Tools for genetic manipulations in Corynebacterium glutamicum and their applications

Applied Microbiology and Biotechnology

Volumn 90, Issue 5, 2011, Pages 1641-1654

  Nešvera, Jan ^a   Pátek, Miroslav ^a  

^a INSTITUTE OF MICROBIOLOGY   (Czech Republic)

Author keywords

Amino acid producing strains; Corynebacterium glutamicum; Gene replacement; Genome manipulations; Plasmid vectors; Promoters

Indexed keywords

AMINO ACID-PRODUCING STRAINS; CORYNEBACTERIUM GLUTAMICUM; GENE REPLACEMENT; PLASMID VECTORS; PROMOTERS;

AMINO ACIDS; CLONING; DNA; METABOLISM; MOLECULAR BIOLOGY; PHYSIOLOGY;

GENE EXPRESSION;

ACYLTRANSFERASE; AMINOGLYCOSIDE PHOSPHOTRANSFERASE; AMYLASE; BETA GALACTOSIDASE; BETA GLUCOSIDASE; CHLORAMPHENICOL; GLUTAMATE DEHYDROGENASE; GREEN FLUORESCENT PROTEIN; NUCLEASE; PHOSPHOTRANSFERASE; PLASMID VECTOR; PYRUVATE CARBOXYLASE; RNA POLYMERASE; UNCLASSIFIED DRUG;

AMINO ACID; BACTERIUM; GENE EXPRESSION; GENETIC ANALYSIS; GENETIC ENGINEERING; GENOME; METABOLISM; METABOLITE; PLASMID; PROTEOMICS;

BACTERIAL CHROMOSOME; BACTERIAL GENE; BACTERIAL GENETICS; BACTERIAL METABOLISM; BACTERIAL STRAIN; BIOMICS; CLONING VECTOR; CORYNEBACTERIUM GLUTAMICUM; DNA MODIFICATION; DNA TRANSFER; ESCHERICHIA COLI; EXPRESSION VECTOR; FLUXOMICS; GENE MUTATION; GENE OVEREXPRESSION; GENE REARRANGEMENT; GENE REPLACEMENT THERAPY; GENE SEQUENCE; GENETIC MANIPULATION; HETEROLOGOUS EXPRESSION; HOMOLOGOUS RECOMBINATION; LOXP SITE; METABOLOMICS; MOLECULAR CLONING; NONHUMAN; OPERON; PROMOTER REGION; PROTEIN LOCALIZATION; PROTEIN SECRETION; PROTEOMICS; SHORT SURVEY; SIGNAL TRANSDUCTION; TRANSCRIPTOMICS;

CORYNEBACTERIUM GLUTAMICUM; GENE EXPRESSION REGULATION, BACTERIAL; GENETIC ENGINEERING;

BACTERIA (MICROORGANISMS); CORYNEBACTERIUM GLUTAMICUM;

EID: 79958149403     PISSN: 01757598     EISSN: 14320614     Source Type: Journal    
DOI: 10.1007/s00253-011-3272-9     Document Type: Short Survey

References (132)

