Chemopreventive effects of the standardized extract (DA-9601) of Artemisia asiatica on azoxymethane-initiated and dextran sulfate sodium-promoted mouse colon carcinogenesis

Nutrition and Cancer

Volumn 60, Issue SUPPL. 1, 2008, Pages 90-97

  Kim, Hyun Soo ^a   Kundu, Joydeb Kumar ^a   Lee, Jeong Sang ^a   Oh, Tae Young ^b   Na, Hye Kyung ^a   Surh, Young Joon ^a  

^a Seoul National University   (South Korea)

^b Dong A Pharmaceutical Company   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

ARTEMISIA ASIATICA EXTRACT; AZOXYMETHANE; BETA CATENIN; CYCLOOXYGENASE 2; DA 9601; DEXTRAN SULFATE; HERBACEOUS AGENT; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; MITOGEN ACTIVATED PROTEIN KINASE P38; PLANT EXTRACT; STILLEN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTEMISIA; ARTEMISIA ASIATICA; CANCER PREVENTION; COLON CARCINOGENESIS; COLON TUMOR; CONFERENCE PAPER; CONTROLLED STUDY; DNA BINDING; DOSE RESPONSE; DRUG EFFECT; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; MALE; MOUSE; NONHUMAN; PROTEIN EXPRESSION;

ANIMALS; ANTICARCINOGENIC AGENTS; ARTEMISIA; AZOXYMETHANE; BETA CATENIN; COLON; COLONIC NEOPLASMS; CYCLOOXYGENASE 2; DEXTRAN SULFATE; DNA; MALE; MICE; MICE, INBRED ICR; NF-KAPPA B; NITRIC OXIDE SYNTHASE TYPE II; PLANT EXTRACTS;

ARTEMISIA ASIATICA; MUS;

EID: 55949131476     PISSN: 01635581     EISSN: None     Source Type: Journal    
DOI: 10.1080/01635580802404170     Document Type: Conference Paper

References (43)

