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Volumn 55, Issue 1, 2011, Pages 145-153

Distinct regulation of adiponutrin/PNPLA3 gene expression by the transcription factors ChREBP and SREBP1c in mouse and human hepatocytes

Author keywords

Adiponutrin; ChREBP; Hepatic steatosis; HepG2; IHH; Lipogenesis; Liver; NAFLD; PNPLA3; SREBP1c

Indexed keywords

CARBOHYDRATE RESPONSE ELEMENT BINDING PROTEIN; PATATIN LIKE PHOSPHOLIPASE DOMAIN CONTAINING PROTEIN 3; STEROL REGULATORY ELEMENT BINDING PROTEIN 1C; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

EID: 79958863581     PISSN: 01688278     EISSN: 01688278     Source Type: Journal    
DOI: 10.1016/j.jhep.2010.10.024     Document Type: Article
Times cited : (117)

References (46)
  • 1
    • 40849083460 scopus 로고    scopus 로고
    • Non-alcoholic fatty liver disease: The mist gradually clears
    • N.M. de Alwis, and C.P. Day Non-alcoholic fatty liver disease: the mist gradually clears J Hepatol 48 2008 S104 S112
    • (2008) J Hepatol , vol.48
    • De Alwis, N.M.1    Day, C.P.2
  • 2
    • 40349094956 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease and diabetes mellitus
    • DOI 10.1080/07435800701743885, PII 788428540
    • L.A. Adams Nonalcoholic fatty liver disease and diabetes mellitus Endocr Res 32 2007 59 69 (Pubitemid 351412067)
    • (2007) Endocrine Research , vol.32 , Issue.3-4 , pp. 59-69
    • Adams, L.A.1
  • 3
    • 4043077961 scopus 로고    scopus 로고
    • Molecular mediators of hepatic steatosis and liver injury
    • DOI 10.1172/JCI200422422
    • J.D. Browning, and J.D. Horton Molecular mediators of hepatic steatosis and liver injury J Clin Invest 114 2004 147 152 (Pubitemid 39071617)
    • (2004) Journal of Clinical Investigation , vol.114 , Issue.2 , pp. 147-152
    • Browning, J.D.1    Horton, J.D.2
  • 4
    • 66349125337 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease
    • S.K. Erickson Nonalcoholic fatty liver disease J Lipid Res 50 2009 S412 S416
    • (2009) J Lipid Res , vol.50
    • Erickson, S.K.1
  • 5
    • 18244382304 scopus 로고    scopus 로고
    • Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease
    • DOI 10.1172/JCI200523621
    • K.L. Donnelly, C.I. Smith, S.J. Schwarzenberg, J. Jessurun, M.D. Boldt, and E.J. Parks Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease J Clin Invest 115 2005 1343 1351 (Pubitemid 40629054)
    • (2005) Journal of Clinical Investigation , vol.115 , Issue.5 , pp. 1343-1351
    • Donnelly, K.L.1    Smith, C.I.2    Schwarzenberg, S.J.3    Jessurun, J.4    Boldt, M.D.5    Parks, E.J.6
  • 6
    • 40549135297 scopus 로고    scopus 로고
    • Contribution of de novo fatty acid synthesis to hepatic steatosis and insulin resistance: Lessons from genetically engineered mice
    • DOI 10.1172/JCI34275
    • C. Postic, and J. Girard Contribution of de novo fatty acid synthesis to hepatic steatosis and insulin resistance: lessons from genetically engineered mice J Clin Invest 118 2008 829 838 (Pubitemid 351364588)
    • (2008) Journal of Clinical Investigation , vol.118 , Issue.3 , pp. 829-838
    • Postic, C.1    Girard, J.2
  • 7
    • 34347406521 scopus 로고    scopus 로고
    • SREBP-1c transcription factor and lipid homeostasis: Clinical perspective
    • DOI 10.1159/000100426
    • P. Ferre, and F. Foufelle SREBP-1c transcription factor and lipid homeostasis: clinical perspective Horm Res 68 2007 72 82 (Pubitemid 47026704)
    • (2007) Hormone Research , vol.68 , Issue.2 , pp. 72-82
    • Ferre, P.1    Foufelle, F.2
  • 8
    • 0033570119 scopus 로고    scopus 로고
