메뉴 건너뛰기




Volumn 224, Issue 3, 2011, Pages 355-366

The biological and clinical impact of inhibition of NF-κB-initiated apoptosis in diffuse large B cell lymphoma (DLBCL)

Author keywords

activated B cell (ABC) phenotype; apoptosis; DLBCL; NF B; NHL therapy; tissue microarray; XIAP

Indexed keywords

3 (4 METHYLPHENYLSULFONYL) 2 PROPENENITRILE; 3 (4 TERT BUTYLPHENYLSULFONYL) 2 PROPENENITRILE; CASPASE; GENE PRODUCT; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PROTEIN BCL 2; PROTEIN BCL XL; SURVIVIN; X LINKED INHIBITOR OF APOPTOSIS;

EID: 79958191515     PISSN: 00223417     EISSN: 10969896     Source Type: Journal    
DOI: 10.1002/path.2864     Document Type: Article
Times cited : (45)

References (56)
  • 1
    • 23744450399 scopus 로고    scopus 로고
    • Advances in the biology and therapy of diffuse large B-cell lymphoma: Moving toward a molecularly targeted approach
    • DOI 10.1182/blood-2005-02-0687
    • Abramson JS, Shipp MA,. Advances in the biology and therapy of diffuse large B-cell lymphoma: moving toward a molecularly targeted approach. Blood 2005; 106: 1164-1174. (Pubitemid 41129574)
    • (2005) Blood , vol.106 , Issue.4 , pp. 1164-1174
    • Abramson, J.S.1    Shipp, M.A.2
  • 3
    • 11344293560 scopus 로고    scopus 로고
    • The biology of human lymphoid malignancies revealed by gene expression profiling
    • DOI 10.1016/S0065-2776(05)87005-1, PII S0065277605870051
    • Staudt LM, Dave S,. The biology of human lymphoid malignancies revealed by gene expression profiling. Adv Immunol 2005; 87: 163-208. (Pubitemid 41135900)
    • (2005) Advances in Immunology , vol.87 , pp. 163-208
    • Staudt, L.M.1    Dave, S.2
  • 5
    • 0036884169 scopus 로고    scopus 로고
    • Lymphoid malignancies: The dark side of B-cell differentiation
    • DOI 10.1038/nri953
    • Shaffer AL, Rosenwald A, Staudt LM,. Lymphoid malignancies: the dark side of B-cell differentiation. Nat Rev Immunol 2002; 2: 920-932. (Pubitemid 37323213)
    • (2002) Nature Reviews Immunology , vol.2 , Issue.12 , pp. 920-932
    • Shaffer, A.L.1    Rosenwald, A.2    Staudt, L.M.3
  • 8
    • 0035905313 scopus 로고    scopus 로고
    • Constitutive nuclear factor κB activity is required for survival of activated B cell-like diffuse large B cell lymphoma cells
    • DOI 10.1084/jem.194.12.1861
    • Davis RE, Brown KD, Siebenlist U, et al., Constitutive nuclear factor κB activity is required for survival of activated B cell-like diffuse large B cell lymphoma cells. J Exp Med 2001; 194: 1861-1874. (Pubitemid 34028664)
    • (2001) Journal of Experimental Medicine , vol.194 , Issue.12 , pp. 1861-1874
    • Eric Davis, R.1    Brown, K.D.2    Siebenlist, U.3    Staudt, L.M.4
  • 11
    • 4444376712 scopus 로고    scopus 로고
    • Signaling to NF-κB
    • Hayden MS, Ghosh S,. Signaling to NF-κB. Genes Dev 2004; 18: 2195-2224.