1. Tanaka T, Kohno H, Suzuki R, Yamada Y, Sugie S, et al.: A novel inflammation-related mouse colon carcinogenesis model induced by azoxymethane and dextran sodium sulfate. Cancer Sci 94, 965-973, 2003.
2. Watanabe K, Kawamori T, Nakatsugi S, and Wakabayashi K: COX-2 and iNOS, good targets for chemoprevention of colon cancer. Biofactors 12, 129-133, 2000.
3. Prescott SM and Fitzpatrick FA: Cyclooxygenase-2 and carcinogenesis. Biochim Biophys Acta 1470, M69-78, 2000.
4. delta716 knockout mice by inhibition of cyclooxygenase 2 (COX-2). Cell 87, 803-809, 1996.
5. Steinbach G, Lynch PM, Phillips RK, Wallace MH, Hawk E, et al.: The effect of celecoxib, a cyclooxygenase-2 inhibitor, in familial adenomatous polyposis. N Engl J Med 342, 1946-1952, 2000.
6. Rao CV: Nitric oxide signaling in colon cancer chemoprevention. Mutat Res 555, 107-119, 2004.
7. Karin M and Greten FR: NF-κB: linking inflammation and immunity to cancer development and progression. Nat Rev Immunol 5, 749-759, 2005.
8. Schreiber S, Nikolaus S, and Hampe J: Activation of nuclear factor-κB inflammatory bowel disease. Gut 42, 477-484, 1998.
9. Broom OJ, Massoumi R, and Sjolander A: Alpha2beta1 integrin signalling enhances cyclooxygenase-2 expression in intestinal epithelial cells. J Cell Physiol 209, 950-958, 2006.
10. Kojima M, Morisaki T, Izuhara K, Uchiyama A, Matsunari Y, et al.: Lipopolysaccharide increases cyclooxygenase-2 expression in a colon carcinoma cell line through nuclear factor-kappa B activation. Oncogene 19, 1225-1231, 2000.
11. Chun KS, Keum YS, Han SS, Song YS, Kim SH, et al.: Curcumin inhibits phorbol ester-induced expression of cyclooxygenase-2 in mouse skin through suppression of extracellular signal-regulated kinase activity and NF-κB activation. Carcinogenesis 24, 1515-1524, 2003.
12. Nakano H, Shindo M, Sakon S, Nishinaka S, Mihara M, et al. Differential regulation of IκB kinase alpha and beta by two upstream kinases, NF-κB-inducing kinase and mitogen-activated protein kinase/ERK kinase kinase-1. Proc Natl Acad Sci USA 95, 3537-3542, 1998.
13. Kim SO, Kundu JK, Shin YK, Park JH, Cho MH, et al. [6]-Gingerol inhibits COX-2 expression by blocking the activation of p38 MAP kinase and NF-κB in phorbol ester-stimulated mouse skin.Oncogene 24, 2558-2567, 2005.
14. Howes LG: Selective COX-2 inhibitors, NSAIDs and cardiovascular events - is celecoxib the safest choice? Ther Clin Risk Manag 3, 831-845, 2007.
15. Roumie CL, Mitchel EF Jr, Kaltenbach L, Arbogast PG, Gideon P, et al.: Nonaspirin NSAIDs, cyclooxygenase 2 inhibitors, and the risk for stroke. Stroke 39, 2037-2045, 2008.
16. Solomon DH, Avorn J, Sturmer T, Glynn RJ, Mogun H, et al.: Cardiovascular outcomes in new users of coxibs and nonsteroidal antiinflammatory drugs: high-risk subgroups and time course of risk. Arthritis Rheum 54, 1378-1389, 2006.
17. Surh Y-J: Cancer chemoprevention with dietary phytochemicals. Nat Rev Cancer 3, 768-780, 2003.
18. Seo HJ, Park KK, Han SS, Chung WY, Son MW, et al.: Inhibitory effects of the standardized extract (DA-9601) of Artemisia asiatica Nakai on phorbol ester-induced ornithine decarboxylase activity, papilloma formation, cyclooxygenase-2 expression, inducible nitric oxide synthase expression and nuclear transcription factor kappa B activation in mouse skin. Int J Cancer 100, 456-462, 2002.
19. Lee JS, Oh TY, Ahn BO, Cho H, Kim WB, et al.: Involvement of oxidative stress in experimentally induced reflux esophagitis and Barrett's esophagus: clue for the chemoprevention of esophageal carcinoma by antioxidants. Mutat Res 480-481, 189-200, 2001.
20. Suzuki R, Kohno H, Sugie S, and Tanaka T: Dose-dependent promoting effect of dextran sodium sulfate on mouse colon carcinogenesis initiated with azoxymethane. Histol Histopathol 20, 483-492, 2005.
21. Cooper HS, Murthy S, Kido K, Yoshitake H, and Flanigan A: Dysplasia and cancer in the dextran sulfate sodium mouse colitis model. Relevance to colitis-associated neoplasia in the human: a study of histopathology, β-catenin and p53 expression and the role of inflammation. Carcinogenesis 21, 757-768, 2000.
