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Volumn 91, Issue 6, 2011, Pages 578-585

The emerging genetic landscape underlying cardiac conduction system function

Author keywords

Cardiac; Conduction; Development; GWAS; Heart; T box; Transcription factor

Indexed keywords

CD34 ANTIGEN; CYCLIN DEPENDENT KINASE INHIBITOR 1A; DICKKOPF 1 PROTEIN; INWARDLY RECTIFYING POTASSIUM CHANNEL SUBUNIT KIR2.1; ION CHANNEL; POTASSIUM CHANNEL KCNQ1; PROTEIN P53; SODIUM CHANNEL NAV1.5; SODIUM CHANNEL NAV1.8; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR NKX2.5; TRANSCRIPTION FACTOR SOX5; TRANSCRIPTION FACTOR TBX3; TRANSCRIPTION FACTOR TBX5; UNCLASSIFIED DRUG; WNT11 PROTEIN; WNT7A PROTEIN;

EID: 79958147805     PISSN: 15420752     EISSN: 15420760     Source Type: Journal    
DOI: 10.1002/bdra.20800     Document Type: Review
Times cited : (15)

References (87)
  • 1
    • 77149153380 scopus 로고    scopus 로고
    • Multiple independent genetic factors at NOS1AP modulate the QT interval in a multi-ethnic population
    • Arking DE, Khera A, Xing C, et al. 2009. Multiple independent genetic factors at NOS1AP modulate the QT interval in a multi-ethnic population. PLoS One 4: e4333.
    • (2009) PLoS One , vol.4
    • Arking, D.E.1    Khera, A.2    Xing, C.3
  • 2
    • 33745237158 scopus 로고    scopus 로고
    • A common genetic variant in the NOS1 regulator NOS1AP modulates cardiac repolarization
    • Arking DE, Pfeufer A, Post W, et al. 2006. A common genetic variant in the NOS1 regulator NOS1AP modulates cardiac repolarization. Nat Genet 38: 644-651.
    • (2006) Nat Genet , vol.38 , pp. 644-651
    • Arking, D.E.1    Pfeufer, A.2    Post, W.3
  • 3
    • 44949102430 scopus 로고    scopus 로고
    • Transcription factor Tbx3 is required for the specification of the atrioventricular conduction system
    • Bakker ML, Boukens BJ, Mommersteeg MT, et al. 2008. Transcription factor Tbx3 is required for the specification of the atrioventricular conduction system. Circ Res 102: 1340-1349.
    • (2008) Circ Res , vol.102 , pp. 1340-1349
    • Bakker, M.L.1    Boukens, B.J.2    Mommersteeg, M.T.3
  • 4
    • 0030986873 scopus 로고    scopus 로고
    • Mutations in human TBX3 alter limb, apocrine and genital development in ulnar-mammary syndrome
    • Bamshad M, Lin RC, Law DJ, et al. 1997. Mutations in human TBX3 alter limb, apocrine and genital development in ulnar-mammary syndrome. Nat Genet 16: 311-315.
    • (1997) Nat Genet , vol.16 , pp. 311-315
    • Bamshad, M.1    Lin, R.C.2    Law, D.J.3
  • 5
    • 69249230852 scopus 로고    scopus 로고
    • Dysfunction of ouabain-induced cardiac contractility in mice with heart-specific ablation of na,K-ATPase beta1-subunit
    • Barwe SP, Jordan MC, Skay A, et al. 2009. Dysfunction of ouabain-induced cardiac contractility in mice with heart-specific ablation of na, K-ATPase beta1-subunit. J Mol Cell Cardiol 47: 552-60.
    • (2009) J Mol Cell Cardiol , vol.47 , pp. 552-560
    • Barwe, S.P.1    Jordan, M.C.2    Skay, A.3
  • 6
    • 0030636780 scopus 로고    scopus 로고
    • Mutations in human TBX5 [corrected] cause limb and cardiac malformation in Holt-Oram syndrome
    • Basson CT, Bachinsky DR, Lin RC, et al. 1997. Mutations in human TBX5 [corrected] cause limb and cardiac malformation in Holt-Oram syndrome. Nat Genet 15: 30-35.
    • (1997) Nat Genet , vol.15 , pp. 30-35
    • Basson, C.T.1    Bachinsky, D.R.2    Lin, R.C.3
  • 7
    • 0028281469 scopus 로고
    • The clinical and genetic spectrum of the Holt-Oram syndrome (heart-hand syndrome)
    • Basson CT, Cowley GS, Solomon SD, et al. 1994. The clinical and genetic spectrum of the Holt-Oram syndrome (heart-hand syndrome). N Engl J Med 330: 885-891.
    • (1994) N Engl J Med , vol.330 , pp. 885-891
    • Basson, C.T.1    Cowley, G.S.2    Solomon, S.D.3
  • 8
    • 68149165772 scopus 로고    scopus 로고
    • Variants in ZFHX3 are associated with atrial fibrillation in individuals of European ancestry
    • Benjamin EJ, Rice KM, Arking DE, et al. 2009. Variants in ZFHX3 are associated with atrial fibrillation in individuals of European ancestry. Nat Genet 41: 879-881.
    • (2009) Nat Genet , vol.41 , pp. 879-881
    • Benjamin, E.J.1    Rice, K.M.2    Arking, D.E.3
  • 9
    • 0042635693 scopus 로고    scopus 로고
    • Wnt11 and Wnt7a are up-regulated in association with differentiation of cardiac conduction cells in vitro and in vivo
    • Bond J, Sedmera D, Jourdan J, et al. 2003. Wnt11 and Wnt7a are up-regulated in association with differentiation of cardiac conduction cells in vitro and in vivo. Dev Dyn 227: 536-543.
