The WD protein Rack1 mediates protein kinase C and integrin-dependent cell migration

Journal of Cell Science

Volumn 114, Issue 9, 2001, Pages 1691-1698

  Buensuceso, Charito S ^a   Woodside, Darren ^a   Huff, Janice L ^b   Plopper, George E ^b   O'Toole, Timothy E ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b UNIVERSITY OF NEVADA   (United States)

Author keywords

Integrin; Migration; Protein kinase C; Rack1

Indexed keywords

ALANINE; CYTOPLASM PROTEIN; INTEGRIN; PROTEIN KINASE C; PROTEIN TYROSINE KINASE;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; BINDING SITE; CELL MIGRATION; CELL MOTILITY; CHO CELL; CONTROLLED STUDY; CYTOPLASM; CYTOSKELETON; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; ENZYME STABILITY; ENZYME SUBSTRATE; FIBER; GENETIC TRANSFECTION; LIGAND BINDING; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FAMILY; PROTEIN LOCALIZATION; PROTEIN STABILITY; SIGNAL TRANSDUCTION; STRESS;

ANIMALS; CELL MOVEMENT; CHO CELLS; CRICETINAE; CYTOSKELETON; INTEGRINS; PEPTIDES; PROTEIN BINDING; PROTEIN KINASE C; SIGNAL TRANSDUCTION; SRC-FAMILY KINASES;

ANIMALIA; CRICETINAE; CRICETULUS GRISEUS;

EID: 0034996167     PISSN: 00219533     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (22)

1. Battaini, F., Pascale, A., Paoletti, R. and Govoni, S. (1997). The role of anchoring protein Rack 1 in PKC activation in the aging rat brain. Trends Neurosd. 20, 410-415.
2. Gary, L. A., Chang, J. F. and Guan, J. (1996). Stimulation of cell migration by overexpression of focal adhesion kinase and its association with src and fyn. J. Cell Sci. 109, 1787-1794.
3. Chang, B. Y., Conroy, K. B., Machleder, E. M. and Cartwright, C. A. (1998). Rack1, a receptor for activated C kinase and a homolog of the β subunit of G proteins, inhibits activity of src tyrosine kinases and growth of NIH3T3 cells. Mol. Cell. Biol. 18, 3245-3256.
4. Chen, P., Xie, H., Sekar, M., Gupta, K. and Wells, A. (1994). Epidermal growth factor receptor-mediated cell motility: phospholipase C activity is required but mitogen-activated protein kinase is not sufficient for induced cell movement. J. Cell Biol. 127, 847-857.
5. Csukai, M., Chen, C.-H., DeMatteis, M. A. and Mochly-Rosen, D. (1997). The coatomer protein β′-COP, a selective binding protein (Rack) for protein kinase Cε. J. Biol. Chem. 272, 29200-29206.
6. Derman, M. P., Toker, A. J., Hartwig, H., Spokes, K., Falck, J. R, Chen, C. S., Cantley, L. C. and Cantley, L. G. (1997). The lipid products of phosphoinositide 3-kinase increase cell motility through protein kinase C. J. Biol. Chem. 272, 6465-6470.
7. Fincham, V. J. and Frame, M. C. (1998). The catalytic activity of Src is dispensible for translocation to focal adhesions but controls the turnover of these structures during cell motility. EMBO J. 17, 81-92.
8. Garcia-Higuera, I., Gaitatzes, C., Smith, T. F. and Neer, E. J. (1998). Folding a WD repeat propeller. J. Biol. Chem. 273, 9041-9049.
9. Geijsen, N., Spaargaren, M., Raaijmakers, J. A. M., Lammers, J.-W. J., Koenderman, L. and Coffer, P. J. (1999). Association of Rack1 and PKCβ with the common β-chain of the IL-5/IL-3/GM-CSF receptor. Oncogene 18, 5126-5130.
10. Gilmore, A. P. and Romer, L. H. (1996). Inhibition of focal adhesion kinase (FAK) signaling in focal adhesions decreases cell motility and proliferation. Mol. Biol. Cell. 7, 1209-1224.
11. Haller, H., Lindschau, C., Maasch, C., Olthoff, H., Kurscheid, D. and Luft, F. C. (1998). Integrin-induced protein kinase Cα and Cε translocation to focal adhesions mediates vascular smooth muscle cell spreading. Circ. Res. 82, 157-165.
12. Huttenlocher, A., Ginsberg, M. H. and Horwitz, A. F. (1996). Modulation of cell migration by integrin-mediated cytoskeletal linkages and ligand-binding affinity. J. Cell Biol. 134, 1551-1562.
13. Huttenlocher, A., Palecek, S. P., Lu, Q., Zhang, W., Mellgren, R. L., Lauffenburger, D. A., Ginsberg, M. H. and Horwitz, A. F. (1997). Regulation of cell migration by the calcium-dependent protease calpain. J. Biol. Chem. 272, 32719-32722.
14. Ilic, D., Furuat, Y., Kanazawa, S., Takeda, N., Sobue, K., Nakatsuji, N., Nomura, J., Fujimoto, J., Okada, M., Yamamoto, T. and Aizawa, S. (1995). Reduced cell motility and enhanced focal adhesion contact formation in cells from FAK-deficient mice. Nature 377, 539-544.
15. Klemke, R. L., Cai, S., Giannini, A. L., Gallagher, P. J., deLanerolle, P. and Cheresh, D. A. (1997). Regulation of cell motility by mitogen-activated protein kinase. J. Cell Biol. 137, 481-492.
16. Klemke, R. L., Leng, J., Molander, R., Brooks, P. C., Vuori, K. and Cheresh, D. A. (1998). Cas/crk coupling serves as a 'molecular switch' for induction of cell migration. J. Cell Biol. 140, 961-972.
17. 5-dependent cytoskeletal associations and focal adhesion kinase phosphorylation. J. Cell Biol. 134, 1323-1332.
18. Liliental, J. and Chang, D. D. (1998). Rack1, a receptor for activated protein kinase C, interacts with integrin β subunit. J. Biol. Chem. 273, 2379-2383.
19. Miranti, C. K., Ohno, S. and Brugge, J. S. (1999). Protein kinase C1 regulates integrin-induced activation of the extracellular regulated kinase pathway upstream of she. J. Biol. Chem. 274, 10571-10581.
20. Mochly-Rosen, D. and Gordon, A. S. (1998). Anchoring proteins for protein kinase C: a means for isozyme selectivity. FASEB J. 12, 35-42.
21. IIb cytoplasmic domain. J. Biol. Chem. 272, 4651-4656.
22. Neer, E. J., Schmidt, C. J., Nambudripad, R. and Smith, T. F. (1994). The ancient regulatory-protein family of WD-repeat proteins. Nature 371, 297-300.