Crystal structure of a metal-dependent phosphoesterase (YP_910028.1) from Bifidobacterium adolescentis: Computational prediction and experimental validation of phosphoesterase activity

Proteins: Structure, Function and Bioinformatics

Volumn 79, Issue 7, 2011, Pages 2146-2160

  Han, Gye Won ^a,b   Ko, Jaeju ^c   Farr, Carol L ^a,b   Deller, Marc C ^a,b   Xu, Qingping ^a,d   Chiu, Hsiu Ju ^a,d   Miller, Mitchell D ^a,d   Sefcikova, Jana ^e   Somarowthu, Srinivas ^e   Beuning, Penny J ^e   Elsliger, Marc André ^a,b   Deacon, Ashley M ^a,d   Godzik, Adam ^a,f,g   Lesley, Scott A ^a,b,h   Wilson, Ian A ^a,b   Ondrechen, Mary Jo ^e  

^a Joint Center for Structural Genomics   (United States)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

^c INDIANA UNIVERSITY OF PENNSYLVANIA   (United States)

^d SLAC NATIONAL ACCELERATOR LABORATORY   (United States)

^e NORTHEASTERN UNIVERSITY   (United States)

^f UNIVERSITY OF CALIFORNIA   (United States)

^g BURNHAM INSTITUTE   (United States)

^h GENOMICS INSTITUTE OF THE NOVARTIS RESEARCH FOUNDATION   (United States)

Author keywords

Active site prediction; Functional annotation; Phosphoesterase; Structural genomics; THEMATICS

Indexed keywords

ADENOSINE PHOSPHATE; APOLIPOPROTEIN; DNA DIRECTED DNA POLYMERASE GAMMA; DNA POLYMERASE; HISTIDINOL PHOSPHATASE; METAL; PHOSPHATASE;

ARTICLE; BIFIDOBACTERIUM ADOLESCENTIS; BINDING AFFINITY; BIOINFORMATICS; CRYSTAL STRUCTURE; DNA DEGRADATION; DNA DETERMINATION; DNA REPLICATION; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME SPECIFICITY; MATHEMATICAL ANALYSIS; NONHUMAN; NUCLEOTIDE BINDING SITE; NUCLEOTIDE SEQUENCE; PHYLOGENY; PREDICTION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; SEQUENCE ANALYSIS;

4-NITROPHENYLPHOSPHATASE; ADENOSINE DIPHOSPHATE; AMINO ACID SEQUENCE; BACTERIAL PROTEINS; BIFIDOBACTERIUM; BINDING SITES; CATALYTIC DOMAIN; COMPUTER SIMULATION; CRYSTALLOGRAPHY; DNA POLYMERASE III; ESTERASES; HISTIDINOL-PHOSPHATASE; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PHYLOGENY; REPRODUCIBILITY OF RESULTS; STRUCTURE-ACTIVITY RELATIONSHIP;

BIFIDOBACTERIUM ADOLESCENTIS;

EID: 79958772627     PISSN: 08873585     EISSN: 10970134     Source Type: Journal    
DOI: 10.1002/prot.23035     Document Type: Article

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