Ligand-based discovery of novel trypanosomicidal drug-like compounds: In silico identification and experimental support

European Journal of Medicinal Chemistry

Volumn 46, Issue 8, 2011, Pages 3324-3330

  Castillo Garit, Juan Alberto ^a,b   Vega, Maria Celeste ^c,d   Rolón, Miriam ^c,d   Marrero Ponce, Yovani ^a,b   Gómez Barrio, Alicia ^c   Escario, José A ^c   Bello, Alfredo Alvarez ^a   Montero, Alina ^a   Torrens, Francisco ^b   Pérez Giménez, Facundo ^b   Arán, Vicente J ^e   Abad, Concepción ^b  

^a CENTRAL UNIVERSITY OF LAS VILLAS   (Cuba)

^b UNIVERSITY OF VALENCIA   (Spain)

^c UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

^d Ctro Para el Desarrollo de la Invest Cientifica Fundacion Moises Bertoni Laboratorio Diaz Gill   (Paraguay)

^e INSTITUTO DE QUÍMICA MÉDICA   (Spain)

Author keywords

Amastigote susceptibility assay; Anti epimastigote elimination; Bond based linear indices; Trypanosoma cruzi; Trypanosomicidal

Indexed keywords

ANTITRYPANOSOMAL AGENT; NIFURTIMOX; UNCLASSIFIED DRUG; VA 7 34; VA 7 35; VA 7 37; VA 7 38; VA 7 68; VA 7 70; VA 7 71; VAX 12; VAX 14;

ALGORITHM; AMASTIGOTE; ARTICLE; COMPUTER MODEL; CONCENTRATION (PARAMETERS); CYTOTOXICITY; DRUG ACTIVITY; DRUG STRUCTURE; EPIMASTIGOTE; EXPERIMENTAL STUDY; NONHUMAN; QUANTITATIVE STRUCTURE ACTIVITY RELATION; TRYPANOSOMA CRUZI;

EID: 79958285680     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2011.04.057     Document Type: Article

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