Red alert for womens heart: The urgent need for more research and knowledge on cardiovascular disease in women

European Heart Journal

Volumn 32, Issue 11, 2011, Pages

  Maas, Angela H E M ^a   Van Der Schouw, Yvonne T ^b   Regitz Zagrosek, Vera ^c   Swahn, Eva ^d   Appelman, Yolande E ^e   Pasterkamp, Gerard ^b   Ten Cate, Hugo ^f   Nilsson, Peter M ^g   Huisman, Menno V ^h   Stam, Hans C G ⁱ   Eizema, Karin ⁱ   Stramba Badiale, Marco ^j  

^a Isala Klinieken ^*  (Netherlands)

^b UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^c Cardiovascular Research Center Berlin   (Germany)

^d LINKÖPING UNIVERSITY   (Sweden)

^e VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^f MAASTRICHT UNIVERSITY   (Netherlands)

^g LUND UNIVERSITY HOSPITAL   (Sweden)

^h LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

ⁱ Netherlands Heart Foundation   (Netherlands)

^j ISTITUTO AUXOLOGICO ITALIANO   (Italy)

more..

Author keywords

Atherosclerosis; Gender; Hormones; Risk factors; Women

Indexed keywords

CLOPIDOGREL; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN CHOLESTEROL; PRASUGREL;

ACUTE CORONARY SYNDROME; AGED; ATHEROSCLEROSIS; CARDIOVASCULAR DISEASE; CARDIOVASCULAR RISK; CLINICAL TRIAL; FEMALE; GENDER BIAS; HEART FAILURE; HUMAN; HYPERTENSION; ISCHEMIC HEART DISEASE; LIFESTYLE MODIFICATION; MALE; MEDICAL RESEARCH; MORTALITY; NEEDS ASSESSMENT; OUTCOME ASSESSMENT; OVARY POLYCYSTIC DISEASE; PATHOPHYSIOLOGY; PREVENTIVE HEALTH SERVICE; PRIORITY JOURNAL; PSYCHOSOCIAL CARE; REVIEW; SEX DIFFERENCE; STROKE; THROMBOSIS; VASCULAR DISEASE; WORKSHOP; EUROPE; HEALTH PROMOTION; HEART MUSCLE ISCHEMIA; MENTAL STRESS; RISK FACTOR;

ACUTE CORONARY SYNDROME; AGED; AGED, 80 AND OVER; CARDIOVASCULAR DISEASES; EUROPE; FEMALE; HEALTH PROMOTION; HEART FAILURE; HUMANS; MALE; MYOCARDIAL ISCHEMIA; RISK FACTORS; SEX FACTORS; STRESS, PSYCHOLOGICAL; STROKE;

EID: 79958109870     PISSN: 0195668X     EISSN: 15229645     Source Type: Journal    
DOI: 10.1093/eurheartj/ehr048     Document Type: Review

References (134)

