbeta1 contributes to growth arrest and senescence response in mouse keratinocytes
    • Vijayachandra K, Higgins W, Lee J, Glick A. Induction of p16(ink4a) and p19(ARF) by TGFbeta1 contributes to growth arrest and senescence response in mouse keratinocytes. Mol Carcinog 2009;48: 181-6.
    • (2009) Mol Carcinog , vol.48 , pp. 181-186
    • Vijayachandra, K.1    Higgins, W.2    Lee, J.3    Glick, A.4
  • 36
    • 0020080466 scopus 로고
    • Divergent responses in epidermal basal cells exposed to the tumor promoter 12-O-tetradecanoylphorbol-13-acetate
    • Yuspa SH, Ben T, Hennings H, Lichti U. Divergent responses in epidermal basal cells exposed to the tumor promoter 12-O-tetradecanoylphorbol-13-acetate. Cancer Res 1982;42:2344-9. (Pubitemid 12121455)
    • (1982) Cancer Research , vol.42 , Issue.6 , pp. 2344-2349
    • Yuspa, S.H.1    Ben, T.2    Hennings, H.3    Lichti, U.4
  • 37
    • 0242425844 scopus 로고    scopus 로고
    • Defining BMP functions in the hair follicle by conditional ablation of BMP receptor IA
    • DOI 10.1083/jcb.200309042
    • Kobielak K, Pasolli HA, Alonso L, Polak L, Fuchs E. Defining BMP functions in the hair follicle by conditional ablation of BMP receptor IA. J Cell Biol 2003;163:609-23. (Pubitemid 37429873)
    • (2003) Journal of Cell Biology , vol.163 , Issue.3 , pp. 609-623
    • Kobielak, K.1    Pasolli, H.A.2    Alonso, L.3    Polak, L.4    Fuchs, E.5
  • 39
    • 72949096792 scopus 로고    scopus 로고
    • Senescence in tumours: Evidence from mice and humans
    • Collado M, Serrano M. Senescence in tumours: evidence from mice and humans. Nat Rev Cancer 2010;10:51-7.
    • (2010) Nat Rev Cancer , vol.10 , pp. 51-57
    • Collado, M.1    Serrano, M.2
  • 40
    • 42049114841 scopus 로고    scopus 로고
    • Signal transduction pathway through activin receptors as a therapeutic target of musculoskeletal diseases and cancer
    • DOI 10.1507/endocrj.KR-110
    • Tsuchida K, Nakatani M, Uezumi A, Murakami T, Cui X. Signal transduction pathway through activin receptors as a therapeutic target of musculoskeletal diseases and cancer. Endocr J 2008;55:11-21. (Pubitemid 351520175)
    • (2008) Endocrine Journal , vol.55 , Issue.1 , pp. 11-21
    • Tsuchida, K.1    Nakatani, M.2    Uezumi, A.3    Murakami, T.4    Cui, X.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.