    • (2004) Genes Dev , vol.18 , pp. 2195-2224
    • Hayden, M.S.1    Ghosh, S.2
  • 12
    • 0035137882 scopus 로고    scopus 로고
    • Control of oncogenesis and cancer therapy resistance by the transcription factor NF-κB
    • Baldwin AS,. Control of oncogenesis and cancer therapy resistance by the transcription factor NF-κB. J Clin Invest 2001; 107: 241-246. (Pubitemid 32157954)
    • (2001) Journal of Clinical Investigation , vol.107 , Issue.3 , pp. 241-246
    • Baldwin, A.S.1
  • 13
    • 0034084163 scopus 로고    scopus 로고
    • Phosphorylation meets ubiquitination: The control of NF-κB activity
    • DOI 10.1146/annurev.immunol.18.1.621
    • Karin M, Ben-Neriah Y,. Phosphorylation meets ubiquitination: the control of NF-κB activity. Annu Rev Immunol 2000; 18: 621-663. (Pubitemid 30365393)
    • (2000) Annual Review of Immunology , vol.18 , pp. 621-663
    • Karin, M.1    Ben-Neriah, Y.2
  • 14
    • 26444605834 scopus 로고    scopus 로고
    • IKK/NF-κB signaling: Balancing life and death - A new approach to cancer therapy
    • DOI 10.1172/JCI26322
    • Luo JL, Kamata H, Karin M,. IKK/NF-κB signaling: balancing life and death-a new approach to cancer therapy. J Clin Invest 2005; 115: 2625-2632. (Pubitemid 41434385)
    • (2005) Journal of Clinical Investigation , vol.115 , Issue.10 , pp. 2625-2632
    • Luo, J.-L.1    Kamata, H.2    Karin, M.3
  • 15
    • 0036009115 scopus 로고    scopus 로고
    • NF-κB at the crossroads of life and death
    • Karin M, Lin A,. NF-κB at the crossroads of life and death. Nat Immunol 2002; 3: 221-227.
    • (2002) Nat Immunol , vol.3 , pp. 221-227
    • Karin, M.1    Lin, A.2
  • 16
    • 20644455960 scopus 로고    scopus 로고
    • Control of lymphocyte development by nuclear factor-kB
    • DOI 10.1038/nri1629
    • Siebenlist U, Brown K, Claudio E,. Control of lymphocyte development by nuclear factor-κB. Nat Rev Immunol 2005; 5: 435-445. (Pubitemid 40835032)
    • (2005) Nature Reviews Immunology , vol.5 , Issue.6 , pp. 435-445
    • Siebenlist, U.1    Brown, K.2    Claudio, E.3
  • 17
    • 66649127621 scopus 로고    scopus 로고
    • Mutations of multiple genes cause deregulation of NF-κB in diffuse large B-cell lymphoma
    • Compagno M, Lim WK, Grunn A, et al., Mutations of multiple genes cause deregulation of NF-κB in diffuse large B-cell lymphoma. Nature 2009; 459: 717-721.
    • (2009) Nature , vol.459 , pp. 717-721
    • Compagno, M.1    Lim, W.K.2    Grunn, A.3
  • 18
    • 33750443289 scopus 로고    scopus 로고
    • IκB kinase complexes: Gateways to NF-κB activation and transcription
    • DOI 10.1038/sj.onc.1209934, PII 1209934
    • Scheidereit C,. IκB kinase complexes: gateways to NF-κB activation and transcription. Oncogene 2006; 25: 6685-6705. (Pubitemid 44657846)
    • (2006) Oncogene , vol.25 , Issue.51 , pp. 6685-6705
    • Scheidereit, C.1
  • 19
    • 33645999706 scopus 로고    scopus 로고
    • NF-κB and IKK as therapeutic targets in cancer
    • Kim HJ, Hawke N, Baldwin AS,. NF-κB and IKK as therapeutic targets in cancer. Cell Death Differ 2006; 13: 738-747.
    • (2006) Cell Death Differ , vol.13 , pp. 738-747
    • Kim, H.J.1    Hawke, N.2    Baldwin, A.S.3
  • 20
    • 33744978564 scopus 로고    scopus 로고
    • NF-κB and cancer: Mechanisms and targets
    • Karin M,. NF-κB and cancer: mechanisms and targets. Mol Carcinog 2006; 45: 355-361.
