메뉴 건너뛰기




Volumn 108, Issue 1, 2011, Pages 116-122

Long-term oral treatment with BAY 41-2272 ameliorates impaired corpus cavernosum relaxations in a nitric oxide-deficient rat model

Author keywords

BAY 41 2272; erectile dysfunction; erection; soluble guanylyl cyclase

Indexed keywords

4 AMINO 5 CYCLOPROPYL 2 [1 (2 FLUOROBENZYL) 1H PYRAZOLO[3,4 B]PYRIDIN 3 YL]PYRIMIDINE; ACETYLCHOLINE; CYCLIC GMP; NITRIC OXIDE; PHENYLEPHRINE;

EID: 79958175354     PISSN: 14644096     EISSN: 1464410X     Source Type: Journal    
DOI: 10.1111/j.1464-410X.2010.09776.x     Document Type: Article
Times cited : (14)

References (36)
  • 1
    • 0034849563 scopus 로고    scopus 로고
    • Pharmacology of penile erection
    • Andersson KE,. Pharmacology of penile erection. Pharmacol Rev 2001; 53: 417-50
    • (2001) Pharmacol Rev , vol.53 , pp. 417-450
    • Andersson, K.E.1
  • 2
    • 0031060411 scopus 로고    scopus 로고
    • Nitric oxide in the penis: Physiology and pathology
    • Burnett AL,. Nitric oxide in the penis: physiology and pathology. Am J Urol 1997; 157: 320-424
    • (1997) Am J Urol , vol.157 , pp. 320-424
    • Burnett, A.L.1
  • 3
    • 0026353632 scopus 로고
    • Nitric oxide as a mediator of relaxation of the corpus cavernosum in response to nonadrenergic, noncholinergic neurotransmission
    • Rajfer J, Aronson WJ, Bush PA, Dorey FJ, Ignarro LJ,. Nitric oxide as a mediator of relaxation of the corpus cavernosum in response to nonadrenergic, noncholinergic neurotransmission. N Engl J Med 1992; 326: 90-4
    • (1992) N Engl J Med , vol.326 , pp. 90-94
    • Rajfer, J.1    Aronson, W.J.2    Bush, P.A.3    Dorey, F.J.4    Ignarro, L.J.5
  • 4
    • 0028837352 scopus 로고
    • Physiology of penile erection
    • Andersson KE, Wagner G,. Physiology of penile erection. Physiol Rev 1995; 75: 191-236
    • (1995) Physiol Rev , vol.75 , pp. 191-236
    • Andersson, K.E.1    Wagner, G.2
  • 7
    • 61749096117 scopus 로고    scopus 로고
    • O-independent, haem-dependent soluble guanylate cyclase stimulators
    • Stasch JP, Hobbs AJN,. O-independent, haem-dependent soluble guanylate cyclase stimulators. Handb Exp Pharmacol 2009; 191: 277-308
    • (2009) Handb Exp Pharmacol , vol.191 , pp. 277-308
    • Stasch, J.P.1    Hobbs, A.J.N.2
  • 8
    • 33748312096 scopus 로고    scopus 로고
    • NO-independent stimulators and activators of soluble guanylate cyclase: Discovery and therapeutic potential
    • DOI 10.1038/nrd2038, PII NRD2038
    • Evgenov OV, Pacher P, Schmidt PM, Haskõ G, Schmidt HH, Stasch JPN,. O-independent stimulators and activators of soluble guanylate cyclase: discovery and therapeutic potential. Nat Rev Drug Discov 2006; 755-68 (Pubitemid 44323702)
    • (2006) Nature Reviews Drug Discovery , vol.5 , Issue.9 , pp. 755-768
    • Evgenov, O.V.1    Pacher, P.2    Schmidt, P.M.3    Hasko, G.4    Schmidt, H.H.H.W.5    Stasch, J.-P.6
  • 11
    • 33645126637 scopus 로고    scopus 로고
    • Molecular mechanisms underlying rat mesenteric artery vasorelaxation induced by the nitric oxide-independent soluble guanylyl cyclase stimulators BAY 41-2272 [5-cyclopropyl-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl] pyrimidin-4-ylamine] and YC-1 [3-(5′-hydroxymethyl-2′-furyl)-1- benzyl Indazole]