    • Increased levels of nuclear SREBP-1c associated with fatty livers in two mouse models of diabetes mellitus
    • I. Shimomura, Y. Bashmakov, and J.D. Horton Increased levels of nuclear SREBP-1c associated with fatty livers in two mouse models of diabetes mellitus J Biol Chem 274 1999 30028 30032
    • (1999) J Biol Chem , vol.274 , pp. 30028-30032
    • Shimomura, I.1    Bashmakov, Y.2    Horton, J.D.3
  • 10
    • 38449087713 scopus 로고    scopus 로고
    • ChREBP, a transcriptional regulator of glucose and lipid metabolism
    • DOI 10.1146/annurev.nutr.27.061406.093618
    • C. Postic, R. Dentin, P.D. Denechaud, and J. Girard ChREBP, a transcriptional regulator of glucose and lipid metabolism Annu Rev Nutr 27 2007 179 192 (Pubitemid 351373354)
    • (2007) Annual Review of Nutrition , vol.27 , pp. 179-192
    • Postic, C.1    Dentin, R.2    Denechaud, P.-D.3    Girard, J.4
  • 11
    • 15744376705 scopus 로고    scopus 로고
    • Direct role of ChREBP·Mlx in regulating hepatic glucose-responsive genes
    • DOI 10.1074/jbc.M413063200
    • L. Ma, N.G. Tsatsos, and H.C. Towle Direct role of ChREBP Mlx in regulating hepatic glucose-responsive genes J Biol Chem 280 2005 12019 12027 (Pubitemid 40418520)
    • (2005) Journal of Biological Chemistry , vol.280 , Issue.12 , pp. 12019-12027
    • Ma, L.1    Tsatsos, N.G.2    Towle, H.C.3
  • 12
    • 2442614148 scopus 로고    scopus 로고
    • Mlx Is the Functional Heteromeric Partner of the Carbohydrate Response Element-binding Protein in Glucose Regulation of Lipogenic Enzyme Genes
    • DOI 10.1074/jbc.M311301200
    • A.K. Stoeckman, L. Ma, and H.C. Towle Mlx is the functional heteromeric partner of the carbohydrate response element-binding protein in glucose regulation of lipogenic enzyme genes J Biol Chem 279 2004 15662 15669 (Pubitemid 38618968)
    • (2004) Journal of Biological Chemistry , vol.279 , Issue.15 , pp. 15662-15669
    • Stoeckman, A.K.1    Ma, L.2    Towle, H.C.3
  • 13
    • 33749370739 scopus 로고    scopus 로고
    • Liver-specific inhibition of ChREBP improves hepatic steatosis and insulin resistance in ob/ob mice
    • DOI 10.2337/db06-0200
    • R. Dentin, F. Benhamed, I. Hainault, V. Fauveau, F. Foufelle, and J.R. Dyck Liver-specific inhibition of ChREBP improves hepatic steatosis and insulin resistance in ob/ob mice Diabetes 55 2006 2159 2170 (Pubitemid 44743612)
    • (2006) Diabetes , vol.55 , Issue.8 , pp. 2159-2170
    • Dentin, R.1    Benhamed, F.2    Hainault, I.3    Fauveau, V.4    Foufelle, F.5    Dyck, J.R.B.6    Girard, J.7    Postic, C.8
  • 15
    • 56749096610 scopus 로고    scopus 로고
    • Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease
    • S. Romeo, J. Kozlitina, C. Xing, A. Pertsemlidis, D. Cox, and L.A. Pennacchio Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease Nat Genet 40 2008 1461 1465
    • (2008) Nat Genet , vol.40 , pp. 1461-1465
    • Romeo, S.1    Kozlitina, J.2    Xing, C.3    Pertsemlidis, A.4    Cox, D.5    Pennacchio, L.A.6
  • 16
    • 0035823621 scopus 로고    scopus 로고
    • Adiponutrin, a transmembrane protein corresponding to a novel dietary- and obesity-linked mRNA specifically expressed in the adipose lineage
    • S. Baulande, F. Lasnier, M. Lucas, and J. Pairault Adiponutrin, a transmembrane protein corresponding to a novel dietary- and obesity-linked mRNA specifically expressed in the adipose lineage J Biol Chem 276 2001 33336 33344
    • (2001) J Biol Chem , vol.276 , pp. 33336-33344
    • Baulande, S.1    Lasnier, F.2    Lucas, M.3    Pairault, J.4
  • 18
    • 75349111467 scopus 로고    scopus 로고
