메뉴 건너뛰기




Volumn 20, Issue 12, 2009, Pages 965-973

The protective effect of dietary eicosapentaenoic acid against impairment of spatial cognition learning ability in rats infused with amyloid β(1-40)

Author keywords

Alzheimer's disease; Amyloid ; Fatty acid; Hippocampus; Rat; Spatial memory

Indexed keywords

AMYLOID BETA PROTEIN[1-40]; ARACHIDONIC ACID; DOCOSAHEXAENOIC ACID; ICOSAPENTAENOIC ACID; LIPID PEROXIDE; REACTIVE OXYGEN METABOLITE;

EID: 71649091172     PISSN: 09552863     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jnutbio.2008.08.009     Document Type: Article
Times cited : (58)

References (46)
  • 1
    • 0029887644 scopus 로고    scopus 로고
    • Docosahexaenoic acid reduces GABA response in substantia nigra neuron of rat
    • Hamano H., Nabekura J., Nishikawa M., and Ogawa T. Docosahexaenoic acid reduces GABA response in substantia nigra neuron of rat. J Neurophysiology 75 (1996) 1264-1270
    • (1996) J Neurophysiology , vol.75 , pp. 1264-1270
    • Hamano, H.1    Nabekura, J.2    Nishikawa, M.3    Ogawa, T.4
  • 2
    • 0037135111 scopus 로고    scopus 로고
    • The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics
    • Hardy J., and Selkoe D.J. The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. Science 297 (2002) 353-356
    • (2002) Science , vol.297 , pp. 353-356
    • Hardy, J.1    Selkoe, D.J.2
  • 5
    • 0033059809 scopus 로고    scopus 로고
    • Chronic administration of docosahexaenoic acid improves reference memory-related learning ability in young rats
    • Gamoh S., Hashimoto M., Sugioka K., Shahdat Hossain M., Hata N., Misawa Y., et al. Chronic administration of docosahexaenoic acid improves reference memory-related learning ability in young rats. Neuroscience 93 (1999) 237-241
    • (1999) Neuroscience , vol.93 , pp. 237-241
    • Gamoh, S.1    Hashimoto, M.2    Sugioka, K.3    Shahdat Hossain, M.4    Hata, N.5    Misawa, Y.6
  • 6
    • 0035089248 scopus 로고    scopus 로고
    • Chronic administration of docosahexaenoic cid improves the performance of radial arm maze task in aged rats
    • Gamoh S., Hashimoto M., Hossain S., and Masumura S. Chronic administration of docosahexaenoic cid improves the performance of radial arm maze task in aged rats. Clin Exp Pharmacol Physiol 28 (2001) 266-270
    • (2001) Clin Exp Pharmacol Physiol , vol.28 , pp. 266-270
    • Gamoh, S.1    Hashimoto, M.2    Hossain, S.3    Masumura, S.4
  • 7
    • 0036319034 scopus 로고    scopus 로고
    • Docosahexaenoic acid provides protection from impairment of learning ability in Alzheimer's disease model rats
    • Hashimoto M., Hossain S., Shimada T., Sugioka K., Yamasaki H., Fujii Y., et al. Docosahexaenoic acid provides protection from impairment of learning ability in Alzheimer's disease model rats. J Neurochem 81 (2002) 1084-1091
    • (2002) J Neurochem , vol.81 , pp. 1084-1091
    • Hashimoto, M.1    Hossain, S.2    Shimada, T.3    Sugioka, K.4    Yamasaki, H.5    Fujii, Y.6
  • 8
    • 14944376646 scopus 로고    scopus 로고
    • Chronic administration of docosahexaenoic acid ameliorates the impairment of spatial cognition learning ability in amyloid beta-infused rats
    • Hashimoto M., Tanabe Y., Fujii Y., Kikuta T., Shibata H., and Shido O. Chronic administration of docosahexaenoic acid ameliorates the impairment of spatial cognition learning ability in amyloid beta-infused rats. J Nutr 135 (2005) 549-555
    • (2005) J Nutr , vol.135 , pp. 549-555
    • Hashimoto, M.1    Tanabe, Y.2    Fujii, Y.3    Kikuta, T.4    Shibata, H.5    Shido, O.6