1. Atella V, Brady A, Catapano AL, Critchley J, Graham IM, Hobbs FD, Leal J, Lindgren P, Vanuzzo D, Volpe M, Wood D, Paoletti R. Bridging science and health policy in cardiovascular disease: focus on lipid management. Atherosclerosis 2009;10(suppl):3-21.
2. Healy B. The Yentl syndrome. N Engl J Med 1991;325:274-276.
3. www.GBD-report-2004update-full.pdf.
4. Towfighi A, Zheng L, Ovbiagele B. Sex-specific trends in midlife coronary heart disease risk and prevalence. Arch Intern Med 2009;169:1762-1766.
5. Kotseva K, Wood D, De Backer G, De Bacquer D, Pyörälä K, Keil U, for the EUROASPIRE Study Group. Cardiovascular prevention guidelines in daily practice: a comparison of EUROASPIRE I,II, and III surveys in eight European countries. Lancet 2009;373:929-940.
6. Stramba-Badiale M. Women and research on cardiovascular diseases in Europe: a report from the European Heart Health Strategy (EuroHeart) project. Eur Heart J 2010;31:1677-1681.
7. Mosca L, Banka CL, Benjamin EJ, Berra K, Bushnell C, Dolor RJ, Ganiats TG, Gomes AS, Gornik HL, Gracia C, Gulati M, Haan CK, Judelson DR, Keenan N, Kelepouris E, Michos ED, Newby LK, Oparil S, Ouyang P, Oz MC, Petitti D, Pinn VW, Redberg RF, Scott R, Sherif K, Smith SC Jr, Sopko G, Steinhorn RH, Stone NJ, Taubert KA, Todd BA, Urbina E, Wenger NK; Expert Panel/Writing Group; American Heart Association; American Academy of Family Physicians; American College of Obstetricians and Gynecologists; American College of Cardiology Foundation; Society of Thoracic Surgeons; American Medical Women's Association; Centers for Disease Control and Prevention; Office of Research on Women's Health; Association of Black Cardiologists; American College of Physicians;World Heart Federation; National Heart, Lung, and Blood Institute; American College of Nurse Practitioners. Evidencebased guidelines for cardiovascular disease prevention in women: 2007 update. Circulation 2007;115:1481-1501. (Pubitemid 46648385)
8. Melloni C, Berger JS, Wang TY, Gunes F, Stebbins A, Pieper KS, Dolor RJ, Douglas PS, Mark DB, Newby LK. Representation of women in randomized clinical trials of cardiovascular disease prevention. Circ Cardiovasc Qual Outcomes 2010;3:135-142.
9. Regitz-Zagrosek V. Therapeutic implications of the gender-specific aspects of cardiovascular disease. Nat Rev Drug Discov 2006;5:425-439. (Pubitemid 43904934)
10. Kim AM, Tingen CM, Woodruff TK. Sex bias in trials and treatment must end. Nature 2010;465:688-689.
11. Kleijn de MJ, Schouw van der YT, Verbeek AL, Peeters PH, Banga JD, Graaf van der Y. Endogenous estrogen exposure and cardiovascular mortality risk in postmenopausal women. Am J Epidemiol 2002;155:339-345. (Pubitemid 34132052)
12. Hu FB, Grodstein F, Hennekens CH, Colditz GA, Johnson M, Manson JE, Rosner B, Stampfer MJ. Age at natural menopause and risk of cardiovascular disease. Arch Intern Med 1999;159:1061-1066. (Pubitemid 29230857)
13. Ossewaarde ME, Bots ML, Verbeek AL, Peeters PH, van der Graaf Y, Grobbee DE, van der Schouw YT. Age at menopause, cause-specific mortality and total life expectancy. Epidemiology 2005;16:556-562. (Pubitemid 40847843)
14. Avalos I, Rho YH, Chung CP, Stein CM. Atherosclerosis in rheumatoid arthritis and systemic lupus erythematosus. Clin Exp Rheumatol 2008;26(5 Suppl 51): S5-S13.
15. Burke AP, Farb A, Malcolm G, Virmani R. Effect of menopause on plaque morphologic characteristics in coronary atherosclerosis. Am Heart J 2001;141: S58-S62. (Pubitemid 32128720)
16. Frink RJ. Gender gap, inflammation and acute coronary disease: are women resistant to atheroma growth? Observations at autopsy. J Invasive Cardiol 2009; 21:270-277.
17. Shaw LJ, Bugiardini R, Bairey Merz CN. Women and ischemic heart disease. Evolving knowledge. J Am Coll Cardiol 2009;54:1561-1575.
18. Burke AP, Farb A, Malcolm GT, Liang Y, Smialek J, Virmani R. Effect of risk factors on the mechanism of acute thrombosis an sudden coronary death in women. Circulation 1998;97:2110-2126.
19. Bugiardini R, Bairey Merz CN. Angina with 'normal' coronary arteries: a changing philosophy. JAMA 2005;293:477-484.
20. Buchthal SD, den Hollander JA, Merz CN, Rogers WJ, Pepine CJ, Reichek N, Sharaf BL, Reis S, Kelsey SF, Pohost GM. Abnormal myocardial phosphorus-31 nuclear magnetic resonance spectroscopy in women with chest pain but normal coronary angiograms. N Engl J Med 2000;342:829-835. (Pubitemid 30165205)
21. Johnson BD, Shaw LJ, Buchthal SD, Bairey Merz CN, Kim HW, Scott KN, Doyle M, Olson MB, Pepine CJ, den Hollander J, Sharaf B, Rogers WJ, Mankad S, Forder JR, Kelsey SF, Pohost GM; National Institutes of Health- National Heart, Lung, and Blood Institute. Prognosis in women with myocardial ischemia in the absence of obstructive coronary disease: results from the National Institutes of Health- national Heart, Lung and Blood Institutesponsored Women's Ischemia Syndrome Evaluation WISE). Circulation 2004; 109:2993-2999. (Pubitemid 38808322)