    • Teixeira CE, Priviero FB, Webb RC,. Molecular mechanisms underlying rat mesenteric artery vasorelaxation induced by the nitric oxide-independent soluble guanylyl cyclase stimulators BAY 41-2272 [5-cyclopropyl-2-[1-(2-fluorobenzyl)- 1H-pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-4-ylamine] and YC-1 [3-(5′-hydroxymethyl-2′-furyl)-1-benzyl Indazole]. J Pharmacol Exp Ther 2006; 317: 258-66
    • (2006) J Pharmacol Exp Ther , vol.317 , pp. 258-266
    • Teixeira, C.E.1    Priviero, F.B.2    Webb, R.C.3
  • 12
    • 33644981623 scopus 로고    scopus 로고
    • Vasorelaxing effect of BAY 41-2272 in rat basilar artery: Involvement of cGMP-dependent and independent mechanisms
    • DOI 10.1161/01.HYP.0000199914.36936.1b
    • Teixeira CE, Priviero FB, Todd J Jr, Webb RC,. Vasorelaxing effect of BAY 41-2272 in rat basilar artery: involvement of cGMP-dependent and independent mechanisms. Hypertension 2006; 596-602 (Pubitemid 43843882)
    • (2006) Hypertension , vol.47 , Issue.3 , pp. 596-602
    • Teixeira, C.E.1    Priviero, F.B.M.2    Todd Jr., J.3    Webb, R.C.4
  • 13
    • 0037304589 scopus 로고    scopus 로고
    • BAY41-2272, a novel nitric oxide independent soluble guanylate cyclase activator, relaxes human and rabbit corpus cavernosum in vitro
    • DOI 10.1016/S0022-5347(05)64009-8
    • Kalsi JS, Rees RW, Hobbs AJ, et al,. BAY41-2272, a novel nitric oxide independent soluble guanylate cyclase activator, relaxes human and rabbit corpus cavernosum in vitro. J Urol 2003; 169: 761-6 (Pubitemid 36133038)
    • (2003) Journal of Urology , vol.169 , Issue.2 , pp. 761-766
    • Kalsi, J.S.1    Rees, R.W.2    Hobbs, A.J.3    Royle, M.4    Kell, P.D.5    Ralph, D.J.6    Moncada, S.7    Cellek, S.8
  • 15
    • 6344233551 scopus 로고    scopus 로고
    • A comparative study of sildenafil, NCX-911 and BAY41-2272 on the anococcygeus muscle of diabetic rats
    • DOI 10.1038/sj.ijir.3901224
    • Kalsi JS, Ralph DJ, Madge DJ, Kell PD, Cellek S,. A comparative study of sildenafil, NCX-911 and BAY41-2272 on the anococcygeus muscle of diabetic rats. Int J Impot Res 2004; 16: 479-85 (Pubitemid 39664854)
    • (2004) International Journal of Impotence Research , vol.16 , Issue.6 , pp. 479-485
    • Kalsi, J.S.1    Ralph, D.J.2    Madge, D.J.3    Kell, P.D.4    Cellek, S.5
  • 16
    • 0037320842 scopus 로고    scopus 로고
    • BAY 41-2272: A stimulator of soluble guanylyl cyclase induces nitric oxide-dependent penile erection in vivo
    • DOI 10.1016/S0090-4295(02)02121-0
    • Bischoff E, Schramm M, Straub A, Feurer A, Stasch JP,. BAY 41-2272: A stimulator of soluble guanylyl cyclase induces nitric oxide-dependent penile erection in vivo. Urology 2003; 61: 464-7 (Pubitemid 36206566)
    • (2003) Urology , vol.61 , Issue.2 , pp. 464-467
    • Bischoff, E.1    Schramm, M.2    Straub, A.3    Feurer, A.4    Stasch, J.-P.5
  • 17
    • 0026782496 scopus 로고
    • Chronic inhibition of nitric oxide synthesis: A new model of arterial hypertension
    • Ribeiro MO, Antunes E, De Nucci G, Lovisolo SM, Zatz R,. Chronic inhibition of nitric oxide synthesis: a new model of arterial hypertension. Hypertension 1992; 20: 298-303
