Short QT syndrome a review

Cardiology in Review

Volumn 17, Issue 6, 2009, Pages 300-303

  Patel, Umang ^a   Pavri, Behzad B ^a  

^a THOMAS JEFFERSON UNIVERSITY HOSPITAL   (United States)

Author keywords

Ion channels; Short QT syndrome; Sudden cardiac death; Ventricular fibrillation

Indexed keywords

AMIODARONE; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; DIHYDROQUINIDINE; DISOPYRAMIDE; FLECAINIDE; IBUTILIDE; NIFEKALANT; POTASSIUM CHANNEL; PROPAFENONE; QUINIDINE; SOTALOL;

CLINICAL FEATURE; DEFIBRILLATOR; DRUG MECHANISM; ECG ABNORMALITY; ELECTROSTIMULATION; GENE MUTATION; HEART ARRHYTHMIA; HEART ATRIUM FIBRILLATION; HEART ELECTROPHYSIOLOGY; HEART VENTRICLE TACHYCARDIA; HUMAN; MOLECULAR GENETICS; PATHOPHYSIOLOGY; POLYMORPHIC VENTRICULAR TACHYCARDIA; QT PROLONGATION; REVIEW; SHORT QT INTERVAL; SHORT QT SYNDROME; ST SEGMENT; SUDDEN DEATH; T WAVE; UNSPECIFIED SIDE EFFECT; ELECTROCARDIOGRAPHY; GENETICS; LONG QT SYNDROME; PHYSIOLOGY; TIME;

ARRHYTHMIAS, CARDIAC; ELECTROCARDIOGRAPHY; HUMANS; LONG QT SYNDROME; POTASSIUM CHANNELS; TIME FACTORS;

EID: 73949108682     PISSN: 10615377     EISSN: None     Source Type: Journal    
DOI: 10.1097/CRD.0b013e3181c07592     Document Type: Review

References (37)

