Erectile function in two-kidney, one-clip hypertensive rats is maintained by a potential increase in nitric oxide production

Journal of Sexual Medicine

Volumn 6, Issue SUPPL. 3, 2009, Pages 279-285

  Linder, A Elizabeth ^a   Dorrance, Anne M ^a   Mills, Thomas M ^b   Webb, R Clinton ^b   Leite, Romulo ^b,c  

^a MICHIGAN STATE UNIVERSITY   (United States)

^b MEDICAL COLLEGE OF GEORGIA   (United States)

^c FEDERAL UNIVERSITY OF OURO PRETO   (Brazil)

Author keywords

Erectile function; Nitric oxide; One clip hypertension; Rho kinase; Two kidney

Indexed keywords

4 (1 AMINOETHYL) N (4 PYRIDYL)CYCLOHEXANECARBOXAMIDE; N(G) NITROARGININE; NITRIC OXIDE; NITRIC OXIDE DONOR; NITROPRUSSIDE SODIUM; PHENYLEPHRINE; RHO KINASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; CONFERENCE PAPER; CONTROLLED STUDY; CORPUS CAVERNOSUM; DISEASE ASSOCIATION; ENZYME SYNTHESIS; ERECTILE DYSFUNCTION; GANGLION; HYPERTENSION; MALE; MEAN ARTERIAL PRESSURE; MUSCLE ISOMETRIC CONTRACTION; MUSCLE RELAXATION; NONHUMAN; PENIS ERECTION; PRIORITY JOURNAL; RAT; SHAM PROCEDURE; SIGNAL TRANSDUCTION;

EID: 61849132911     PISSN: 17436095     EISSN: 17436109     Source Type: Journal    
DOI: 10.1111/j.1743-6109.2008.01185.x     Document Type: Conference Paper

References (45)