    • The expression level of non-alcoholic fatty liver disease-related gene PNPLA3 in hepatocytes is highly influenced by hepatic lipid status
    • M. Hoekstra, Z. Li, J.K. Kruijt, M.V. Eck, T.J. Berkel, and J. Kuiper The expression level of non-alcoholic fatty liver disease-related gene PNPLA3 in hepatocytes is highly influenced by hepatic lipid status J Hepatol 52 2010 244 251
    • (2010) J Hepatol , vol.52 , pp. 244-251
    • Hoekstra, M.1    Li, Z.2    Kruijt, J.K.3    Eck, M.V.4    Berkel, T.J.5    Kuiper, J.6
  • 20
    • 33644764922 scopus 로고    scopus 로고
    • Adipose triglyceride lipase: Function, regulation by insulin, and comparison with adiponutrin
    • DOI 10.2337/diabetes.55.1.148
    • E.E. Kershaw, J.K. Hamm, L.A. Verhagen, O. Peroni, M. Katic, and J.S. Flier Adipose triglyceride lipase: function, regulation by insulin, and comparison with adiponutrin Diabetes 55 2006 148 157 (Pubitemid 43343310)
    • (2006) Diabetes , vol.55 , Issue.1 , pp. 148-157
    • Kershaw, E.E.1    Hamm, J.K.2    Verhagen, L.A.W.3    Peroni, O.4    Katic, M.5    Flier, J.S.6
  • 24
    • 66349121084 scopus 로고    scopus 로고
    • Mammalian patatin domain containing proteins: A family with diverse lipolytic activities involved in multiple biological functions
    • P.C. Kienesberger, M. Oberer, A. Lass, and R. Zechner Mammalian patatin domain containing proteins: a family with diverse lipolytic activities involved in multiple biological functions J Lipid Res 50 2009 S63 S68
    • (2009) J Lipid Res , vol.50
    • Kienesberger, P.C.1    Oberer, M.2    Lass, A.3    Zechner, R.4
  • 25
    • 77952352488 scopus 로고    scopus 로고
    • Unravelling the pathogenesis of fatty liver disease: Patatin-like phospholipase domain-containing 3 protein
    • S. Romeo, I. Huang-Doran, M.G. Baroni, and A. Kotronen Unravelling the pathogenesis of fatty liver disease: patatin-like phospholipase domain-containing 3 protein Curr Opin Lipid 21 2010 247 252
    • (2010) Curr Opin Lipid , vol.21 , pp. 247-252
    • Romeo, S.1    Huang-Doran, I.2    Baroni, M.G.3    Kotronen, A.4
  • 26
    • 77950607738 scopus 로고    scopus 로고
    • Homozygosity for the patatin-like phospholipase-3/adiponutrin I148M polymorphism influences liver fibrosis in patients with nonalcoholic fatty liver disease
    • L. Valenti, A. Al-Serri, A.K. Daly, E. Galmozzi, R. Rametta, and P. Dongiovanni Homozygosity for the patatin-like phospholipase-3/adiponutrin I148M polymorphism influences liver fibrosis in patients with nonalcoholic fatty liver disease Hepatology 51 2010 1209 1217
    • (2010) Hepatology , vol.51 , pp. 1209-1217
    • Valenti, L.1    Al-Serri, A.2    Daly, A.K.3    Galmozzi, E.4    Rametta, R.5    Dongiovanni, P.6
  • 27
    • 77949895032 scopus 로고    scopus 로고
    • A sequence variation (I148M) in PNPLA3 associated with nonalcoholic fatty liver disease disrupts triglyceride hydrolysis
    • S. He, C. McPhaul, J.Z. Li, R. Garuti, L. Kinch, and N.V. Grishin A sequence variation (I148M) in PNPLA3 associated with nonalcoholic fatty liver disease disrupts triglyceride hydrolysis J Biol Chem 285 2010 6706 6715
    • (2010) J Biol Chem , vol.285 , pp. 6706-6715
    • He, S.1    McPhaul, C.2    Li, J.Z.3    Garuti, R.4    Kinch, L.5    Grishin, N.V.6
  • 29
    • 0033607176 scopus 로고    scopus 로고
    • Sterol regulatory element binding protein-1c is a major mediator of insulin action on the hepatic expression of glucokinase and lipogenesis- related genes
    • DOI 10.1073/pnas.96.22.12737
