The Opioid Component of Delayed Gastrointestinal Recovery After Bowel Resection

Journal of Gastrointestinal Surgery

Volumn 15, Issue 7, 2011, Pages 1259-1268

  Beard, Timothy L ^a   Leslie, John B ^b   Nemeth, Jeffrey ^c  

^a Bend Memorial Clinic   (United States)

^b MAYO CLINIC   (United States)

^c ENGLEWOOD HOSPITAL AND MEDICAL CENTER   (United States)

Author keywords

Drug effects; Gastrointestinal motility; Mu opioid receptor antagonists; Perioperative care

Indexed keywords

NARCOTIC ANALGESIC AGENT;

ABDOMINAL SURGERY; ARTICLE; CONVALESCENCE; DRUG EFFECT; GASTROINTESTINAL DISEASE; GASTROINTESTINAL MOTILITY; HUMAN; PAIN; PATHOPHYSIOLOGY; PHYSIOLOGY; POSTOPERATIVE PAIN;

ANALGESICS, OPIOID; DIGESTIVE SYSTEM SURGICAL PROCEDURES; GASTROINTESTINAL DISEASES; GASTROINTESTINAL MOTILITY; HUMANS; PAIN; PAIN, POSTOPERATIVE; RECOVERY OF FUNCTION;

EID: 79958800617     PISSN: 1091255X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11605-011-1500-3     Document Type: Article

References (63)

