메뉴 건너뛰기




Volumn 73, Issue 3, 1996, Pages 307-315

Regulation of P-glycoprotein 1 and 2 gene expression and protein activity in two MCF-7/Dox cell line subclones

Author keywords

Flow cytometry; Gene expression; MCF 7; Multidrug resistance; Protein kinase C

Indexed keywords

DOXORUBICIN; GLYCOPROTEIN P;

EID: 0030039548     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: 10.1038/bjc.1996.54     Document Type: Article
Times cited : (36)

References (46)
  • 1
    • 0027256373 scopus 로고
    • Expression of the antisense cDNA for protein kinase C alpha attenuates resistance in doxorubicin-resistant MCF-7 breast carcinoma cells
    • AHMAD S AND GLAZER RI. (1993). Expression of the antisense cDNA for protein kinase C alpha attenuates resistance in doxorubicin-resistant MCF-7 breast carcinoma cells. Mol. Pharmacol., 43, 858-862.
    • (1993) Mol. Pharmacol. , vol.43 , pp. 858-862
    • Ahmad, S.1    Glazer, R.I.2
  • 2
    • 0028107948 scopus 로고
    • Modulation of P-glycoprotein by protein kinase C alpha in a baculovirus expression system
    • AHMAD S, SAFA AR AND GLAZER RI. (1994). Modulation of P-glycoprotein by protein kinase C alpha in a baculovirus expression system. Biochemistry, 33, 10313-10318.
    • (1994) Biochemistry , vol.33 , pp. 10313-10318
    • Ahmad, S.1    Safa, A.R.2    Glazer, R.I.3
  • 3
    • 0027853682 scopus 로고
    • Differential modulation of P-glycoprotein transport by protein kinase C inhibition
    • BATES SE, LEE JS, DICKSTEIN B, SPOLYAR M AND FOJO AT. (1993). Differential modulation of P-glycoprotein transport by protein kinase C inhibition. Biochemistry, 32, 9156-9164.
    • (1993) Biochemistry , vol.32 , pp. 9156-9164
    • Bates, S.E.1    Lee, J.S.2    Dickstein, B.3    Spolyar, M.4    Fojo, A.T.5
  • 4
    • 0023037085 scopus 로고
    • Overexpression of a novel anionic glutathione transferase in multidrug-resistant human breast cancer cells
    • BATIST G, TULPULE A, SINHA BK, KATKI AG, MYERS C AND COWAN KH. (1986). Overexpression of a novel anionic glutathione transferase in multidrug-resistant human breast cancer cells. J. Biol. Chem., 261, 15544-15549.
    • (1986) J. Biol. Chem. , vol.261 , pp. 15544-15549
    • Batist, G.1    Tulpule, A.2    Sinha, B.K.3    Katki, A.G.4    Myers, C.5    Cowan, K.H.6
  • 5
    • 0018770071 scopus 로고
    • Altered surface membrane glycoproteins in vinca alkaloid-resistant human leukaemic lymphoblasts
    • BECK W, MUELLER TJ AND TANZER LR. (1979). Altered surface membrane glycoproteins in vinca alkaloid-resistant human leukaemic lymphoblasts. Cancer Res., 39, 2070-2076.
    • (1979) Cancer Res. , vol.39 , pp. 2070-2076
    • Beck, W.1    Mueller, T.J.2    Tanzer, L.R.3
  • 6
    • 0017184389 scopus 로고
    • A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein dye binding
    • BRADFORD MM. (1976). A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein dye binding. Anal. Biochem., 72, 248-254.
    • (1976) Anal. Biochem. , vol.72 , pp. 248-254
    • Bradford, M.M.1
  • 8
    • 0025318529 scopus 로고
    • Protein kinase C phosphorylates P-glycoprotein in multidrug resistant human KB carcinoma cells
    • CHAMBERS TC, McAVOY EM, JACOBS JW AND EILON G. (1990). Protein kinase C phosphorylates P-glycoprotein in multidrug resistant human KB carcinoma cells. J. Biol. Chem., 265, 7679-7686.