  • 9
    • 4444223956 scopus 로고    scopus 로고
    • Docosahexaenoic acid protects from dendritic pathology in an Alzheimer's disease mouse model
    • Calon F., Lim G.P., Yang F., et al. Docosahexaenoic acid protects from dendritic pathology in an Alzheimer's disease mouse model. Neuron 43 (2004) 633-635
    • (2004) Neuron , vol.43 , pp. 633-635
    • Calon, F.1    Lim, G.P.2    Yang, F.3
  • 10
    • 2542505265 scopus 로고    scopus 로고
    • Omega-3 fatty acid ethyl-eicosapentaenoate, but not soybean oil, attenuates memory impairment induced by central IL-1beta administration
    • Song C., and Horrobin D. Omega-3 fatty acid ethyl-eicosapentaenoate, but not soybean oil, attenuates memory impairment induced by central IL-1beta administration. J Lipid Res 45 (2004) 1112-1121
    • (2004) J Lipid Res , vol.45 , pp. 1112-1121
    • Song, C.1    Horrobin, D.2
  • 11
    • 0037022628 scopus 로고    scopus 로고
    • The role of n-3 polyunsaturated fatty acids in brain: modulation of rat brain gene expression by dietary n-3 fatty acids
    • Kitajka K., Puskas L.G., Zvara A., Hackler Jr. L., Barcelo-Coblijn G., Yeo Y.K., et al. The role of n-3 polyunsaturated fatty acids in brain: modulation of rat brain gene expression by dietary n-3 fatty acids. Proc Natl Acad Sci U S A 99 (2002) 2619-2624
    • (2002) Proc Natl Acad Sci U S A , vol.99 , pp. 2619-2624
    • Kitajka, K.1    Puskas, L.G.2    Zvara, A.3    Hackler Jr., L.4    Barcelo-Coblijn, G.5    Yeo, Y.K.6
  • 12
    • 0035183230 scopus 로고    scopus 로고
    • The essentiality of long chain n-3 fatty acids in relation to development and function of the brain and retina
    • Lauritzen L., Hansen H.S., Jorgensen M.H., and Michaelson K.F. The essentiality of long chain n-3 fatty acids in relation to development and function of the brain and retina. Prog Lipid Res 40 (2001) 1-94
    • (2001) Prog Lipid Res , vol.40 , pp. 1-94
    • Lauritzen, L.1    Hansen, H.S.2    Jorgensen, M.H.3    Michaelson, K.F.4
  • 13
    • 0009893930 scopus 로고
    • Studies on the metabolic disposition of ethyl eicosapentaenoate (EPA-E) in rats and dogs
    • Ishiguro J., Tada T., Ogihara T., Murakami K., and Kunihiro Y. Studies on the metabolic disposition of ethyl eicosapentaenoate (EPA-E) in rats and dogs. Drug Metabol Dispos 2 (1987) 683-702
    • (1987) Drug Metabol Dispos , vol.2 , pp. 683-702
    • Ishiguro, J.1    Tada, T.2    Ogihara, T.3    Murakami, K.4    Kunihiro, Y.5
  • 14
    • 0034913963 scopus 로고    scopus 로고
    • Polyunsaturated fatty acid synthesis and release by brain-derived cells in vitro
    • [discussion 215-1]
    • Moore S.A. Polyunsaturated fatty acid synthesis and release by brain-derived cells in vitro. J Mol Neurosci 16 (2001) 195-200 [discussion 215-1]
    • (2001) J Mol Neurosci , vol.16 , pp. 195-200
    • Moore, S.A.1
  • 15
    • 0018384650 scopus 로고
    • Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction
    • Ohkawa H., Ohishi N., and Yagi K. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem 95 (1979) 351-358
    • (1979) Anal Biochem , vol.95 , pp. 351-358
    • Ohkawa, H.1    Ohishi, N.2    Yagi, K.3
  • 17
    • 10544256600 scopus 로고    scopus 로고
    • Expression monitoring by hybridization to high-density oligonucleotide arrays
    • Lockhart D.J., Dong H., Byrne M.C., et al. Expression monitoring by hybridization to high-density oligonucleotide arrays. Nat Biotechnol 14 (1996) 1675-1680
    • (1996) Nat Biotechnol , vol.14 , pp. 1675-1680
    • Lockhart, D.J.1    Dong, H.2    Byrne, M.C.3