    • (2003) Dev Dyn , vol.227 , pp. 536-543
    • Bond, J.1    Sedmera, D.2    Jourdan, J.3
  • 10
    • 53249096015 scopus 로고    scopus 로고
    • Perinatal loss of Nkx2-5 results in rapid conduction and contraction defects
    • Briggs LE, Takeda M, Cuadra AE, et al. 2008. Perinatal loss of Nkx2-5 results in rapid conduction and contraction defects. Circ Res 103: 580-590.
    • (2008) Circ Res , vol.103 , pp. 580-590
    • Briggs, L.E.1    Takeda, M.2    Cuadra, A.E.3
  • 11
    • 17944378083 scopus 로고    scopus 로고
    • A murine model of Holt-Oram syndrome defines roles of the T-box transcription factor Tbx5 in cardiogenesis and disease
    • Bruneau BG, Nemer G, Schmitt JP, et al. 2001. A murine model of Holt-Oram syndrome defines roles of the T-box transcription factor Tbx5 in cardiogenesis and disease. Cell 106: 709-721.
    • (2001) Cell , vol.106 , pp. 709-721
    • Bruneau, B.G.1    Nemer, G.2    Schmitt, J.P.3
  • 12
    • 21044454606 scopus 로고    scopus 로고
    • T-box genes coordinate regional rates of proliferation and regional specification during cardiogenesis
    • Cai CL, Zhou W, Yang L, et al. 2005. T-box genes coordinate regional rates of proliferation and regional specification during cardiogenesis. Development 132: 2475-2487.
    • (2005) Development , vol.132 , pp. 2475-2487
    • Cai, C.L.1    Zhou, W.2    Yang, L.3
  • 13
    • 21844463045 scopus 로고    scopus 로고
    • Alpha-myosin heavy chain: a sarcomeric gene associated with dilated and hypertrophic phenotypes of cardiomyopathy
    • Carniel E, Taylor MR, Sinagra G, et al. 2005. Alpha-myosin heavy chain: a sarcomeric gene associated with dilated and hypertrophic phenotypes of cardiomyopathy. Circulation 112: 54-59.
    • (2005) Circulation , vol.112 , pp. 54-59
    • Carniel, E.1    Taylor, M.R.2    Sinagra, G.3
  • 14
    • 75749102498 scopus 로고    scopus 로고
    • Genetic variation in SCN10A influences cardiac conduction
    • Chambers JC, Zhao J, Terracciano CM, et al. 2010. Genetic variation in SCN10A influences cardiac conduction. Nat Genet 42: 149-152.
    • (2010) Nat Genet , vol.42 , pp. 149-152
    • Chambers, J.C.1    Zhao, J.2    Terracciano, C.M.3
  • 15
    • 67649218781 scopus 로고    scopus 로고
    • Long-term outcomes in individuals with prolonged PR interval or first-degree atrioventricular block
    • Cheng S, Keyes MJ, Larson MG, et al. 2009. Long-term outcomes in individuals with prolonged PR interval or first-degree atrioventricular block. JAMA 301: 2571-2577.
    • (2009) JAMA , vol.301 , pp. 2571-2577
    • Cheng, S.1    Keyes, M.J.2    Larson, M.G.3
  • 16
    • 20144387341 scopus 로고    scopus 로고
    • Mutation in myosin heavy chain 6 causes atrial septal defect
    • Ching YH, Ghosh TK, Cross SJ, et al. 2005. Mutation in myosin heavy chain 6 causes atrial septal defect. Nat Genet 37: 423-428.
    • (2005) Nat Genet , vol.37 , pp. 423-428
    • Ching, Y.H.1    Ghosh, T.K.2    Cross, S.J.3
  • 17
    • 67349188883 scopus 로고    scopus 로고
    • A large-scale genome-wide association study of Asian populations uncovers genetic factors influencing eight quantitative traits
    • Cho YS, Go MJ, Kim YJ, et al. 2009. A large-scale genome-wide association study of Asian populations uncovers genetic factors influencing eight quantitative traits. Nat Genet 41: 527-534.
    • (2009) Nat Genet , vol.41 , pp. 527-534
    • Cho, Y.S.1    Go, M.J.2    Kim, Y.J.3
  • 18
    • 0037286898 scopus 로고    scopus 로고
    • Comparison of connexin expression patterns in the developing mouse heart and human foetal heart
    • Coppen SR, Kaba RA, Halliday D, et al. 2003. Comparison of connexin expression patterns in the developing mouse heart and human foetal heart. Mol Cell Biochem 242: 121-127.
    • (2003) Mol Cell Biochem , vol.242 , pp. 121-127
    • Coppen, S.R.1    Kaba, R.A.2    Halliday, D.3
  • 19
    • 1242317690 scopus 로고    scopus 로고
    • Heart rate-corrected QT interval prolongation predicts risk of coronary heart disease in black and white middle-aged men and women: the ARIC study
    • Dekker JM, Crow RS, Hannan PJ, et al. 2004. Heart rate-corrected QT interval prolongation predicts risk of coronary heart disease in black and white middle-aged men and women: the ARIC study. J Am Coll Cardiol 43: 565-571.
    • (2004) J Am Coll Cardiol , vol.43 , pp. 565-571
    • Dekker, J.M.1    Crow, R.S.2    Hannan, P.J.3
  • 20
    • 0027989760 scopus 로고
    • Association between QT interval and coronary heart disease in middle-aged and elderly men. The Zutphen Study
    • Dekker JM, Schouten EG, Klootwijk P, et al. 1994. Association between QT interval and coronary heart disease in middle-aged and elderly men. The Zutphen Study. Circulation 90: 779-785.