22. Kohno H, Suzuki R, Sugie S, and Tanaka T: β-Catenin mutations in a mouse model of inflammation-related colon carcinogenesis induced by 1,2-dimethylhydrazine and dextran sodium sulfate. Cancer Sci 96, 69-76, 2005.
23. Kundu JK, Choi KY, and Surh Y-J: β-Catenin-mediated signaling: a novel molecular target for chemoprevention with anti-inflammatory substances. Biochim Biophys Acta 1765, 14-24, 2006.
24. Kundu JK and Surh Y-J: Inflammation: Gearing the journey to cancer. Mutat Res 659, 15-30, 2008.
25. Marx J: Cancer research. Inflammation and cancer: the link grows stronger. Science 306, 966-968, 2004.
26. Inoue T, Hirata I, and Murano M: Effects of nimesulide, a cyclooxygenase-2 selective inhibitor, on colitis induced tumors. Inflammopharmacology 16, 36-39, 2008.
27. (Min/+) mice. Int J Cancer 121, 506-513, 2007.
28. Harris RE, Beebe-Donk J, and Alshafie GA: Cancer chemoprevention by cyclooxygenase 2 (COX-2) blockade: results of case control studies. Subcell Biochem 42, 193-212, 2007.
29. Aggarwal BB and Shishodia S: Molecular targets of dietary agents for prevention and therapy of cancer. Biochem Pharmacol 71, 1397-1421, 2006.
30. Kundu JK and Surh Y-J: Breaking the relay in deregulated cellular signal transduction as a rationale for chemoprevention with anti-inflammatory phytochemicals. Mutat Res 591, 123-146, 2005.
31. Hahm KB, Kim JH, You BM, Kim YS, Cho SW, et al.: Induction of apoptosis with an extract of Artemisia asiatica attenuates the severity of cerulein-induced pancreatitis in rats. Pancreas 17, 153-157, 1998.
32. Yoo BM, Oh TY, Kim YB, Yeo M, Lee JS, et al.: Novel antioxidant ameliorates the fibrosis and inflammation of cerulein-induced chronic pancreatitis in a mouse model. Pancreatology 5, 165-176, 2005.
33. Kim JY, Kim DY, Lee YS, Lee BK, Lee KH, et al.: DA-9601, Artemisia asiatica herbal extract, ameliorates airway inflammation of allergic asthma in mice. Mol Cells 22, 104-112, 2006.
34. Oh TY, Lee JS, Ahn BO, Cho H, Kim WB, et al.: Oxidative stress is more important than acid in the pathogenesis of reflux oesophagitis in rats. Gut 49, 364-371, 2001.
35. Hokari R, Kato S, Matsuzaki K, Kuroki M, Iwai A, et al.: Reduced sensitivity of inducible nitric oxide synthase-deficient mice to chronic colitis. Free Radic Biol Med 31, 153-163, 2001.
36. Pikarsky E, Porat RM, Stein I, Abramovitch R, Amit S, et al. NF-κB functions as a tumor promoter in inflammation-associated cancer. Nature 431, 461-466, 2004.
37. Murano M, Maemura K, Hirata I, Toshina K, Nishikawa T, et al.: Therapeutic effect of intracolonically administered nuclear factor kappa B (p65) antisense oligonucleotide on mouse dextran sulphate sodium (DSS)-induced colitis. Clin Exp Immunol 120, 51-58, 2000.
38. Hirata I, Yasumoto S, Toshina K, Inoue T, Nishikawa T, et al.: Evaluation of the effect of pyrrolidine dithiocarbamate in suppressing inflammation in mice with dextran sodium sulfate-induced colitis. World J Gastroenterol 13, 1666-1671, 2007.
39. Cheon JH, Kim JS, Kim JM, Kim N, Jung HC, et al.: Plant sterol guggulsterone inhibits nuclear factor-κB signaling in intestinal epithelial cells by blocking IκB kinase and ameliorates acute murine colitis. Inflamm Bowel Dis 12, 1152-1161, 2006.
40. Kristof AS, Marks-Konczalik J, and Moss J: Mitogen-activated protein kinases mediate activator protein-1-dependent human inducible nitric-oxide synthase promoter activation. J Biol Chem 276, 8445-8452, 2001.
41. Lee JK, Choi SS, Won JS, and Suh HW: The regulation of inducible nitric oxide synthase gene expression induced by lipopolysaccharide and tumor necrosis factor-α in C6 cells: involvement of AP-1 and NF-κB. Life Sci 73, 595-609, 2003.
42. Moriyama I, Ishihara S, Rumi MA, Aziz MD, Mishima Y, et al.: Decoy oligodeoxynucleotide targeting activator protein-1 (AP-1) attenuates intestinal inflammation in murine experimental colitis. Lab Invest 88, 652-663, 2008.
43. Schandl L, Ebert MP, and Malfertheiner P: Cadherins and catenins in inflammation and oncogenesis. Dig Liver Dis 32, S184-S187, 2000.