22. Camici PG, Crea F. Coronary microvascular dysfunction. N Engl J Med 2007;356: 830-840.
23. Hellings WE, Pasterkamp G, Verhoeven BAN, de Kleijn DPV, de Vries JPPM, Seldenrijk KA, van den Broek T, Moll FL. Gender-associated differences in plaque phenotype of patients undergoing carotid endarteriectomy. J Vasc Surg 2007;45:289-297.
24. Hellings WE, Peeters W, Moll FL, Piers RD, van Setten J, Van der Spek PJ, de Vries JPPM, Seldenrijk KA, de Bruin PC, Vink A, Velema E, de Kleijn DP, Pasterkamp G. Composition of carotid atherosclerotic plaque is associated with cardiovascular outcome. A prognostic study. Circulation 2010;121: 1941-1950.
25. Anand SS, Islam S, Rosengren A, Franzosi MG, Steyn K, Yusufali AH, Keltai M, Diaz R, Rangarajan S, Yusuf S; INTERHEART Investigators. Risk factors for myocardial infarction in women and men: insights from the INTERHEART study. Eur Heart J 2008;29:932-940. (Pubitemid 351499478)
26. Tan YY, Gast GCM, van der Schouw YT. Gender differences in risk factors for coronary heart disease. Maturitas 2010;65:149-160.
27. Cooney MT, Dudina AL, Graham IA. Value and limitations of existing scores for the assessment of cardiovascular risk. J Am Coll Cardiol 2009;54:1209-1227.
28. Prescott E, Hippe M, Schnohr P, Hein HO, Vestbo J. Smoking and risk of myocardial infarction in women and men: longitudinal population study. BMJ 1998; 316:1043-1047. (Pubitemid 28143100)
29. Burt VL, Whelton P, Roccella EJ, Brown C, Cutler JA, Higgins M, Horan MJ, Labarthe D. Prevalence of hypertension in the US adult population. Results from the Third National Health and Nutrition Examination Survey, 1988- .1991. Hypertension 1995;25:305-313.
30. Staessen JA, van der Heijden-Spek JJ, Safar ME, Den Hond E, Gasowski J, Fagard RH, Wang JG, Struijker Boudier HA, van Bortel LM. Menopause and the characteristics of the large arteries in a population study. J Hum Hypertens 2001;15:511-518. (Pubitemid 32780641)
31. Coylewright M, Reckelhoff JF, Ouyang P. Menopause and hypertension. An age-old debate. Hypertension 2008;51:952-959.
32. Vasan RS, Larson MG, Leip EP, Evans JC, O'Donnell CJ, Kannel WB, Levy D. Impact of high-normal blood pressure on the risk of cardiovascular disease. N Engl J Med 2001;345:1291-1297.
33. Huxley R, Barzi F, Woodward M. Excess risk of fatal coronary heart disease associated with diabetes in men and women: meta-analysis of 37 prospective cohort studies. BMJ 2006;332:73-78.
34. Preis SR, Hwang SJ, Coady S, Pencina MJ, D'Agostino RB, Savage PJ, Levy D, Fox CS. Trends in all-cause and cardiovascular disease mortality among women and men with and without diabetes mellitus in the Framingham Heart Study, 1950-2005. Circulation 2009;119:1728-1735.
35. Aboyans V, Lacroix P, Criqui MH. Large and small vessels atherosclerosis: similarities and differences. Prog Cardiovasc Dis 2007;50:112-125. (Pubitemid 47336945)
36. De Simone G, Devereux RB, Chinali M, Lee ET, Galloway JM, Barac A, Panza JA, Howard BV. Diabetes and incident heart failure in hypertensive and normotensive participants of the Strong Heart Study. J Hypertens 2010;28:353-360.
37. Horwich TB, Fonarow GC. Glucose, obesity, metabolic syndrome and diabetes. Relevance to incidence of heart failure. J Am Coll Cardiol 2010;55:283-293.
38. Abbey M, Owen A, Suzakawa M, Roach P, Nestel PJ. Effects of menopause and hormone replacement therapy on plasma lipids, lipoproteins and LDL-receptor activity. Maturitas 1999;33:259-269.
39. Kannel WB, Castelli WP, Gordon T, McNamar PM. Serum cholesterol, lipoproteins, and the risk of coronary heart disease. The Framingham Study. Ann Intern Med 1971;74:1-12.
40. Regitz-Zagrosek V, Lehmkuhl E, Mahmoodzadeh S. Gender aspects of the role of the metabolic syndrome as a risk factor for cardiovascular disease. Gend Med 2007;4(suppl):S162-S177.
41. Wong ND, Pio J, Valencia R, Thakal G. Distribution of C-reactive protein and its relation to risk factors and coronary heart disease risk estimation in the National Health and Nutrition Examination Survey (NHANES) III. Prev Cardiol 2001;4: 109-114. (Pubitemid 32613801)
42. Johnson BD, Dwyer KM, Stanczyk FZ, Bitner V, Berga SL, Braunstein GD, Azziz R, Yang Y, Hale GE, Bairey Merz CN. The relationship of menopausal status and rapid menopausal transition with carotid intima-media thickness progression in women: a report from the Los Angeles atherosclerosis study. J Clin Endocrinol Metab 2010;95:4432-4440.
43. Mendelsohn ME, Karas RH. The protective effects of estrogen on the cardiovascular system. N Engl J Med 1999;340:1801-1811. (Pubitemid 29266405)
44. Stampfer MJ, Colditz GA. Estrogen replacement therapy and coronary heart disease: a quantitative assessment of the epidemiologic evidence. Prev Med 1991;20:47-63.