1. Adham SA, Campelo AB, Ramos A, Gil JA (2001) Construction of a xylanase-producing strain of Brevibacterium lactofermentum by stable integration of an engineered xysA gene from Streptomyces halstedii JM8. Appl Environ Microbiol 67:5425-5430 (Pubitemid 33640971)
2. Amador E, Martín JF, Castro JM(2000) A Brevibacterium lactofermentum 16S rRNA gene used as target site for homologous recombination. FEMS Microbiol Lett 185:199-204 (Pubitemid 30168999)
3. Arndt A, Eikmanns BJ (2007) The alcohol dehydrogenase gene adhA in Corynebacterium glutamicum is subject to carbon catabolite repression. J Bacteriol 189:7408-7416 (Pubitemid 47557357)
4. Asakura Y, Kimura E, Usuda Y, Kawahara Y, Matsui K, Osumi T, Nakamatsu T (2007) Altered metabolic flux due to deletion of odhA causes L-glutamate overproduction in Corynebacterium glutamicum. Appl Environ Microbiol 73:1308-1319
5. Barrett E, Stanton C, Zelder O, Fitzgerald G, Ross RP (2004) Heterologous expression of lactose- and galactose-utilizing pathways from lactic acid bacteria in Corynebacterium glutamicum for production of lysine in whey. Appl Environ Microbiol 70:2861-2866 (Pubitemid 38657803)
6. Barriuso-Iglesias M, Barreiro C, Flechoso F, Martín JF (2006) Transcriptional analysis of the F0F1 ATPase operon of Corynebacterium glutamicum ATCC 13032 reveals strong induction by alkaline pH. Microbiology 152:11-21 (Pubitemid 43092389)
7. Barriuso-Iglesias M, Schluesener D, Barreiro C, Poetsch A, Martín JF (2008) Response of the cytoplasmic and membrane proteome of Corynebacterium glutamicum ATCC 13032 to pH changes. BMC Microbiol 8:225
8. Bartek T, Zönnchen E, Klein B, Gerstmeir R, Makus P, Lang S, Oldiges M (2010) Analysing overexpression of L-valine biosynthesis genes in pyruvate-dehydrogenase deficient Corynebacterium glutamicum. J Ind Microbiol Biotechnol 37:263-270
9. Baumbach J, Wittkop T, Kleindt CK, Tauch A (2009) Integrated analysis and reconstruction of microbial transcriptional gene regulatory networks using CoryneRegNet. Nat Protoc 4:992-1005
10. Becker J, Klopprogge C, Herold A, Zelder O, Bolten CJ, Wittmann C (2007) Metabolic flux engineering of L-lysine production in Corynebacterium glutamicum-over expression and modification of G6P dehydrogenase. J Biotechnol 132:99-109 (Pubitemid 47599710)
11. Becker J, Zelder O, Häfner S, Schröder H, Wittmann C (2011) From zero to hero - design-based systems metabolic engineering of Corynebacterium glutamicum for l-lysine production. Metab Eng 13:159-168
12. Ben-Samoun K, Leblon G, Reyes O (1999) Positively regulated expression of the Escherichia coli araBAD promoter in Corynebacterium glutamicum. FEMS Microbiol Lett 174:125-130 (Pubitemid 29179442)
13. Brabetz W, Liebl W, Schleifer KH (1991) Studies on the utilization of lactose by Corynebacterium glutamicum, bearing the lactose operon of Escherichia coli. Arch Microbiol 155:607-612
14. Brune I, Brinkrolf K, Kalinowski J, Pühler A, Tauch A (2005) The individual and common repertoire of DNA-binding transcriptional regulators of Corynebacterium glutamicum, Corynebacterium efficiens, Corynebacterium diphtheriae and Corynebacterium jeikeium deduced from the complete genome sequences. BMC Genomics 6:86
15. Buschke N, Schröder H, Wittmann C (2011) Metabolic engineering of Corynebacterium glutamicum for production of 1,5-diaminopentane from hemicellulose. Biotechnol J 6:306-317
16. Carpinelli J, Krämer R, Agosin E (2006) Metabolic engineering of Corynebacterium glutamicum for trehalose overproduction: role of the TreYZ trehalose biosynthetic pathway. Appl Environ Microbiol 72:1949-1955
17. Chinen A, Kozlov YI, Hara Y, Izui H, Yasueda H (2007) Innovative metabolic pathway design for efficient L-glutamate production by suppressing CO2 emission. J Biosci Bioeng 103:262-269 (Pubitemid 46552277)
18. Date M, Itaya H, Matsui H, Kikuchi Y (2006) Secretion of human epidermal growth factor by Corynebacterium glutamicum. Lett Appl Microbiol 42:66-70
19. Eggeling L, Reyes O (2005) Experiments. In: Eggeling L, Bott M (eds) Handbook of Corynebacterium glutamicum. CRC, Boca Raton, pp 535-566
