Effect of adding ketorolac to intravenous morphine patient-controlled analgesia on bowel function in colorectal surgery patients - A prospective, randomized, double-blind study

Acta Anaesthesiologica Scandinavica

Volumn 49, Issue 4, 2005, Pages 546-551

  Chen, J Y ^a,b   Wu, G J ^a   Mok, M S ^c   Chou, Y H ^a   Sun, W Z ^d   Chen, P L ^e   Chan, W S ^a   Yien, H W ^b   Wen, Yeong Ray ^a  

^a SHIN KONG WU HO SU MEMORIAL HOSPITAL   (Taiwan)

^b NATIONAL YANG MING UNIVERSITY   (Taiwan)

^c TAIPEI MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^d NATIONAL TAIWAN UNIVERSITY HOSPITAL   (Taiwan)

^e TAIPEI MEDICAL UNIVERSITY   (Taiwan)

Author keywords

Bowel movement; Ketorolac; Opioids; Patient controlled analgesia; Postoperative ileus; Postoperative pain

Indexed keywords

KETOROLAC; MORPHINE; OPIATE;

ABDOMINAL SURGERY; ADULT; AGED; ARTICLE; CLINICAL TRIAL; COLORECTAL SURGERY; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIZZINESS; DOUBLE BLIND PROCEDURE; DRUG EFFECT; FEMALE; HUMAN; INTESTINE FUNCTION; INTESTINE MOTILITY; MAJOR CLINICAL STUDY; MALE; NAUSEA; PARALYTIC ILEUS; PATIENT CONTROLLED ANALGESIA; PRIORITY JOURNAL; PROSPECTIVE STUDY; PRURITUS; RANDOMIZED CONTROLLED TRIAL; SIDE EFFECT; SOMNOLENCE; SURGICAL PATIENT; VOMITING;

ADULT; AGED; ANALGESIA, PATIENT-CONTROLLED; ANALGESICS, OPIOID; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; COLON; DIGESTIVE SYSTEM SURGICAL PROCEDURES; DOUBLE-BLIND METHOD; FEMALE; HUMANS; INFUSIONS, INTRAVENOUS; INTESTINAL OBSTRUCTION; KETOROLAC; LENGTH OF STAY; MALE; MIDDLE AGED; MORPHINE; PAIN MEASUREMENT; PAIN, POSTOPERATIVE; PROSPECTIVE STUDIES; RECTUM; TREATMENT OUTCOME;

EID: 16844362543     PISSN: 00015172     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1399-6576.2005.00674.x     Document Type: Article

References (25)

1. Livingston EH, Passaro EP Jr. Postoperative ileus. Digest Dis Sci 1990; 35: 121-32.
2. Spiller CM. Mechanisms of postoperative intestinal motor dysfunction. Curr Opin Gastroenterol 2003; 19: 103-5.
3. Moss G, Regal ME, Lichtig L. Reducing postoperative pain, narcotics, and length of hospitalization. Surgery 1986; 99: 206-10.
4. Ferraz AA, Cowles VE, Condon RE et al. Nonopioid analgesics shorten the duration of postoperative ileus. Am Surgeon 1995; 61: 1079-83.
5. Kehlet H, Holte K. Review of postoperative ileus. Am J Surg 2001; 182: S3-S10.
6. Friedman JD, Dello Buono FA. Opioid antagonists in the treatment of opioid-induced constipation and pruritus. Ann Pharmacother 2001; 35: 85-91.
7. Graber JN, Schulte WJ, Condon RE, Cowles VE. Relationship of duration of postoperative ileus to extent and site of operative dissection. Surgery 1982; 92: 87-92.
8. Pavy TJ, Paech MJ, Evans SF. The effect of intravenous ketorolac on opioid requirement and pain after cesarean delivery. Anesth Analg 2001; 92: 1010-4.
9. Waldhausen JH, Shaffrey ME, Skenderis BS, Jones RS, Schirmer BD. Gastrointestinal myoelectric and clinical patterns of recovery after laparotomy. Ann Surg 1990; 211: 777-84.
10. Luckey A, Livingston E, Tache Y. Mechanisms and treatment of postoperative ileus. Arch Surg 2003; 138: 206-14.
11. Reissman P, Teoh TA, Cohen SM, Weiss EG, Nogueras JJ, Wexner SD. Is early oral feeding safe after elective colorectal surgery? A prospective randomized trial. Ann Surg 1995; 222: 73-7.
12. Cali RL, Meade PG, Swanson MS, Freeman C. Effect of morphine and incision length on bowel function after colectomy. Dis Colon Rectum 2000; 43: 163-8.
13. Kaufman PN, Krevsky B, Malmud LS et al. Role of opiate receptors in the regulation of colonic transit. Gastroenterology 1988; 94: 1351-6.
14. Chan KC, Cheng YJ, Huang GT et al. The effect of IVPCA morphine on post-hysterectomy bowel function. Acta Anaesth Sinica 2002; 40: 61-4.
15. Holte K, Kehlet H. Postoperative ileus: progress towards effective management. Drugs 2002; 62: 2603-15.
16. Pasero C. Epidural Analgesia for Postoperative Pain, Part 2: Multimodal recovery programs improve patient outcomes. Am J Nurs 2003; 103: 43-5.
17. Basse L, Billesbolle P, Kehlet H. Early recovery after abdominal rectopexy with multimodal rehabilitation. Dis Colon Rectum 2002; 45: 195-9.
18. Picard P Bazin JE, Conio N, Ruiz F, Schoeffler P. Ketorolac potentiates morphine in postoperative patient-controlled analgesia. Pain 1997; 73: 401-6.
19. O'Hara DA, Fanciullo G, Hubbard L et al. Evaluation of the safety and efficacy of ketorolac versus morphine by patient-controlled analgesia for postoperative pain. Pharmacotherapy 1997; 17: 891-9.
20. Cataldo PA, Senagore AJ, Kilbride MJ. Ketorolac and patient controlled analgesia in the treatment of postoperative pain. Surg Gynecol Obstet 1993; 176: 435-8.
21. Yukioka H, Bogod DG, Rosen M. Recovery of bowel motility after surgery. Detection of time of first flatus from carbon dioxide concentration and patient estimate after nalbuphine and placebo. Br J Anaesth 1987; 59: 581-4.
22. Di Fronzo LA, Cymerman J, O'Connell TX. Factors affecting early postoperative feeding following elective open colon resection. Arch Surg 1999; 134: 941-5.
23. Carli F, Trudel JL, Belliveau P. The effect of intraoperative thoracic epidural anesthesia and postoperative analgesia on bowel function after colorectal surgery: a prospective, randomized trial. Dis Colon Rectum 2001; 44: 1083-9.
24. Steinberg RB, Liu SS, Wu CL et al. Comparison of ropivacaine-fentanyl patient-controlled epidural analgesia with morphine intravenous patient-controlled analgesia for perioperative analgesia and recovery after open colon surgery. J Clin Anesth 2002; 14: 571-7.
25. Brix-Christensen V, Tonnesen E, Sanchez RG, Bilfinger TV, Stefano GB. Endogenous morphine levels increase following cardiac surgery as part of the antiinflammatory response? Int J Cardiol 1997; 62: 191-7.