    • (2006) Mol Carcinog , vol.45 , pp. 355-361
    • Karin, M.1
  • 23
    • 44649183930 scopus 로고    scopus 로고
    • Reduced or absent cyclin H expression is an independent prognostic marker for poor outcome in diffuse large B-cell lymphoma
    • Bavi P, Abubaker J, Hussain A, et al., Reduced or absent cyclin H expression is an independent prognostic marker for poor outcome in diffuse large B-cell lymphoma. Hum Pathol 2008; 39: 885-894.
    • (2008) Hum Pathol , vol.39 , pp. 885-894
    • Bavi, P.1    Abubaker, J.2    Hussain, A.3
  • 25
    • 67649846427 scopus 로고    scopus 로고
    • Expression of COX-2, NF-κB-p65, NF-κB-p50 and IKKα in malignant and adjacent normal human colorectal tissue
    • Charalambous MP, Lightfoot T, Speirs V, et al., Expression of COX-2, NF-κB-p65, NF-κB-p50 and IKKα in malignant and adjacent normal human colorectal tissue. Br J Cancer 2009; 101: 106-115.
    • (2009) Br J Cancer , vol.101 , pp. 106-115
    • Charalambous, M.P.1    Lightfoot, T.2    Speirs, V.3
  • 26
    • 77957961226 scopus 로고    scopus 로고
    • Prognostic significance of XIAP expression in DLBCL and effect of its inhibition on AKT signalling
    • Hussain AR, Uddin S, Ahmed M, et al., Prognostic significance of XIAP expression in DLBCL and effect of its inhibition on AKT signalling. J Pathol 2010.
    • (2010) J Pathol
    • Hussain, A.R.1    Uddin, S.2    Ahmed, M.3
  • 27
    • 0034254432 scopus 로고    scopus 로고
    • Regulation of interleukin-6 gene expression by pro-inflammatory cytokines in a colon cancer cell line
    • Legrand-Poels S, Schoonbroodt S, Piette J,. Regulation of interleukin-6 gene expression by pro-inflammatory cytokines in a colon cancer cell line. Biochem J 2000; 349: 765-773. (Pubitemid 30609407)
    • (2000) Biochemical Journal , vol.349 , Issue.3 , pp. 765-773
    • Legrand-Poels, S.1    Schoonbroodt, S.2    Piette, J.3
  • 28
    • 72249091662 scopus 로고    scopus 로고
    • Prognostic significance of alterations in KRAS isoforms KRAS-4A/4B and KRAS mutations in colorectal carcinoma
    • Abubaker J, Bavi P, Al-Haqawi W, et al., Prognostic significance of alterations in KRAS isoforms KRAS-4A/4B and KRAS mutations in colorectal carcinoma. J Pathol 2009; 219: 435-445.
    • (2009) J Pathol , vol.219 , pp. 435-445
    • Abubaker, J.1    Bavi, P.2    Al-Haqawi, W.3
  • 29
    • 8444244786 scopus 로고    scopus 로고
    • X-tile: A new bio-informatics tool for biomarker assessment and outcome-based cut-point optimization
    • DOI 10.1158/1078-0432.CCR-04-0713
    • Camp RL, Dolled-Filhart M, Rimm DL,. X-tile: a new bio-informatics tool for biomarker assessment and outcome-based cut-point optimization. Clin Cancer Res 2004; 10: 7252-7259. (Pubitemid 39487712)
    • (2004) Clinical Cancer Research , vol.10 , Issue.21 , pp. 7252-7259
    • Camp, R.L.1    Dolled-Filhart, M.2    Rimm, D.L.3
  • 31
    • 75949104432 scopus 로고    scopus 로고
    • Epstein-Barr virus-positive diffuse large B-cell lymphoma in elderly patients is rare in Western populations
    • Hoeller S, Tzankov A, Pileri SA, et al., Epstein-Barr virus-positive diffuse large B-cell lymphoma in elderly patients is rare in Western populations. Hum Pathol 2010; 41: 352-357.