    • (1990) J. Biol. Chem. , vol.265 , pp. 7679-7686
    • Chambers, T.C.1    Mcavoy, E.M.2    Jacobs, J.W.3    Eilon, G.4
  • 9
    • 0027076780 scopus 로고
    • Regulation by phorbol ester and protein kinase C inhibitors and by a protein phosphatase inhibitor (okadaic acid), of P-glycoprotein phosphorylation and relationship to drug accumulation in multidrug-resistant human KB cells
    • CHAMBERS TC, ZHENG B AND KUO JF. (1992). Regulation by phorbol ester and protein kinase C inhibitors and by a protein phosphatase inhibitor (okadaic acid), of P-glycoprotein phosphorylation and relationship to drug accumulation in multidrug-resistant human KB cells. Mol. Pharmacol., 41, 1008-1015.
    • (1992) Mol. Pharmacol. , vol.41 , pp. 1008-1015
    • Chambers, T.C.1    Zheng, B.2    Kuo, J.F.3
  • 10
    • 0024249048 scopus 로고
    • A sensitive method for immunocytochemical detection of P-glycoprotein in multidrug resistant human ovarian carcinoma cell lines
    • CHAN HSL, BRADLEY G, THORNER P, HADDAD G, GALLIE BL AND LING V. (1988). A sensitive method for immunocytochemical detection of P-glycoprotein in multidrug resistant human ovarian carcinoma cell lines. Methods Lab. Invest., 59, 870-875.
    • (1988) Methods Lab. Invest. , vol.59 , pp. 870-875
    • Chan, H.S.L.1    Bradley, G.2    Thorner, P.3    Haddad, G.4    Gallie, B.L.5    Ling, V.6
  • 11
    • 0027005480 scopus 로고
    • Activation of MDR1 (P-glycoprotein) gene expression in human cells by protein kinase C agonists
    • CHAUDHARY PM AND RONINSON IB. (1992). Activation of MDR1 (P-glycoprotein) gene expression in human cells by protein kinase C agonists. Oncology Research, 4, 281-290.
    • (1992) Oncology Research , vol.4 , pp. 281-290
    • Chaudhary, P.M.1    Roninson, I.B.2
  • 12
    • 0024414605 scopus 로고
    • Structure and expression of the human MDR (P-glycoprotein) gene family
    • CHIN JE, SOFFIR R, NOONAN KE, CHOI K AND RONINSON IB. (1989). Structure and expression of the human MDR (P-glycoprotein) gene family. Mol. Cell. Biol., 9, 3808-3820.
    • (1989) Mol. Cell. Biol. , vol.9 , pp. 3808-3820
    • Chin, J.E.1    Soffir, R.2    Noonan, K.E.3    Choi, K.4    Roninson, I.B.5
  • 13
    • 0025861828 scopus 로고
    • Multidrug resistance after retroviral transfer of the human MDR1 gene correlates with P-glycoprotein density in the plasma membrane and is not affected by cytotoxic selection
    • CHOI K, FROMMEL THO, STERN RK, PEREZ CF, KRIEGLER M, TSURUO T AND RONINSON IB. (1991). Multidrug resistance after retroviral transfer of the human MDR1 gene correlates with P-glycoprotein density in the plasma membrane and is not affected by cytotoxic selection. Proc. Natl Acad. Sci. USA. 88, 7386-7390.
    • (1991) Proc. Natl Acad. Sci. USA , vol.88 , pp. 7386-7390
    • Choi, K.1    Frommel, T.H.O.2    Stern, R.K.3    Perez, C.F.4    Kriegler, M.5    Tsuruo, T.6    Roninson, I.B.7
  • 14
    • 0038134267 scopus 로고
    • Similar biochemical changes associated with multidrug resistance in human breast cancer cells and carcinogen-induced resistance to xenobiotics in rats
    • COWAN KH, BATIST G, TUPULE A, SINHA BK AND MYERS CE. (1986). Similar biochemical changes associated with multidrug resistance in human breast cancer cells and carcinogen-induced resistance to xenobiotics in rats. Proc. Natl Acad. Sci. USA, 83, 9328-9332.
