Assessment of UDP-glucuronosyltransferase catalyzed formation of Picroside II glucuronide in microsomes of different species and recombinant UGTs

Xenobiotica

Volumn 41, Issue 7, 2011, Pages 530-537

  Li, Tingting ^a   Zheng, Yi ^a   Fu, Feifei ^a   Ji, Hui ^a   Chen, Xijing ^a   Zhao, Ying ^a   Zhao, Di ^a   Li, Ning ^a   Zhang, Lingli ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

human intestinal microsomes; liver microsomes; Picrosode II glucuronidation; recombinant human UGT; UDP glucuronosyltransferase

Indexed keywords

ANTIOXIDANT; BETA GLUCURONIDASE; DRUG METABOLITE; EMODIN; GLUCURONOSYLTRANSFERASE 1A10; GLUCURONOSYLTRANSFERASE 1A7; GLUCURONOSYLTRANSFERASE 1A8; GLUCURONOSYLTRANSFERASE 1A9; INTESTINE ENZYME; LIVER PROTECTIVE AGENT; MICROSOME ENZYME; MYCOPHENOLIC ACID; PICROSIDE II; PICROSIDE II GLUCURONIDE; PLANT GLYCOSIDE; RECOMBINANT ENZYME; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DOG; DRUG CLEARANCE; DRUG GLUCURONIDATION; DRUG METABOLISM; DRUG STRUCTURE; ENZYME KINETICS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; IC 50; INTESTINE MICROSOME; LIVER MICROSOME; MALE; MASS SPECTROMETRY; MICROSOME; MOUSE; NONHUMAN; PROTEIN FUNCTION; RAT; SPECIES DIFFERENCE;

ANIMALS; BIOCATALYSIS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CINNAMATES; DOGS; GLUCURONIDES; GLUCURONOSYLTRANSFERASE; HUMANS; INTESTINES; IRIDOID GLUCOSIDES; ISOENZYMES; KINETICS; MALE; MICE; MICROSOMES, LIVER; RATS; RECOMBINANT PROTEINS; SPECIES SPECIFICITY; SUBSTRATE SPECIFICITY;

CANIS FAMILIARIS; RATTUS;

EID: 79958819816     PISSN: 00498254     EISSN: 13665928     Source Type: Journal    
DOI: 10.3109/00498254.2011.573018     Document Type: Article

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