45. Hulley S, Grady D, Bush T, Furberg C, Herrington DM, Riggs B, Vittinghoff E. The Heart and Estrogen/progestin Replacement Study (HERS) research group. Randomized trial of estrogen plus progestin for secondary prevention of coronary heart disease in postmenopausal women. JAMA 1998;280:605-613. (Pubitemid 28502636)
46. Writing group for theWomen's Health Initiative Investigators. Risks and benefits of estrogen plus progestin in healthy postmenopausal women. Principal results from the Women's Health Initiative randomized controlled trial. JAMA 2002; 288:321-333.
47. Manson JE, Hsia J, Johnson KC, Rossouw JE, Assaf AR, Lasser NL, Trevisan M, Black HR, Heckbert SR, Detrano R, Strickland OL, Wong ND, Crouse JR, Stein E, Cushman M. Women's Health Initiative investigators. Estrogen plus progestin and the risk of coronary heart disease. N Engl J Med 2003;349:523-534. (Pubitemid 36951364)
48. Mikkola TS, Clarkson TB. Estrogen replacement therapy, atherosclerosis and vascular function. Cardiovasc Res 2002;53:605-619. (Pubitemid 34175253)
49. Herrington DM, Espeland MA, Crouse JR III, Robertson J, Riley WA, McBurnie MA, Burke GL. Estrogen replacement and brachial artery flowmediated vasodilatation in older women. Arterioscler Thromb Vasc Biol 2001;21: 1955-1961. (Pubitemid 34219747)
50. Kok HS, van Asselt KM, van der Schouw YT, van der Tweel I, Peeters PH, Wilson PW, Pearson PL, Grobbee DE. Heart disease risk determines menopausal age rather than the reverse. J Am Coll Cardiol 2006;47:1976-1984.
51. Matthews KA, Crawford SL, Chae CU, Everson-Rose SA, Sowers MF, Sternfeld B, Sutton-Tyrrell K. Are changes in cardiovascular disease risk factors in midlife women due to chronological aging or due to the menopausal transitioni J Am Coll Cardiol 2009;54:2366-2373.
52. Van der Schouw YT, Grobbee DE. Menopausal complaints, oestrogens, and heart disease risk: an explanation for discrepant findings on the benefits of postmenopausal hormone therapy. Eur Heart J 2005;26:1358-1361. (Pubitemid 41373511)
53. Gast G-CM, Grobbee DE, Pop VJM, Keyzer JJ, Wijnands-van Gent CJM, Samsioe GN, Nilsson PM, van der Schouw YT. Menopausal complaints are associated with cardiovascular risk factors. Hypertension 2008;51:1492-1498.
54. Gast G-CM, Pop VJ, Samsioe GN, Grobbee DE, Nilsson PM, Keyzer JJ, Wijnands-van Gent CJ, van der Schouw YT. Vasomotor menopausal symptoms are associated with increased risk of coronary heart disease. Menopause 2011; 18:146-151.
55. Bairey Merz CN, Johnson BD, Sharaf BL, Bittner V, Berga SL, Braunstein GD, Hodgson TK, Matthews KA, Pepine CJ, Reis SE, Reichek N, Rogers WJ, Pohost GM, Kelsey SF, Sopko G; WISE Study Group. Hypoestrogenemia of hypothalamic origin and coronary artery disease in premenopausal women: a report from the NHLBI-sponsored WISE study. J Am Coll Cardiol 2003;41: 413-419. (Pubitemid 36164495)
56. Shaw LJ, Bairey Merz CN, Azziz R, Stanczyk FZ, Sopko G, Braunstein GD, Kelsey SF, Kip KE, Cooper-Dehoff RM, Johnson BD, Vaccarino V, Reis SE, Bittner V, Hodgson TK, Rogers W, Pepine CJ. Postmenopausal women with a history of irregular menses and elevated androgen measurements at high risk for worsening cardiovascular event-free survival: results from the National Institutes of Health-NHLBI sponsored Women's Ischemia Syndrome Evaluation. J Clin Endocrinol Metab 2008;93:1276-1284. (Pubitemid 351519721)
57. Bellamy L, Casas JP, Hingorani AD, Williams DJ. Preeclampsia and risk of cardiovascular disease and cancer later in life: systematic review and meta-analysis. BMJ 2007;335:974-983.
58. Magnussen EB, Vatten LJ, Smith GD, Romundstad PR. Hypertensive disorders in pregnancy and subsequently measured cardiovascular risk factors. Obstet Gynaecol 2009;114:961-970.
59. McDonald SD, Malinowski A, Zhou Q, Yusuf S, Devereaux PJ. Cardiovascular sequelae of preeclampsia/eclampsia: a systematic review and meta-analysis. Am Heart J 2008;156:918-930.
60. Retnakaran R, Ying Q, Zinman B, Sermer M, Hanley A, Conelly P. Glucose intolerance in pregnancy and postpartum risk of metabolic syndrome in young women. J Clin Endocrinol Metab 2010;95:670-677.
61. Bellamy L, Casas JP, Hingorani AD, Williams DJ. Type 2 diabetes mellitus after gestational diabetes: a systematic review and meta-analysis. Lancet 2009;373: 1773-1779.
62. Drost JT, Maas AH, van Eyck J, van der Schouw YT. Preeclampsia as a femalespecific risk factor for chronic hypertension. Maturitas 2010;67:321-326.
63. Rozanski A, Blumenthal JA, Davidson KW, Saab PG, Kubzansky L. The epidemiology, pathophysiology and management of psychosocial risk factors in cardiac practice. J Am Coll Cardiol 2005;45:637-651. (Pubitemid 40278960)
64. Low CA, Thurston RC, Matthews KA. Psychosocial factors in the development of heart disease in women: current research and future directions. Psychosom Med 2010;72:842-854.