    • (1992) Hypertension , vol.20 , pp. 298-303
    • Ribeiro, M.O.1    Antunes, E.2    De Nucci, G.3    Lovisolo, S.M.4    Zatz, R.5
  • 19
    • 33745699566 scopus 로고    scopus 로고
    • Protective effects of BAY 41-2272 (sGC stimulator) on hypertension, heart, and cardiomyocyte hypertrophy induced by chronic L-NAME treatment in rats
    • DOI fjc.0000210071.54828.9b, PII 0000534420060300000009
    • Zanfolin M, Faro R, Araujo EG, Guaraldo AM, Antunes E, De Nucci G,. Protective effects of BAY 41-2272 (sGC stimulator) on hypertension, heart, and cardiomyocyte hypertrophy induced by chronic L-NAME treatment in rats. J Cardiovasc Pharmacol 2006; 47: 391-5 (Pubitemid 44309692)
    • (2006) Journal of Cardiovascular Pharmacology , vol.47 , Issue.3 , pp. 391-395
    • Zanfolin, M.1    Faro, R.2    Araujo, E.G.3    Guaraldo, A.M.A.4    Antunes, E.5    Nucci, G.D.6
  • 20
    • 0025081992 scopus 로고
    • Nitric oxide and cyclic GMP formation upon electrical field stimulation cause relaxation of corpus cavernosum smooth muscle
    • DOI 10.1016/0006-291X(90)92168-Y
    • Ignarro LJ, Bush PA, Buga GM, Wood KS, Fukuto JM, Rajfer J,. Nitric oxide and cyclic GMP formation upon electrical field stimulation cause relaxation of corpus cavernosum smooth muscle. Biochem Biophys Res Commun 1990; 170: 843-50 (Pubitemid 20249496)
    • (1990) Biochemical and Biophysical Research Communications , vol.170 , Issue.2 , pp. 843-850
    • Ignarro, L.J.1    Bush, P.A.2    Buga, G.M.3    Wood, K.S.4    Fukuto, J.M.5    Rajfer, J.6
  • 21
    • 0025999803 scopus 로고
    • The effect of inhibitors of nitric oxide biosynthesis and cyclic GMP formation on nerve-evoked relaxation of human cavernosal smooth muscle
    • Pickard RS, Powell PH, Zar MA,. The effect of inhibitors of nitric oxide biosynthesis and cyclic GMP formation on nerve-evoked relaxation of human cavernosal smooth muscle. Br J Pharmacol 1991; 104: 755-9
    • (1991) Br J Pharmacol , vol.104 , pp. 755-759
    • Pickard, R.S.1    Powell, P.H.2    Zar, M.A.3
  • 24
    • 77955370744 scopus 로고    scopus 로고
    • Exploring the potential of NO-independent stimulators and activators of soluble guanylate cyclase for the medical treatment of erectile dysfunction
    • Gur S, Kadowitz PJ, Hellstrom WJ,. Exploring the potential of NO-independent stimulators and activators of soluble guanylate cyclase for the medical treatment of erectile dysfunction. Curr Pharm Des 2010; 16: 1619-33
    • (2010) Curr Pharm des , vol.16 , pp. 1619-1633
    • Gur, S.1    Kadowitz, P.J.2    Hellstrom, W.J.3
  • 25
    • 74049143429 scopus 로고    scopus 로고
    • Pharmacotherapy for erectile dysfunction
    • Eardley I, Donatucci C, Corbin J, et al. Pharmacotherapy for erectile dysfunction. J Sex Med 2010; 7: 524-40
    • (2010) J Sex Med , vol.7 , pp. 524-540
    • Eardley, I.1    Donatucci, C.2    Corbin, J.3
  • 26
  • 28
    • 77953211239 scopus 로고    scopus 로고
    • Chronic inhibition of nitric-oxide synthase induces hypertension and erectile dysfunction in the rat that is not reversed by sildenafil
    • Gur S, Kadowitz PJ, Gurkan L, et al,. Chronic inhibition of nitric-oxide synthase induces hypertension and erectile dysfunction in the rat that is not reversed by sildenafil. BJU Int 2010; 106: 78-83