1. Luckey A, Livingston E, Tache Y. Mechanisms and treatment of postoperative ileus. Arch Surg 2003; 138: 206-214.
2. Person B, Wexner SD. The management of postoperative ileus. Curr Probl Surg 2006; 43: 6-65.
3. Stewart D, Waxman K. Management of postoperative ileus. Dis Mon 2010; 56: 204-214.
4. Augestad KM, Delaney CP. Postoperative ileus: impact of pharmacological treatment, laparoscopic surgery and enhanced recovery pathways. World J Gastroenterol 2010; 16: 2067-2074.
5. Boeckxstaens GE, de Jonge WJ. Neuroimmune mechanisms in postoperative ileus. Gut 2009; 58: 1300-1311.
6. Iyer S, Saunders WB, Stemkowski S. Economic burden of postoperative ileus associated with colectomy in the United States. J Manag Care Pharm 2009; 15: 485-494.
7. Moraca RJ, Sheldon DG, Thirlby RC. The role of epidural anesthesia and analgesia in surgical practice. Ann Surg 2003; 238: 663-673.
8. Wood JD. Opioids, the enteric nervous system, and postoperative ileus. Semin Colon Rectal Surg 2005; 16: 188-196.
9. Kurz A, Sessler DI. Opioid-induced bowel dysfunction: pathophysiology and potential new therapies. Drugs 2003; 63: 649-671.
10. Kalff JC, Carlos TM, Schraut WH, Billiar TR, Simmons RL, Bauer AJ. Surgically induced leukocytic infiltrates within the rat intestinal muscularis mediate postoperative ileus. Gastroenterology 1999; 117: 378-387.
11. The FO, de Jonge WJ, Bennink RJ, van den Wijngaard RM, Boeckxstaens GE. The ICAM-1 antisense oligonucleotide ISIS-3082 prevents the development of postoperative ileus in mice. Br J Pharmacol 2005; 146: 252-258.
12. de Jonge WJ, The FO, van der Coelen D, Bennink RJ, Reitsma PH, van Deventer SJ, van den Wijngaard RM, Boeckxstaens GE. Mast cell degranulation during abdominal surgery initiates postoperative ileus in mice. Gastroenterology 2004; 127: 535-545.
13. Schwarz NT, Beer-Stolz D, Simmons RL, Bauer AJ. Pathogenesis of paralytic ileus: intestinal manipulation opens a transient pathway between the intestinal lumen and the leukocytic infiltrate of the jejunal muscularis. Ann Surg 2002; 235: 31-40.
14. The FO, Bennink RJ, Ankum WM, Buist MR, Busch OR, Gouma DJ, van der Heide S, van den Wijngaard RM, de Jonge WJ, Boeckxstaens GE. Intestinal handling-induced mast cell activation and inflammation in human postoperative ileus. Gut 2008; 57: 33-40.
15. Viscusi ER, Gan TJ, Leslie JB, Foss JF, Talon MD, Du W, Owens G. Peripherally acting mu-opioid receptor antagonists and postoperative ileus: mechanisms of action and clinical applicability. Anesth Analg 2009; 108: 1811-1822.
16. Cali RL, Meade PG, Swanson MS, Freeman C. Effect of morphine and incision length on bowel function after colectomy. Dis Colon Rectum 2000; 43: 163-168.
17. Singleton PA, Moss J. Effect of perioperative opioids on cancer recurrence: a hypothesis. Future Oncol 2010; 6: 1237-1242.
18. Wheeler M, Oderda GM, Ashburn MA, Lipman AG. Adverse events associated with postoperative opioid analgesia: a systematic review. J Pain 2002; 3: 159-180.
19. Kehlet H. Postoperative opioid sparing to hasten recovery: what are the issues? Anesthesiology 2005; 102: 1083-1085.
20. White PF, Kehlet H. Improving postoperative pain management: what are the unresolved issues? Anesthesiology 2010; 112: 220-225.
21. Sternini C, Patierno S, Selmer IS, Kirchgessner A. The opioid system in the gastrointestinal tract. Neurogastroenterol Motil 2004; 16 Suppl 2: 3-16.
22. Holzer P. Opioid receptors in the gastrointestinal tract. Regul Pept 2009; 155: 11-17.
23. Henderson G, McKnight AT. The orphan opioid receptor and its endogenous ligand-nociceptin/orphanin FQ. Trends in Pharmacological Sciences 1997; 18: 293-300.
24. Cadet P, Mantione KJ, Stefano GB. Molecular identification and functional expression of mu 3, a novel alternatively spliced variant of the human mu opiate receptor gene. J Immunol 2003; 170: 5118-5123.
25. Zadina JE, Hackler L, Ge LJ, Kastin AJ. A potent and selective endogenous agonist for the mu-opiate receptor. Nature 1997; 386: 499-502.
26. Brix-Christensen V, Tonnesen E, Sanchez RG, Bilfinger TV, Stefano GB. Endogenous morphine levels increase following cardiac surgery as part of the antiinflammatory response? Int J Cardiol 1997; 62: 191-197.