1. Liberthson RR. Sudden death from cardiac causes in children and young adults. N Engl J Med. 1996;334:1039-1044.
2. Morentin B, Suárez-Mier MP, Aguilera B. Sudden unexplained death among persons 1-35 years old. Forensic Sci Int. 2003;135:213-217.
3. Algra A, Tijssen JG, Roelandt JR, et al. QT interval variables from 24 hour electrocardiography and the two year risk of sudden death. Br Heart J. 1993;70:43-48.
4. Gussak I, Liebl N, Nouri S, et al. Deceleration-dependent shortening of the QT interval: a new electrocardiographic phenomenon? Clin Cardiol. 1999; 22:124-126.
5. Gussak I, Brugada P, Brugada J, et al. Idiopathic short QT interval: a new clinical syndrome? Cardiology. 2000;94:99-102.
6. Gaita F, Giustetto C, Bianchi F, et al. Short QT Syndrome: a familial cause of sudden death. Circulation. 2003;108:965-970.
7. Brugada R, Hong K, Dumaine R, et al. Sudden death associated with short-QT syndrome linked to mutations in HERG. Circulation. 2004;109:30-35.
8. Extramiana F, Antzelevitch C. Amplified transmural dispersion of repolarization as the basis for arrhythmogenesis in a canine ventricular-wedge model of short-QT syndrome. Circulation. 2004;110:3661-3666.
9. Schimpf R, Wolpert C, Gaita F, et al. Short QT syndrome. Cardiovasc Res. 2005;67:357-366.
10. Bellocq C, van Ginneken AC, Bezzina CR, et al. Mutation in the KCNQ1 gene leading to the short QT-interval syndrome. Circulation. 2004;109:2394-2397.
11. Hong K, Piper DR, Diaz-Valdecantos A, et al. De novo KCNQ1 mutation responsible for atrial fibrillation and short QT syndrome in utero. Cardiovasc Res. 2005;68:433-440. (Pubitemid 41566563)
12. Priori SG, Pandit SV, Rivolta I, et al. A novel form of short QT syndrome (SQT3) is caused by a mutation in the KCNJ2 gene. Circ Res. 2005;96:800-807.
13. Antzelevitch C, Pollevick GD, Cordeiro JM, et al. Loss-of-function mutations in the cardiac calcium channel underlie a new clinical entity characterized by ST-segment elevation, short QT intervals, and sudden cardiac death. Circulation. 2007;115:442-449.
14. Brugada R, Hong K, Cordeiro JM, et al. Short QT syndrome. CMAJ. 2005;173:1349-1354.
15. Giustetto C, Di Monte F, Wolpert C, et al. Short QT syndrome: clinical findings and diagnostic-therapeutic implications. Eur Heart J. 2006;27: 2440-2447.
16. Morphet JA. The short QT syndrome and sudden infant death syndrome. Can J Cardiol. 2007;23:105-108.
17. Pérez Riera AR, Ferreira C, Dubner SJ, et al. Brief review of the recently described short QT syndrome and other cardiac channelopathies. Ann Noninvasive Electrocardiol. 2005;10:371-377.
18. Schimpf R, Wolpert C, Gaita F, et al. Short QT syndrome. Cardiovasc Res. 2005;67:357-366.
19. Gallagher M, Magliano G, Yap Y, et al. Distribution and prognostic significance of QT intervals in the lowest half centile in 12,012 apparently healthy persons. Am J Cardiol. 2006;98:933-935.
20. Reinig MG, Engel TR. The shortage of short QT intervals. Chest. 2007;132: 246-1240
21. Anttonen O, Junttila MJ, Rissanen H, et al. Prevalence and prognostic significance of short QT interval an a middle-aged Finnish population. Circulation. 2007;116:714-720.
22. Moriya M, Seto S, Yano K, et al. Two cases of short QT interval. Pacing Clin Electrophysiol. 2007;30:1522-1526.
23. Rautaharju PM, Zhou SH, Wong S, et al. Sex differences in the evolution of the electrocardiographic QT interval with age. Can J Cardiol. 1992;8:690-695.
24. Viskin S, Zeltser D, Ish-Shalom M, et al. Is idiopathic ventricular fibrillation a short QT syndrome? Comparison of QT intervals of patients with idiopathic ventricular fibrillation and healthy controls. Heart Rhythm. 2004;1:587-591.
25. Bjerregaard P, Gussak I. Short QT Syndrome: mechanisms, diagnosis and treatment. Nat Clin Pract Cardiovasc Med. 2005;2:84-87.
26. Borggrefe M, Wolpert C, Antzelevitch C, et al. Short QT syndrome. Genotype- phenotype correlations. J Electrocardiol. 2005;38(suppl 4):75-80.
27. Schimpf R, Antzelevitch C, Haghi D, et al. Electromechanical coupling in patients with the short QT syndrome: further insights into the mechanoelectrical hypothesis of the U wave. Heart Rhythm. 2008;5:241-245.
28. Bjerregaard P, Collier JL, Gussak I. Upper Limit of QT/QTc Intervals in the Short QT Syndrome. Review of the world-wide short QT syndrome population and 3 new USA families. Heart Rhythm. 2008;5(5S):S91.
29. Cheng TO. Digitalis administration: an underappreciated but common cause of short QT interval. Circulation. 2004;109:e152.
30. Shah RR. Drug-induced QT interval shortening: potential harbinger of proarrhythmia and regulatory perspectives. Br J Pharmacol. In press.
31. Hong K, Bjerregaard P, Gussak I, et al. Short QT syndrome and atrial fibrillation caused by mutation in KCNH2. J Cardiovasc Electrophysiol. 2005;16:394-396.
32. Schimpf R, Wolpert C, Bianchi F, et al. Congenital short QT syndrome and implantable cardioverter defibrillator treatment: inherent risk for inappropriate shock delivery. J Cardiovasc Electrophysiol. 2003;14:1273-1277.
33. Gaita F, Giustetto C, Bianchi F, et al. Short QT syndrome: pharmacological treatment. J Am Coll Cardiol. 2004;43:1494-1499.
34. Wolpert C, Schimpf R, Giustetto C, et al. Further insights into the effect of quinidine in short QT syndrome caused by a mutation in HERG. J Cardiovasc Electrophysiol. 2005;16:54-58.
35. Schimpf R, Veltmann C, Giustetto C, et al. In vivo effects of mutant HERG K+ channel inhibition by disopyramide in patients with a short QT-1 syndrome: a pilot study. J Cardiovasc Electrophysiol. 2007;18:1157-1160.
36. Mizobuchi M, Enjoji Y, Yamamoto R, et al. Nifekalant and disopyramide in a patient with short QT syndrome: evaluation of pharmacological effects and electrophysiological properties. Pacing Clin Electrophysiol. 2008;31:1229-1232.
37. Lu LX, Zhou W, Zhang X, et al. Short QT syndrome: a case report and review of literature. Resuscitation. 2006;71:115-121.