65. Von Känel R, Orth-Gomér K. Autonomic function and prothrombotic activity in women after an acute coronary event. J Womens Health 2008;17:1331-1337.
66. Orth-Gomer K, Leineweber C. Multiple stressors and coronary disease in women. The Stockholm female coronary risk study. Biol Psychol 2005;69:57-66. (Pubitemid 40299382)
67. Prasad A, Lerman A, Rihal CS. Apical ballooning syndrome (Tako-Tsubo or stress cardiomyopathy): a mimic of acute myocardial infarction. Am Heart J 2008;155:408-417.
68. Vidi V, Rajesh V, Singh PP, Mukherjee JT, Lago RM, Venesy DM, Waxman S, Pyne CT, Piemonte TC, Gossman DE, Nesto RW. Clinical characteristics of Tako-Tsubo cardiomyopathy. Am J Cardiol 2009;104:578-582.
69. Summers MR, Lennon RJ, Prasad A. Pre-morbid psychiatric and cardiovascular diseases in apical ballooning syndrome (Tako-Tsubo/stress-induced cardiomyopathy). J Am Coll Cardiol 2010;55:700-701.
70. Leifheit-Limson EC, Reid KJ, Kasl SV, Lin H, Jones PG, Buchanan DM, Parashar S, Peterson PN, Spertus JA, Lichtman JH. The role for social support in health status and depressive symptoms after acute myocardial infarction: evidence for a stronger relationship among women. Circ Cardiovasc Qual Outcomes 2010; 3:143-150.
71. Orth-Gomér K, Schneiderman N, Wang HX, Walldin C, Blom M, Jernberg T. Stress reduction prolongs life in women with coronary disease. The Stockholm women's intervention trial for coronary heart disease (SWITCHD). Circ Cardiovasc Qual Outcomes 2009;2:25-32.
72. Graham I, Atar D, Borch-Johnsen K, Boysen G, Burell G, Cifkova R, Dallongeville J, De Backer G, Ebrahim S, Gjelsvik B, Herrmann-Lingen C, Hoes A, Humphries S, Knapton M, Perk J, Priori SG, Pyorala K, Reiner Z, Ruilope L, Sans-Menendez S, Op Reimer WS, Weissberg P, Wood D, Yarnell J, Zamorano JL, Walma E, Fitzgerald T, Cooney MT, Dudina A, Vahanian A, Camm J, De Caterina R, Dean V, Dickstein K, Funck-Brentano C, Filippatos G, Hellemans I, Kristensen SD, McGregor K, Sechtem U, Silber S, Tendera M, Widimsky P, Zamorano JL, Altiner A, Bonora E, Durrington PN, Fagard R, Giampaoli S, Hemingway H, Hakansson J, Kjeldsen SE, Larsen L, Mancia G, Manolis AJ, Orth-Gomer K, Pedersen T, Rayner M, Ryden L, Sammut M, Schneiderman N, Stalenhoef AF, Tokgözoglu L, Wiklund O, Zampelas A; European Society of Cardiology (ESC); European Association for Cardiovascular Prevention and Rehabilitation (EACPR); Council on Cardiovascular Nursing; European Association for Study of Diabetes (EASD); International Diabetes Federation Europe (IDF-Europe); European Stroke Initiative (EUSI); Society of Behavioural Medicine (ISBM); European Society of Hypertension (ESH); WONCA Europe (European Society of General Practice/Family Medicine); European Heart Network (EHN); European Atherosclerosis Society (EAS). European guidelines for cardiovascular disease prevention in clinical practice. Eur J Cardiovasc Prev Rehabil 2007;14(suppl.2):S1-S113.
73. Mosca L, Linfante AH, Benjamin EJ, Berra K, Hayes SN, Walsh BW, Fabunmi RP, Kwan J, Mills T, Simpson SL. National study of physician awareness and adherence to cardiovascular disease prevention guidelines. Circulation 2005;111: 499-510. (Pubitemid 40204436)
74. Bairey Merz CN, Mark S, Boyan BD, Jacobs AK, Shah PK, Shaw LJ, Taylor D, Marbán E. Proceedings from the Scientific Symposium: sex differences in cardiovascular disease and implications for therapies. J Womens Health 2010;19: 1059-1072.
75. Pope JH, Aufderheide JP, Ruthazer R, Woolard RH, Feldman JA, Beshansky JR, Griffith JL, Selker HP. Missed diagnoses of acute cardiac ischemia in the emergency department. N Engl J Med 2000;342:1163-1170. (Pubitemid 30211047)
76. Canto JG, Goldberg RJ, Han MM, Bonow RO, Sopko G, Pepine CJ, Long T. Symptom presentation of women with acute coronary syndromes. Myth vs reality. Arch Intern Med 2007;167:2405-2413. (Pubitemid 350258446)
77. Dey S, Flather MD, Devlin G, Brieger D, Gurfunkel EP, Steg PG, Fitzgerald G, Jackson EA, Eagle KA; Global Registry of Acute Coronary Events investigators. Sex-related differences in the presentation, treatment and outcomes among patients with acute coronary syndromes: the Global Registry of Acute Coronary Events. Heart 2009;95:20-26.
78. Daly CA, Clemens F, Sendon JLL, Tavazzi L, Boersma E, Danchin N, Delahaye F, Gitt A, Julian D, Mulcahy D, Ruzyllo W, Thygesen K, Verheugt F, Fox KM; Euro Heart Survey Investigators. Gender differences in the management and clinical outcome in stable angina. Circulation 2006;113:490-498.
79. Mieres JH, Shaw LJ, Arai A, Budoff MJ, Flamm SD, Hundley WG, Marwick TH, Mosca L, Patel AR, Quinones MA, Redberg RF, Taubert KA, Taylor AJ, Thomas GS, Wenger NK; Cardiac Imaging Committee, Council on Clinical Cardiology, and the Cardiovascular Imaging and Intervention Committee, Council on Cardiovascular Radiology and Intervention, American Heart Association. Role of noninvasive testing in the clinical evaluation of women with suspected coronary artery disease. Circulation 2005;111:682-696.