27. Wood JD, Galligan JJ. Function of opioids in the enteric nervous system. Neurogastroenterol Motil 2004; 16 Suppl 2: 17-28.
28. Noel JK, Fahrbach K, Estok R, Cella C, Frame D, Linz H, Cima RR, Dozois EJ, Senagore AJ. Minimally invasive colorectal resection outcomes: short-term comparison with open procedures. J Am Coll Surg 2007; 204: 291-307.
29. Popping DM, Elia N, Marret E, Remy C, Tramer MR. Protective effects of epidural analgesia on pulmonary complications after abdominal and thoracic surgery: a meta-analysis. Arch Surg 2008; 143: 990-999; discussion 1000.
30. Madbouly KM, Senagore AJ, Delaney CP. Endogenous morphine levels after laparoscopic versus open colectomy. Br J Surg 2010; 97: 759-764.
31. Marret E, Kurdi O, Zufferey P, Bonnet F. Effects of nonsteroidal antiinflammatory drugs on patient-controlled analgesia morphine side effects: meta-analysis of randomized controlled trials. Anesthesiology 2005; 102: 1249-1260.
32. Sim R, Cheong DM, Wong KS, Lee BM, Liew QY. Prospective randomized, double-blind, placebo-controlled study of pre- and postoperative administration of a COX-2-specific inhibitor as opioid-sparing analgesia in major colorectal surgery. Colorectal Dis 2007; 9: 52-60.
33. Chen JY, Wu GJ, Mok MS, Chou YH, Sun WZ, Chen PL, Chan WS, Yien HW, Wen YR. Effect of adding ketorolac to intravenous morphine patient-controlled analgesia on bowel function in colorectal surgery patients-a prospective, randomized, double-blind study. Acta Anaesthesiol Scand 2005; 49: 546-551.
34. Xu Y, Tan Z, Chen J, Lou F, Chen W. Intravenous flurbiprofen axetil accelerates restoration of bowel function after colorectal surgery. Can J Anaesth 2008; 55: 414-422.
35. Varrassi G, Marinangeli F, Agro F, Aloe L, De Cillis P, De Nicola A, Giunta F, Ischia S, Ballabio M, Stefanini S. A double-blinded evaluation of propacetamol versus ketorolac in combination with patient-controlled analgesia morphine: analgesic efficacy and tolerability after gynecologic surgery. Anesth Analg 1999; 88: 611-616.
36. Remy C, Marret E, Bonnet F. Effects of acetaminophen on morphine side-effects and consumption after major surgery: meta-analysis of randomized controlled trials. Br J Anaesth 2005; 94: 505-513.
37. Dauri M, Faria S, Gatti A, Celidonio L, Carpenedo R, Sabato AF. Gabapentin and pregabalin for the acute post-operative pain management. A systematic-narrative review of the recent clinical evidences. Curr Drug Targets 2009; 10: 716-733.
38. Dierking G, Duedahl TH, Rasmussen ML, Fomsgaard JS, Moiniche S, Romsing J, Dahl JB. Effects of gabapentin on postoperative morphine consumption and pain after abdominal hysterectomy: a randomized, double-blind trial. Acta Anaesthesiol Scand 2004; 48: 322-327.
39. Lightner A, Lin M, Yoo J. Anesthesia and pain management. Semin Colon Rectal Surg 2010; 21: 165-169.
40. Werawatganon T, Charuluxanun S. Patient controlled intravenous opioid analgesia versus continuous epidural analgesia for pain after intra-abdominal surgery. Cochrane Database Syst Rev 2005: CD004088.
41. Jorgensen H, Wetterslev J, Moiniche S, Dahl JB. Epidural local anaesthetics versus opioid-based analgesic regimens on postoperative gastrointestinal paralysis, PONV and pain after abdominal surgery. Cochrane Database Syst Rev 2000: CD001893.
42. Liu SS, Carpenter RL, Mackey DC, Thirlby RC, Rupp SM, Shine TS, Feinglass NG, Metzger PP, Fulmer JT, Smith SL. Effects of perioperative analgesic technique on rate of recovery after colon surgery. Anesthesiology 1995; 83: 757-765.
43. Steinberg RB, Liu SS, Wu CL, Mackey DC, Grass JA, Ahlen K, Jeppsson L. Comparison of ropivacaine-fentanyl patient-controlled epidural analgesia with morphine intravenous patient-controlled analgesia for perioperative analgesia and recovery after open colon surgery. J Clin Anesth 2002; 14: 571-577.
44. Zingg U, Miskovic D, Hamel CT, Erni L, Oertli D, Metzger U. Influence of thoracic epidural analgesia on postoperative pain relief and ileus after laparoscopic colorectal resection: benefit with epidural analgesia. Surg Endosc 2009; 23: 276-282.
45. Marret E, Remy C, Bonnet F. Meta-analysis of epidural analgesia versus parenteral opioid analgesia after colorectal surgery. Br J Surg 2007; 94: 665-673.