    • (1994) Circulation , vol.90 , pp. 779-785
    • Dekker, J.M.1    Schouten, E.G.2    Klootwijk, P.3
  • 21
    • 78549244038 scopus 로고    scopus 로고
    • Identification of genomic predictors of atrioventricular conduction: using electronic medical records as a tool for genome science
    • Denny JC, Ritchie MD, Crawford DC, et al. 2010. Identification of genomic predictors of atrioventricular conduction: using electronic medical records as a tool for genome science. Circulation 122: 2016-2021
    • (2010) Circulation , vol.122 , pp. 2016-2021
    • Denny, J.C.1    Ritchie, M.D.2    Crawford, D.C.3
  • 22
    • 33745892610 scopus 로고    scopus 로고
    • Prognostic significance of quantitative QRS duration
    • Desai AD, Yaw TS, Yamazaki T, et al. 2006. Prognostic significance of quantitative QRS duration. Am J Med 119: 600-606.
    • (2006) Am J Med , vol.119 , pp. 600-606
    • Desai, A.D.1    Yaw, T.S.2    Yamazaki, T.3
  • 23
    • 33646123080 scopus 로고    scopus 로고
    • Electrocardiographic QRS duration and the risk of congestive heart failure: the Framingham Heart Study
    • Dhingra R, Pencina MJ, Wang TJ, et al. 2006. Electrocardiographic QRS duration and the risk of congestive heart failure: the Framingham Heart Study. Hypertension 47: 861-867.
    • (2006) Hypertension , vol.47 , pp. 861-867
    • Dhingra, R.1    Pencina, M.J.2    Wang, T.J.3
  • 24
    • 3543043744 scopus 로고    scopus 로고
    • Analysis of primitive CD34- and CD34+ hematopoietic cells from adults: gain and loss of CD34 antigen by undifferentiated cells are closely linked to proliferative status in culture
    • Dooley DC, Oppenlander BK, Xiao M. 2004. Analysis of primitive CD34- and CD34+ hematopoietic cells from adults: gain and loss of CD34 antigen by undifferentiated cells are closely linked to proliferative status in culture. Stem Cells 22: 556-569.
    • (2004) Stem Cells , vol.22 , pp. 556-569
    • Dooley, D.C.1    Oppenlander, B.K.2    Xiao, M.3
  • 26
    • 26244446925 scopus 로고    scopus 로고
    • Relation of QRS duration on the surface 12-lead electrocardiogram with mortality in patients with known or suspected coronary artery disease
    • Elhendy A, Hammill SC, Mahoney DW, Pellikka PA. 2005. Relation of QRS duration on the surface 12-lead electrocardiogram with mortality in patients with known or suspected coronary artery disease. Am J Cardiol 96: 1082-1088.
    • (2005) Am J Cardiol , vol.96 , pp. 1082-1088
    • Elhendy, A.1    Hammill, S.C.2    Mahoney, D.W.3    Pellikka, P.A.4
  • 27
    • 77951226494 scopus 로고    scopus 로고
    • Mesodermal Wnt signaling organizes the neural plate via Meis3
    • Elkouby YM, Elias S, Casey ES, et al. 2010. Mesodermal Wnt signaling organizes the neural plate via Meis3. Development 137: 1531-1541.
    • (2010) Development , vol.137 , pp. 1531-1541
    • Elkouby, Y.M.1    Elias, S.2    Casey, E.S.3
  • 28
    • 77649191092 scopus 로고    scopus 로고
    • Common variants in KCNN3 are associated with lone atrial fibrillation
    • Ellinor PT, Lunetta KL, Glazer NL, et al. 2010. Common variants in KCNN3 are associated with lone atrial fibrillation. Nat Genet 42: 240-244.
    • (2010) Nat Genet , vol.42 , pp. 240-244
    • Ellinor, P.T.1    Lunetta, K.L.2    Glazer, N.L.3
  • 29
    • 0032170470 scopus 로고    scopus 로고
    • The prognostic value of the QT interval and QT interval dispersion in all-cause and cardiac mortality and morbidity in a population of Danish citizens
    • Elming H, Holm E, Jun L, et al. 1998. The prognostic value of the QT interval and QT interval dispersion in all-cause and cardiac mortality and morbidity in a population of Danish citizens. Eur Heart J 19: 1391-1400.
    • (1998) Eur Heart J , vol.19 , pp. 1391-1400
    • Elming, H.1    Holm, E.2    Jun, L.3
  • 30
    • 0032052025 scopus 로고    scopus 로고
    • Patterns of expression in the developing myocardium: towards a morphologically integrated transcriptional model
    • Franco D, Lamers WH, Moorman AF. 1998. Patterns of expression in the developing myocardium: towards a morphologically integrated transcriptional model. Cardiovasc Res 38: 25-53.
    • (1998) Cardiovasc Res , vol.38 , pp. 25-53
    • Franco, D.1    Lamers, W.H.2    Moorman, A.F.3
  • 31
    • 34447515621 scopus 로고    scopus 로고
    • Variants conferring risk of atrial fibrillation on chromosome 4q25
    • Gudbjartsson DF, Arnar DO, Helgadottir A, et al. 2007. Variants conferring risk of atrial fibrillation on chromosome 4q25. Nature 448: 353-357.
    • (2007) Nature , vol.448 , pp. 353-357
    • Gudbjartsson, D.F.1    Arnar, D.O.2    Helgadottir, A.3
  • 32
    • 0035895649 scopus 로고    scopus 로고
    • Conduction slowing and sudden arrhythmic death in mice with cardiac-restricted inactivation of connexin43
    • Gutstein DE, Morley GE, Tamaddon H, et al. 2001. Conduction slowing and sudden arrhythmic death in mice with cardiac-restricted inactivation of connexin43. Circ Res 88: 333-339.