80. Stangl V, Witzel V, Baumann G, Stangl K. Current diagnostic concepts to detect coronary artery disease in women. Eur Heart J 2008;29:707-717. (Pubitemid 351431027)
81. Wenger NK, Shaw LJ, Vaccarino V. Coronary heart disease in women: update .2008. Clin Pharmacol Ther 2008;83:37-51.
82. Jacobs AK. Coronary intervention in 2009. Are women no different than meni Circ Cardiovasc Intervent 2009;2:69-78.
83. Pepine CJ, Anderson RD, Sharaf BL, Reis SE, Smith KM, Handberg EM, Johnson BD, Sopko G, Bairey Merz CN. Coronary microvascular reactivity to adenosine predicts adverse outcome in women evaluated for suspected ischemia. Results from the National Heart, Lung and Blood Institute WISE (Women's Ischemia Syndrome Evaluation) Study. J Am Coll Cardiol 2010;55: 2825-2832.
84. Kruk M, Pregowski J, Mintz GS, Maehara A, Tyczynski P, Witkowski A, Kalinczuk L, Hong YJ, Pichard AD, Satler LF, Kent KM, Suddath WO, Waksman R, Weissman NJ. Intravascular ultrasonic study of gender differences in ruptured coronary plaque morphology and its associated clinical presentation. Am J Cardiol 2007;100:185-189.
85. Doyle M, Weinberg N, Pohost GM, Bairey Merz CN, Shaw LJ, Sopko G, Fuisz A, Rogers WJ, Walsh EG, Johnson BD, Sharaf BL, Pepine CJ, Mankad S, Reis SE, Vido DA, Rayaro G, Bittner V, Tauxe L, Olson MB, Kelsey SF, Biederman RWW. Prognostic value of global MR myocardial perfusion imaging in women with suspected myocardial ischemia and no obstructive coronary disease. Results from the NHLBI-sponsored WISE (Women's Ischemic Syndrome Evaluation) Study. J Am Coll Cardiol Img 2010;3:1030-1036.
86. Shaw LJ, Min JK, Narula J, Lin F, Bairey Merz CN, Callister TQ, Berman DS. Sex differences in mortality associated with computed tomographic angiographic measurements of obstructive and nonobstructive coronary artery disease. An exploratory analysis. Circ Cardiovasc Imaging 2010;3:473-481.
87. Clayton TC, Pocock SJ, Henderson RA, Poole-Wilson PA, Shaw TR, Knight R, Fox KA. Do men benefit more than women from an interventional strategy in patients with unstable angina or non-ST-elevation myocardial infarctioni The impact of gender in the RITA3 trial. Eur Heart J 2004;25:1641-1650. (Pubitemid 39209285)
88. O'Donoghue M, Boden WE, Braunwald E, Cannon CP, Clayton TC, de Winter RJ, Fox KA, Lagerqvist B, McCullough PA, Murphy SA, Spacek R, Swahn E, Wallentin L, Windhausen F, Sabatine MS. Early invasive versus conservative treatment strategies in women and men with unstable angina and non-ST-elevation myocardial infarction: a meta-analysis. JAMA 2008;300:71-80. (Pubitemid 351920406)
89. Vaccarino V, Parsons L, Every NR, Barron HV, Krumholz HM. Sex-based differences in early mortality after myocardial infarction. National Registry of Myocardial Infarction 2 Participants. N Engl J Med 1999;341:217-225. (Pubitemid 29334519)
90. Lawesson SS, Stenestrand U, Lagerqvist B, Wallentin L, Swahn E. Gender perspective on risk factors, coronary lesions and long-term outcome in young patients with ST- elevation myocardial infarction. Heart 2010;96:453-459.
91. Berger JS, Elliott L, Gallup D, Roe M, Granger CB, Armstrong PW, Simes RJ, White HD, Van de Werf F, Topol EJ, Hochman JS, Newby LK, Harrington RA, Califf RM, Becker RC, Douglas PS. Sex differences in mortality following acute coronary syndromes. JAMA 2009;302:874-882.
92. Hochman JS, Tamis JE, Thompson TD,Weaver WD, White HD, Van deWerf F, Aylward P, Topol EJ, Califf RM. Sex, clinical presentation, and outcome in patients with acute coronary syndromes. N Engl J Med 1999;341:226-232. (Pubitemid 29334520)
93. Gulati M, Cooper-DeHoff RM, McClure C, Johnson D, Shaw LJ, Handberg EM, Zineh I, Kelsey SF, Arnsdorf MF, Black HR, Pepine CJ, Merz CN. Adverse cardiovascular outcomes in women with nonobstructive coronary artery disease. A report from the Women's Ischemia Syndrome Evaluation Study and the St James Women take Heart Project. Arch Intern Med 2009;169:843-850.
94. Arant CB, Wessel TR, Ridker PM, Olson MB, Reis SE, Johnson DB, Sharaf BL, Pauly DF, Handberg E, Zineh I, Sopko G, Kelsey SF, Noel Bairey Merz C, Pepine CJ. Multimarker approach predicts adverse cardiovascular events in women evaluated for suspected ischemia: a report from the NHLBI-sponsored WISE-study. Clin Cardiol 2009;32:244-250.
95. Alexander KP, Chen AY, Newby LK, Schwartz JB, Redberg RF, Hochman JS, Roe MT, Gibler WB, Ohman EM, Peterson ED; CRUSADE (Can Rapid risk stratification of Unstable angina patients Suppress ADverse outcomes with Early implementation of the ACC/AHA guidelines) Investigators. Sex differences in major bleeding with glycoprotein IIb/IIIa inhibitors: results from the CRUSADE initiative. Circulation 2006;114:1380-1387. (Pubitemid 44462663)