  • 18
    • 0031905606 scopus 로고    scopus 로고
    • Antihypertensive effect of all-cis-5,8,11,14,17-icosapentaenoate of aged rats is associated with an increase in the release of ATP from the caudal artery
    • Hashimoto M., Shinozuka K., Hossain M.S., Kwon Y.M., Tanabe Y., Kunitomo M., et al. Antihypertensive effect of all-cis-5,8,11,14,17-icosapentaenoate of aged rats is associated with an increase in the release of ATP from the caudal artery. J Vasc Res 35 (1998) 55-62
    • (1998) J Vasc Res , vol.35 , pp. 55-62
    • Hashimoto, M.1    Shinozuka, K.2    Hossain, M.S.3    Kwon, Y.M.4    Tanabe, Y.5    Kunitomo, M.6
  • 19
    • 0032947014 scopus 로고    scopus 로고
    • The hypotensive effect of docosahexaenoic acid is associated with the enhanced release of ATP from the caudal artery of aged rats
    • Hashimoto M., Shinozuka K., Gamoh S., et al. The hypotensive effect of docosahexaenoic acid is associated with the enhanced release of ATP from the caudal artery of aged rats. J Nutr 129 (1999) 70-76
    • (1999) J Nutr , vol.129 , pp. 70-76
    • Hashimoto, M.1    Shinozuka, K.2    Gamoh, S.3
  • 20
    • 0034913114 scopus 로고    scopus 로고
    • Plasma free fatty acid and lipoproteins as sources of polyunsaturated fatty acid for the brain
    • [discussion 215-1]
    • Spector A.A. Plasma free fatty acid and lipoproteins as sources of polyunsaturated fatty acid for the brain. J Mol Neurosci 16 (2001) 159-165 [discussion 215-1]
    • (2001) J Mol Neurosci , vol.16 , pp. 159-165
    • Spector, A.A.1
  • 21
    • 0000208605 scopus 로고
    • Omega-3 fatty acids: molecular and biochemical aspects
    • Spiller G.A., and Scala J. (Eds), Alan R. Liss, New York
    • Salem Jr. N. Omega-3 fatty acids: molecular and biochemical aspects. In: Spiller G.A., and Scala J. (Eds). New protective roles for selected nutrients (1989), Alan R. Liss, New York 109-228
    • (1989) New protective roles for selected nutrients , pp. 109-228
    • Salem Jr., N.1
  • 22
    • 0034920086 scopus 로고    scopus 로고
    • Alterations in brain function after loss of docosahexaenoate due to dietary restriction of n-3 fatty acids
    • Salem Jr. N., Moriguchi T., Greiner R.S., McBride K., Ahmad A., Catalan J.N., et al. Alterations in brain function after loss of docosahexaenoate due to dietary restriction of n-3 fatty acids. J Mol Neurosci 16 (2001) 299-307
    • (2001) J Mol Neurosci , vol.16 , pp. 299-307
    • Salem Jr., N.1    Moriguchi, T.2    Greiner, R.S.3    McBride, K.4    Ahmad, A.5    Catalan, J.N.6
  • 23
    • 0037098866 scopus 로고    scopus 로고
    • Antioxidant neuroprotection in Alzheimer's disease as preventive and therapeutic approach
    • Behl C., and Moosmann B. Antioxidant neuroprotection in Alzheimer's disease as preventive and therapeutic approach. Free Radic Biol Med 33 (2002) 182-191
    • (2002) Free Radic Biol Med , vol.33 , pp. 182-191
    • Behl, C.1    Moosmann, B.2
  • 24
    • 0033009199 scopus 로고    scopus 로고
    • Antioxidative effects of docosahexaenoic acid in the cerebrum versus cerebellum and brainstem of aged hypercholesterolemic rats
    • Hossain M.S., Hashimoto M., Gamoh S., and Masumura S. Antioxidative effects of docosahexaenoic acid in the cerebrum versus cerebellum and brainstem of aged hypercholesterolemic rats. Neurochem 72 (1999) 1133-1138
    • (1999) Neurochem , vol.72 , pp. 1133-1138
    • Hossain, M.S.1    Hashimoto, M.2    Gamoh, S.3    Masumura, S.4
  • 25
    • 31044440027 scopus 로고    scopus 로고