    • (2001) Circ Res , vol.88 , pp. 333-339
    • Gutstein, D.E.1    Morley, G.E.2    Tamaddon, H.3
  • 33
    • 0024502214 scopus 로고
    • Genetic factors in the electrocardiogram and heart rate of twins reared apart and together
    • Hanson B, Tuna N, Bouchard T, et al. 1989. Genetic factors in the electrocardiogram and heart rate of twins reared apart and together. Am J Cardiol 63: 606-609.
    • (1989) Am J Cardiol , vol.63 , pp. 606-609
    • Hanson, B.1    Tuna, N.2    Bouchard, T.3
  • 34
    • 33644973530 scopus 로고    scopus 로고
    • Differentiation of cardiac Purkinje fibers requires precise spatiotemporal regulation of Nkx2-5 expression
    • Harris BS, Spruill L, Edmonson AM, et al. 2006. Differentiation of cardiac Purkinje fibers requires precise spatiotemporal regulation of Nkx2-5 expression. Dev Dyn 235: 38-49.
    • (2006) Dev Dyn , vol.235 , pp. 38-49
    • Harris, B.S.1    Spruill, L.2    Edmonson, A.M.3
  • 35
    • 70349876494 scopus 로고    scopus 로고
    • Specification of the cardiac conduction system by transcription factors
    • Hatcher CJ, Basson CT. 2009. Specification of the cardiac conduction system by transcription factors. Circ Res 105: 620-630.
    • (2009) Circ Res , vol.105 , pp. 620-630
    • Hatcher, C.J.1    Basson, C.T.2
  • 36
    • 0018913049 scopus 로고
    • Variability of heart rate, P-R, QRS and Q-T durations in twins
    • Havlik RJ, Garrison RJ, Fabsitz R, et al. 1980. Variability of heart rate, P-R, QRS and Q-T durations in twins. J Electrocardiol 13: 45-48.
    • (1980) J Electrocardiol , vol.13 , pp. 45-48
    • Havlik, R.J.1    Garrison, R.J.2    Fabsitz, R.3
  • 37
    • 70449435450 scopus 로고    scopus 로고
    • The genetic basis of long QT and short QT syndromes: a mutation update
    • Hedley PL, Jøorgensen P, Schlamowitz S, et al. 2009. The genetic basis of long QT and short QT syndromes: a mutation update. Hum Mutat 30: 1486-1511.
    • (2009) Hum Mutat , vol.30 , pp. 1486-1511
    • Hedley, P.L.1    Jøorgensen, P.2    Schlamowitz, S.3
  • 38
    • 0037076795 scopus 로고    scopus 로고
    • Small amounts of alpha-myosin heavy chain isoform expression significantly increase power output of rat cardiac myocyte fragments
    • Herron TJ, McDonald KS. 2002. Small amounts of alpha-myosin heavy chain isoform expression significantly increase power output of rat cardiac myocyte fragments. Circ Res 90: 1150-1152.
    • (2002) Circ Res , vol.90 , pp. 1150-1152
    • Herron, T.J.1    McDonald, K.S.2
  • 39
    • 75749122164 scopus 로고    scopus 로고
    • Several common variants modulate heart rate, PR interval and QRS duration
    • Holm H, Gudbjartsson DF, Arnar DO, et al. 2010. Several common variants modulate heart rate, PR interval and QRS duration. Nat Genet 42: 117-122.
    • (2010) Nat Genet , vol.42 , pp. 117-122
    • Holm, H.1    Gudbjartsson, D.F.2    Arnar, D.O.3
  • 40
    • 0032997363 scopus 로고    scopus 로고
    • Identification of a specific role for the na,K-ATPase alpha 2 isoform as a regulator of calcium in the heart
    • James PF, Grupp IL, Grupp G, et al. 1999. Identification of a specific role for the na, K-ATPase alpha 2 isoform as a regulator of calcium in the heart. Mol Cell 3: 555-563.
    • (1999) Mol Cell , vol.3 , pp. 555-563
    • James, P.F.1    Grupp, I.L.2    Grupp, G.3
  • 41
    • 11144355678 scopus 로고    scopus 로고
    • Nkx2-5 mutation causes anatomic hypoplasia of the cardiac conduction system
    • Jay PY, Harris BS, Maguire CT, et al. 2004. Nkx2-5 mutation causes anatomic hypoplasia of the cardiac conduction system. J Clin Invest 113: 1130-1137.
    • (2004) J Clin Invest , vol.113 , pp. 1130-1137
    • Jay, P.Y.1    Harris, B.S.2    Maguire, C.T.3
  • 42
    • 18344367496 scopus 로고    scopus 로고
    • Heart-rate profile during exercise as a predictor of sudden death
    • Jouven X, Empana JP, Schwartz PJ, et al. 2005. Heart-rate profile during exercise as a predictor of sudden death. N Engl J Med 352: 1951-1958.
    • (2005) N Engl J Med , vol.352 , pp. 1951-1958
    • Jouven, X.1    Empana, J.P.2    Schwartz, P.J.3
  • 43
    • 0030871638 scopus 로고    scopus 로고
    • QT interval as a cardiac risk factor in a middle aged population
    • Karjalainen J, Reunanen A, Ristola P, Viitasalo M. 1997. QT interval as a cardiac risk factor in a middle aged population. Heart 77: 543-548.
