Effect of posttranslational modifications on the thermal stability of a recombinant monoclonal antibody

Immunology Letters

Volumn 106, Issue 2, 2006, Pages 144-153

  Liu, Hongcheng ^a   Bulseco, Georgeen Gaza ^a   Sun, Joanne ^a  

^a ABBOTT LABORATORIES   (United States)

Author keywords

C terminal lysine; Differential scanning calorimetry; N linked oligosaccharides; Recombinant monoclonal antibody

Indexed keywords

IMMUNOGLOBULIN F(AB) FRAGMENT; IMMUNOGLOBULIN FC FRAGMENT; MONOCLONAL ANTIBODY; OLIGOSACCHARIDE; PAPAIN; RECOMBINANT IMMUNOGLOBULIN G 1 MONOCLONAL ANTIBODY; UNCLASSIFIED DRUG;

ANTIBODY STRUCTURE; ARTICLE; CARBOXY TERMINAL SEQUENCE; DIFFERENTIAL SCANNING CALORIMETRY; DISULFIDE BOND; IMMUNOGLOBULIN AGGREGATE; IMMUNOGLOBULIN STRUCTURE; MOLECULAR STABILITY; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FOLDING; PROTEIN GLYCOSYLATION; PROTEIN PROCESSING; PROTEIN STABILITY; STRUCTURE ANALYSIS; THERMOSTABILITY;

ANIMALS; ANTIBODIES, MONOCLONAL; CALORIMETRY, DIFFERENTIAL SCANNING; GLYCOSYLATION; HEAT; HUMANS; IMMUNOGLOBULIN FAB FRAGMENTS; IMMUNOGLOBULIN FC FRAGMENTS; IMMUNOGLOBULIN G; OLIGOSACCHARIDES; PAPAIN; PROTEIN DENATURATION; PROTEIN FOLDING; PROTEIN PROCESSING, POST-TRANSLATIONAL; RECOMBINANT PROTEINS;

EID: 33747099227     PISSN: 01652478     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.imlet.2006.05.011     Document Type: Article

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