    • M. Foretz, C. Guichard, P. Ferre, and F. Foufelle Sterol regulatory element binding protein-1c is a major mediator of insulin action on the hepatic expression of glucokinase and lipogenesis-related genes Proc Natl Acad Sci USA 96 1999 12737 12742 (Pubitemid 29513572)
    • (1999) Proceedings of the National Academy of Sciences of the United States of America , vol.96 , Issue.22 , pp. 12737-12742
    • Foretz, M.1    Guichard, C.2    Ferre, P.3    Foufelle, F.4
  • 30
    • 0026761973 scopus 로고
    • Primary cultures of human hepatocytes: A unique system for studies in toxicology, virology, parasitology, and liver pathophysiology in man
    • H. Moshage, and S.H. Yap Primary cultures of human hepatocytes: a unique system for studies in toxicology, virology, parasitology, and liver pathophysiology in man J Hepatol 15 1992 404 413
    • (1992) J Hepatol , vol.15 , pp. 404-413
    • Moshage, H.1    Yap, S.H.2
  • 31
    • 62749188867 scopus 로고    scopus 로고
    • The role of the lipogenic pathway in the development of hepatic steatosis
    • C. Postic, and J. Girard The role of the lipogenic pathway in the development of hepatic steatosis Diabetes Metab 34 2008 643 648
    • (2008) Diabetes Metab , vol.34 , pp. 643-648
    • Postic, C.1    Girard, J.2
  • 33
    • 0022357327 scopus 로고
    • Increased metabolic efficiency in obese mutant mice
    • D. Coleman Increased metabolic efficiency in obese mutant mice Int J Obes (Lond) 9 1985 69 73 (Pubitemid 16177131)
    • (1985) International Journal of Obesity , vol.9 , Issue.SUPPL. 2 , pp. 69-73
    • Coleman, D.L.1
  • 34
    • 66449137379 scopus 로고    scopus 로고
    • GRP78 expression inhibits insulin and ER stress-induced SREBP-1c activation and reduces hepatic steatosis in mice
    • H.L. Kammoun, H. Chabanon, I. Hainault, S. Luquet, C. Magnan, and T. Koike GRP78 expression inhibits insulin and ER stress-induced SREBP-1c activation and reduces hepatic steatosis in mice J Clin Invest 119 2009 1201 1215
    • (2009) J Clin Invest , vol.119 , pp. 1201-1215
    • Kammoun, H.L.1    Chabanon, H.2    Hainault, I.3    Luquet, S.4    Magnan, C.5    Koike, T.6
  • 35
    • 33749407193 scopus 로고    scopus 로고
    • ChREBP·Mlx is the principal mediator of glucose-induced gene expression in the liver
    • DOI 10.1074/jbc.M601576200
    • L. Ma, L.N. Robinson, and H.C. Towle ChREBPMlx is the principal mediator of glucose-induced gene expression in the liver J Biol Chem 281 2006 28721 28730 (Pubitemid 44507014)
    • (2006) Journal of Biological Chemistry , vol.281 , Issue.39 , pp. 28721-28730
    • Ma, L.1    Robinson, L.N.2    Towle, H.C.3
  • 36
    • 0030007427 scopus 로고    scopus 로고
    • ADD1/SREBP1 promotes adipocyte differentiation and gene expression linked to fatty acid metabolism
    • J.B. Kim, and B.M. Spiegelman ADD1/SREBP1 promotes adipocyte differentiation and gene expression linked to fatty acid metabolism Genes Dev 10 1996 1096 1107 (Pubitemid 26152851)
    • (1996) Genes and Development , vol.10 , Issue.9 , pp. 1096-1107
    • Kim, J.B.1    Spiegelman, B.M.2
  • 37
    • 0040799893 scopus 로고    scopus 로고
    • Identification of conserved cis-elements and transcription factors required for sterol-regulated transcription of stearoyl-CoA desaturase 1 and 2
    • D.E. Tabor, J.B. Kim, B.M. Spiegelman, and P.A. Edwards Identification of conserved cis-elements and transcription factors required for sterol-regulated transcription of stearoyl-CoA desaturase 1 and 2 J Biol Chem 274 1999 20603 20610
    • (1999) J Biol Chem , vol.274 , pp. 20603-20610
    • Tabor, D.E.1    Kim, J.B.2    Spiegelman, B.M.3    Edwards, P.A.4
  • 38