    • (1997) Heart , vol.77 , pp. 543-548
    • Karjalainen, J.1    Reunanen, A.2    Ristola, P.3    Viitasalo, M.4
  • 44
    • 1442280664 scopus 로고    scopus 로고
    • Identification and characterization of ARHGAP24 and ARHGAP25 genes in silico
    • Katoh M, Katoh M. 2004. Identification and characterization of ARHGAP24 and ARHGAP25 genes in silico. Int J Mol Med 14: 333-338.
    • (2004) Int J Mol Med , vol.14 , pp. 333-338
    • Katoh, M.1    Katoh, M.2
  • 45
    • 34547738523 scopus 로고    scopus 로고
    • Mutations in cardiac T-box factor gene TBX20 are associated with diverse cardiac pathologies, including defects of septation and valvulogenesis and cardiomyopathy
    • Kirk EP, Sunde M, Costa MW, et al. 2007. Mutations in cardiac T-box factor gene TBX20 are associated with diverse cardiac pathologies, including defects of septation and valvulogenesis and cardiomyopathy. Am J Hum Genet 81: 280-291.
    • (2007) Am J Hum Genet , vol.81 , pp. 280-291
    • Kirk, E.P.1    Sunde, M.2    Costa, M.W.3
  • 46
    • 67349085745 scopus 로고    scopus 로고
    • Developmental signaling in myocardial progenitor cells: a comprehensive view of Bmp- and Wnt/beta-catenin signaling
    • Klaus A, Birchmeier W. 2009. Developmental signaling in myocardial progenitor cells: a comprehensive view of Bmp- and Wnt/beta-catenin signaling. Pediatr Cardiol 30: 609-616.
    • (2009) Pediatr Cardiol , vol.30 , pp. 609-616
    • Klaus, A.1    Birchmeier, W.2
  • 47
    • 0023764031 scopus 로고
    • Molecular cloning and characterization of human cardiac alpha- and beta-form myosin heavy chain complementary DNA clones. Regulation of expression during development and pressure overload in human atrium
    • Kurabayashi M, Tsuchimochi H, Komuro I, et al. 1988. Molecular cloning and characterization of human cardiac alpha- and beta-form myosin heavy chain complementary DNA clones. Regulation of expression during development and pressure overload in human atrium. J Clin Invest 82: 524-531.
    • (1988) J Clin Invest , vol.82 , pp. 524-531
    • Kurabayashi, M.1    Tsuchimochi, H.2    Komuro, I.3
  • 48
    • 64949123001 scopus 로고    scopus 로고
    • Familial aggregation and heritability of electrocardiographic intervals and heart rate in a rural Chinese population
    • Li J, Huo Y, Zhang Y, et al. 2009. Familial aggregation and heritability of electrocardiographic intervals and heart rate in a rural Chinese population. Ann Noninvasive Electrocardiol 14: 147-152.
    • (2009) Ann Noninvasive Electrocardiol , vol.14 , pp. 147-152
    • Li, J.1    Huo, Y.2    Zhang, Y.3
  • 49
    • 1842413728 scopus 로고    scopus 로고
    • Holt-Oram syndrome is caused by mutations in TBX5, a member of the Brachyury (T) gene family
    • Li QY, Newbury-Ecob RA, Terrett JA, et al. 1997. Holt-Oram syndrome is caused by mutations in TBX5, a member of the Brachyury (T) gene family. Nat Genet 15: 21-29.
    • (1997) Nat Genet , vol.15 , pp. 21-29
    • Li, Q.Y.1    Newbury-Ecob, R.A.2    Terrett, J.A.3
  • 50
    • 71949119476 scopus 로고    scopus 로고
    • Ulnar mammary syndrome and TBX3: expanding the phenotype
    • Linden H, Williams R, King J, et al. 2009. Ulnar mammary syndrome and TBX3: expanding the phenotype. Am J Med Genet A 149A: 2809-2812.
    • (2009) Am J Med Genet A , vol.149 A , pp. 2809-2812
    • Linden, H.1    Williams, R.2    King, J.3
  • 51
    • 0021153417 scopus 로고
    • Expression of the cardiac ventricular alpha- and beta-myosin heavy chain genes is developmentally and hormonally regulated
    • Lompré AM, Nadal-Ginard B, Mahdavi V. 1984. Expression of the cardiac ventricular alpha- and beta-myosin heavy chain genes is developmentally and hormonally regulated. J Biol Chem 259: 6437-6446.
    • (1984) J Biol Chem , vol.259 , pp. 6437-6446
    • Lompré, A.M.1    Nadal-Ginard, B.2    Mahdavi, V.3
  • 52
    • 0038464639 scopus 로고    scopus 로고
    • Phospholamban: a crucial regulator of cardiac contractility
    • MacLennan DH, Kranias EG. 2003. Phospholamban: a crucial regulator of cardiac contractility. Nat Rev Mol Cell Biol 4: 566-577.
    • (2003) Nat Rev Mol Cell Biol , vol.4 , pp. 566-577
    • MacLennan, D.H.1    Kranias, E.G.2
  • 53
    • 13444310919 scopus 로고    scopus 로고
    • The Hand1 and Hand2 transcription factors regulate expansion of the embryonic cardiac ventricles in a gene dosage-dependent manner
    • McFadden DG, Barbosa AC, Richardson JA, et al. 2005. The Hand1 and Hand2 transcription factors regulate expansion of the embryonic cardiac ventricles in a gene dosage-dependent manner. Development 132: 189-201.
    • (2005) Development , vol.132 , pp. 189-201
    • McFadden, D.G.1    Barbosa, A.C.2    Richardson, J.A.3
  • 54
    • 33847656148 scopus 로고    scopus 로고
    • Nkx2.5 cell-autonomous gene function is required for the postnatal formation of the peripheral ventricular conduction system
    • Meysen S, Marger L, Hewett KW, et al. 2007. Nkx2.5 cell-autonomous gene function is required for the postnatal formation of the peripheral ventricular conduction system. Dev Biol 303: 740-753.
