FTIR markers of methionine oxidation for early detection of oxidized protein therapeutics

European Biophysics Journal

Volumn 40, Issue 3, 2011, Pages 339-345

  Ravi, Jascindra ^a   Hills, Anna E ^b   Cerasoli, Eleonora ^a   Rakowska, Paulina D ^a   Ryadnov, Maxim G ^a  

^a NATIONAL PHYSICAL LABORATORY   (United Kingdom)

^b LONZA AG   (Switzerland)

Author keywords

Early detection; Fourier transform infrared; IR marker bands; Methionine oxidation; Protein therapeutics (IgG1 and antigen binding fragment)

Indexed keywords

BIOLOGICAL MARKER; DRUG DERIVATIVE; IMMUNOGLOBULIN F(AB) FRAGMENT; IMMUNOGLOBULIN FACB FRAGMENT; IMMUNOGLOBULIN FC FRAGMENT; IMMUNOGLOBULIN G; METHIONINE; METHIONINE SULFOXIDE;

ARTICLE; CHEMISTRY; CIRCULAR DICHROISM; INFRARED SPECTROSCOPY; METHODOLOGY; OXIDATION REDUCTION REACTION; OXIDATIVE STRESS; QUANTITATIVE STRUCTURE ACTIVITY RELATION; SPECTROFLUOROMETRY;

BIOLOGICAL MARKERS; CIRCULAR DICHROISM; IMMUNOGLOBULIN FAB FRAGMENTS; IMMUNOGLOBULIN FC FRAGMENTS; IMMUNOGLOBULIN G; METHIONINE; OXIDATION-REDUCTION; OXIDATIVE STRESS; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; SPECTROMETRY, FLUORESCENCE; SPECTROSCOPY, FOURIER TRANSFORM INFRARED;

EID: 79958746305     PISSN: 01757571     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00249-010-0656-1     Document Type: Article

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