20. Ehira S, Teramoto H, Inui M, Yukawa H (2009) Regulation of Corynebacterium glutamicum heat shock response by the extracytoplasmic-function sigma factor SigH and transcriptional regulators HspR and HrcA. J Bacteriol 191:2964-2972
21. Eikmanns BJ, Thum-Schmitz N, Eggeling L, Ludtke KU, Sahm H (1994) Nucleotide sequence, expression and transcriptional analysis of the Corynebacterium glutamicum gltA gene encoding citrate synthase. Microbiology 140:1817-1828 (Pubitemid 24259015)
22. Fiuza M, Letek M, Leiba J, Villadangos AF, Vaquera J, Zanella-Cleon I, Mateos LM, Molle V, Gil JA (2010) Phosphorylation of a novel cytoskeletal protein (RsmP) regulates rod-shaped morphology in Corynebacterium glutamicum. J Biol Chem 285:29387-29397
23. Fränzel B, Poetsch A, Trötschel C, Persicke M, Kalinowski J, Wolters DA (2010a) Quantitative proteomic overview on the Corynebacterium glutamicum L-lysine producing strain DM1730. J Proteomics 73:2336-2353
24. Fränzel B, Trötschel C, Rückert C, Kalinowski J, Poetsch A, Wolters DA (2010b) Adaptation of Corynebacterium glutamicum to salt-stress conditions. Proteomics 10:445-457
25. Frunzke J, Bramkamp M, Schweitzer JE, Bott M (2008) Population heterogeneity in Corynebacterium glutamicum ATCC 13032 caused by prophage CGP3. J Bacteriol 190:5111-5119 (Pubitemid 351991079)
26. Gerstmeir R, Cramer A, Dangel P, Schaffer S, Eikmanns BJ (2004) RamB, a novel transcriptional regulator of genes involved in acetate metabolism of Corynebacterium glutamicum. J Bacteriol 186:2798-2809 (Pubitemid 38525935)
27. Glanemann C, Loos A, Gorret N, Willis L, O'Brien XM, Lessard P, Sinskey AJ (2003) Disparity between changes in mRNA abundance and enzyme activity in Corynebacterium glutamicum: implications for DNA microarray analysis. Appl Microbiol Biotechnol 61:61-68 (Pubitemid 36458054)
28. Hänssler E, Müller T, Palumbo K, Pátek M, Brocker M, Krämer R, Burkovski A (2009) A game with many players: control of gdh transcription in Corynebacterium glutamicum. J Biotechnol 142:114-122
29. Haussmann U, Qi SW, Wolters D, Rogner M, Liu SJ, Poetsch A (2009) Physiological adaptation of Corynebacterium glutamicum to benzoate as alternative carbon source-a membrane proteomecentric view. Proteomics 9:3635-3651
30. Hayashi M, Mizoguchi H, Shiraishi N, Obayashi M, Nakagawa S, Imai J, Watanabe S, Ota T, Ikeda M (2002) Transcriptome analysis of acetate metabolism in Corynebacterium glutamicum using a newly developed metabolic array. Biosci Biotechnol Biochem 66:1337-1344 (Pubitemid 39251264)
31. Hayashi M, Ohnishi J, Mitsuhashi S, Yonetani Y, Hashimoto S, Ikeda M (2006) Transcriptome analysis reveals global expression changes in an industrial L-lysine producer of Corynebacterium glutamicum. Biosci Biotechnol Biochem 70:546-550 (Pubitemid 43289444)
32. Hermann T (2003) Industrial production of amino acids by coryneform bacteria. J Biotechnol 104:155-172
33. Hermann T, Pfefferle W, Baumann C, Busker E, Schaffer S, Bott M, Sahm H, Dusch N, Kalinowski J, Pühler A, Bendt AK, Krämer R, Burkovski A (2001) Proteome analysis of Corynebacterium glutamicum. Electrophoresis 22:1712-1723
34. HoffelderM, Raasch K, van Ooyen J, Eggeling L (2010) The E2 domain of OdhA of Corynebacterium glutamicum has succinyltransferase activity dependent on lipoyl residues of the acetyltransferase AceF. J Bacteriol 192:5203-5211
35. Holátko J, Elišáková V, Prouza M, Sobotka M, Nešvera J, Pátek M (2009) Metabolic engineering of the L-valine biosynthesis pathway in Corynebacterium glutamicum using promoter activity modulation. J Biotechnol 139:203-210
36. Hüser AT, Chassagnole C, Lindley ND, Merkamm M, Guyonvarch A, Elišáková V, Pátek M, Kalinowski J, Brune I, Pühler A, Tauch A (2005) Rational design of a Corynebacterium glutamicum pantothenate production strain and its characterization by metabolic flux analysis and genome-wide transcriptional profiling. Appl Environ Microbiol 71:3255-3268 (Pubitemid 40807237)
37. Ikeda M, Nakagawa S (2003) The Corynebacterium glutamicum genome: features and impacts on biotechnological processes. Appl Microbiol Biotechnol 62:99-109 (Pubitemid 36995160)