    • (2007) Dev Biol , vol.303 , pp. 740-753
    • Meysen, S.1    Marger, L.2    Hewett, K.W.3
  • 55
    • 4544277159 scopus 로고    scopus 로고
    • The T-Box transcription factor Tbx5 is required for the patterning and maturation of the murine cardiac conduction system
    • Moskowitz IP, Pizard A, Patel VV, et al. 2004. The T-Box transcription factor Tbx5 is required for the patterning and maturation of the murine cardiac conduction system. Development 131: 4107-4116.
    • (2004) Development , vol.131 , pp. 4107-4116
    • Moskowitz, I.P.1    Pizard, A.2    Patel, V.V.3
  • 56
    • 34250754981 scopus 로고    scopus 로고
    • A molecular pathway including Id2, Tbx5, and Nkx2-5 required for cardiac conduction system development
    • Moskowitz IP, Kim JB, Moore ML, et al. 2007. A molecular pathway including Id2, Tbx5, and Nkx2-5 required for cardiac conduction system development. Cell 129: 1365-1376.
    • (2007) Cell , vol.129 , pp. 1365-1376
    • Moskowitz, I.P.1    Kim, J.B.2    Moore, M.L.3
  • 57
    • 69049085659 scopus 로고    scopus 로고
    • Cx30.2 enhancer analysis identifies Gata4 as a novel regulator of atrioventricular delay
    • Munshi NV, McAnally J, Bezprozvannaya S, et al. 2009. Cx30.2 enhancer analysis identifies Gata4 as a novel regulator of atrioventricular delay. Development 136: 2665-2674.
    • (2009) Development , vol.136 , pp. 2665-2674
    • Munshi, N.V.1    McAnally, J.2    Bezprozvannaya, S.3
  • 58
    • 58449127797 scopus 로고    scopus 로고
    • Genetic influences on resting electrocardiographic variables in older women: a twin study
    • Mutikainen S, Ortega-Alonso A, Alén M, et al. 2009. Genetic influences on resting electrocardiographic variables in older women: a twin study. Ann Noninvasive Electrocardiol 14: 57-64.
    • (2009) Ann Noninvasive Electrocardiol , vol.14 , pp. 57-64
    • Mutikainen, S.1    Ortega-Alonso, A.2    Alén, M.3
  • 59
    • 63449136073 scopus 로고    scopus 로고
    • Common variants at ten loci influence QT interval duration in the QTGEN Study
    • Newton-Cheh C, Eijgelsheim M, Rice KM, et al. 2009. Common variants at ten loci influence QT interval duration in the QTGEN Study. Nat Genet 41: 399-406.
    • (2009) Nat Genet , vol.41 , pp. 399-406
    • Newton-Cheh, C.1    Eijgelsheim, M.2    Rice, K.M.3
  • 60
    • 35748985581 scopus 로고    scopus 로고
    • Genome-wide association study of electrocardiographic and heart rate variability traits: the Framingham Heart Study
    • Newton-Cheh C, Guo CY, Wang TJ, et al. 2007. Genome-wide association study of electrocardiographic and heart rate variability traits: the Framingham Heart Study. BMC Med Genet 8 Suppl 1: S7.
    • (2007) BMC Med Genet 8 Suppl , vol.1
    • Newton-Cheh, C.1    Guo, C.Y.2    Wang, T.J.3
  • 61
    • 14644439232 scopus 로고    scopus 로고
    • QT interval is a heritable quantitative trait with evidence of linkage to chromosome 3 in a genome-wide linkage analysis: The Framingham Heart Study
    • Newton-Cheh C, Larson MG, Corey DC, et al. 2005. QT interval is a heritable quantitative trait with evidence of linkage to chromosome 3 in a genome-wide linkage analysis: The Framingham Heart Study. Heart Rhythm 2: 277-284.
    • (2005) Heart Rhythm , vol.2 , pp. 277-284
    • Newton-Cheh, C.1    Larson, M.G.2    Corey, D.C.3
  • 62
    • 2342561242 scopus 로고    scopus 로고
    • QRS duration and QT interval predict mortality in hypertensive patients with left ventricular hypertrophy: the Losartan Intervention for Endpoint Reduction in Hypertension Study
    • Oikarinen L, Nieminen MS, Viitasalo M, et al. 2004. QRS duration and QT interval predict mortality in hypertensive patients with left ventricular hypertrophy: the Losartan Intervention for Endpoint Reduction in Hypertension Study. Hypertension 43: 1029-1034.
    • (2004) Hypertension , vol.43 , pp. 1029-1034
    • Oikarinen, L.1    Nieminen, M.S.2    Viitasalo, M.3
  • 63
    • 0034602837 scopus 로고    scopus 로고
    • Assessment of QT interval and QT dispersion for prediction of all-cause and cardiovascular mortality in American Indians: The Strong Heart Study
    • Okin PM, Devereux RB, Howard BV, et al. 2000. Assessment of QT interval and QT dispersion for prediction of all-cause and cardiovascular mortality in American Indians: The Strong Heart Study. Circulation 101: 61-66.
    • (2000) Circulation , vol.101 , pp. 61-66
    • Okin, P.M.1    Devereux, R.B.2    Howard, B.V.3
  • 64
    • 12344330346 scopus 로고    scopus 로고
    • Elevated heart rate: a major risk factor for cardiovascular disease
    • Palatini P, Julius S. 2004. Elevated heart rate: a major risk factor for cardiovascular disease. Clin Exp Hypertens 26: 637-644.