96. Hemingway H, Langenberg C, Damant J, Frost C, Pyörälä K, Barrett-Connor E. Prevalence of angina in women versus men. A systematic review and meta-analysis of international variations across 31 countries. Circulation 2008; 117:1526-1536. (Pubitemid 351440641)
97. Robinson JG, Wallace R, Limacher M, Ren H, Cochrane B, Wassertheil-Smoller S, Ockene JK, Blanchette PL, Ko MG. Cardiovascular risk in women with non-specific chest pain (from the Women's Health Initiative hormone trials). Am J Cardiol 2008;102:693-699.
98. Bugiardini R, Manfrini O, Pizzi C, Fontana F, Morgagni G. Endothelial function predicts future development of coronary artery disease: a study of women with chest pain and normal coronary angiograms. Circulation 2004;109:2993-2999.
99. Xhyheri B, Bugiardini R. Diagnosis and treatment of heart disease: are women different from meni Prog Cardiovasc Dis 2010;53:227-236.
100. Borissoff JI, Heeneman S, Kilinç E, KassáK P, van Oerle R, Winckers K, Govers-Riemslag JW, Hamulyák K, Hackeng TM, Daemen MJ, ten Cate H, Spronk HM. Early atherosclerosis exhibits an enhanced procoagulant state. Circulation 2010;122:821-830.
101. Mackman N. Triggers, targets and treatments for thrombosis. Nature 2008;451: 914-918. (Pubitemid 351301746)
102. Roshan TM, Normah J, Rehman A, Naing L. Effect of menopause on platelet activation markers determined by flow cytometry. Am J Hematol 2005;80:257-261. (Pubitemid 41746172)
103. Sowers MR, Matthews KA, Jannausch M, Randolph JF, McConnell D, Sutton-Tyrrell K, Little R, Lasley B, Pasternak R. Hemostatic factors and estrogen during the menopausal transition. J Clin Endocrinol Metab 2005;90:5942-5948. (Pubitemid 41606509)
104. Herrington DM, Potvin Klein K. Genome and hormones: gender differences in physiology. Invited review: pharmacogenetics of estrogen replacement therapy. J Appl Physiol 2001;91:2776-2784. (Pubitemid 33108045)
105. Ridker PM, Cook NR, Lee IM, Gordon D, Gaziano JM, Manson JE, Hennekens CH, Buring JE. A randomized trial of low-dose aspirin in the primary prevention of cardiovascular disease in women. N Engl J Med 2005; 352:1293-1304.
106. Steering Committee of the Physicians' Health Study Research Group. Final report on the aspirin component of the ongoing Physicians' Health Study. N Engl J Med 1989;321:129-135.
107. Berger JS, Roncaglioni MC, Avanzini F, Pangrazzi I, Tognoni G, Brown DL. Aspirin for the primary prevention of cardiovascular events in women and men. A sexspecific meta-analysis of randomized controlled trials. JAMA 2006;95:306-313.
108. Capodanno D, Angiolillo DJ. Impact of race and gender on antithrombotic therapy. Thromb Haemost 2010;104:471-484.
109. Fang MC, Singer DE, Chang Y, Hylek EM, Henault LE, Jensvold NG, Go AS. Gender differences in the risk of ischemic stroke and peripheral embolism in atrial fibrillation: the AnTicoagulation and Risk factors In Atrial fibrillation (ATRIA) study. Circulation 2005;112:1687-1691. (Pubitemid 41368143)
110. European Heart Rhythm Association; European Association for Cardio-Thoracic Surgery, Camm AJ, Kirchhof P, Lip GY, Schotten U, Savelieva I, Ernst S, Van Gelder IC, Al-Attar N, Hindricks G, Prendergast B, Heidbuchel H, Alfieri O, Angelini A, Atar D, Colonna P, De Caterina R, De Sutter J, Goette A, Gorenek B, Heldal M, Hohloser SH, Kolh P, Le Heuzey JY, Ponikowski P, Rutten FH. Guidelines for the management of atrial fibrillation. Eur Heart J 2010;31:2369-2429.
111. Mosterd A, Hoes AW. Clinical epidemiology of heart failure. Heart 2007;93: 1137-1146. (Pubitemid 47311002)
112. Task Force for Diagnosis and Treatment of Acute and Chronic Heart Failure 2008 of European Society of Cardiology, Dickstein K, Cohen-Solal A, Filippatos G, McMurray JJ, Ponikowski P, Poole-Wilson PA, Strömberg A, van Veldhuisen DJ, Atar D, Hoes AW, Keren A, Mebazaa A, Nieminen M, Priori SG, Swedberg K; ESC Committee for Practice Guidelines, Vahanian A, Camm J, De Caterina R, Dean V, Dickstein K, Filippatos G, Funck-Brentano C, Hellemans I, Kristensen SD, McGregor K, Sechtem U, Silber S, Tendera M, Widimsky P, Zamorano JL. ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure 2008. Eur Heart J 2008;29:2388-2442.
113. Owan TE, Hodge DO, Herges RM, Jacobsen SJ, Roger VL, Redfield MM. Trends in prevalence and outcome of heart failure with preserved ejection fraction. N Engl J Med 2006;355:251-259. (Pubitemid 44079340)
114. Nieminen MS, Harjola VP, Hochadel M, Drexler H, Komadja M, Brutsaert D, Dickstein K, Ponikowski P, Tavazzi L, Follath F, Lopez-Sendon JL. Gender-related differences in patients presenting with acute heart failure. Results from Euro Heart Failure Survey II. Eur J Heart Fail 2008;10:140-148. (Pubitemid 351221390)
115. Regitz-Zagrosek V, Brokat S, Tschope C. Role of gender in heart failure with normal left ventricular ejection fraction. Prog Cardiovasc Dis 2007;49:241-251. (Pubitemid 44932176)