    • (1986) Proc. Natl Acad. Sci. USA , vol.83 , pp. 9328-9332
    • Cowan, K.H.1    Batist, G.2    Tupule, A.3    Sinha, B.K.4    Myers, C.E.5
  • 15
    • 0026473238 scopus 로고
    • Identification of residues in the first cytoplasmic loop of P-glycoprotein involved in the function of chimeric human MDR1-MDR2 transporters
    • CURRIER SJ, KANE SE, WILLINGHAM MC, CARDARELLI CO, PASTAN I AND GOTTESMAN MM. (1992). Identification of residues in the first cytoplasmic loop of P-glycoprotein involved in the function of chimeric human MDR1-MDR2 transporters. J. Biol. Chem., 267, 25153-25159.
    • (1992) J. Biol. Chem. , vol.267 , pp. 25153-25159
    • Currier, S.J.1    Kane, S.E.2    Willingham, M.C.3    Cardarelli, C.O.4    Pastan, I.5    Gottesman, M.M.6
  • 16
    • 0027742810 scopus 로고
    • Clinical relevance of the MDR-I gene and its gene product, P-glycoprotein, for cancer chemotherapy: A meta analysis
    • EFFERTH T AND OSIEKA R. (1993). Clinical relevance of the MDR-I gene and its gene product, P-glycoprotein, for cancer chemotherapy: A meta analysis. Tumor Diagnostik und Therapie, 14, 238-243.
    • (1993) Tumor Diagnostik und Therapie , vol.14 , pp. 238-243
    • Efferth, T.1    Osieka, R.2
  • 17
    • 0024329881 scopus 로고
    • The biochemistry of P-glycoprotein mediated multidrug resistance
    • ENDICOTT JA AND LING V. (1989). The biochemistry of P-glycoprotein mediated multidrug resistance. Ann. Rev. Biochem., 58, 137-171.
    • (1989) Ann. Rev. Biochem. , vol.58 , pp. 137-171
    • Endicott, J.A.1    Ling, V.2
  • 19
    • 1842387251 scopus 로고
    • Phorbol esters induce multidrug resistance in human breast cancer cells
    • FINE RL, PATEL J AND CHABNER BA. (1988). Phorbol esters induce multidrug resistance in human breast cancer cells. Proc. Natl Acad. Sci. USA, 85, 582-586.
    • (1988) Proc. Natl Acad. Sci. USA , vol.85 , pp. 582-586
    • Fine, R.L.1    Patel, J.2    Chabner, B.A.3
  • 20
    • 0022423216 scopus 로고
    • Various rat tissues express only one major mRNA species from the glyceraldehyde-3-phosphate-dehydrogenase multigenic family
    • FORT P, MARTY L, PIECHAEZYL M, SABROUTY SE, DANI C, JEANTEUR P AND BLANCHARD JM. (1985). Various rat tissues express only one major mRNA species from the glyceraldehyde-3-phosphate-dehydrogenase multigenic family. Nucleic Acids Res., 13, 1431-1443.
    • (1985) Nucleic Acids Res. , vol.13 , pp. 1431-1443
    • Fort, P.1    Marty, L.2    Piechaezyl, M.3    Sabrouty, S.E.4    Dani, C.5    Jeanteur, P.6    Blanchard, J.M.7
  • 21
    • 0027240368 scopus 로고
    • Quantitative polymerase chain reaction analysis of mdr1 mRNA in multiple myeloma cell lines and clinical specimens
    • FUTSCHER BW, BLAKE LL, GERLACH JH, GROGAN TIM AND DALTON WS. (1993). Quantitative polymerase chain reaction analysis of mdr1 mRNA in multiple myeloma cell lines and clinical specimens. Anal. Biochem., 213, 414-421.