    • (2004) Clin Exp Hypertens , vol.26 , pp. 637-644
    • Palatini, P.1    Julius, S.2
  • 65
    • 77955659695 scopus 로고    scopus 로고
    • Wnt11 patterns a myocardial electrical gradient through regulation of the L-type Ca(2+) channel
    • Panáaková D, Werdich AA, Macrae CA. 2010. Wnt11 patterns a myocardial electrical gradient through regulation of the L-type Ca(2+) channel. Nature 466: 874-878.
    • (2010) Nature , vol.466 , pp. 874-878
    • Panáaková, D.1    Werdich, A.A.2    Macrae, C.A.3
  • 66
    • 0037043688 scopus 로고    scopus 로고
    • Wnt-11 activation of a non-canonical Wnt signalling pathway is required for cardiogenesis
    • Pandur P, Läasche M, Eisenberg LM, Kü M. 2002. Wnt-11 activation of a non-canonical Wnt signalling pathway is required for cardiogenesis. Nature 418: 636-641.
    • (2002) Nature , vol.418 , pp. 636-641
    • Pandur, P.1    Läasche, M.2    Eisenberg, L.M.3    Kü, M.4
  • 67
    • 73949108682 scopus 로고    scopus 로고
    • Short QT syndrome: a review
    • Patel U, Pavri BB. 2009. Short QT syndrome: a review. Cardiol Rev 17: 300-303.
    • (2009) Cardiol Rev , vol.17 , pp. 300-303
    • Patel, U.1    Pavri, B.B.2
  • 68
    • 33846925067 scopus 로고    scopus 로고
    • Crim1KST264/KST264 mice display a disruption of the Crim1 gene resulting in perinatal lethality with defects in multiple organ systems
    • Pennisi DJ, Wilkinson L, Kolle G, et al. 2007. Crim1KST264/KST264 mice display a disruption of the Crim1 gene resulting in perinatal lethality with defects in multiple organ systems. Dev Dyn 236: 502-511.
    • (2007) Dev Dyn , vol.236 , pp. 502-511
    • Pennisi, D.J.1    Wilkinson, L.2    Kolle, G.3
  • 69
    • 63449109595 scopus 로고    scopus 로고
    • Common variants at ten loci modulate the QT interval duration in the QTSCD Study
    • Pfeufer A, Sanna S, Arking DE, et al. 2009. Common variants at ten loci modulate the QT interval duration in the QTSCD Study. Nat Genet 41: 407-414.
    • (2009) Nat Genet , vol.41 , pp. 407-414
    • Pfeufer, A.1    Sanna, S.2    Arking, D.E.3
  • 70
    • 75749097235 scopus 로고    scopus 로고
    • Genome-wide association study of PR interval
    • Pfeufer A, van Noord C, Marciante KD, et al. 2010. Genome-wide association study of PR interval. Nat Genet 42: 153-159.
    • (2010) Nat Genet , vol.42 , pp. 153-159
    • Pfeufer, A.1    van Noord, C.2    Marciante, K.D.3
  • 71
    • 0031740691 scopus 로고    scopus 로고
    • A tetrodotoxin-resistant voltage-gated sodium channel from human dorsal root ganglia, hPN3/SCN10A
    • Rabert DK, Koch BD, Ilnicka M, et al. 1998. A tetrodotoxin-resistant voltage-gated sodium channel from human dorsal root ganglia, hPN3/SCN10A. Pain 78: 107-114.
    • (1998) Pain , vol.78 , pp. 107-114
    • Rabert, D.K.1    Koch, B.D.2    Ilnicka, M.3
  • 72
    • 43049105408 scopus 로고    scopus 로고
    • A loss-of-function mutation in the binding domain of HAND1 predicts hypoplasia of the human hearts
    • Reamon-Buettner SM, Ciribilli Y, Inga A, Borlak J. 2008. A loss-of-function mutation in the binding domain of HAND1 predicts hypoplasia of the human hearts. Hum Mol Genet 17: 1397-1405.
    • (2008) Hum Mol Genet , vol.17 , pp. 1397-1405
    • Reamon-Buettner, S.M.1    Ciribilli, Y.2    Inga, A.3    Borlak, J.4
  • 73
    • 70350757745 scopus 로고    scopus 로고
    • A functional genetic study identifies HAND1 mutations in septation defects of the human heart
    • Reamon-Buettner SM, Ciribilli Y, Traverso I, et al. 2009. A functional genetic study identifies HAND1 mutations in septation defects of the human heart. Hum Mol Genet 18: 3567-3578.
    • (2009) Hum Mol Genet , vol.18 , pp. 3567-3578
    • Reamon-Buettner, S.M.1    Ciribilli, Y.2    Traverso, I.3
  • 74
    • 67649547603 scopus 로고    scopus 로고
    • Sodium channel mutations and arrhythmias
    • Ruan Y, Liu N, Priori SG. 2009. Sodium channel mutations and arrhythmias. Nat Rev Cardiol 6: 337-348.
    • (2009) Nat Rev Cardiol , vol.6 , pp. 337-348
    • Ruan, Y.1    Liu, N.2    Priori, S.G.3
  • 75
  • 76
    • 0037470512 scopus 로고    scopus 로고
    • Dilated cardiomyopathy and heart failure caused by a mutation in phospholamban
    • Schmitt JP, Kamisago M, Asahi M, et al. 2003. Dilated cardiomyopathy and heart failure caused by a mutation in phospholamban. Science 299: 1410-1413.
