Epigenetic profiling of the antitumor natural product psammaplin A and its analogues

Bioorganic and Medicinal Chemistry

Volumn 19, Issue 12, 2011, Pages 3637-3649

  García, José ^a   Franci, Gianluigi ^b,e   Pereira, Raquel ^a   Benedetti, Rosaria ^b,c   Nebbioso, Angela ^b   Rodríguez Barrios, Fátima ^a   Gronemeyer, Hinrich ^d   Altucci, Lucia ^b   Lera, Angel R De ^a  

^a UNIVERSITY OF VIGO   (Spain)

^b SECOND UNIVERSITY OF NAPLES   (Italy)

^c UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^d INSTITUT DE GÉNÉTIQUE ET DE BIOLOGIE MOLÉCULAIRE ET CELLULAIRE   (France)

^e INSTITUTE OF GENETICS AND BIOPHYSICS ADRIANO BUZZATI TRAVERSO   (Italy)

Author keywords

DNMT; Epigenetics; HDAC; Natural products; Psammaplin A; Total synthesis

Indexed keywords

ANTINEOPLASTIC AGENT; CYCLIN DEPENDENT KINASE INHIBITOR 1; DEPSIPEPTIDE; DNA METHYLTRANSFERASE 1; DNA METHYLTRANSFERASE 3A; FR 901375; HISTONE ACETYLTRANSFERASE PCAF; HISTONE DEACETYLASE 1; HISTONE DEACETYLASE 8; HISTONE H3; NATURAL PRODUCT; PSAMMAPLIN A; PSAMMAPLIN A DERIVATIVE; PSAMMAPLIN A THIOL; ROMIDEPSIN; SIRTUIN 1; THIOL DERIVATIVE; TUBULIN; UNCLASSIFIED DRUG; ZINC ION;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CELL CYCLE REGULATION; CELL DIFFERENTIATION; COMPLEX FORMATION; CONTROLLED STUDY; DISULFIDE BOND; DRUG MECHANISM; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME INHIBITION; EPIGENETICS; GENE INDUCTION; HISTONE ACETYLATION; HUMAN; HUMAN CELL; LEUKEMIA CELL; MOLECULAR MODEL; PROTEIN CLEAVAGE; STRUCTURE ACTIVITY RELATION;

ACETYLATION; ANTINEOPLASTIC AGENTS; APOPTOSIS; BLOTTING, WESTERN; CELL CYCLE; CELL DIFFERENTIATION; CELL LINE, TUMOR; CYCLIN-DEPENDENT KINASE INHIBITOR P21; DISULFIDES; DRUG SCREENING ASSAYS, ANTITUMOR; EPIGENOMICS; HISTONES; HUMANS; LIGANDS; MOLECULAR DYNAMICS SIMULATION; PROTEIN ARRAY ANALYSIS; TUBULIN; TYROSINE;

EID: 79958267335     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2010.12.026     Document Type: Article

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