Tetracycline-regulated transactivators driven by the involucrin promoter to achieve epidermal conditional gene expression

Journal of Investigative Dermatology

Volumn 123, Issue 2, 2004, Pages 313-318

  Jaubert, Jean ^a   Patel, Satyakam ^a   Cheng, Jun ^a   Segre, Julia A ^a  

^a NATIONAL HUMAN GENOME RESEARCH INSTITUTE   (United States)

Author keywords

Conditional gene expression; Differentiation; Epidermis; Involucrin promoter; Tetracycline regulated

Indexed keywords

BETA GALACTOSIDASE; INVOLUCRIN; TETRACYCLINE; TRANSACTIVATOR PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BASAL CELL; CELL DIFFERENTIATION; CELL DIVISION; CONTROLLED STUDY; CROSSING OVER; DNA RESPONSIVE ELEMENT; GENE CONTROL; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENE INDUCTION; GENE INTERACTION; GENE TARGETING; IMMUNOHISTOCHEMISTRY; LACTOSE OPERON; MITOSIS RATE; MOUSE; MOUSE STRAIN; NONHUMAN; PERINATAL PERIOD; PRIORITY JOURNAL; PROMOTER REGION; QUANTITATIVE ANALYSIS; TISSUE SPECIFICITY; TRANSACTIVATION; TRANSCRIPTION REGULATION; TRANSGENIC MOUSE;

EID: 3242671305     PISSN: 0022202X     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.0022-202X.2004.23203.x     Document Type: Article

References (24)

1. Banks-Schlegel S, Green H: Involucrin synthesis and tissue assembly by keratinocytes in natural and cultured human epithelia. J Cell Biol 90:732-777, 1981
2. Byrne C, Tainsky M, Fuchs E: Programming gene expression in developing epidermis. Development 120:2369-2383, 1994
3. Carroll JM, Albers KM, Garlick JA, Harrington R, Taichman LB: Tissue- and stratum-specific expression of the human involucrin promoter in transgenic mice. Proc Natl Acad Sci USA 90:10270-10274, 1993
4. Carroll JM, Taichman LB: Characterization of the human involucrin promoter using a transient beta-galactosidase assay. J Cell Sci 103:925-930, 1992
5. Corbel SY, Rossi FM: Latest developments and in vivo use of the Tet system: Ex vivo and in vivo delivery of tetracycline-regulated genes. Curr Opin Biotechnol 13:448-452, 2002
6. Crish JF, Bone F, Banks EB, Eckert RL: The human involucrin gene contains spatially distinct regulatory elements that regulate expression during early versus late epidermal differentiation. Oncogene 21:738-747, 2002
7. Crish JF, Zaim TM, Eckert RL: The distal regulatory region of the human involucrin promoter is required for expression in epidermis. J Biol Chem 273:30460-30465, 1998
8. Diamond I, Owolabi T, Marco M, Lam C, Glick A: Conditional gene expression in the epidermis of transgenic mice using the tetracycline-regulated transactivators tTA and rTA linked to the keratin 5 promoter. J Invest Dermatol 115:788-794, 2000
9. DiSepio D, Bickenbach JR, Longley MA, Bundman DS, Rothnagel JA, Roop DR: Characterization of loricrin regulation in vitro and in transgenic mice. Differentiation 64:225-235, 1999
10. Djian P, Phillips M, Easley K, Huang E, Simon M, Rice RH, Green H: The involucrin genes of the mouse and the rat: Study of their shared repeats. Mol Biol Evol 10:1136-1149, 1993
11. Eckert RL, Green H: Structure and evolution of the human involucrin gene. Cell 46:583-589, 1986
12. Elias PM, Matsuyoshi N, Wu H, Lin C, Wang ZH, Brown BE, Stanley JR: Desmoglein isoform distribution affects stratum corneum structure and function. J Cell Biol 153:243-249, 2001
13. Fuchs E, Raghavan S: Getting under the skin of epidermal morphogenesis. Nat Rev Genet 3:199-209, 2002
14. Furth PA, St Onge L, Boger H, et al: Temporal control of gene expression in transgenic mice by a tetracycline-responsive promoter. Proc Natl Acad Sci USA 91:9302-9306, 1994
15. Greenhalgh DA, Rothnagel JA, Wang XJ, et al: Hyperplasia, hyperkeratosis and benign tumor production in transgenic mice by a targeted v-fos oncogene suggest a role for fos in epidermal differentiation and neoplasia. Oncogene 8:2145-2157, 1993
16. Hardman MJ, Sisi P, Banbury DN, Byrne C: Patterned acquisition of skin barrier function during development. Development 125:1541-1552, 1998
17. Hogan BL, Constantini F, Lacy E: Manipulating the Mouse Embryo: A Laboratory Manual. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory, 1986
18. Lewandoski M: Conditional control of gene expression in the mouse. Nat Rev Genet 2:743-755, 2001
19. Li ER, Owens DM, Djian P, Watt FM: Expression of involucrin in normal, hyperproliferative and neoplastic mouse keratinocytes. Exp Dermatol 9:431-438, 2000
20. Merritt AJ, Berika MY, Zhai W, Kirk SE, Ji B, Hardman MJ, Garrod DR: Suprabasal desmoglein 3 expression in the epidermis of transgenic mice results in hyperproliferation and abnormal differentiation. Mol Cell Biol 22:5846-5858, 2002
21. Niemann C, Watt FM: Designer skin: Lineage commitment in postnatal epidermis. Trends Cell Biol 12:185-192, 2002
22. Rice RH, Green H: Presence in human epidermal cells of a soluble protein precursor of the cross-linked envelope: Activation of the cross-linking by calcium ions. Cell 18:681-694, 1979
23. Urlinger S, Baron U, Thellmann M, Hasan MT, Bujard H, Hillen W: Exploring the sequence space for tetracycline-dependent transcriptional activators: Novel mutations yield expanded range and sensitivity. Proc Natl Acad Sci USA 97:7963-7968, 2000
24. Xie W, Chow LT, Paterson AJ, Chin E, Kudlow JE: Conditional expression of the ErbB2 oncogene elicits reversible hyperplasia in stratified epithelia and up-regulation of TGFalpha expression in transgenic mice. Oncogene 18:3593-3607, 1999