    • (2003) Science , vol.299 , pp. 1410-1413
    • Schmitt, J.P.1    Kamisago, M.2    Asahi, M.3
  • 77
    • 0032479573 scopus 로고    scopus 로고
    • Congenital heart disease caused by mutations in the transcription factor NKX2-5
    • Schott JJ, Benson DW, Basson CT, et al. 1998. Congenital heart disease caused by mutations in the transcription factor NKX2-5. Science 281: 108-111.
    • (1998) Science , vol.281 , pp. 108-111
    • Schott, J.J.1    Benson, D.W.2    Basson, C.T.3
  • 78
    • 0025990396 scopus 로고
    • QT interval prolongation predicts cardiovascular mortality in an apparently healthy population
    • Schouten EG, Dekker JM, Meppelink P, et al. 1991. QT interval prolongation predicts cardiovascular mortality in an apparently healthy population. Circulation 84: 1516-1523.
    • (1991) Circulation , vol.84 , pp. 1516-1523
    • Schouten, E.G.1    Dekker, J.M.2    Meppelink, P.3
  • 79
    • 70449367296 scopus 로고    scopus 로고
    • Prevalence of the congenital long-QT syndrome
    • Schwartz PJ, Stramba-Badiale M, Crotti L, et al. 2009. Prevalence of the congenital long-QT syndrome. Circulation 120: 1761-1767.
    • (2009) Circulation , vol.120 , pp. 1761-1767
    • Schwartz, P.J.1    Stramba-Badiale, M.2    Crotti, L.3
  • 80
    • 0031594226 scopus 로고    scopus 로고
    • Prolonged QTc interval, impaired pulmonary function, and a very lean body mass jointly predict all-cause mortality in elderly men
    • Sharp DS, Masaki K, Burchfiel CM, et al. 1998. Prolonged QTc interval, impaired pulmonary function, and a very lean body mass jointly predict all-cause mortality in elderly men. Ann Epidemiol 8: 99-106.
    • (1998) Ann Epidemiol , vol.8 , pp. 99-106
    • Sharp, D.S.1    Masaki, K.2    Burchfiel, C.M.3
  • 81
    • 0032933769 scopus 로고    scopus 로고
    • Heritability of heart rate variability: the Framingham Heart Study
    • Singh JP, Larson MG, O'Donnell CJ, et al. 1999. Heritability of heart rate variability: the Framingham Heart Study. Circulation 99: 2251-2254.
    • (1999) Circulation , vol.99 , pp. 2251-2254
    • Singh, J.P.1    Larson, M.G.2    O'Donnell, C.J.3
  • 82
    • 84947899543 scopus 로고    scopus 로고
    • Common variants in 22 loci are associated with QRS duration and cardiac ventricular conduction
    • Sotoodehnia N, Isaacs A, de Bakker PI, et al. 2010. Common variants in 22 loci are associated with QRS duration and cardiac ventricular conduction. Nat Genet 42: 1068-1076.
    • (2010) Nat Genet , vol.42 , pp. 1068-1076
    • Sotoodehnia, N.1    Isaacs, A.2    de Bakker, P.I.3
  • 83
    • 36549017966 scopus 로고    scopus 로고
    • Abnormal conduction and morphology in the atrioventricular node of mice with atrioventricular canal targeted deletion of Alk3/Bmpr1a receptor
    • Stroud DM, Gaussin V, Burch JB, et al. 2007. Abnormal conduction and morphology in the atrioventricular node of mice with atrioventricular canal targeted deletion of Alk3/Bmpr1a receptor. Circulation 116: 2535-2543.
    • (2007) Circulation , vol.116 , pp. 2535-2543
    • Stroud, D.M.1    Gaussin, V.2    Burch, J.B.3
  • 84
    • 69349086498 scopus 로고    scopus 로고
    • Slow progressive conduction and contraction defects in loss of Nkx2-5 mice after cardiomyocyte terminal differentiation
    • Takeda M, Briggs LE, Wakimoto H, et al. 2009. Slow progressive conduction and contraction defects in loss of Nkx2-5 mice after cardiomyocyte terminal differentiation. Lab Invest 89: 983-993.
    • (2009) Lab Invest , vol.89 , pp. 983-993
    • Takeda, M.1    Briggs, L.E.2    Wakimoto, H.3
  • 85
    • 34047098378 scopus 로고    scopus 로고
    • Role of bone morphogenetic proteins in cardiac differentiation
    • van Wijk B, Moorman AF, van den Hoff MJ. 2007. Role of bone morphogenetic proteins in cardiac differentiation. Cardiovasc Res 74: 244-255.
    • (2007) Cardiovasc Res , vol.74 , pp. 244-255
    • van Wijk, B.1    Moorman, A.F.2    van den Hoff, M.J.3
  • 86
    • 0141668933 scopus 로고    scopus 로고
    • CRIM1 regulates the rate of processing and delivery of bone morphogenetic proteins to the cell surface
    • Wilkinson L, Kolle G, Wen D, et al. 2003. CRIM1 regulates the rate of processing and delivery of bone morphogenetic proteins to the cell surface. J Biol Chem 278: 34181-34188.
    • (2003) J Biol Chem , vol.278 , pp. 34181-34188
    • Wilkinson, L.1    Kolle, G.2    Wen, D.3
  • 87
    • 0037143769 scopus 로고    scopus 로고
    • Defects in caveolin-1 cause dilated cardiomyopathy and pulmonary hypertension in knockout mice
    • Zhao YY, Liu Y, Stan RV, et al. 2002. Defects in caveolin-1 cause dilated cardiomyopathy and pulmonary hypertension in knockout mice. Proc Natl Acad Sci U S A 99: 11375-11380.
    • (2002) Proc Natl Acad Sci U S A , vol.99 , pp. 11375-11380
    • Zhao, Y.Y.1    Liu, Y.2    Stan, R.V.3


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