38. Inui M, Kawaguchi H, Murakami S, Vertes AA, Yukawa H (2004) Metabolic engineering of Corynebacterium glutamicum for fuel ethanol production under oxygen-deprivation conditions. J Mol Microbiol Biotechnol 8:243-254 (Pubitemid 41368969)
39. Inui M, Suda M, Okino S, Nonaka H, Puskas LG, Vertes AA, Yukawa H (2007) Transcriptional profiling of Corynebacterium glutamicum metabolism during organic acid production under oxygen deprivation conditions. Microbiology 153:2491-2504 (Pubitemid 47262039)
40. Ishige T, Krause M, Bott M, Wendisch VF, Sahm H (2003) The phosphate starvation stimulon of Corynebacterium glutamicum determined by DNA microarray analyses. J Bacteriol 185:4519-4529 (Pubitemid 36890499)
41. Jäger W, Schäfer A, Pühler A, Labes G, Wohlleben W (1992) Expression of the Bacillus subtilis sacB gene leads to sucrose sensitivity in the gram-positive bacterium Corynebacterium glutamicum but not in Streptomyces lividans. J Bacteriol 174:5462-5465
42. Jäger W, Schäfer A, Kalinowski J, Pühler A (1995) Isolation of insertion elements from gram-positive Brevibacterium, Corynebacterium and Rhodooccus strains using the Bacillus subtilis sacB gene as a positive selection marker. FEMS Microbiol Lett 126:1-6
43. Jakoby M, Ngouoto-Nkili CE, Burkovski A (1999) Construction and application of new Corynebacterium glutamicum vectors. Biotechnol Tech 13:437-441 (Pubitemid 29341830)
44. Jo SJ, Maeda M, Ooi T, Taguchi S (2006) Production system for biodegradable polyester polyhydroxybutyrate by Corynebacterium glutamicum. J Biosci Bioeng 102:233-236 (Pubitemid 44540407)
45. Jojima T, Fujii M, Mori E, Inui M, Yukawa H (2010) Engineering of sugar metabolism of Corynebacterium glutamicum for production of amino acid L-alanine under oxygen deprivation. Appl Microbiol Biotechnol 87:159-165
46. Jungwirth B, Emer D, Brune I, Hansmeier N, Pühler A, Eikmanns BJ, Tauch A (2008) Triple transcriptional control of the resuscitation promoting factor 2 (rpf2) gene of Corynebacterium glutamicum by the regulators of acetate metabolism RamA and RamB and the cAMP-dependent regulator GlxR. FEMS Microbiol Lett 281:190-197 (Pubitemid 351422944)
47. Kalinowski J, Bathe B, Bartels D, Bischoff N, Bott M, Burkovski A, Dusch N, Eggeling L, Eikmanns BJ, Gaigalat L, Goesmann A, Hartmann M, Huthmacher K, Krämer R, Linke B, McHardy AC, Meyer F, Möckel B, Pfefferle W, Pühler A, Rey DA, Rückert C, Rupp O, Sahm H, Wendisch VF, Wiegräbe I, Tauch A (2003) The complete Corynebacterium glutamicum ATCC 13032 genome sequence and its impact on the production of L-aspartate-derived amino acids and vitamins. J Biotechnol 104:5-25 (Pubitemid 37011345)
48. Kawaguchi H, Vertes AA, Okino S, Inui M, Yukawa H (2006) Engineering of a xylose metabolic pathway in Corynebacterium glutamicum. Appl Environ Microbiol 72:3418-3428 (Pubitemid 43740465)
49. Kawaguchi H, Sasaki M, Vertes AA, Inui M, Yukawa H (2008) Engineering of an L-arabinose metabolic pathway in Corynebacterium glutamicum. Appl Microbiol Biotechnol 77:1053-1062 (Pubitemid 350264444)
50. Kikuchi Y, Date M, Yokoyama K, Umezawa Y, Matsui H (2003) Secretion of active-form Streptoverticillium mobaraense transglutaminase by Corynebacterium glutamicum: processing of the pro-transglutaminase by a cosecreted subtilisin-like protease from Streptomyces albogriseolus. Appl Environ Microbiol 69:358-366 (Pubitemid 36077496)
51. Kikuchi Y, Itaya H, Date M, Matsui K, Wu LF (2008) Production of Chryseobacterium proteolyticum protein-glutaminase using the twin-arginine translocation pathway in Corynebacterium glutamicum. Appl Microbiol Biotechnol 78:67-74
52. Kikuchi Y, Itaya H, Date M, Matsui K, Wu LF (2009) TatABC overexpression improves Corynebacterium glutamicum Tat-dependent protein secretion. Appl Environ Microbiol 75:603-607
53. Kim IK, Jeong WK, Lim SH, Hwang IK, Kim YH (2010) The small ribosomal protein S12P gene rpsL as an efficient positive selection marker in allelic exchange mutation systems for Corynebacterium glutamicum. J Microbiol Methods 84:128-130