    • Docosahexaenoic acid-induced amelioration on impairment of memory learning in amyloid beta-infused rats relates to the decreases of amyloid beta and cholesterol levels in detergent-insoluble membrane fractions
    • Hashimoto M., Hossain S., Agdul H., and Shido O. Docosahexaenoic acid-induced amelioration on impairment of memory learning in amyloid beta-infused rats relates to the decreases of amyloid beta and cholesterol levels in detergent-insoluble membrane fractions. Biochim Biophys Acta 1738 (2005) 91-98
    • (2005) Biochim Biophys Acta , vol.1738 , pp. 91-98
    • Hashimoto, M.1    Hossain, S.2    Agdul, H.3    Shido, O.4
  • 26
    • 0035150309 scopus 로고    scopus 로고
    • Changes in maze behavior of mice occur after sufficient accumulation of docosahexaenoic acid in brain
    • Lim S., and Suzuki H. Changes in maze behavior of mice occur after sufficient accumulation of docosahexaenoic acid in brain. J Nutr 131 (2001) 319-324
    • (2001) J Nutr , vol.131 , pp. 319-324
    • Lim, S.1    Suzuki, H.2
  • 27
    • 9144266990 scopus 로고    scopus 로고
    • Improvement of spatial cognition with dietary docosahexaenoic acid is associated with an increase in Fos expression in rat CA1 hippocampus
    • Tanabe Y., Hashimoto M., Sugioka K., Maruyama M., Fujii Y., Hagiwara R., et al. Improvement of spatial cognition with dietary docosahexaenoic acid is associated with an increase in Fos expression in rat CA1 hippocampus. Clin Exp Pharmacol Physiol l31 (2004) 700-703
    • (2004) Clin Exp Pharmacol Physiol , vol.l31 , pp. 700-703
    • Tanabe, Y.1    Hashimoto, M.2    Sugioka, K.3    Maruyama, M.4    Fujii, Y.5    Hagiwara, R.6
  • 28
    • 0035200179 scopus 로고    scopus 로고
    • GABA(B) receptor activation enhances mGluR-mediated responses at cerebellar excitatory synapses
    • Hirono M., Yoshioka T., and Konishi S. GABA(B) receptor activation enhances mGluR-mediated responses at cerebellar excitatory synapses. Neuroscience 12 (2001) 1207-1216
    • (2001) Neuroscience , vol.12 , pp. 1207-1216
    • Hirono, M.1    Yoshioka, T.2    Konishi, S.3
  • 29
    • 0035919189 scopus 로고    scopus 로고
    • Suppression of transmitter release by Tat HPC-1/syntaxin 1A fusion protein
    • Fujiwara T., Yamamori T., and Akagawa K. Suppression of transmitter release by Tat HPC-1/syntaxin 1A fusion protein. Biochim Biophys Acta 1539 (2001) 225-232
    • (2001) Biochim Biophys Acta , vol.1539 , pp. 225-232
    • Fujiwara, T.1    Yamamori, T.2    Akagawa, K.3
  • 30
    • 0037335481 scopus 로고    scopus 로고
    • A regulated interaction of syntaxin 1A with the antidepressant-sensitive norepinephrine transporter establishes catecholamine clearance capacity
    • Sung U., Apparsundaram S., Galli A., Kahlig K.M., Savchenko V., Schroeter S., et al. A regulated interaction of syntaxin 1A with the antidepressant-sensitive norepinephrine transporter establishes catecholamine clearance capacity. J Neurosci 23 (2003) 1697-1699
    • (2003) J Neurosci , vol.23 , pp. 1697-1699
    • Sung, U.1    Apparsundaram, S.2    Galli, A.3    Kahlig, K.M.4    Savchenko, V.5    Schroeter, S.6
  • 31
    • 0023024774 scopus 로고
    • Isolation of six cysteine proteinase inhibitors from human urine
    • Abrahamson M., Barrett A.J., Salvesen G., and Grubb A. Isolation of six cysteine proteinase inhibitors from human urine. J Biol Chem 261 (1986) 11282-11289
    • (1986) J Biol Chem , vol.261 , pp. 11282-11289
    • Abrahamson, M.1    Barrett, A.J.2    Salvesen, G.3    Grubb, A.4
  • 32
    • 0030836345 scopus 로고    scopus 로고