    • 33644547706 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease: From steatosis to cirrhosis
    • G.C. Farrell, and C.Z. Larter Nonalcoholic fatty liver disease: from steatosis to cirrhosis Hepatology 43 2006 S99 S112
    • (2006) Hepatology , vol.43
    • Farrell, G.C.1    Larter, C.Z.2
  • 41
    • 69249238074 scopus 로고    scopus 로고
    • Glucose induces FGF21 mRNA expression through ChREBP activation in rat hepatocytes
    • K. Iizuka, J. Takeda, and Y. Horikawa Glucose induces FGF21 mRNA expression through ChREBP activation in rat hepatocytes FEBS Lett 583 2009 2882 2886
    • (2009) FEBS Lett , vol.583 , pp. 2882-2886
    • Iizuka, K.1    Takeda, J.2    Horikawa, Y.3
  • 42
    • 0028897395 scopus 로고
    • In vivo effects of hyperinsulinemia on lipogenic enzymes and glucose transporter expression in rat liver and adipose tissues
    • F. Assimacopoulos-Jeannet, S. Brichard, F. Rencurel, I. Cusin, and B. Jeanrenaud In vivo effects of hyperinsulinemia on lipogenic enzymes and glucose transporter expression in rat liver and adipose tissues Metabolism 44 1995 228 233
    • (1995) Metabolism , vol.44 , pp. 228-233
    • Assimacopoulos-Jeannet, F.1    Brichard, S.2    Rencurel, F.3    Cusin, I.4    Jeanrenaud, B.5
  • 43
    • 0142105834 scopus 로고    scopus 로고
    • Differences in the regulation of adipose tissue and liver lipogenesis by carbohydrates in humans
    • DOI 10.1194/jlr.M200461-JLR200
    • F. Diraison, V. Yankah, D. Letexier, E. Dusserre, P. Jones, and M. Beylot Differences in the regulation of adipose tissue and liver lipogenesis by carbohydrates in humans J Lipid Res 44 2003 846 853 (Pubitemid 37279687)
    • (2003) Journal of Lipid Research , vol.44 , Issue.4 , pp. 846-853
    • Diraison, F.1    Yankah, V.2    Letexier, D.3    Dusserre, E.4    Jones, P.5    Beylot, M.6
  • 44
    • 0037372623 scopus 로고    scopus 로고
    • Addition of inulin to a moderately high-carbohydrate diet reduces hepatic lipogenesis and plasma triacylglycerol concentrations in humans
    • D. Letexier, F. Diraison, and M. Beylot Addition of inulin to a moderately high-carbohydrate diet reduces hepatic lipogenesis and plasma triacylglycerol concentrations in humans Am J Clin Nutr 77 2003 559 564 (Pubitemid 36258562)
    • (2003) American Journal of Clinical Nutrition , vol.77 , Issue.3 , pp. 559-564
    • Letexier, D.1    Diraison, F.2    Beylot, M.3
  • 45
    • 10344262633 scopus 로고    scopus 로고
    • 2 family members possessing triacylglycerol lipase and acylglycerol transacylase activities
    • DOI 10.1074/jbc.M407841200
    • C.M. Jenkins, D.J. Mancuso, W. Yan, H.F. Sims, B. Gibson, and R.W. Gross Identification, cloning, expression, and purification of three novel human calcium-independent phospholipase A2 family members possessing triacylglycerol lipase and acylglycerol transacylase activities J Biol Chem 279 2004 48968 48975 (Pubitemid 39625778)
    • (2004) Journal of Biological Chemistry , vol.279 , Issue.47 , pp. 48968-48975
    • Jenkins, C.M.1    Mancuso, D.J.2    Yan, W.3    Sims, H.F.4    Gibson, B.5    Gross, R.W.6
  • 46
    • 77956625538 scopus 로고    scopus 로고
    • Patatin-like phospholipase domain-containing 3/adiponutrin deficiency in mice is not associated with fatty liver disease
    • W. Chen, B. Chang, L. Li, and L. Chan Patatin-like phospholipase domain-containing 3/adiponutrin deficiency in mice is not associated with fatty liver disease Hepatology 52 2010 1134 1142
    • (2010) Hepatology , vol.52 , pp. 1134-1142
    • Chen, W.1    Chang, B.2    Li, L.3    Chan, L.4


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