Autocrine growth factor revisited: PC-cell-derived growth factor (progranulin), a critical player in breast cancer tumorigenesis

Biochemical and Biophysical Research Communications

Volumn 308, Issue 3, 2003, Pages 409-413

  Serrero, Ginette ^a  

^a A&G Pharmaceutical   (United States)

Author keywords

Autocrine growth factor; Breast cancer; Granulin epithelin precursor; PC cell derived growth factor; Progranulin; Tumorigenesis

Indexed keywords

DOXORUBICIN; ESTRADIOL; GROWTH FACTOR; PROGRANULIN; TAMOXIFEN; UNCLASSIFIED DRUG;

AUTOCRINE EFFECT; BREAST CANCER; CANCER INVASION; CANCER THERAPY; CARCINOGENESIS; CELL PROLIFERATION; CELL STIMULATION; CELLULAR DISTRIBUTION; CORRELATION ANALYSIS; DRUG TARGETING; ENZYME ACTIVATION; ENZYME ACTIVITY; HORMONE ACTION; HUMAN; IMMUNOHISTOCHEMISTRY; KIDNEY CARCINOMA; MULTIPLE MYELOMA; NONHUMAN; OVARY CANCER; PATHOGENESIS; PRIORITY JOURNAL; PROGNOSIS; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FAMILY; PROTEIN FUNCTION; PROTEIN STRUCTURE; REGULATORY MECHANISM; REVIEW; TUMOR BIOPSY; TUMOR GROWTH;

EID: 0042666803     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-291X(03)01452-9     Document Type: Review

References (36)