    • (2010) BJU Int , vol.106 , pp. 78-83
    • Gur, S.1    Kadowitz, P.J.2    Gurkan, L.3
  • 29
    • 77950299010 scopus 로고    scopus 로고
    • phox Subunit of NAD(P)H oxidase contributes to erectile dysfunction caused by long-term nitric oxide inhibition in rats: Reversion by regular physical training
    • phox Subunit of NAD(P)H oxidase contributes to erectile dysfunction caused by long-term nitric oxide inhibition in rats: reversion by regular physical training. Urology 2010; 75: 961-7
    • (2010) Urology , vol.75 , pp. 961-967
    • Claudino, M.A.1    Franco-Penteado, C.F.2    Priviero, F.B.M.3
  • 30
    • 0024586296 scopus 로고
    • Effect of moxisylyte hydrochloride on isolated human penile corpus cavernosum tissue
    • DOI 10.1016/0024-3205(89)90194-X
    • Imagawa A, Kimura K, Kawanishi Y, Tamura M,. Effect of moxisylyte hydrochloride on isolated human penile corpus cavernosum tissue. Life Sci 1989; 44: 619-23 (Pubitemid 19064707)
    • (1989) Life Sciences , vol.44 , Issue.9 , pp. 619-623
    • Imagawa, A.1    Kimura, K.2    Kawanishi, Y.3    Tamura, M.4
  • 31
    • 0025148725 scopus 로고
    • Pharmacological studies of human erectile tissue: Characteristics of spontaneous contractions and alterations in α-adrenoceptor responsiveness with age and disease in isolated tissues
    • Christ GJ, Maayani S, Valcic M, Melman A,. Pharmacological studies of human erectile tissue: characteristics of spontaneous contractions and alterations in alpha-adrenoceptor responsiveness with age and disease in isolated tissues. Br J Pharmacol 1990; 101: 375-81 (Pubitemid 20292893)
    • (1990) British Journal of Pharmacology , vol.101 , Issue.2 , pp. 375-381
    • Christ, G.J.1    Maayani, S.2    Valcic, M.3    Melman, A.4
  • 32
    • 0022410668 scopus 로고
    • Effect of local alpha-adrenergic blockade on human penile erection
    • Blum MD, Bahnson RR, Porter TN, Carter MF,. Effect of local alpha-adrenergic blockade on human penile erection. J Urol 1985; 134: 479-81 (Pubitemid 16236377)
    • (1985) Journal of Urology , vol.134 , Issue.3 , pp. 479-481
    • Blum, M.D.1    Bahnson, R.R.2    Porter, T.N.3    Carter, M.F.4
  • 33
    • 0022458999 scopus 로고
    • Maintenance treatment of erectile impotence by cavernosal unstriated muscle relaxant injection
    • Brindley GS,. Maintenance treatment of erectile impotence by cavernosal unstriated muscle relaxant injection. Br J Psych 1986; 149: 210-5 (Pubitemid 16076253)
    • (1986) British Journal of Psychiatry , vol.149 , Issue.AUG. , pp. 210-215
    • Brindley, G.S.1
  • 35
    • 61849132911 scopus 로고    scopus 로고
    • Erectile function in two-kidney, one-clip hypertensive rats is maintained by a potential increase in nitric oxide production
    • Linder AE, Dorrance AM, Mills TM, Webb RC, Leite R,. Erectile function in two-kidney, one-clip hypertensive rats is maintained by a potential increase in nitric oxide production. J Sex Med 2009; 3: 279-85
    • (2009) J Sex Med , vol.3 , pp. 279-285
    • Linder, A.E.1    Dorrance, A.M.2    Mills, T.M.3    Webb, R.C.4    Leite, R.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.