    • Increased neuronal endocytosis and protease delivery to early endosomes in sporadic Alzheimer's disease: neuropathologic evidence for a mechanism of increased β-amyloidogenesis
    • Cataldo A.M., Barnett J.L., Pieroni C., and Nixon R.A. Increased neuronal endocytosis and protease delivery to early endosomes in sporadic Alzheimer's disease: neuropathologic evidence for a mechanism of increased β-amyloidogenesis. J Neurosci 17 (1997) 6142-6151
    • (1997) J Neurosci , vol.17 , pp. 6142-6151
    • Cataldo, A.M.1    Barnett, J.L.2    Pieroni, C.3    Nixon, R.A.4
  • 33
    • 0033635021 scopus 로고    scopus 로고
    • FGF-2-responsive neural stem cell proliferation requires CCg, a novel autocrine/paracrine cofactor
    • Taupin P., Ray J., Fischer V.M., Suhr S.T., Hakansson K., Grubb A., et al. FGF-2-responsive neural stem cell proliferation requires CCg, a novel autocrine/paracrine cofactor. Neuron 28 (2000) 385-387
    • (2000) Neuron , vol.28 , pp. 385-387
    • Taupin, P.1    Ray, J.2    Fischer, V.M.3    Suhr, S.T.4    Hakansson, K.5    Grubb, A.6
  • 34
    • 33646138943 scopus 로고    scopus 로고
    • Docosahexaenoic acid promotes neurogenesis in vitro and in vivo
    • Kawakita E., Hashimoto M., and Shido O. Docosahexaenoic acid promotes neurogenesis in vitro and in vivo. Neuroscience 139 (2006) 991-997
    • (2006) Neuroscience , vol.139 , pp. 991-997
    • Kawakita, E.1    Hashimoto, M.2    Shido, O.3
  • 35
    • 0030840865 scopus 로고    scopus 로고
    • Phospholipase D stimulates release of nascent secretory vesicles from the trans-Golgi network
    • Chen Y.G., Siddhanta A., Austin C.D., Hammond S.M., Sung T.C., Frohman M.A., et al. Phospholipase D stimulates release of nascent secretory vesicles from the trans-Golgi network. Cell Biol 138 (1997) 495-504
    • (1997) Cell Biol , vol.138 , pp. 495-504
    • Chen, Y.G.1    Siddhanta, A.2    Austin, C.D.3    Hammond, S.M.4    Sung, T.C.5    Frohman, M.A.6
  • 37
    • 32444439640 scopus 로고    scopus 로고
    • Phospholipase D1 corrects impaired beta APP trafficking and neurite outgrowth in familial Alzheimer's disease-linked presenilin-1 mutant neurons
    • Cai D., Zhong M., Wang R., Netzer W.J., Shields D., Zheng H., et al. Phospholipase D1 corrects impaired beta APP trafficking and neurite outgrowth in familial Alzheimer's disease-linked presenilin-1 mutant neurons. Proc Natl Acad Sci U S A 103 (2006) 1936-1940
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 1936-1940
    • Cai, D.1    Zhong, M.2    Wang, R.3    Netzer, W.J.4    Shields, D.5    Zheng, H.6
  • 38
    • 0034772572 scopus 로고    scopus 로고
    • VCP/p97 in abnormal protein aggregates, cytoplasmic vacuoles, and cell death, phenotypes relevant to neurodegeneration
    • Hirabayashi M., Inoue K., Tanaka K., Nakadate K., Ohsawa Y., Kamei Y., et al. VCP/p97 in abnormal protein aggregates, cytoplasmic vacuoles, and cell death, phenotypes relevant to neurodegeneration. Cell Death Differ 8 (2001) 977-984
    • (2001) Cell Death Differ , vol.8 , pp. 977-984
    • Hirabayashi, M.1    Inoue, K.2    Tanaka, K.3    Nakadate, K.4    Ohsawa, Y.5    Kamei, Y.6
  • 39
    • 1642465431 scopus 로고    scopus 로고
    • Synaptic plasma membrane-bound acetylcholinesterase activity is not affected by docosahexaenoic acid-induced decrease in membrane order
    • Shahdat H., Hashimoto M., Shimada T., and Shido O. Synaptic plasma membrane-bound acetylcholinesterase activity is not affected by docosahexaenoic acid-induced decrease in membrane order. Life Sci 74 (2004) 3009-3024