    • (2010) Hum Pathol , vol.41 , pp. 352-357
    • Hoeller, S.1    Tzankov, A.2    Pileri, S.A.3
  • 35
    • 55749098119 scopus 로고    scopus 로고
    • Curcumin suppresses constitutive activation of nuclear factor-κB and requires functional Bax to induce apoptosis in Burkitt's lymphoma cell lines
    • Hussain AR, Ahmed M, Al-Jomah NA, et al., Curcumin suppresses constitutive activation of nuclear factor-κB and requires functional Bax to induce apoptosis in Burkitt's lymphoma cell lines. Mol Cancer Ther 2008; 7: 3318-3329.
    • (2008) Mol Cancer Ther , vol.7 , pp. 3318-3329
    • Hussain, A.R.1    Ahmed, M.2    Al-Jomah, N.A.3
  • 38
    • 0022480751 scopus 로고
    • A lymphoid-specific protein binding to the octamer motif of immunoglobulin genes
    • Staudt LM, Singh H, Sen R, et al., A lymphoid-specific protein binding to the octamer motif of immunoglobulin genes. Nature 1986; 323: 640-643. (Pubitemid 16008559)
    • (1986) Nature , vol.323 , Issue.6089 , pp. 640-643
    • Staudt, L.M.1    Singh, H.2    Sen, R.3
  • 40
    • 0030004897 scopus 로고    scopus 로고
    • Site-specific phosphorylation of IκBα by a novel ubiquitination- dependent protein kinase activity
    • DOI 10.1016/S0092-8674(00)81064-8
    • Chen ZJ, Parent L, Maniatis T,. Site-specific phosphorylation of IκBα by a novel ubiquitination-dependent protein kinase activity. Cell 1996; 84: 853-862. (Pubitemid 26106855)
    • (1996) Cell , vol.84 , Issue.6 , pp. 853-862
    • Chen, Z.J.1    Parent, L.2    Maniatis, T.3
  • 41
    • 0037305821 scopus 로고    scopus 로고
    • Curcumin (diferuloylmethane) down-regulates the constitutive activation of nuclear factor-κB and IκBα kinase in human multiple myeloma cells, leading to suppression of proliferation and induction of apoptosis
    • DOI 10.1182/blood-2002-05-1320
    • Bharti AC, Donato N, Singh S, et al., Curcumin (diferuloylmethane) down-regulates the constitutive activation of nuclear factor-κB and IκBα kinase in human multiple myeloma cells, leading to suppression of proliferation and induction of apoptosis. Blood 2003; 101: 1053-1062. (Pubitemid 36139379)
    • (2003) Blood , vol.101 , Issue.3 , pp. 1053-1062
    • Bharti, A.C.1    Donato, N.2    Singh, S.3    Aggarwal, B.B.4
  • 43
    • 33947586159 scopus 로고    scopus 로고
    • Aberrant NF-κB signaling in lymphoma: Mechanisms, consequences, and therapeutic implications
    • DOI 10.1182/blood-2006-07-025809
    • Jost PJ, Ruland J,. Aberrant NF-κB signaling in lymphoma: mechanisms, consequences, and therapeutic implications. Blood 2007; 109: 2700-2707. (Pubitemid 46482061)
    • (2007) Blood , vol.109 , Issue.7 , pp. 2700-2707
    • Jost, P.J.1    Ruland, J.2
  • 44
    • 52649091710 scopus 로고    scopus 로고
    • Activation of the NF-κB signalling pathway in diffuse large B-cell lymphoma: Clinical implications
    • Espinosa I, Briones J, Bordes R, et al., Activation of the NF-κB signalling pathway in diffuse large B-cell lymphoma: clinical implications. Histopathology 2008; 53: 441-449.
