Optimization of a high shear wet granulation process using focused beam reflectance measurement and particle vision microscope technologies

Journal of Pharmaceutical Sciences

Volumn 100, Issue 8, 2011, Pages 3431-3440

  Arp, Zane ^a   Smith, Ben ^b   Dycus, Eric ^b   O'grady, Des ^b  

^a GLAXOSMITHKLINE   (United States)

^b Mettler Toledo   (United States)

Author keywords

FBRM ; Granulation; Online monitoring; Particle size; Particle technology; Physical characterization; Process analytical technology (PAT); Process control; Processing; Quality by design (QBD)

Indexed keywords

CROSCARMELLOSE SODIUM; LACTOSE; MICROCRYSTALLINE CELLULOSE; PARACETAMOL; POVIDONE;

ARTICLE; MICROSCOPY; PARTICLE SIZE; PROCESS MONITORING; PROCESS OPTIMIZATION; PROCESS TECHNOLOGY; TECHNOLOGY;

EID: 79958777009     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.22556     Document Type: Article

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