1. Benet AE, Melman A. The epidemiology of erectile dysfunction. Urol Clin North Am 1995; 22: 699-709.
2. Meuleman EJ. Prevalence of erectile dysfunction: Need for treatment? Int J Impot Res 2002; 14 (1 suppl): S22-8.
3. Mitchell BM, Dorrance AM, Webb RC. GTP cyclohydrolase 1 downregulation contributes to glucocorticoid hypertension in rats. Hypertension 2003; 41: 669-74.
4. Linder AE, Weber DS, Whitesall SE, D'Alecy LG, Webb RC. Altered vascular reactivity in mice made hypertensive by nitric oxide synthase inhibition. J Cardiovasc Pharmacol 2005; 46: 438-44.
5. Linder AE, Leite R, Lauria K, Mills TM, Webb RC. Penile erection requires association of soluble guanylyl cyclase with endothelial caveolin-1 in rat corpus cavernosum. Am J Physiol Regul Integr Comp Physiol 2006; 290: R1302-8.
6. Bivalacqua TJ, Champion HC, Usta MF, Cellek S, Chitaley K, Webb RC, Lewis RL, Mills TM, Hellstrom WJ, Kadowitz PJ. RhoA/Rho-kinase suppresses endothelial nitric oxide synthase in the penis: A mechanism for diabetes-associated erectile dysfunction. Proc Natl Acad Sci USA 2004; 101: 9121-6.
7. Lue TF. Erectile dysfunction. N Engl J Med 2000; 342: 1802-13.
8. Burnett AL, Lowenstein CJ, Bredt DS, Chang TS, Snyder SH. Nitric oxide: A physiologic mediator of penile erection. Science 1992; 257: 401-3.
9. Andersson KE, Wagner G. Physiology of penile erection. Physiol Rev 1995; 75: 191-236.
10. Dorrance AM, Lewis RW, Mills TM. Captopril treatment reverses erectile dysfunction in male stroke prone spontaneously hypertensive rats. Int J Impot Res 2002; 14: 494-7.
11. Jin L, Lagoda G, Leite R, Webb RC, Burnett AL. NADPH oxidase activation: A mechanism of hypertension-associated erectile dysfunction. J Sex Med 2008; 5: 544-51.
12. Behr-Roussel D, Gorny D, Mevel K, Compagnie S, Kern P, Sivan V, BernabéJ, Bedigian MP, Alexandre L, Giuliano F. Erectile dysfunction: An early marker for hypertension? A longitudinal study in spontaneously hypertensive rats. Am J Physiol Cell Physiol 2005; 288: R276-83.
13. Chitaley K, Webb RC, Dorrance AM, Mills TM. Decreased penile erection in DOCA-salt and stroke prone-spontaneously hypertensive rats. Int J Impot Res 2001; 13 (5 suppl): S16-20.
14. Feldman HA, Goldstein I, Hatzichristou DG, Krane RJ, McKinlay JB. Impotence and its medical and psychosocial correlates: Results of the Massachusetts Male Aging Study. J Urol 1994; 151: 54-61.
15. Rosen RC, Fisher WA, Eardley I, Niederberger C, Nadel A, Sand M. The multinational Men's Attitudes to Life Events and Sexuality (MALES) study: I. Prevalence of erectile dysfunction and related health concerns in the general population. Curr Med Res Opin 2004; 20: 607-17.
16. Montorsi P, Ravagnani PM, Galli S, Rotatori F, Briganti A, Salonia A, Rigatti P, Montorsi F. The artery size hypothesis: A macrovascular link between erectile dysfunction and coronary artery disease. Am J Cardiol 2005; 96: 19M-23M.
17. Uehata M, Ishizaki T, Satoh H, Ono T, Kawahara T, Morishita T, Tamakawa H, Yamagami K, Inui J, Maekawa M, Narumiya S. Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension. Nature 1997; 389: 990-4.
18. Somlyo AP, Somlyo AV. Signal transduction by G-proteins, rho-kinase and protein phosphatase to smooth muscle and non-muscle myosin II. J Physiol 2000; 522: 177-85.
19. Chitaley K, Wingard CJ, Clinton Webb R, Branam H, Stopper VS, Lewis RW, Mills TM. Antagonism of Rho-kinase stimulates rat penile erection via a nitric oxide-independent pathway. Nat Med 2001; 7: 119-22.
20. Sauzeau V, Le Jeune H, Cario-Toumaniantz C, Smolenski A, Lohmann SM, Bertoglio J, Chardin P, Pacaud P, Loirand G. Cyclic GMP-dependent protein kinase signaling pathway inhibits RhoA-induced Ca2+ sensitization of contraction in vascular smooth muscle. J Biol Chem 2000; 275: 21722-9.
21. Mills TM, Chitaley K, Lewis RW, Webb RC. Nitric oxide inhibits RhoA/ Rho-kinase signaling to cause penile erection. Eur J Pharmacol 2002; 439: 173-4.
22. Callera GE, Varanda WA, Bendhack LM. Impaired relaxation to acetylcholine in 2K-1C hypertensive rat aortas involves changes in membrane hyperpolarization instead of an abnormal contribution of endothelial factors. Gen Pharmacol 2000; 34: 379-89.
23. Sendao Oliveira AP, Bendhack LM. Relaxation induced by acetylcholine involves endothelium-derived hyperpolarizing factor in 2-kidney 1-clip hypertensive rat carotid arteries. Pharmacology 2004; 72: 231-9.