54. Kind S, Jeong WK, Schröder H, Wittmann C (2010) Systems-wide metabolic pathway engineering in Corynebacterium glutamicum for bio-based production of diaminopentane. Metab Eng 12:341-351
55. Kirchner O, Tauch A (2003) Tools for genetic engineering in the amino acid-producing bacterium Corynebacterium glutamicum. J Biotechnol 104:287-299 (Pubitemid 37011364)
56. Kjeldsen KR, Nielsen J (2009) In silico genome-scale reconstruction and validation of the Corynebacterium glutamicum metabolic network. Biotechnol Bioeng 102:583-597
57. Knoppová M, Phensaijai M, Veselý M, Zemanová M, Nešvera J, Pátek M (2007) Plasmid vectors for testing in vivo promoter activities in Corynebacterium glutamicum and Rhodococcus erythropolis. Curr Microbiol 55:234-239
58. Krause FS, Henrich A, Blombach B, Krämer R, Eikmanns BJ, Seibold GM (2010) Increased glucose utilization in Corynebacterium glutamicum by use of maltose, and its application for the improvement of L-valine productivity. Appl Environ Microbiol 76:370-374
59. Larisch C, Nakunst D, Hüser AT, Tauch A, Kalinowski J (2007) The alternative sigma factor SigB of Corynebacterium glutamicum modulates global gene expression during transition from exponential growth to stationary phase. BMC Genomics 8:4
60. Letek M, Valbuena N, Ramos A, Ordonez E, Gil JA, Mateos LM (2006) Characterization and use of catabolite-repressed promoters from gluconate genes in Corynebacterium glutamicum. J Bacteriol 188:409-423 (Pubitemid 43100528)
61. Li L, Wada M, Yokota A (2007) Cytoplasmic proteome reference map for a glutamic acid-producing Corynebacterium glutamicum ATCC 14067. Proteomics 7:4317-4322 (Pubitemid 350250476)
62. Liebl W, Sinskey AJ, Schleifer KH (1992) Expression, secretion, and processing of staphylococcal nuclease by Corynebacterium glutamicum. J Bacteriol 174:1854-1861
63. Liu Q, Ouyang SP, Kim J, Chen GQ (2007) The impact of PHB accumulation on L-glutamate production by recombinant Corynebacterium glutamicum. J Biotechnol 132:273-279 (Pubitemid 47632863)
64. Liu Q, Zhang J, Wei XX, Ouyang SP, Wu Q, Chen GQ (2008) Microbial production of L-glutamate and L-glutamine by recombinant Corynebacterium glutamicum harboring Vitreoscilla hemoglobin gene vgb. Appl Microbiol Biotechnol 77:1297-1304
65. Loos A, Glanemann C, Willis LB, O'Brien XM, Lessard PA, Gerstmeir R, Guillouet S, Sinskey AJ (2001) Development and validation of Corynebacterium DNA microarrays. Appl Environ Microbiol 67:2310-2318 (Pubitemid 33641422)
66. Mimitsuka T, Sawai H, Hatsu M, Yamada K (2007) Metabolic engineering of Corynebacterium glutamicum for cadaverine fermentation. Biosci Biotechnol Biochem 71:2130-2135 (Pubitemid 350113121)
67. Moreau S, Blanco C, Trautwetter A (1999) Site-specific integration of corynephage phi16: construction of an integration vector. Microbiology 145:539-548 (Pubitemid 29127033)
68. Muffler A, Bettermann S, Haushalter M, Horlein A, Neveling U, Schramm M, Sorgenfrei O (2002) Genome-wide transcription profiling of Corynebacterium glutamicum after heat shock and during growth on acetate and glucose. J Biotechnol 98:255-268 (Pubitemid 34874550)
69. Nakamura J, Kanno S, Kimura E, Matsui K, Nakamatsu T, Wachi M (2006) Temperature-sensitive cloning vector for Corynebacterium glutamicum. Plasmid 56:179-186 (Pubitemid 44649208)
70. Nakata K, Inui M, Kos PB, Vertes AA, Yukawa H (2004) Vectors for genetic engineering of corynebacteria. In: Saha BC (ed) Fermentation biotechnology.American Chemical Society, Washington, pp 175-191
71. Nakunst D, Larisch C, Hüser AT, Tauch A, Pühler A, Kalinowski J (2007) The extracytoplasmic function-type sigma factor SigM of Corynebacterium glutamicum ATCC 13032 is involved in transcription of disulfide stress-related genes. J Bacteriol 189:4696-4707 (Pubitemid 47025581)
72. Nešvera J, Pátek M (2008) Plasmids and promoters in corynebacteria and their applications. In: Burkovski A (ed) Corynebacteria. Genomics and molecular biology. Caister, Norfolk, pp 113-154