1. Hoskins K., Weber B.L. The biology of breast cancer. Curr. Opin. Oncol. 6:1994;554-559.
2. Dickson R.B., Lippman M.E. Growth factors in breast cancer. Endocrinol. Rev. 16:1995;559-589.
3. Favoni R.E., de Cupis A. The role of polypeptide growth factors in human carcinomas: new targets for a novel pharmacological approach. Pharmacol. Rev. 52:2000;179-206.
4. Pegram M., Slamon D. Biological rationale for HER2/neu (c-erbB2) as a target for monoclonal antibody therapy. Semin. Oncol. 27:2000;13-19.
5. Bateman A., Bennett H.P. Granulins: the structure and function of an emerging family of growth factors. J. Endocrinol. 158:1998;145-151.
6. Daniel R., He Z., Carmichael K.P., Halper J., Bateman A. Cellular localization of gene expression for progranulin. J. Histochem. Cytochem. 48:2000;999-1009.
7. Shoyab M., McDonald V.L., Byles C., Todaro G.J., Plowman G.D. Epithelins 1 and 2: isolation and characterization of two cysteine-rich growth-modulating proteins. Proc. Natl. Acad. Sci. USA. 87:1990;7912-7916.
8. Bateman A., Belcourt D., Bennett H., Lazure C., Solomon S. Granulins, a novel class of peptide from leukocytes. Biochem. Biophys. Res. Commun. 173:1990;1161-1168.
9. Bhandari V., Palfree R.G., Bateman A. Isolation and sequence of the granulin precursor cDNA from human bone marrow reveals tandem cysteine-rich granulin domains. Proc. Natl. Acad. Sci. USA. 89:1992;1715-1719.
10. Plowman G.D., Green J.M., Neubauer M.G., Buckley S.D., McDonald V.L., Todaro G.J., Shoyab M. The epithelin precursor encodes two proteins with opposing activities on epithelial cell growth. J. Biol. Chem. 267:1992;13073-13078.
11. Zhou J., Gao G., Crabb J.W., Serrero G. Purification of an autocrine growth factor homologous with mouse epithelin precursor from a highly tumorigenic cell line. J. Biol. Chem. 268:1993;10863-10869.
12. Zhang H., Serrero G. Inhibition of tumorigenicity of the teratoma PC cell line by transfection with antisense cDNA for PC cell-derived growth factor (PCDGF, epithelin/granulin precursor). Proc. Natl. Acad. Sci. USA. 95:1998;14202-14207.
13. Sparro G., Galdenzi G., Eleuteri A.M., Angeletti M., Schroeder W., Fioretti E. Isolation and N-terminal sequence of multiple forms of granulins in human urine. Protein Expr. Purif. 10:1997;169-174.
14. Parnell P.G., Carter B.J., Halper J. Identification of a membrane-associated receptor for transforming growth factor type E. J. Recept Signal Transduct. Res. 15:1995;747-756.
15. Diaz-Cueto L., Stein P., Jacobs A., Schultz R.M., Gerton G.L. Modulation of mouse preimplantation embryo development by acrogranin (epithelin/granulin precursor). Dev. Biol. 217:2000;406-418.
16. Baba T., Hoff III H.B., Nemoto H., Lee H., Orth J., Arai Y., Gerton G.L. Acrogranin, an acrosomal cysteine-rich glycoprotein, is the precursor of the growth-modulating peptides, granulins, and epithelins, and is expressed in somatic as well as male germ cells. Mol. Reprod. Dev. 34:1993;233-243.
17. Lu R., Serrero G. Inhibition of PC cell-derived growth factor (PCDGF, epithelin/granulin precursor) expression by antisense PCDGF cDNA transfection inhibits tumorigenicity of the human breast carcinoma cell line MDA-MB-468. Proc. Natl. Acad. Sci. USA. 97:2000;3993-3998.
18. Lu R., Serrero G. Stimulation of PC cell-derived growth factor (epithelin/granulin precursor) expression by estradiol in human breast cancer cells. Biochem. Biophys. Res. Commun. 256:1999;204-207.
19. Bhandari V., Daniel R., Lim P.S., Bateman A. Structural and functional analysis of a promoter of the human granulin/epithelin gene. Biochem. J. 319(Pt 2):1996;441-447.
20. Xia X., Serrero G. Identification of cell surface binding sites for PC-cell-derived growth factor, PCDGF, (epithelin/granulin precursor) on epithelial cells and fibroblasts. Biochem. Biophys. Res. Commun. 245:1998;539-543.
21. Culouscou J.M., Carlton G.W., Shoyab M. Biochemical analysis of the epithelin receptor. J. Biol. Chem. 268:1993;10458-10462.
22. He Z., Bateman A. Progranulin gene expression regulates epithelial cell growth and promotes tumor growth in vivo. Cancer Res. 59:1999;3222-3229.
23. Lu R., Serrero G. Mediation of estrogen mitogenic effect in human breast cancer MCF-7 cells by PC-cell-derived growth factor (PCDGF/granulin precursor). Proc. Natl. Acad. Sci. USA. 98:2001;142-147.
24. Xu S.Q., Tang D., Chamberlain S., Pronk G., Masiarz F.R., Kaur S., Prisco M., Zanocco-Marani T., Baserga R. The granulin/epithelin precursor abrogates the requirement for the insulin-like growth factor 1 receptor for growth in vitro. J. Biol. Chem. 273:1998;20078-20083.
25. Zanocco-Marani T., Bateman A., Romano G., Valentinis B., He Z.H., Baserga R. Biological activities and signaling pathways of the granulin/epithelin precursor. Cancer Res. 59:1999;5331-5340.
26. Jones M.B., Michener C.M., Blanchette J.O., Kuznetsov V.A., Raffeld M., Serrero G., Emmert-Buck M.R., Petricoin E.F., Krizman D.B., Liotta L.A., Kohn E.C. The granulin-epithelin precursor/PC-cell-derived growth factor is a growth factor for epithelial ovarian cancer. Clin. Cancer Res. 9:2003;44-51.
27. Wang W., Hayashi J., Kim W.E., Serrero G. PC cell-derived growth factor (granulin precursor) expression and action in human multiple myeloma. Clin. Cancer Res. 9:2003;2221-2228.
28. Kudoh K., Ramanna M., Ravatn R., Elkahloun A.G., Bittner M.L., Meltzer P.S., Trent J.M., Dalton W.S., Chin K.V. Monitoring the expression profiles of doxorubicin-induced and doxorubicin-resistant cancer cells by cDNA microarray. Cancer Res. 60:2000;4161-4166.
29. Leung L.K., Wang T.T. Differential effects of chemotherapeutic agents on the Bcl-2/Bax apoptosis pathway in human breast cancer cell line MCF-7. Breast Cancer Res. Treat. 55:1999;73-83.
30. Zhang G.J., Kimijima I., Onda M., Kanno M., Sato H., Watanabe T., Tsuchiya A., Abe R., Takenoshita S. Tamoxifen-induced apoptosis in breast cancer cells relates to down-regulation of bcl-2, but not bax and bcl-X(L), without alteration of p53 protein levels. Clin. Cancer Res. 5:1999;2971-2977.
31. He Z., Ismail A., Kriazhev L., Sadvakassova G., Bateman A. Progranulin (PC-cell-derived growth factor/acrogranin) regulates invasion and cell survival. Cancer Res. 62:2002;5590-5596.
32. Virtaneva K., Wright F.A., Tanner S.M., Yuan B., Lemon W.J., Caligiuri M.A., Bloomfield C.D., de La Chapelle A., Krahe R. Expression profiling reveals fundamental biological differences in acute myeloid leukemia with isolated trisomy 8 and normal cytogenetics. Proc. Natl. Acad. Sci. USA. 98:2001;1124-1129.
33. Chow M.L., Moler E.J., Mian I.S. Identifying marker genes in transcription profiling data using a mixture of feature relevance experts. Physiol. Genom. 5:2001;99-111.
34. Liau L.M., Lallone R.L., Seitz R.S., Buznikov A., Gregg J.P., Kornblum H.I., Nelson S.F., Bronstein J.M. Identification of a human glioma-associated growth factor gene, granulin, using differential immuno-absorption. Cancer Res. 60:2000;1353-1360.
35. Markert J.M., Fuller C.M., Gillespie G.Y., Bubien J.K., McLean L.A., Hong R.L., Lee K., Gullans S.R., Mapstone T.B., Benos D.J. Differential gene expression profiling in human brain tumors. Physiol. Genom. 5:2001;21-33.
36. Donald C.D., Laddu A., Chandham P., Lim S.D., Cohen C., Amin M., Gerton G.L., Marshall F.F., Petros J.A. Expression of progranulin and the epithelin/granulin precursor acrogranin correlates with neoplastic state in renal epithelium. Anticancer Res. 21:2001;3739-3742.