46. Senagore AJ, Delaney CP, Mekhail N, Dugan A, Fazio VW. Randomized clinical trial comparing epidural anaesthesia and patient-controlled analgesia after laparoscopic segmental colectomy. Br J Surg 2003; 90: 1195-1199.
47. Delaney CP, Weese JL, Hyman NH, Bauer J, Techner L, Gabriel K, Du W, Schmidt WK, Wallin BA. Phase III trial of alvimopan, a novel, peripherally acting, mu opioid antagonist, for postoperative ileus after major abdominal surgery. Dis Colon Rectum 2005; 48: 1114-1125; discussion 1125-1126; author reply 1127-1129.
48. Ludwig K, Enker WE, Delaney CP, Wolff BG, Du W, Fort JG, Cherubini M, Cucinotta J, Techner L. Gastrointestinal tract recovery in patients undergoing bowel resection: results of a randomized trial of alvimopan and placebo with a standardized accelerated postoperative care pathway. Arch Surg 2008; 143: 1098-1105.
49. Thomas J, Slatkin N, Lipman A, Karver S, Israel RJ. Methylnaltrexone: clinical results from two phase 3 studies for opioid-induced constipation. Anesthesiology 2006; 105: Abstract 329.
50. Viscusi ER, Goldstein S, Witkowski T, Andonakakis A, Jan R, Gabriel K, Du W, Techner L, Wallin B. Alvimopan, a peripherally acting mu-opioid receptor antagonist, compared with placebo in postoperative ileus after major abdominal surgery: results of a randomized, double-blind, controlled study [published Erratum appears in Surg Endosc. 2006; 20: 537]. Surg Endosc 2006; 20: 64-70.
51. Wolff BG, Michelassi F, Gerkin TM, Techner L, Gabriel K, Du W, Wallin BA. Alvimopan, a novel, peripherally acting mu opioid antagonist: results of a multicenter, randomized, double-blind, placebo-controlled, phase III trial of major abdominal surgery and postoperative ileus. Ann Surg 2004; 240: 728-734; discussion 734-735.
52. Kraft M, Maclaren R, Du W, Owens G. Alvimopan (entereg) for the management of postoperative ileus in patients undergoing bowel resection. P T 2010; 35: 44-49.
53. Wolff BG, Weese JL, Ludwig KA, Delaney CP, Stamos MJ, Michelassi F, Du W, Techner L. Postoperative ileus-related morbidity profile in patients treated with alvimopan after bowel resection. J Am Coll Surg 2007; 204: 609-616.
54. Absher RK, Gerkin TM, Banares LW. Alvimopan use in laparoscopic and open bowel resections: clinical results in a large community hospital system. Ann Pharmacother 2010; 44: 1701-1708.
55. Popescu I, Fleshner PR, Pezzullo JC, Charlton PA, Kosutic G, Senagore AJ. The Ghrelin agonist TZP-101 for management of postoperative ileus after partial colectomy: a randomized, dose-ranging, placebo-controlled clinical trial. Dis Colon Rectum 2010; 53: 126-134.
56. Venkova K, Mann W, Nelson R, Greenwood-van Meerveld B. Efficacy of ipamorelin, a novel ghrelin mimetic, in a rodent model of postoperative ileus. J Pharmacol Exp Ther 2009; 329: 1110-1116.
57. Manabe N, Camilleri M, Rao A, Wong BS, Burton D, Busciglio I, Zinsmeister AR, Haruma K. Effect of daikenchuto (TU-100) on gastrointestinal and colonic transit in humans. Am J Physiol Gastrointest Liver Physiol 2010; 298: G970-975.
58. Narita K, Tsunoda A, Takenaka K, Watanabe M, Nakao K, Kusano M. Effect of mosapride on recovery of intestinal motility after hand-assisted laparoscopic colectomy for carcinoma. Dis Colon Rectum 2008; 51: 1692-1695.
59. Xie Q, Zong X, Ge B, Wang S, Ji J, Ye Y, Pan L. Pilot postoperative ileus study of escin in cancer patients after colorectal surgery. World J Surg 2009; 33: 348-354.
60. Zingg U, Miskovic D, Pasternak I, Meyer P, Hamel CT, Metzger U. Effect of bisacodyl on postoperative bowel motility in elective colorectal surgery: a prospective, randomized trial. Int J Colorectal Dis 2008; 23: 1175-1183.
61. Senagore A, Delaney CP, Beard TL, Gerkin TM, Zingaro WM, Tomaszewski KJ, Walton LK, Poston SA. Care practice and physician characteristic drivers of length of stay after elective bowel resection: results of a national survey [poster]. Presented at: American College of Surgeons 95th Annual Clinical Congress; October 11-15, 2009; Chicago, IL.
62. Ellis CN. Bowel preparation before elective colorectal surgery: what is the evidence. Semin Colon Rectal Surg 2010; 21: 144-147.
63. Stein SL. Incorporating enhanced care pathways into colorectal practice. Semin Colon Rectal Surg 2010; 21: 180-183.