    • (2004) Life Sci , vol.74 , pp. 3009-3024
    • Shahdat, H.1    Hashimoto, M.2    Shimada, T.3    Shido, O.4
  • 40
    • 33748907870 scopus 로고    scopus 로고
    • Docosahexaenoic acid-induced protective effect against impaired learning in amyloid beta-infused rats is associated with increased synaptosomal membrane fluidity
    • Hashimoto M., Hossain S., Shimada T., and Shido O. Docosahexaenoic acid-induced protective effect against impaired learning in amyloid beta-infused rats is associated with increased synaptosomal membrane fluidity. Clin Exp Pharmacol Physiol 33 (2006) 934-939
    • (2006) Clin Exp Pharmacol Physiol , vol.33 , pp. 934-939
    • Hashimoto, M.1    Hossain, S.2    Shimada, T.3    Shido, O.4
  • 41
    • 0033396981 scopus 로고    scopus 로고
    • Plasma membrane ordering agent pluronic F-68 (PF-68) reduces neurotransmitter uptake and release and produces learning and memory deficits in rats
    • Clarke M.S., Prendergast M.A., and Terry Jr. A.V. Plasma membrane ordering agent pluronic F-68 (PF-68) reduces neurotransmitter uptake and release and produces learning and memory deficits in rats. Learn Mem 6 (1999) 634-639
    • (1999) Learn Mem , vol.6 , pp. 634-639
    • Clarke, M.S.1    Prendergast, M.A.2    Terry Jr., A.V.3
  • 42
    • 0031407013 scopus 로고    scopus 로고
    • Dietary docosahexaenoic acid increases cerebral acetylcholine levels and improves passive avoidance performance in stroke-prone spontaneously hypertensive rats
    • Minami M., Kimura S., Endo T., Hamaue N., Hirafuji M., Togashi H., et al. Dietary docosahexaenoic acid increases cerebral acetylcholine levels and improves passive avoidance performance in stroke-prone spontaneously hypertensive rats. Pharmacol Biochem Behavior 58 (1997) 1123-1129
    • (1997) Pharmacol Biochem Behavior , vol.58 , pp. 1123-1129
    • Minami, M.1    Kimura, S.2    Endo, T.3    Hamaue, N.4    Hirafuji, M.5    Togashi, H.6
  • 43
    • 0037452724 scopus 로고    scopus 로고
    • Short-term administration of omega 3 fatty acids from fish oil results in increased transthyretin transcription in old rat hippocampus
    • Puskàs L.G., Kitajka K., Nyakas C., Barcelo-Coblijn G., and Farkas T. Short-term administration of omega 3 fatty acids from fish oil results in increased transthyretin transcription in old rat hippocampus. Proc Natl Acad Sci U S A 100 (2003) 1580-1585
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 1580-1585
    • Puskàs, L.G.1    Kitajka, K.2    Nyakas, C.3    Barcelo-Coblijn, G.4    Farkas, T.5
  • 44
    • 16244416174 scopus 로고    scopus 로고
    • A diet enriched with the omega-3 fatty acid docosahexaenoic acid reduces amyloid burden in an aged Alzheimer mouse model
    • Lim G.P., Calon F., Morihara T., Yang F., Teter B., Ubeda O., et al. A diet enriched with the omega-3 fatty acid docosahexaenoic acid reduces amyloid burden in an aged Alzheimer mouse model. J Neurosci 25 (2005) 3032-3040
    • (2005) J Neurosci , vol.25 , pp. 3032-3040
    • Lim, G.P.1    Calon, F.2    Morihara, T.3    Yang, F.4    Teter, B.5    Ubeda, O.6
  • 46
    • 1442274909 scopus 로고    scopus 로고
    • Integrin activation. A link between β-amyloid deposition and neuronal death in aging hippocampal neurons
    • Anderson K.L., and Ferreira A. Integrin activation. A link between β-amyloid deposition and neuronal death in aging hippocampal neurons. J Neurosci Res 75 (2004) 688-697
    • (2004) J Neurosci Res , vol.75 , pp. 688-697
    • Anderson, K.L.1    Ferreira, A.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.