73. Neuner A, Heinzle E (2011) Mixed glucose and lactate uptake by Corynebacterium glutamicum through metabolic engineering. Biotechnol J 6:318-329
74. Ogino H, Teramoto H, Inui M, Yukawa H (2008) DivS, a novel SOS-inducible cell-division suppressor in Corynebacterium glutamicum. Mol Microbiol 67:597-608
75. Ohnishi J, Mitsuhashi S, Hayashi M, Ando S, Yokoi H, Ochiai K, Ikeda M (2002) A novel methodology employing Corynebacterium glutamicum genome information to generate a new L-lysine-producing mutant. Appl Microbiol Biotechnol 58:217-223 (Pubitemid 34118998)
76. Okibe N, Suzuki N, Inui M, Yukawa H (2009) Isolation, evaluation and use of two strong, carbon source-inducible promoters from Corynebacterium glutamicum. Lett Appl Microbiol 50:173-180
77. Okibe N, Suzuki N, Inui M, Yukawa H (2011) Efficient markerless gene replacement in Corynebacterium glutamicum using a new temperature-sensitive plasmid. J Microbiol Meth. doi:10.1016/j.mimet.2011.02.012
78. Oram M, Woolston JE, Jacobson AD, Holmes RK, Oram DM (2007) Bacteriophage-based vectors for site-specific insertion of DNA in the chromosome of corynebacteria. Gene 391:53-62 (Pubitemid 46356786)
79. Ozaki A, Katsumata R, Oka T, Furuya A (1984) Functional expression of the genes of Escherichia coli in gram-positive Corynebacterium glutamicum. Mol Gen Genet 196:175-178 (Pubitemid 14035806)
80. Park JU, Jo JH, Kim YJ, Chung SS, Lee JH, Lee HH (2008) Construction of heat-inducible expression vector of Corynebacterium glutamicum and C. ammoniagenes: fusion of lambda operator with promoters isolated from C. ammoniagenes. J Microbiol Biotechnol 18:639-647
81. Pátek M, Nešvera J (2011a) Promoters and plasmid vectors of Corynebacterium glutamicum. In: Yukawa H, Inui M (eds) Biology and biotechnology of Corynebacterium glutamicum. Springer (in press)
82. Pátek M, Nešvera J (2011b) Sigma factors and promoters in Corynebacterium glutamicum. J Biotechnol. doi:10.1016/j.jbiotec.2011.01.017
83. Pátek M, Eikmanns BJ, Pátek J, Sahm H (1996) Promoters from Corynebacterium glutamicum: cloning, molecular analysis and search for a consensus motif. Microbiology 142:1297-1309 (Pubitemid 26154941)
84. Pátek M, Nešvera J, Guyonvarch A, Reyes O, Leblon G (2003) Promoters of Corynebacterium glutamicum. J Biotechnol 104:311-323 (Pubitemid 37011366)
85. Peters-Wendisch PG, Schiel B, Wendisch VF, Katsoulidis E, Möckel B, Sahm H, Eikmanns BJ (2001) Pyruvate carboxylase is a major bottleneck for glutamate and lysine production by Corynebacterium glutamicum. J Mol Microbiol Biotechnol 3:295-300 (Pubitemid 32257916)
86. Pfefferle W, Möckel B, Bathe B, Marx A (2003) Biotechnological manufacture of lysine. Adv Biochem Eng Biotechnol 79:59-112
87. Radford AJ, Hodgson AL (1991) Construction and characterization of a Mycobacterium-Escherichia coli shuttle vector. Plasmid 25:149-153
88. Ramos A, Honrubia MP, Valbuena N, Vaquera J, Mateos LM, Gil JA (2003) Involvement of DivIVA in themorphology of the rod-shaped actinomycete Brevibacterium lactofermentum. Microbiology 149:3531-3542 (Pubitemid 38016680)
89. Rittmann D, Lindner SN, Wendisch VF (2008) Engineering of a glycerol utilization pathway for amino acid production by Corynebacterium glutamicum. Appl Environ Microbiol 74:6216-6222
90. Salim K, Haedens V, Content J, Leblon G, Huygen K (1997) Heterologous expression of the Mycobacterium tuberculosis gene encoding antigen 85A in Corynebacterium glutamicum. Appl Environ Microbiol 63:4392-4400 (Pubitemid 27485766)
91. Santamaría R, Gil JA, Mesas JM, Martín JF (1984) Characterization of endogenous plasmid and development of cloning vectors and a transformation system in Brevibacterium lactofementum. J Gen Microbiol 130:2237-2246
92. Sato H, Orishimo K, Shirai T, Hirasawa T, Nagahisa K, Shimizu H, Wachi M (2008) Distinct roles of two anaplerotic pathways in glutamate production induced by biotin limitation in Corynebacterium glutamicum. J Biosci Bioeng 106:51-58
93. Schäfer A, Tauch A, Jäger W, Kalinowski J, Thierbach G, Pühler A (1994) Small mobilizable multi-purpose cloning vectors derived from the Escherichia coli plasmids pK18 and pK19: selection of defined deletions in the chromosome of Corynebacterium glutamicum. Gene 145:69-73