    • (2008) Histopathology , vol.53 , pp. 441-449
    • Espinosa, I.1    Briones, J.2    Bordes, R.3
  • 45
    • 0029874138 scopus 로고    scopus 로고
    • The NF-κB and IκB proteins: New discoveries and insights
    • DOI 10.1146/annurev.immunol.14.1.649
    • Baldwin AS, Jr,. The NF-κB and IκB proteins: new discoveries and insights. Annu Rev Immunol 1996; 14: 649-683. (Pubitemid 26130197)
    • (1996) Annual Review of Immunology , vol.14 , pp. 649-683
    • Baldwin Jr., A.S.1
  • 49
    • 0036234459 scopus 로고    scopus 로고
    • Missing pieces in the NF-κB puzzle
    • Ghosh S, Karin M,. Missing pieces in the NF-κB puzzle. Cell 2002; 109:(suppl): S81-96.
    • (2002) Cell , vol.109 , Issue.SUPPL.
    • Ghosh, S.1    Karin, M.2
  • 50
    • 0034595687 scopus 로고    scopus 로고
    • Dynamics of NF κB and IκBα studied with green fluorescent protein (GFP) fusion proteins: Investigation of GFP-p65 binding to DNA by fluorescence resonance energy transfer
    • DOI 10.1074/jbc.M000291200
    • Schmid JA, Birbach A, Hofer-Warbinek R, et al., Dynamics of NF-κB and IκBα studied with green fluorescent protein (GFP) fusion proteins. Investigation of GFP-p65 binding to DNa by fluorescence resonance energy transfer. J Biol Chem 2000; 275: 17035-17042. (Pubitemid 30398945)
    • (2000) Journal of Biological Chemistry , vol.275 , Issue.22 , pp. 17035-17042
    • Schmid, J.A.1    Birbach, A.2    Hofer-Warbinek, R.3    Pengg, M.4    Burner, U.5    Furtmuller, P.G.6    Binder, B.R.7    De Martin, R.8
  • 51
    • 0035049060 scopus 로고    scopus 로고
    • Apoptosis and its clinical impact
    • Gastman BR,. Apoptosis and its clinical impact. Head Neck 2001; 23: 409-425.
    • (2001) Head Neck , vol.23 , pp. 409-425
    • Gastman, B.R.1
  • 52
    • 0344389027 scopus 로고    scopus 로고
    • Caspases: The proteases of the apoptotic pathway
    • Nunez G, Benedict MA, Hu Y, et al., Caspases: the proteases of the apoptotic pathway. Oncogene 1998; 17: 3237-3245. (Pubitemid 29043976)
    • (1998) Oncogene , vol.17 , Issue.25 , pp. 3237-3245
    • Nunez, G.1    Benedict, M.A.2    Hu, Y.3    Inohara, N.4
  • 55
    • 70350504882 scopus 로고    scopus 로고
    • TNFAIP3/A20 functions as a novel tumor suppressor gene in several subtypes of non-Hodgkin lymphomas
    • Honma K, Tsuzuki S, Nakagawa M, et al., TNFAIP3/A20 functions as a novel tumor suppressor gene in several subtypes of non-Hodgkin lymphomas. Blood 2009; 114: 2467-2475.
    • (2009) Blood , vol.114 , pp. 2467-2475
    • Honma, K.1    Tsuzuki, S.2    Nakagawa, M.3
  • 56
    • 66649112854 scopus 로고    scopus 로고
    • Frequent inactivation of A20 in B-cell lymphomas
    • Kato M, Sanada M, Kato I, et al., Frequent inactivation of A20 in B-cell lymphomas. Nature 2009; 459: 712-716.
    • (2009) Nature , vol.459 , pp. 712-716
    • Kato, M.1    Sanada, M.2    Kato, I.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.