Online process control of a pharmaceutical intermediate in a fluidized-bed drier environment using near-infrared spectroscopy

Analytical Chemistry

Volumn 82, Issue 10, 2010, Pages 4209-4215

  Märk, Julia ^a,b   Karner, Martin ^b   Andre, Max ^b   Rueland, Jochen ^b   Huck, Christian W ^a  

^a UNIVERSITY OF INNSBRUCK   (Austria)

^b NOVARTIS PHARMA AG   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

BYPASS SYSTEMS; CROSS VALIDATION; END POINTS; HIGH-THROUGHPUT; MONITORING SYSTEM; MULTIVARIATE CALIBRATION; NEAR INFRARED; OFF-LINE ANALYSIS; ONLINE PROCESS CONTROL; PHARMACEUTICAL INDUSTRY; PHARMACEUTICAL INTERMEDIATES; PRODUCT INFORMATION; PRODUCT QUALITY; PRODUCTION PLANT; REFERENCE DATA; RESIDUAL SOLVENTS; ROOT-MEAN SQUARE ERRORS; ROUTINE ANALYSIS; SAMPLING SYSTEMS;

ACETONE; ANTIBIOTICS; CALIBRATION; DRUG PRODUCTS PLANTS; FLUIDIZATION; FLUIDIZED BED PROCESS; INFRARED DEVICES; INFRARED DRYING; INFRARED SPECTROSCOPY; PROBES; WATER CONTENT;

PROCESS CONTROL;

DRUG; SOLVENT; WATER;

ARTICLE; CALIBRATION; CHEMISTRY; DRUG DOSAGE FORM; METHODOLOGY; NEAR INFRARED SPECTROSCOPY; ONLINE SYSTEM; PHARMACEUTICS; PHYSICAL PHENOMENA;

CALIBRATION; CHEMISTRY, PHARMACEUTICAL; DOSAGE FORMS; ONLINE SYSTEMS; PHARMACEUTICAL PREPARATIONS; PHYSICAL PROCESSES; SOLVENTS; SPECTROSCOPY, NEAR-INFRARED; TECHNOLOGY, PHARMACEUTICAL; WATER;

EID: 77952540359     PISSN: 00032700     EISSN: None     Source Type: Journal    
DOI: 10.1021/ac1004579     Document Type: Article

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