    • (1993) Anal. Biochem. , vol.213 , pp. 414-421
    • Futscher, B.W.1    Blake, L.L.2    Gerlach, J.H.3    Grogan, T.I.M.4    Dalton, W.S.5
  • 22
    • 0026327875 scopus 로고
    • Regulation of 2-acetylamino-fluorene-and 3-methylcholanthrene-mediated induction of multidrug resistance and cytochrome P450IA gene family expression in primary hepatocyte cultures and rat liver
    • GANT TW, SILVERMAN JA, BISGAARD HC, BURT RK, MARINO PA AND THORGEIRSSON SS. (1991). Regulation of 2-acetylamino-fluorene-and 3-methylcholanthrene-mediated induction of multidrug resistance and cytochrome P450IA gene family expression in primary hepatocyte cultures and rat liver. Mol. Carcinog., 4, 499-509.
    • (1991) Mol. Carcinog. , vol.4 , pp. 499-509
    • Gant, T.W.1    Silverman, J.A.2    Bisgaard, H.C.3    Burt, R.K.4    Marino, P.A.5    Thorgeirsson, S.S.6
  • 23
    • 0026764538 scopus 로고
    • Regulation of P-glycoprotein expression in hepatocyte cultures and liver cell lines by a trans-acting transcriptional repressor
    • GANT TW, SILVERMAN JA AND THORGEIRSSON SS. (1992). Regulation of P-glycoprotein expression in hepatocyte cultures and liver cell lines by a trans-acting transcriptional repressor. Nucleic Acids Res., 20, 2841-2846.
    • (1992) Nucleic Acids Res. , vol.20 , pp. 2841-2846
    • Gant, T.W.1    Silverman, J.A.2    Thorgeirsson, S.S.3
  • 24
    • 0026563893 scopus 로고
    • The protein kinase C related PKC-L (Eta) gene product is localized to cell nucleus
    • GREIF H, BEN-CHAIM J, SHIMON T, BECHOR E, ELDAR H AND LIVNEH E. (1992). The protein kinase C related PKC-L (Eta) gene product is localized to cell nucleus. Mol. Cell. Biol., 12, 1304-1311.
    • (1992) Mol. Cell. Biol. , vol.12 , pp. 1304-1311
    • Greif, H.1    Ben-Chaim, J.2    Shimon, T.3    Bechor, E.4    Eldar, H.5    Livneh, E.6
  • 25
    • 0020578356 scopus 로고
    • Cell surface P-glycoprotein associated with multidrug resistance in mammalian cell lines
    • KARTNER N, RIORDAN JR AND LING V. (1983a). Cell surface P-glycoprotein associated with multidrug resistance in mammalian cell lines. Science, 221, 1285-1288.
    • (1983) Science , vol.221 , pp. 1285-1288
    • Kartner, N.1    Riordan, J.R.2    Ling, V.3
  • 26
    • 0020605073 scopus 로고
    • Daunorubicin-resistant chinese hamster ovary cells expressing multidrug resistance and cell surface P-glycoprotein
    • KARTNER N, SHALES M, RIORDAN JR AND LING V. (1983b). Daunorubicin-resistant chinese hamster ovary cells expressing multidrug resistance and cell surface P-glycoprotein. Cancer Res., 43, 44143-4419.
    • (1983) Cancer Res. , vol.43 , pp. 44143-44419
    • Kartner, N.1    Shales, M.2    Riordan, J.R.3    Ling, V.4
  • 27
    • 0027937587 scopus 로고
    • Cellular control of human multidrug resistance 1 (mdr-1) gene expression in absence and presence of gene amplification in human cancer cells
    • KOHNO K, TANIMURA H, SATO S, NAKAYAMA Y, MAKINO Y, WADA M, FOJO AT AND KUWANO M. (1994). Cellular control of human multidrug resistance 1 (mdr-1) gene expression in absence and presence of gene amplification in human cancer cells. J. Biol. Chem., 269, 20503-20508.