116. Petrov G, Regitz-Zagrosek V, Lehmkuhl E, Krabatsch T, Dunkel A, Dandel M, Dworatzek E, Mahmoodzadeh S, Schubert C, Becher E, Hampl H, Hetzer R. Regression of myocardial hypertrophy after aortic valve replacement. Faster in womeni Circulation 2010;122(Suppl. 11 ):S23-S28.
117. Fliegner D, Schubert C, Penkalla A, Witt H, Kararigas G, Dworatzek E, Staub E, Martus P, Ruiz Noppinger P, Kintscher U, Gustafsson JA, Regitz-Zagrosek V. Female sex and estrogen receptor-beta attenuate cardiac remodeling and apoptosis in pressure overload. Am J Physiol Regul Integr Comp Physiol 2010;298: R1597-R1606.
118. Regitz-Zagrosek V, Oertelt-Prigione S, Seeland U, Hetzer R. Sex and gender differences in myocardial hypertrophy and heart failure. Circ J 2010;74: 1265-7123.
119. Heidecker B, Lamirault G, Kasper EK, Wittstein IS, Champion HC, Breton E, Russell SD, Hall J, Kittleson MM, Baughman KL, Hare JM. The gene expression profile of patients with new-onset heart failure reveals important gender-specific differences. Eur Heart J 2010;31:1188-1196.
120. Ntusi NB, Mayosi BM. Aetiology and risk factors of peripartum cardiomyopathy: a systematic review. Int J Cardiol 2009;131:168-179.
121. Yamac H, Bultman I, Sliwa K, Hilfiker-Kleiner D. Prolactin: a new therapeutic target in peripartum cardiomyopathy. Heart 2010;96:1352-1357.
122. Jones LW, Haykowsky MJ, Swartz JJ, Douglas PS, Mackey JR. Early breast cancer therapy and cardiovascular injury. J Am Coll Cardiol 2007;50:1435-1441. (Pubitemid 47494586)
123. Gerdes AM, Iervasi G. Thyroid replacement therapy and heart failure. Circulation 2010;122:385-393.
124. Dö rr M, Ittermann T, Aumann N, Obst A, Reffelmann T, Nauck M, Wallaschofski H, Felix SB, Vö lzke H. Subclinical hyperthyroidism is not associated with progression of cardiac mass and development of left ventricular hypertrophy in middle-aged and older subjects. Results from a five-year follow-up. Clin Endocrinol 2010;73:821-826.
125. Cleland JGF, Swedberg K, Follath F, Komadja M, Cohen-Solal A, Aguilar AC, Dietz R, Gavazzi A, Hobbs R, Korewicki J, Madeira HC, Moiseyev VS, Preda I, van Gilst WH, Widimsky J, Freemantle N, Eastaugh J, Mason J; Study Group on Diagnosis of the Working Group on Heart Failure of the European Society of Cardiology. The EuroHeart Failure survey programme-a survey on the quality of care among patients with heart failure in Europe. Eur Heart J 2003;24:442-463. (Pubitemid 36286187)
126. Nieminen MS, Brutsaert D, Dickstein K, Drexler H, Follath F, Harjola VP, Hochadel M, Komadja M, Lassus J, Lopez-Sendon JL, Ponikowski P, Tavazzi L, on behalf of the EuroHeart Survey investigators. EuroHeart Failure Survey II (EHFS II): a survey on hospitalized acute heart failure patients: description of population. Eur Heart J 2006;27:2725-2736. (Pubitemid 44729876)
127. Rathore SS, Wang Y, Krumholz HM. Sex-based differences in the effect of digoxin for the treatment of heart failure. N Engl J Med 2002;347:1403-1411. (Pubitemid 35239712)
128. Simon T, Mary-Krause M, Funck-Brentano C, Jaillon P. Sex differences in the prognosis of congestive heart failure: results from the Cardiac Insufficiency bispoprolol Study (CIBIS II). Circulation 2001;103:375-380. (Pubitemid 32105976)
129. Parashar S, Katz R, Smith NL, Arnold AM, Vaccarino V, Wenger NK, Gottdiener JS. Race, gender and mortality in adults ≥65 years of age with incident heart failure (from the Cardiovascular Health Study). Am J Cardiol 2009; 103:1120-1127.
130. Moss AJ, Hall WJ, Cannom DS, Klein H, Brown MW, Daubert JP, Estes NA III, Foster E, Greenberg H, Higgins SL, Pfeffer MA, Solomon SD, Wilber D, Zareba W; MADIT-CRT Trial Investigators. Cardiac-resynchronization therapy for the prevention of heart-failure events. N Engl J Med 2009;361:1329-1338.
131. Peterson PN, Daugherty SL, Wang Y, Vidaillet HJ, Heidenreich PA, Curtis JP, Masoudi FA. Gender differences in procedure-related adverse events in patients receiving implantable cardioverter-defibrillator therapy. Circulation 2009;119: 1078-1084.
132. Stramba-Badiale M, Fox KM, Priori SG, Collins P, Daly C, Graham I, Jonsson B, Schenck-Gustafsson K, Tendera M. Cardiovascular diseases in women: a statement from the policy conference of the European Society of Cardiology. Eur Heart J 2006;27:994-1005.
133. Collins P, Rosano G, Casey C, Daly C, Gambacciani M, Hadji P, Kaaja R, Mikkola T, Palacios S, Preston R, Simon T, Stevenson J, Stramba-Badiale M. Management of cardiovascular risk in the perimenopausal woman: a consensus statement of European cardiologist and gynaecologists. Eur Heart J 2007;28: 2028-2040. (Pubitemid 47579557)
134. Dallongevillle J, De Bacquer D, Heidrich J, De Backer G, Prugger C, Kotseva K, Montaye M, Amouyel P; EUROASPIRE Study Group. Gender differences in the implementation of cardiovascular prevention measures after an acute coronary event. Heart 2010;96:1744-1749.