94. Schneider J, Wendisch VF (2010) Putrescine production by engineered Corynebacterium glutamicum. Appl Microbiol Biotechnol 88:859-868
95. Schneider J, Niermann K, Wendisch VF (2011) Production of the amino acids L-glutamate, L-lysine, L-ornithine and L-arginine from arabinose by recombinant Corynebacterium glutamicum. J Biotechnol. doi:10.1016/j.jbiotec.2010.07.009
96. Schröder J, Tauch A (2010) Transcriptional regulation of gene expression in Corynebacterium glutamicum: the role of global, master and local regulators in the modular and hierarchical gene regulatory network. FEMS Microbiol Rev 34:685-737
97. Schröder J, Jochmann N, Rodionov DA, Tauch A (2010) The Zur regulon of Corynebacterium glutamicum ATCC 13032. BMC Genomics 11:12
98. Schweitzer JE, Stolz M, Diesveld R, Etterich H, Eggeling L (2009) The serine hydroxymethyltransferase gene glyA in Corynebacterium glutamicum is controlled by GlyR. J Biotechnol 139:214-221
99. Seibold G, Auchter M, Berens S, Kalinowski J, Eikmanns BJ (2006) Utilization of soluble starch by a recombinant Corynebacterium glutamicum strain: growth and lysine production. J Biotechnol 124:381-391
100. Silberbach M, Burkovski A (2006) Application of global analysis techniques to Corynebacterium glutamicum: new insights into nitrogen regulation. J Biotechnol 126:101-110 (Pubitemid 44402770)
101. Smith KM, Cho KM, Liao JC (2010) Engineering Corynebacterium glutamicum for isobutanol production. Appl Microbiol Biotechnol 87:1045-1055
102. Sonnen H, Thierbach G, Kautz S, Kalinowski J, Schneider J, Pühler A, Kutzner HJ (1991) Characterization of pGA1, a new plasmid from Corynebacterium glutamicum LP-6. Gene 107:69-74
103. Srivastava P, Deb JK (2002) Construction of fusion vectors of corynebacteria: expression of glutathione-S-transferase fusion protein in Corynebacterium acetoacidophilum ATCC 21476. FEMS Microbiol Lett 212:209-216 (Pubitemid 34756599)
104. Stäbler N, Oikawa T, Bott M, Eggeling L (2011) Corynebacterium glutamicum as a host for the synthesis and export of D-amino acids. J Bacteriol. doi:10.1128/JB.01295-10
105. Suzuki N, Nonaka H, Tsuge Y, Inui M, Yukawa H (2005a) New multiple-deletion method for the Corynebacterium glutamicum genome, using a mutant lox sequence. Appl Environ Microbiol 71:8472-8480 (Pubitemid 41803978)
106. Suzuki N, Nonaka H, Tsuge Y, Okayama S, Inui M, Yukawa H (2005b) Multiple large segment deletion method for Corynebacterium glutamicum. Appl Microbiol Biotechnol 69:151-161 (Pubitemid 41795088)
107. Suzuki N, Tsuge Y, Inui M, Yukawa H (2005c) Cre/loxP-mediated deletion system for large genome rearrangements in Corynebacterium glutamicum. Appl Microbiol Biotechnol 67:225-233 (Pubitemid 40591274)
108. Suzuki N, Okai N, Nonaka H, Tsuge Y, Inui M, Yukawa H (2006) High-throughput transposon mutagenesis of Corynebacterium glutamicum and construction of a single-gene disruptant mutant library. Appl Environ Microbiol 72:3750-3755 (Pubitemid 43728035)
109. Suzuki N, Watanabe K, Okibe N, Tsuchida Y, Inui M, Yukawa H (2009) Identification of new secreted proteins and secretion of heterologous amylase by C. glutamicum. Appl Microbiol Biotechnol 82:491-500
110. Tateno T, Fukuda H, Kondo A (2007a) Direct production of L-lysine from raw corn starch by Corynebacterium glutamicum secreting Streptococcus bovis alpha-amylase using cspB promoter and signal sequence. Appl Microbiol Biotechnol 77:533-541 (Pubitemid 350125507)
111. Tateno T, Fukuda H, Kondo A (2007b) Production of L-lysine from starch by Corynebacterium glutamicum displaying alpha-amylase on its cell surface. Appl Microbiol Biotechnol 74:1213-1220 (Pubitemid 46674061)
112. Tateno T, Hatada K, Tanaka T, Fukuda H, Kondo A (2009a) Development of novel cell surface display in Corynebacterium glutamicum using porin. Appl Microbiol Biotechnol 84:733-739