    • (1994) J. Biol. Chem. , vol.269 , pp. 20503-20508
    • Kohno, K.1    Tanimura, H.2    Sato, S.3    Nakayama, Y.4    Makino, Y.5    Wada, M.6    Fojo, A.T.7    Kuwano, M.8
  • 28
    • 0027493626 scopus 로고
    • Differential expression of P-glycoprotein genes in primary rat hepatocyte culture
    • LEE CH, BRADLEY G, ZHANG JT AND LING V. (1993). Differential expression of P-glycoprotein genes in primary rat hepatocyte culture. J. Cell. Physiol., 157, 392-402.
    • (1993) J. Cell. Physiol. , vol.157 , pp. 392-402
    • Lee, C.H.1    Bradley, G.2    Zhang, J.T.3    Ling, V.4
  • 30
    • 0025945570 scopus 로고
    • Analysis of P-glycoprotein phosphorylation in HL60 cells isolated for resistance to vincristine
    • MA L, MARQUARDT D, TAKEMOTO L AND CENTER MS. (1991). Analysis of P-glycoprotein phosphorylation in HL60 cells isolated for resistance to vincristine. J. Biol. Chem., 266, 5593-5599.
    • (1991) J. Biol. Chem. , vol.266 , pp. 5593-5599
    • Ma, L.1    Marquardt, D.2    Takemoto, L.3    Center, M.S.4
  • 31
    • 0027483327 scopus 로고
    • Identification of 5′ and 3′ sequences involved in the regulation of transcription of the human mdr1 gene in vivo
    • MADDEN MJ, MORROW CS, NAKAGAWA M, GOLDSMITH ME, FAIRCHILD CR AND COWAN KH. (1993). Identification of 5′ and 3′ sequences involved in the regulation of transcription of the human mdr1 gene in vivo. J. Biol. Chem., 268, 8290-8297.
    • (1993) J. Biol. Chem. , vol.268 , pp. 8290-8297
    • Madden, M.J.1    Morrow, C.S.2    Nakagawa, M.3    Goldsmith, M.E.4    Fairchild, C.R.5    Cowan, K.H.6
  • 33
    • 0026745056 scopus 로고
    • Posttranscriptional control of glutathione S-transferase π gene expression in human breast cancer cells
    • MORROW CS, CHIU J AND COWAN KH. (1992). Posttranscriptional control of glutathione S-transferase π gene expression in human breast cancer cells. J. Biol. Chem., 267, 10544-10550.
    • (1992) J. Biol. Chem. , vol.267 , pp. 10544-10550
    • Morrow, C.S.1    Chiu, J.2    Cowan, K.H.3
  • 35
    • 0018566696 scopus 로고
    • Purification of P-Glycoprotein from plasma membrane vesicles of chinese hamster ovary cell mutants with reduced colchicine permeability
    • RIORDAN JR AND LING V. (1979). Purification of P-Glycoprotein from plasma membrane vesicles of chinese hamster ovary cell mutants with reduced colchicine permeability. J. Biol. Chem., 254, 12701-12705.
    • (1979) J. Biol. Chem. , vol.254 , pp. 12701-12705
    • Riordan, J.R.1    Ling, V.2
  • 37
    • 0025893114 scopus 로고
    • Characterization of the human MDR3 P-glycoprotein and its recognition by P-glycoprotein-specific antibodies
    • SCHINKEL AH, ROELOFS MEM AND BORST P. (1991). Characterization of the human MDR3 P-glycoprotein and its recognition by P-glycoprotein-specific antibodies. Cancer Res., 51, 2628-2635.