24. Sigmon DH, Beierwaltes WH. Angiotensin II: Nitric oxide interaction and the distribution of blood flow. Am J Physiol 1993; 265: R1276-83.
25. Cervenka L, Horacek V, Vaneckova I, Hubácek JA, Oliverio MI, Coffman TM, Navar LG. Essential role of AT1A receptor in the development of 2K1C hypertension. Hypertension 2002; 40: 735-41.
26. Turkstra E, Boer P, Braam B, Koomans HA. Increased availability of nitric oxide leads to enhanced nitric oxide dependency of tubuloglomerular feedback in the contralateral kidney of rats with 2-kidney, 1-clip Goldblatt hypertension. Hypertension 1999; 34: 679-84.
27. Lazartigues E, Lawrence AJ, Lamb FS, Davisson RL. Renovascular hypertension in mice with brain-selective overexpression of AT1a receptors is buffered by increased nitric oxide production in the periphery. Circ Res 2004; 95: 523-31.
28. Hiyoshi H, Yayama K, Takano M, Okamoto H. Angiotensin type 2 receptor-mediated phosphorylation of eNOS in the aortas of mice with 2-kidney, 1-clip hypertension. Hypertension 2005; 45: 967-73.
29. Linder AE, Bendhack LM. Endothelin-1-induced contraction is impaired in the tail artery of renal hypertensive rats. Vascul Pharmacol 2002; 39: 77-82.
30. Ushiyama M, Morita T, Kuramochi T, Yagi S, Katayama S. Erectile dysfunction in hypertensive rats results from impairment of the relaxation evoked by neurogenic carbon monoxide and nitric oxide. Hypertens Res 2004; 27: 253-61.
31. Shamloul R, Wang R. Increased intracavernosal pressure response in hypertensive rats after chronic hemin treatment. J Sex Med 2006; 3: 619-27.
32. Hannan JL, Smallegange C, Hale TM, Heaton JP, Adams MA. Impact of antihypertensive treatments on erectile responses in aging spontaneously hypertensive rats. J Hypertens 2006; 24: 159-68.
33. Jensen J, Lendorf A, Stimpel H, Frost J, Ibsen H, Rosenkilde P. The prevalence and etiology of impotence in 101 male hypertensive outpatients. Am J Hypertens 1999; 12: 271-5.
34. Linder AE, Webb RC, Mills TM, Ying Z, Lewis RW, Teixeira CE. Rho-kinase Rho RGS-containing RhoGEFs as molecular targets for the treatment of erectile dysfunction. Curr Pharm Des 2005; 11: 4029-40.
35. Carneiro FS, Giachini FR, Lima VV, Carneiro ZN, Nunes KP, Ergul A, Leite R, Tostes RC, Webb RC. DOCA-salt treatment enhances responses to endothelin-1 in murine corpus cavernosum. Can J Physiol Pharmacol 2008; 86: 320-8.
36. Jin L, Ying Z, Webb RC. Activation of Rho/Rho kinase signaling pathway by reactive oxygen species in rat aorta. Am J Physiol Heart Circ Physiol 2004; 287: H1495-500.
37. Chitaley K, Webb RC. Nitric oxide induces dilation of rat aorta via inhibition of rho-kinase signaling. Hypertension 2002; 39: 438-42.
38. Teixeira CE, Jin L, Ying Z, Palmer T, Priviero FB, Webb RC. Expression and functional role of the RhoA/Rho-kinase pathway in rat coeliac artery. Clin Exp Pharmacol Physiol 2005; 32: 817-24.
39. Teixeira CE, Jin L, Ying Z, Palmer T, Webb RC. Ca2+ sensitization and the regulation of contractility in rat anococcygeus and retractor penis muscle. Biochem Pharmacol 2005; 69: 1483-92.
40. Teixeira CE, Ying Z, Webb RC. Pro-erectile effects of the Rho-kinase inhibitor (S)-(+)-2-methyl-1-(4-methyl-5-isoquinolinyl) sulfonylhomopiperazine (H-1152) in the rat penis. J Pharmacol Exp Ther 2005; 315: 155-62.
41. Seko T, Ito M, Kureishi Y, Okamoto R, Moriki N, Onishi K, Isaka N, Hartshorne DJ, Nakano T. Activation of RhoA and inhibition of myosin phosphatase as important components in hypertension in vascular smooth muscle. Circ Res 2003; 92: 411-8.
42. Weber DS, Webb RC. Enhanced relaxation to the rho-kinase inhibitor Y-27632 in mesenteric arteries from mineralocorticoid hypertensive rats. Pharmacology 2001; 63: 129-33.
43. Jin L, Liu T, Lagoda GA, Champion HC, Bivalacqua TJ, Burnett AL. Elevated RhoA/Rho-kinase activity in the aged rat penis: Mechanism for age-associated erectile dysfunction. FASEB J 2006; 20: 536-8.
44. Ying Z, Jin L, Dorrance AM, Webb RC. Increased expression of mRNA for RGS containing RhoGEFs in aorta from stroke-prone spontaneously hypertensive rats. Am J Hypertension 2004; 17: 981-5.
45. Tang J, Kusaka I, Massey AR, Rollins S, Zhang JH. Increased RhoA translocation in aorta of diabetic rats. Acta Pharmacol Sin 2006; 27: 543-8.