113. Tateno T, Okada Y, Tsuchidate T, Tanaka T, Fukuda H, Kondo A (2009b) Direct production of cadaverine from soluble starch using Corynebacterium glutamicum coexpressing alpha-amylase and lysine decarboxylase. Appl Microbiol Biotechnol 82:115-121
114. Tauch A (2005) Native plasmids of amino acid-producing corynebacteria. In: Eggeling L, Bott M (eds) Handbook of Corynebacterium glutamicum. CRC, Boca Raton, pp 57-80
115. Tauch A, Götker S, Pühler A, Kalinowski J, Thierbach G (2002) The alanine racemase gene alr is an alternative to antibiotic resistance genes in cloning systems for industrial Corynebacterium glutamicum strains. J Biotechnol 99:79-91 (Pubitemid 35223042)
116. Tauch A, Pühler A, Kalinowski J, Thierbach G (2003) Plasmids in Corynebacterium glutamicum and their molecular classification by comparative genomics. J Biotechnol 104:27-40 (Pubitemid 37011346)
117. Tsuchidate T, Tateno T, Okai N, Tanaka T, Ogino C, Kondo A (2011) Glutamate production from β-glucan using endoglucanase-secreting Corynebacterium glutamicum. Appl Microbiol Biotechnol. doi:10.1007/s00253-011- 3116-7
118. Tsuchiya M, Morinaga Y (1988) Genetic control systems of Escherichia coli can confer inducible expression of cloned genes in coryneform bacteria. Bio/Technology 6:428-430
119. Tsuge Y, Suzuki N, Inui M, Yukawa H (2007a) Random segment deletion based on IS31831 and Cre/loxP excision system in Corynebacterium glutamicum. Appl Microbiol Biotechnol 74:1333-1341 (Pubitemid 46674079)
120. Tsuge Y, Suzuki N, Ninomiya K, Inui M, Yukawa H (2007b) Isolation of a new insertion sequence, IS13655, and its application to Corynebacterium glutamicum genome mutagenesis. Biosci Biotechnol Biochem 71:1683-1690
121. Vašicová P, Abrhámová Z, Nešvera J, Pátek M, Sahm H, Eikmanns B (1998) Integrating and autonomously replicating vectors for analysis of promoters in Corynebacterium glutamicum. Biotechnol Tech 12:743-746 (Pubitemid 28542051)
122. Vašicová P, Pátek M, Nešvera J, Sahm H, Eikmanns B (1999) Analysis of the Corynebacterium glutamicum dapA promoter. J Bacteriol 181:6188-6191 (Pubitemid 29459934)
123. Vertes AA, Inui M, Kobayashi M, Kurusu Y, Yukawa H (1994) Isolation and characterization of IS31831, a transposable element from Corynebacterium glutamicum. Mol Microbiol 11:739-746 (Pubitemid 24197466)
124. Wendisch VF (2003) Genome-wide expression analysis in Corynebacterium glutamicum using DNA microarrays. J Biotechnol 104:273-285
125. Wendisch VF, Bott M, Kalinowski J, Oldiges M, Wiechert W (2006) Emerging Corynebacterium glutamicum systems biology. J Biotechnol 124:74-92 (Pubitemid 43898689)
126. Wittmann C, Heinzle E (2002) Genealogy profiling through strain improvement by using metabolic network analysis: metabolic flux genealogy of several generations of lysine-producing corynebacteria. Appl Environ Microbiol 68:5843-5859 (Pubitemid 36342415)
127. Woo HM, Noack S, Seibold GM, Willbold S, Eikmanns BJ, Bott M(2010) Link between phosphate starvation and glycogen metabolism in Corynebacterium glutamicum, revealed by metabolomics. Appl Environ Microbiol 76:6910-6919
128. Xu D, Tan Y, Huan X, Hu X, Wang X (2010) Construction of a novel shuttle vector for use in Brevibacterium flavum, an industrial amino acid producer. J Microbiol Methods 80:86-92
129. Yao W, Deng X, Liu M, Zheng P, Sun Z, Zhang Y (2009) Expression and localization of the Corynebacterium glutamicum NCgl1221 protein encoding an L-glutamic acid exporter. Microbiol Res 164:680-687
130. Yasuda K, Jojima T, Suda M, Okino S, Inui M, Yukawa H (2007) Analyses of the acetate-producing pathways in Corynebacterium glutamicum under oxygen-deprived conditions. Appl Microbiol Biotechnol 77:853-860 (Pubitemid 350159855)
131. Youn JW, Jolkver E, Krämer R, Marin K, Wendisch VF (2008) Identification and characterization of the dicarboxylate uptake system DccT in Corynebacterium glutamicum. J Bacteriol 190:6458-6466
132. Yukawa H, Omumasaba CA, Nonaka H, Kos P, Okai N, Suzuki N, Suda M, Tsuge Y, Watanabe J, Ikeda Y, Vertes AA, Inui M (2007) Comparative analysis of the Corynebacterium glutamicum group and complete genome sequence of strain R. Microbiology 153:1042-1058 (Pubitemid 46605802)