    • (1991) Cancer Res. , vol.51 , pp. 2628-2635
    • Schinkel, A.H.1    Roelofs, M.E.M.2    Borst, P.3
  • 39
    • 0023030685 scopus 로고
    • Multiple drug resistant human KB carcinoma cells independently selected for high-level resistance to colchicine, adriamycin or vinblastine show changes in expression of specific proteins
    • SHEN D, CARDARELLI C, HWANG J, CORNWELL MM, RICHERT N, ISHI S, PASTAN I AND GOTTESMAN MM. (1986a). Multiple drug resistant human KB carcinoma cells independently selected for high-level resistance to colchicine, adriamycin or vinblastine show changes in expression of specific proteins. J. Biol. Chem., 261, 7762-7770.
    • (1986) J. Biol. Chem. , vol.261 , pp. 7762-7770
    • Shen, D.1    Cardarelli, C.2    Hwang, J.3    Cornwell, M.M.4    Richert, N.5    Ishi, S.6    Pastan, I.7    Gottesman, M.M.8
  • 40
    • 0022457103 scopus 로고
    • Human multidrug-resistant cell lines: Increased mdr1 expression can precede gene amplification
    • SHEN D-W, FOJO A, CHIN JE, RONINSON IB, RICHERT N, PASTAN I AND GOTTESMAN MM. (1986b). Human multidrug-resistant cell lines: Increased mdr1 expression can precede gene amplification. Science, 232, 643-645.
    • (1986) Science , vol.232 , pp. 643-645
    • Shen, D.-W.1    Fojo, A.2    Chin, J.E.3    Roninson, I.B.4    Richert, N.5    Pastan, I.6    Gottesman, M.M.7
  • 41
    • 0027289714 scopus 로고
    • Defective translocation of protein kinase C in multidrug-resistant HL-60 cells confers a reversible loss of phorbol ester-induced monocytic differentiation
    • SLAPAK CA, KHARBANDA S, SALEEM A AND KUFE DW. (1993). Defective translocation of protein kinase C in multidrug-resistant HL-60 cells confers a reversible loss of phorbol ester-induced monocytic differentiation. J. Biol. Chem., 268, 12267-12273.
    • (1993) J. Biol. Chem. , vol.268 , pp. 12267-12273
    • Slapak, C.A.1    Kharbanda, S.2    Saleem, A.3    Kufe, D.W.4
  • 42
    • 0028205593 scopus 로고
    • The role of protein kinase C isoenzymes in the growth inhibition caused by bryostatin 1 in human A549 lung and MCF-7 breast carcinoma cells
    • STANWELL C, GESCHER A, BRADSHAW TD AND PETTIT GR. (1994). The role of protein kinase C isoenzymes in the growth inhibition caused by bryostatin 1 in human A549 lung and MCF-7 breast carcinoma cells. Int. J. Cancer, 56, 585-592.
    • (1994) Int. J. Cancer , vol.56 , pp. 585-592
    • Stanwell, C.1    Gescher, A.2    Bradshaw, T.D.3    Pettit, G.R.4
  • 43
    • 0008632564 scopus 로고
    • Expression of a full length cDNA for the human 'MDR1' gene confers resistance to colchicine, doxorubicin and vinblastine
    • UEDA K, CARDARELLI C, GOTTESMAN MM AND PASTAN I. (1987). Expression of a full length cDNA for the human 'MDR1' gene confers resistance to colchicine, doxorubicin and vinblastine. Proc. Natl Acad. Sci. USA, 84, 3004-3008.
    • (1987) Proc. Natl Acad. Sci. USA , vol.84 , pp. 3004-3008
    • Ueda, K.1    Cardarelli, C.2    Gottesman, M.M.3    Pastan, I.4
  • 46
    • 0030021416 scopus 로고    scopus 로고
    • Use of internally controlled reverse transcriptase-polymerase chain reaction for absolute quantitation of individual multidrug resistance gene transcripts in tissue samples
    • in press
    • ZHANG F, RILEY J AND GANT TN. (1996). Use of internally controlled reverse transcriptase-polymerase chain reaction for absolute quantitation of individual multidrug resistance gene transcripts in tissue samples. Electrophoresis, 17, (in press).
    • (1996) Electrophoresis , vol.17
    • Zhang, F.1    Riley, J.2    Gant, T.N.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.